Cited by 15Liver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseDrug-Induced Hepatotoxicity and Protection

High-carbohydrate diet-induced metabolic disorders in Gerbillus tarabuli (a new model of non-alcoholic fatty-liver disease). Protective effects of 20-hydroxyecdysone

Agoun, Hadjer, Semiane, Nesrine, Mallek, Aicha, Bellahreche, Zineb, Hammadi, Soumia, Madjerab, Maha, Abdlalli, Mohamed, Khalkhal, Ali +1 more·2021·Archives of Physiology and Biochemistry

Abstract

The aim of our study was to reveal the effects of long-term consumption of a high-carbohydrate diet (HCD) on metabolic dysfunctions and histopathological liver alterations in Gerbillus tarabuli, as well as to assess the preventive effects of 20-hydroxyecdysone (20E) in the same animals. Contrary to control diet, HCD induces several metabolic disorders including increased adiposity, dyslipidemia, ectopic fat deposition in the liver, associated with higher levels of plasma AST and ALT. These gerbils showed enhanced oxidative stress with liver damages characteristic of steatohepatitis development. By contrast, adding 20E to HCD resulted in a dose-dependent reduction of all changes induced by HCD. In addition, the hepatoprotective effect of 20E was demonstrated by decreased plasma concentrations of AST, ALT and of hepatic malondialdehyde. Our results suggest that G. tarabuli represents a good model to study diet-induced metabolic disorders and hepatic dysfunctions. Moreover, they demonstrate the efficacy of 20E treatment to counteract the damaging effects of HCD.

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Crossref · 10.1080/13813455.2019.1621350

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Authors
Agoun, H., Semiane, N., Mallek, A., Bellahreche, Z., Hammadi, S., Madjerab, M., Abdlalli, M., Khalkhal, A., & Dahmani, Y.
Affiliations
  • University of Sciences and Technology Houari Boumediene (DZ)
  • Service of Pathology and Anatomy, CHU Hussein Dey: Ex: Parnet, Algiers, Algeria
Corresponding author
Agoun, Hadjer
Venue
Archives of Physiology and Biochemistry
Published
2019-06-13
Volume
127
Issue
2
Pages
127-135
ISSN
  • 0778-3124 (ISSN-L)
  • 1381-3455
  • 1744-4160
OpenAlex
W2953377598
Cited by
15
References
48
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Physiology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Algerian Ministry of Higher Education and Scientific Research
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
high-carbohydrate diet, non-alcoholic fatty liver disease, 20-hydroxyecdysone, steatohepatitis, hepatic steatosis, oxidative stress, malondialdehyde, dyslipidemia, adiposity, hepatoprotection, ALT and AST, animal models
MeSH terms
Diet, Carbohydrate Loading, Animals, Ecdysterone, Gerbillinae, Male, Metabolic Diseases, Oxidative Stress, Protective Agents, Non-alcoholic Fatty Liver Disease

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