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Cost-Effectiveness Analysis Alongside Clinical Trials II—An ISPOR Good Research Practices Task Force Report

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Ramsey, Scott D., Willke, Richard J., Glick, Henry, Reed, Shelby D., Augustovski, Federico, Jonsson, Bengt, Briggs, Andrew, Sullivan, Sean D.·2015·Value in Health

DOI 10.1016/j.jval.2015.02.001

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Abstract

Clinical trials evaluating medicines, medical devices, and procedures now commonly assess the economic value of these interventions. The growing number of prospective clinical/economic trials reflects both widespread interest in economic information for new technologies and the regulatory and reimbursement requirements of many countries that now consider evidence of economic value along with clinical efficacy. As decision makers increasingly demand evidence of economic value for health care interventions, conducting high-quality economic analyses alongside clinical studies is desirable because they broaden the scope of information available on a particular intervention, and can efficiently provide timely information with high internal and, when designed and analyzed properly, reasonable external validity. In 2005, ISPOR published the Good Research Practices for Cost-Effectiveness Analysis Alongside Clinical Trials: The ISPOR RCT-CEA Task Force report. ISPOR initiated an update of the report in 2014 to include the methodological developments over the last 9 years. This report provides updated recommendations reflecting advances in several areas related to trial design, selecting data elements, database design and management, analysis, and reporting of results. Task force members note that trials should be designed to evaluate effectiveness (rather than efficacy) when possible, should include clinical outcome measures, and should obtain health resource use and health state utilities directly from study subjects. Collection of economic data should be fully integrated into the study. An incremental analysis should be conducted with an intention-to-treat approach, complemented by relevant subgroup analyses. Uncertainty should be characterized. Articles should adhere to established standards for reporting results of cost-effectiveness analyses. Economic studies alongside trials are complementary to other evaluations (e.g., modeling studies) as information for decision makers who consider evidence of economic value along with clinical efficacy when making resource allocation decisions.

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MethodInfluential
Photodynamic Diagnosis-guided Transurethral Resection of Bladder Tumour in Participants with a First Suspected Diagnosis of Intermediate- or High-risk Non–muscle-invasive Bladder Cancer: Cost-effectiveness Analysis Alongside a Randomised Controlled Trial
Yu, G., Rice, S. J. C., Heer, R., Lewis, R., Vadiveloo, T., Mariappan, P., Penegar, S., Clark, E., Tandoğdu, Z., Hall, E., et al. (2023) · European Urology Open Science · doi:10.1016/j.euros.2023.05.003 · Cited by 8
“tional Society For Pharmacoeconomics and Outcomes Research guidelines [14].”
Background
Cost-effectiveness of craniotomy versus decompressive craniectomy for UK patients with traumatic acute subdural haematoma
Pyne, S., Barton, G., Turner, D., Mee, H., GREGSON, B. A., Kolias, A. G., Turner, C. L., Adams, H., Mohan, M., Uff, C. E. G., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085084 · Cited by 8
Health Economic Evaluation of Lung Cancer Screening Using a Diagnostic Blood Test: The Early Detection of Cancer of the Lung Scotland (ECLS)
Robles‐Zurita, J. A., McMeekin, N., Sullivan, F., Mair, F. S., & Briggs, A. H. (2024) · Current Oncology · doi:10.3390/curroncol31060261 · Cited by 8
“Best practice methods and Consolidated Health Economic Evaluation Reporting Standards (CHEERS) reporting guidelines were followed as appropriate [23–25].”
