Anti-inflammatory effects of banana (Musa balbisiana) peel extract on acne vulgaris: In vivo and in silico study
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Objective: ) peel extract (MBPE) against AV. Methods: Thirty rats were divided into five groups (n = 6 rats per group): an AV group, AV group treated with 0.15% MBPE, AV group administered 0.30% MBPE, AV group administered 0.60% MBPE, and AV group administered clindamycin (the standard drug treatment). We assessed nodule size, bacterial count, histopathology, and cytokine levels (IL-1α, IFN-γ, tumor necrosis factor (TNF)-α, and IL-8). Enzyme linked immunoassays were used to measure the cytokine levels. In addition, we performed molecular docking studies to determine the interactions between phytochemicals (trigonelline, vanillin, ferulic acid, isovanillic acid, rutin, and salsolinol) via the Toll-like receptor 2 (TLR2) and nuclear factor-kappa B (NF-κB) pathways. Results: All MBPE treatment groups, compared with the AV group, showed suppression of both bacterial growth and proinflammatory cytokine production, as well as resolved tissue inflammation. The nodule size was significantly suppressed in the groups receiving the two highest doses of MBPE, compared with the AV group. However, the pharmacological action of MBPE remained inferior to that of clindamycin. Docking studies demonstrated that rutin was the phytocompound with the most negative interaction energy with TLR2 or NF-κB. Conclusions: Our results indicated that MBPE has anti-inflammatory effects against AV, by suppressing nodule formation, inhibiting bacterial growth, and decreasing proinflammatory cytokine production.
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Most of the literature has focused on simple antioxidant tests, antimicrobial studies or animal models, with limited translation to evaluate application performance, safety in RHE or scalability for use in cosmeceutical preparations.
“Notwithstanding these encouraging results, most of the literature has focused on simple antioxidant tests, antimicrobial studies or animal models, with limited translation to evaluate application performance, safety in RHE or scalability for the use in cosmeceutical preparations [12 - 17].”
From Formulation development, physical stability, and preliminary safety screening of cosmetic emulsions containing banana peel extract (2026) · cites this paper as [14]
The Discussion (page not available) describes this study as an acne-vulgaris rat model assessing anti-inflammatory and antibacterial effects, so it exemplifies the animal-model and antimicrobial work mentioned in the citing sentence. The paper does not establish that most of the literature has this focus or assess the broader literature’s application performance, safety in reconstructed human epidermis (RHE), or cosmeceutical scalability. (LLM, conf=0.84)
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- Authors
- Savitri, D., Wahyuni, S., Bukhari, A., Djawad, K., Hatta, M., Riyanto, P., Bahar, B., Wahab, S., Hamid, F., & Rifai, Y.
- Affiliations
- Hasanuddin University (ID)
- Corresponding author
- Savitri, Dwiana
- ORCID
- Venue
- Journal of Taibah University Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2023-12
- Volume
- 18
- Issue
- 6
- Pages
- 1586-1598
- ISSN
- 1658-3612 (ISSN-L)
- PMC
- PMC10492217
- OpenAlex
- W4385382759
- Cited by
- 13
- References
- 63
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 1
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Taibah University Medical Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- banana peel extract, Musa balbisiana, acne, anti-inflammatory activity, inflammatory cytokines, TLR2, NF-κB signaling, rutin, phytochemicals, Staphylococcus aureus, clindamycin
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