Effective method to remove wound bacteria: comparison of various debridement modalities in an in vivo porcine model
Abstract
Background Debridement is one of the crucial steps for successful wound care. In addition to removing necrotic tissue, debridement has been shown to reduce wound-associated bacteria that delay healing. Using an in vivo porcine model, we compared the effects of various methods of debridement, including hydrosurgery and plasma-mediated bipolar radiofrequency ablation (PBRA), on bacterial removal and wound healing.Methods One hundred thirty-five deep dermal wounds were inoculated with methicillin resistant Staphylococcus aureus (MRSA) and covered with a polyurethane dressing for 48 h to allow for biofilm formation. Wounds were then treated with either PBRA (at two settings), hydrosurgery, sharp debridement, or no debridement. Biopsies were collected for microbiology and histologic assessment on d 0, 2, 9, and 21 post-treatment.Results All treatment groups showed a statistically significant reduction in MRSA counts relative to no debridement at all times points (P < 0.05). PBRA at a maximum setting had the lowest MRSA counts at all recovery times and, compared with all other treatment groups, a statistically significant difference was observed on d 21 (P < 0.05). No detrimental effects on the healing process were noted with any of the debridement methods.Conclusion While sharp debridement has been established as the traditional gold standard for rapid removal of necrotic, infected tissue, our results suggest that novel debridement modalities show clinical promise for the treatment of chronic ulcers and burn wounds, especially when bacteria are present.
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We utilized a well-established porcine partial thickness wound healing model.
“We utilized a well-established porcine partial thickness wound healing model”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [19]
The porcine skin wound model is well-established.
“In order to investigate functional consequences of polymicrobial infection with USA300 and P. aeruginosa on acute wound healing we utilized a well-established porcine skin wound model [19], [43], [46].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [19]
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Mesenchymal Stem Cell–Based Therapies for Repair and Regeneration of Skin Wounds
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- Authors
- Nusbaum, A. G., Gil, J., Rippy, M. K., Warne, B., Valdes, J., Claro, A., & Davis, S. C.
- Affiliations
- University of Miami (US)
- Good Samaritan Hospital (US)
- Corresponding author
- Davis, Stephen C.
- Venue
- Journal of Surgical Research
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 176
- Issue
- 2
- Pages
- 701-707
- ISSN
- 0022-4804 (ISSN-L)
- OpenAlex
- W2032992088
- Cited by
- 75
- References
- 52
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 2
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Keywords
- wound debridement, bacterial removal, methicillin-resistant Staphylococcus aureus, MRSA biofilm, hydrosurgery, sharp debridement, wound healing, chronic wounds, burn wounds, porcine model
- MeSH terms
- Animals, Debridement, Disease Models, Animal, Female, Fibrosis, Hydrotherapy, Leukocytes, Necrosis, Staphylococcal Skin Infections, Swine, Wound Healing, Wounds and Injuries, Catheter Ablation, Methicillin-Resistant Staphylococcus aureus
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