MethodSelf-citation
Descemet Endothelial Thickness Comparison Trial II (DETECT II): multicentre, outcome assessor-masked, placebo-controlled trial comparing Descemet membrane endothelial keratoplasty (DMEK) to Descemet stripping only (DSO) with adjunctive ripasudil for Fuchs dystrophy
Lin, C. C., Chamberlain, W., Benetz, B. A., Gensheimer, W. G., Li, J. Y., Jeng, B. H., Clover, J. M., Varnado, N. E., Abdelrahman, S., Srinivasan, A., et al. (2024) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2024-001725 · Cited by 8
The Burden of Fecal Incontinence: Evaluating the Societal Impact in Terms of Economic Burden and Health‐Related Quality of Life
Assmann, S. L., Kimman, M., Breukink, S. O., & Keszthelyi, D. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70036 · Cited by 8
Economic evaluation of the randomised, double-blind, placebo-controlled study of subcutaneous ketamine in the management of chronic cancer pain
McCaffrey, N., Flint, T., Kaambwa, B., Fazekas, B. S., Rowett, D. S., Currow, D. C., Hardy, J. R., Agar, M. R., Quinn, S., & Eckermann, S. D. (2018) · Palliative Medicine · doi:10.1177/0269216318801754 · Cited by 8
Evaluating the effectiveness and cost-effectiveness of a digital, app-based intervention for depression (VMood) in community-based settings in Vietnam: Protocol for a stepped-wedge randomized controlled trial
Chau, L. W., Murphy, J., Nguyen, V. C., Xie, H. W., Lam, R. W. M., Minas, H., Zheng, Y., Krebs, E., Hayashi, K., Anh, S. D., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290328 · Cited by 9
Economic Evaluation of a Personalized Nutrition Plan Based on Omic Sciences Versus a General Nutrition Plan in Adults with Overweight and Obesity: A Modeling Study Based on Trial Data in Denmark
Galekop, M. M. J., Groot, C. U.-D., & Redekop, K. (2023) · PharmacoEconomics - Open · doi:10.1007/s41669-023-00461-8 · Cited by 9
“This is not recommended in good research practice guidelines for cost-effectiveness analysis alongside clinical trials [98].”
Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT
Bradshaw, L. E., Wyatt, L. A., Brown, S., Haines, R., Montgomery, A. A., Perkin, M. R., Sach, T., Lawton, S., Flohr, C., Ridd, M. J., et al. (2024) · Health Technology Assessment · doi:10.3310/rhdn9613 · Cited by 8
Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT
Santer, M., Lawrence, M. M., Pyne, S., Renz, S., Stuart, B. L., Sach, T., Ridd, M. J., Thomas, K. S., Nuttall, J., Permyakova, N. V., et al. (2024) · Health Technology Assessment · doi:10.3310/myjt6804 · Cited by 8
An Outreach Rehabilitation Program for Nursing Home Residents After Hip Fracture May Be Cost-Saving
Beaupré, L. A., Lier, D. A., Magaziner, J. S., Jones, C. A., Johnston, D. W. C., Wilson, D. M., & Majumdar, S. R. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa074 · Cited by 8
“38 ≤2 11 (24) 4 (13) 3 or more 35 (76) 25 (86) Walker type 1.”
Method
Cost-effectiveness of a collaborative care program for managing major depression and chronic musculoskeletal pain in primary care: Economic evaluation alongside a randomized controlled trial
Aragonès, E., Sánchez, E., López-Cortacans, G., Tomé‐Pires, C., Rambla, C., & Sánchez‐Rodríguez, E. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.110167 · Cited by 8
BLEND-A: blending internet treatment into conventional face-to-face treatment for alcohol use disorder - a study protocol
Mellentin, A. I., Behrendt, S., Bilberg, R., Blankers, M., Folker, M. P., Tarp, K., Uffelmann, J., & Nielsen, A. S. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03122-4 · Cited by 9
Longer-term health and social care strategies for stroke survivors and their carers: the LoTS2Care research programme including cluster feasibility RCT
Förster, A., Ozer, S., Crocker, T. F., House, A. O., Hewison, J., Roberts, E., Dickerson, J., Carter, G., Hulme, C. T., Fay, M., et al. (2021) · Programme Grants for Applied Research · doi:10.3310/pgfar09030 · Cited by 9
Burden and preference-based quality of life associated with bullying in children
Le, L. K., Chatterton, M. L., Rapee, R. M., Fitzpatrick, S., Bussey, K., Hudson, J. L., Hunt, C. J., CROSS, D. S., Magnus, A., & Mihalopoulos, C. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01807-5 · Cited by 8
“Therefore, the data were analysed using a generalized linear model (GLM) with and without covariates as recommended by the International Society for Pharmacoeconomics and Outcomes Research guidelines [26].”
Method
Costs, benefits, and cost-benefit of Collaborative Assessment and Management of Suicidality versus enhanced treatment as usual
McCutchan, P. K., Yates, B. T., Jobes, D. A., Kerbrat, A. H., & Comtois, K. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262592 · Cited by 12
“Multiple imputation using chained equations with predictive mean matching was used to minimize uncertainty related to the replacement of missing data for health services utilization [56].”
