Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis
Abstract
Progesterone, estrogens, androgens and glucocorticoids are involved in pregnancy from implantation to parturition. Their biosynthesis and their metabolism result from complex pathways involving the fetus, the placenta and the mother. The absence of expression of some steroïdogenic enzymes as CYP17 in placenta and in adrenal fetal zone and the better determination of the onset and variation of others especially HSD3B2 during the pregnancy explain the production of the steroid hormones. Moreover the consequences of some disorders of steroidogenesis (especially aromatase, POR, CYP11A1 and 21-hydroxylase deficiencies) in fetus and mother during the pregnancy have permit to elucidate these complex pathways. This better knowledge of steroid hormones production associated with their dosages in maternal plasma/urine or amniotic fluid using new specific assays as LC-MS MS could facilitate the follow-up of normal and pathological pregnancies. Moreover, these advances should be a basis to evaluate the impact of multiple pathologies of the pregnancy and pharmacologic and xenobiotic consequences on their metabolism.
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Developing mammals are exposed to progesterone from fetal and maternal sources.
“Developing mammals are exposed to progesterone, both from fetal and maternal sources (reviewed in [2, 3]).”
From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [3]
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- Authors
- Morel, Y., Roucher, F., Plotton, I., Goursaud, C., Tardy, V., & Mallet, D.
- Affiliations
- Hospices Civils de Lyon (FR)
- Corresponding author
- Morel, Yves
- Venue
- Annales d'Endocrinologie
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 77
- Issue
- 2
- Pages
- 82-89
- ISSN
- 0003-4266 (ISSN-L)
- OpenAlex
- W2346539821
- Cited by
- 119
- References
- 76
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 9 · 2023: 15 · 2022: 18 · 2021: 17 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annales d Endocrinologie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- progesterone, estrogen, androgens, glucocorticoids, CYP17, HSD3B2, aromatase deficiency, P450 oxidoreductase deficiency, 21-hydroxylase deficiency
- MeSH terms
- Androgens, Estrogens, Female, Fetus, Glucocorticoids, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy
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