Cited by 173Adrenal Hormones and DisordersHormonal and reproductive studiesStress Responses and Cortisol

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Dehydroepiandrosterone as a regulator of immune cell function

Hazeldine, Jon, Arlt, Wiebke, Lord, Janet M.·2010·The Journal of Steroid Biochemistry and Molecular Biology

DOI 10.1016/j.jsbmb.2009.12.016

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Abstract

Dehydroepiandrosterone (DHEA) is a C19 steroid of adrenal origin. Notably, its secretion declines with age, a phenomenon referred to as the "adrenopause". For many years, the physiological significance of DHEA remained elusive. However, many studies have now shown that DHEA has significant immune modulatory function, exhibiting both immune stimulatory and anti-glucocorticoid effects. Although several of these studies are limited by the fact that they were carried out in rodents, who are incapable of adrenal DHEA production, and therefore have very low circulating levels of this steroid, evidence from the study of immune cells is now accumulating to suggest a role for DHEA in regulating human immunity. This ability to regulate immune function has raised interest in the therapeutic potential of DHEA as a treatment for the immunological abnormalities that arise in subjects with low circulating levels of this hormone. This has included attempts at reversing the impaired immune response of older individuals to vaccination and restoring immune regulation in patients with chronic autoimmune disease. This review summarises the reported effects of DHEA on immune function and discusses the therapeutic potential of this steroid in geriatric medicine and particularly in age-related disease with an immune component.

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Authors: Hazeldine, J., Arlt, W., & Lord, J. M.
Affiliations: University of Birmingham (GB)
Corresponding author: Lord, Janet M.
ORCID: Hazeldine, Jon
Arlt, Wiebke
Lord, Janet M.
Venue: The Journal of Steroid Biochemistry and Molecular Biology
Publisher: Elsevier BV
Published: 2010-05
Volume: 120
Issue: 2-3
Pages: 127-136
ISSN: 0960-0760 (ISSN-L)
DOI: 10.1016/j.jsbmb.2009.12.016
OpenAlex: W2028573458
Cited by: 173
References: 130
Citations by year: 2026: 5 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 14 · 2018: 15 · 2017: 10 · 2016: 13 · 2015: 15 · 2014: 14 · 2013: 11 · 2012: 8
FWCI: 9.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council
MRC (0900567)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: dehydroepiandrosterone, immunomodulation, aging, glucocorticoid antagonism, immunostimulation, immunosenescence, autoimmune disease, immunotherapy, sex steroids
MeSH terms: Aging, Animals, Dehydroepiandrosterone, Humans, Leukocytes, Lupus Erythematosus, Systemic, Lymphoid Tissue

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Dehydroepiandrosterone as a regulator of immune cell function

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