Method
Cost-effectiveness analysis of a GP- and parent-directed intervention to reduce antibiotic prescribing for children with respiratory tract infections in primary care
Dekker, A. R. J., van der Velden, A. W., Luijken, J., Verheij, T. J., & van Giessen, A. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky552 · Cited by 8
Cost Effectiveness of Neonatal Resuscitation at 22 Weeks of Gestation
Yieh, L., Dukhovny, D., Zhou, C. G., Gievers, L. L., & Caughey, A. B. (2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003264 · Cited by 8
Effectiveness of a digital alcohol moderation intervention as an add-on to depression treatment for young adults: study protocol of a multicentre pragmatic randomized controlled trial
Schouten, M. J. E., Dekker, J., de Bruijn, T., Ebert, D. D., Koomen, L. E. M., Kosterman, S. L. A., Riper, H. M., Schaub, M. P., Goudriaan, A. E., & Blankers, M. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03222-1 · Cited by 9
“The economic evaluation will be performed in line with the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines [54].”
Method
Evaluating the efficacy of Seattle-PAP for the respiratory support of premature neonates: study protocol for a randomized controlled trial
Backes, C. H., Notestine, J. L., Lamp, J. M., Balough, J. C., Notestine, A. M., Alfred, C. M., Kern, J. M., Stenger, M., Rivera, B. K., Moallem, M., et al. (2019) · Trials · doi:10.1186/s13063-018-3166-6 · Cited by 8
Social recovery therapy for young people with emerging severe mental illness: the Prodigy RCT
Fowler, D., Berry, C., Hodgekins, J., Banerjee, R., Barton, G., Byrne, R., Clarke, T., Fraser, R., Grant, K., Greenwood, K., et al. (2021) · Health Technology Assessment · doi:10.3310/hta25700 · Cited by 7
Cost-Utility Analysis of Chuna Manual Therapy and Usual Care for Chronic Neck Pain: A Multicenter Pragmatic Randomized Controlled Trial
Ha, I., Kim, E., Lee, S., Lee, Y. J., Song, H. J., Kim, Y., Kim, K., Cho, J., Lee, J., Shin, B., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.896422 · Cited by 7
“The Consolidated Health Economic Evaluation Reporting Standards Statement (CHEERS) checklist (16) is supplemented according to the guidelines (17).”
Method
Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial)
Rwebembera, J., Ndagire, E., Carvalho, N., Webel, A. R., Sable, C., Okello, E., Sarnacki, R., Spaziani, A. M., Atukunda, M., Engelman, D., et al. (2024) · American Heart Journal · doi:10.1016/j.ahj.2024.05.012 · Cited by 7
A Universal Digital Stress Management Intervention for Employees: Randomized Controlled Trial with Health-Economic Evaluation
Freund, J., Smit, F., Lehr, D., Zarski, A., Berking, M., Riper, H. M., Funk, B., Ebert, D. D., & Buntrock, C. (2024) · Journal of Medical Internet Research · doi:10.2196/48481 · Cited by 9
“We carried out and reported the health economic evaluation in accordance with the guidelines of the International Society for Pharmacoeconomics and Outcomes Research [17] and the Consolidated Health Economic Evaluation Reporting Standards statement [18] (more details in Multimedia Appendix 1).”
Economic Evaluations of Music Therapy and Other Music-Based Interventions: A Scoping Review
Riedl, H., Else, B. A., Grünhaus, C., & Holck, U. (2024) · Journal of Music Therapy · doi:10.1093/jmt/thae023 · Cited by 7
A cost‐effectiveness analysis alongside trial of a digital health‐supported and community pharmacy‐based prediabetes management programme ( PRIME Programme) in Malaysia
Teoh, K. W., Baek, Y., Ademi, Z., & Lee, S. W. H. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16350 · Cited by 7
Development of a cost of illness inventory questionnaire for children with autism spectrum disorder in South Asia
Chaudhary, D., Bhat, B., Shields, G., Davies, L. M., Green, J., Verghis, T., Roy, R., Kumar, D., Abhilashi, M. K., Vajaratkar, V. P., et al. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-08508-y · Cited by 7
“Current guidelines recommend that economic evaluations alongside clinical trials prioritise high-cost resources and those that are expected to differ between treatment arms [22].”
Background
Cost Analysis of a Transition Care Bundle Compared with Usual Care for COPD Patients Being Discharged from Hospital: Evaluation of a Randomized Controlled Trial
Yan, C., Round, J. A., Akpinar, İ., Atwood, C. E., Deuchar, L., Bhutani, M., Leigh, R., & Stickland, M. K. (2023) · PharmacoEconomics - Open · doi:10.1007/s41669-023-00400-7 · Cited by 7
“This model followed the guidelines for cost-effectiveness analysis (CEA) alongside clinical trials by the Professional Society for Health Economics and Outcomes Research (ISPOR) Good Research Practices Task Force [35, 39] and the 2022 Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement [40].”
