Metabolic Effects of 20-OH-Ecdysone in Ovariectomized Rats
Abstract
Postmenopausal women develop often obesity which may be prevented by 20-OH-Ecdysone (Ecd). This was investigated in ovariectomized (ovx) rats. They were orally treated with 3 doses of Ecd (18, 56 or 116 mg/day/animal). Positive controls received 159 microg estradiol (E2). Quantitative computer tomography at the level of the abdomen and the metaphysis of the tibia allowed estimation of surface, fat depots and muscles. The highest dose of Ecd resulted in serum concentrations of 0.4 x 10(-6)M. Serum E2 concentrations in the positive controls were 73.3+/-24.41 pg/ml. E2 but not Ecd stimulated uterine weights. Under Ecd ovx animals gained less fat but had more muscle mass. Serum TSH, T4 and T3 levels remained unaffected while E2 treatment increases T4 but decreases T3 levels. Ecd at the lowest dose lowered serum LDL and did not result in increased serum triglycerides, an effect seen in the E2 treated rats. At the Ecd highest dose serum HDL was higher than in the controls. In conclusion Ecd has beneficial effects on fat and muscle tissue and may be able to prevent the metabolic syndrome and sarcopenia by a non-estrogenic mechanism.
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Ovariectomized rats fed dosages of up to 500 mg/kg daily for three months showed no obvious adverse responses.
“Seidlova-Wuttke et al. conducted a study in which ovariectomized rats were fed dosages of up to 500 mg/kg daily for three months with no obvious adverse responses [47].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [47]
Ecdysterone does not appear to possess any severe side effects.
“Furthermore, ecdysterone does not appear to possess any severe side effects [19,47,49,50,51,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [47]
Ecdysterone exerts its anabolic effects primarily through interaction with nuclear receptors, though its mechanism differs from that of traditional anabolic steroids.
“Ecdysterone, like other ecdysteroids, exerts its anabolic effects primarily through interaction with nuclear receptors, though its mechanism differs from that of traditional anabolic steroids.”
From Molecular insights into the role of Estrogen Receptor Beta in Ecdysterone Mediated Anabolic Activity (2025) · cites this paper as [5]
Significant structural differences between ecdysteroids and anabolic-androgenic steroids may account for their distinct anabolic mechanisms.
“The significant structural differences between ecdysteroids and anabolic-androgenic steroids may account for their distinct anabolic mechanisms [4,5].”
From Molecular insights into the role of Estrogen Receptor Beta in Ecdysterone Mediated Anabolic Activity (2025) · cites this paper as [5]
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- Authors
- Seidlova-Wuttke, D., Ehrhardt, C., & Wuttke, W.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Wuttke, Wolfgang
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 119
- Issue
- 3-5
- Pages
- 121-126
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2029214471
- Cited by
- 57
- References
- 33
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 6
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- 20-hydroxyecdysone, ovariectomy, postmenopausal obesity, estradiol, fat mass, muscle mass, thyroid hormones, serum lipids, LDL cholesterol, HDL cholesterol, triglycerides, uterine weight, metabolic syndrome, sarcopenia
- MeSH terms
- Animals, Body Composition, Dose-Response Relationship, Drug, Ecdysterone, Estrogens, Female, Hindlimb, Lipids, Obesity, Organ Size, Ovariectomy, Thyroid Hormones, Thyrotropin, Uterus, Rats, Sprague-Dawley, Postmenopause, Leptin, Metabolic Syndrome, Intra-Abdominal Fat, Rats, Sarcopenia
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