Cited by 119Sexual Differentiation and DisordersAdrenal Hormones and DisordersPregnancy and preeclampsia studies

Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis

Morel, Yves, Roucher, Florence, Plotton, Ingrid, Goursaud, Claire, Tardy, Véronique, Mallet, Delphine·2016·Annales d'Endocrinologie

Abstract

Progesterone, estrogens, androgens and glucocorticoids are involved in pregnancy from implantation to parturition. Their biosynthesis and their metabolism result from complex pathways involving the fetus, the placenta and the mother. The absence of expression of some steroïdogenic enzymes as CYP17 in placenta and in adrenal fetal zone and the better determination of the onset and variation of others especially HSD3B2 during the pregnancy explain the production of the steroid hormones. Moreover the consequences of some disorders of steroidogenesis (especially aromatase, POR, CYP11A1 and 21-hydroxylase deficiencies) in fetus and mother during the pregnancy have permit to elucidate these complex pathways. This better knowledge of steroid hormones production associated with their dosages in maternal plasma/urine or amniotic fluid using new specific assays as LC-MS MS could facilitate the follow-up of normal and pathological pregnancies. Moreover, these advances should be a basis to evaluate the impact of multiple pathologies of the pregnancy and pharmacologic and xenobiotic consequences on their metabolism.

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Crossref · 10.1016/j.ando.2016.04.023

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Authors
Morel, Y., Roucher, F., Plotton, I., Goursaud, C., Tardy, V., & Mallet, D.
Affiliations
Hospices Civils de Lyon (FR)
Corresponding author
Morel, Yves
Venue
Annales d'Endocrinologie
Publisher
Elsevier BV
Published
2016-06
Volume
77
Issue
2
Pages
82-89
ISSN
0003-4266 (ISSN-L)
OpenAlex
W2346539821
Cited by
119
References
76
Citations by year
2026: 9 · 2025: 13 · 2024: 9 · 2023: 15 · 2022: 18 · 2021: 17 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 1
FWCI
4.85
Type
journal article
Language
en
Open access
closed
Locations
  • Annales d Endocrinologie (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
progesterone, estrogen, androgens, glucocorticoids, CYP17, HSD3B2, aromatase deficiency, P450 oxidoreductase deficiency, 21-hydroxylase deficiency
MeSH terms
Androgens, Estrogens, Female, Fetus, Glucocorticoids, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy

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