Method
Economic Evaluations of mHealth Interventions for the Management of Type 2 Diabetes: A Scoping Review
Tornvall, I., Kenny, D., Wubishet, B. L., Russell, A. W., Menon, A., & Comans, T. A. (2023) · Journal of Diabetes Science and Technology · doi:10.1177/19322968231183956 · Cited by 8
“43 However, the purpose of EEs is to inform decision-making for resource-allocation, 44 and when studies fail to report on key items, such as perspective, time horizon, or uncertainty, it could be argued that the economic outcomes are not accurately captured or conveyed.”
Long-Term Outcomes and Cost-Effectiveness of an Internet-Based Self-Help Intervention for Social Anxiety Disorder in University Students: Results of a Randomized Controlled Trial
Kählke, F., Buntrock, C., Smit, F., Berger, T., Baumeister, H., & Ebert, D. D. (2023) · Depression and Anxiety · doi:10.1155/2023/7912017 · Cited by 9
Evaluation of training in guideline‐oriented biopsychosocial management of low back pain in occupational health services: Protocol of a cluster randomized trial
Karppinen, J. I., Simula, A. S., Holopainen, R., Lausmaa, M., Remes, J., Paukkunen, M., Ussing, K., Booth, N., Ryynänen, K., Koski, T. P. K., et al. (2021) · Health Science Reports · doi:10.1002/hsr2.251 · Cited by 7
“The costs of the training will be considered in the analyses.(36) Finally, we will evaluate the need for presenting treatment effects among specific subgroups (according to, e.”
Background
Protocol for a multicenter, double-blinded placebo-controlled randomized controlled trial comparing intravenous ferric derisomaltose to oral ferrous sulfate for the treatment of iron deficiency anemia in pregnancy: The IVIDA2 trial
Lewkowitz, A. K., Stout, M. J., Carter, E. B., Ware, C. F., Jackson, T. L., D’Sa, V. A., Deoni, S., Odibo, A. O., Gopalakrishnan, R., Liu, J., et al. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.106992 · Cited by 7
The Value of Decision Analytical Modeling in Surgical Research
Tax, C., Govaert, P. H. M., Stommel, M. W. J., Besselink, M. G., Gooszen, H. G., & Rovers, M. M. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000002553 · Cited by 7
Within-Trial Evaluation of Medical Resources, Costs, and Quality of Life Among Patients With Type 2 Diabetes Participating in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)
Reed, S. D., Li, Y., Dakin, H., Becker, F., Leal, J., Gustavson, S. M., Kartman, B., Wittbrodt, E. T., Mentz, R. J., Pagidipati, N. J., et al. (2019) · Diabetes Care · doi:10.2337/dc19-0950 · Cited by 7
Self-citation
Economic evaluation of culprit lesion only PCI vs. immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: the CULPRIT-SHOCK trial
Robles‐Zurita, J. A., Briggs, A. H., Rana, D., Quayyum, Z., Oldroyd, K. G., Zeymer, U., Desch, S., de Waha‐Thiele, S., & Thiele, H. (2020) · The European Journal of Health Economics · doi:10.1007/s10198-020-01235-3 · Cited by 8
Self-citation
Protocol for a Single-Blind, Randomized, Parallel-Group Study of a Nonpharmacological Integrated Care Intervention to Reduce the Impact of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease
Smith, T., Roberts, M. M., Cho, J., Klimkeit, E., Luckett, T., McCaffrey, N., Kirby, A. C., & Wheatley, J. R. (2020) · Palliative Medicine Reports · doi:10.1089/pmr.2020.0081 · Cited by 7
“Further sensitivity and scenario analyses will be undertaken to examine the effect of varying key parameter estimates on the outcome of the economic evaluation (33).”
Background
Depression, anxiety, pain and chronic opioid management in primary care: Type II effectiveness-implementation hybrid stepped wedge cluster randomized trial
Price‐Haywood, E. G., Burton, J. H., Harden-Barrios, J., Bazzano, A. N., Lefante, J. J., Shi, L., & Jamison, R. N. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106250 · Cited by 7
“All analyses will follow the guidelines on cost-effectiveness analysis conducted alongside clinical trials and economic modeling [33].”
Method
Clinical- and Cost Effectiveness of a Guided Internet-Based Intervention for Children (12–18 Years) of Parents With Mental Disorders (iCHIMPS): Study Protocol of a Multicentered Cluster-Randomized Controlled Trial
Dülsen, P., Barck, K., Daubmann, A., Höller, A., Zeidler, J., Kilian, R., Wiegand‐Grefe, S., & Baumeister, H. (2022) · Frontiers in Digital Health · doi:10.3389/fdgth.2022.816412 · Cited by 9
“For Abbreviations: AOK; Allgemeine Ortskrankenkasse; APOI; Attitudes toward Psychological Online Interventions Questionnaire; AUC; area under the curve; Brief COPE; Brief Coping Orientation to Problems Experienced Inventory; CAMSHRI-EU; Children and Adolescent Mental Health Services Receipt Inventory; CBCL; Child Beha…”
Method
A Cost-Utility Analysis of the Syncope: Pacing or Recording in The Later Years (SPRITELY) Trial
Hofmeister, M., Sheldon, R. S., Spackman, E., Raj, S. R., Talajic, M. R., Becker, G., Essebag, V., Ritchie, D., Morillo, C. A., Krahn, A. D., et al. (2022) · CJC Open · doi:10.1016/j.cjco.2022.03.009 · Cited by 7
Commentary: Demon$trating (Our) Value
Harris, M. A., Wagner, D. V., & Dukhovny, D. (2016) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsw029 · Cited by 7
Digital thErapy For Improved tiNnitus carE Study (DEFINE): Protocol for a randomised controlled trial
Smith, M. E., Sharma, D., Rivero‐Arias, O., Rand, K., Barrack, L., Ogburn, E., Young, M. R., Field, P., Multmeier, J., & Muzaffar, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0292562 · Cited by 5
Clinical and cost‐effectiveness of pessary self‐management versus clinic-based care for pelvic organ prolapse in women: the TOPSY RCT with process evaluation
Bugge, C., Hagen, S., Elders, A., Mason, H., Goodman, K., Dembinsky, M., Melone, L., Best, C. S., Manoukian, S., Dwyer, L., et al. (2023) · Health Technology Assessment · doi:10.3310/nwtb5403 · Cited by 8
Alitretinoin versus phototherapy as the first-line treatment in adults with severe chronic hand eczema: the ALPHA RCT
Wittmann, M., Smith, I. L., Brown, S. T., Berekméri, A., Vargas‐Palacios, A., Sunderland, L., Barker, A., Cowdell, F., Ersser, S. J., Gilberts, R. M., et al. (2024) · Health Technology Assessment · doi:10.3310/twqc0141 · Cited by 7
Incorporating healthcare access and equity in economic evaluations: a scoping review of guidelines
Dawkins, B., Shinkins, B., Ensor, T., Jayne, D. G., & Meads, D. M. (2024) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462324000618 · Cited by 8
The 1,7-malaria reactive community-based testing and response (1,7-mRCTR) approach in Tanzania: a cost-effectiveness analysis
Tampi, R. P., Wang, D., Abdulla, S., Mahende, M. K., Gavana, T., Msuya, H. M., Kuwawenaruwa, A., Mihayo, M., Brown, F., Masanja, H., et al. (2024) · Infectious Diseases of Poverty · doi:10.1186/s40249-024-01261-w · Cited by 6
Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation
Tarride, J., Blackhouse, G., Rochwerg, B., Fox-Robichaud, A., Ball, I. M., Burns, K. E., Seely, A., Muscedere, J., Berney, S., Pastva, A., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.29399 · Cited by 8
Economic evaluations for intensive care unit randomised clinical trials in Australia and New Zealand: Practical recommendations for researchers
Taylor, C. B., Thompson, K., Hodgson, C. L., Liew, C., Litton, E., McGain, F., Nichol, A., Rauniyar, R., Ridley, E. J., & Higgins, A. M. (2022) · Australian Critical Care · doi:10.1016/j.aucc.2022.02.002 · Cited by 6

Authors: Ramsey, S. D., Willke, R. J., Glick, H., Reed, S. D., Augustovski, F., Jonsson, B., Briggs, A., & Sullivan, S. D.
Affiliations: University of Washington (US)
Pfizer (United States) (US)
University of Pennsylvania (US)
Duke University (US)
Universidad de Buenos Aires (AR)
University of Glasgow (GB)
Corresponding author: Ramsey, Scott D.
ORCID: Ramsey, Scott D.
Willke, Richard J.
Reed, Shelby D.
Augustovski, Federico
Briggs, Andrew
Sullivan, Sean D.
Venue: Value in Health
Publisher: Elsevier BV
Published: 2015-03
Volume: 18
Issue: 2
Pages: 161-172
ISSN: 1098-3015 (ISSN-L)
DOI: 10.1016/j.jval.2015.02.001
OpenAlex: W2139814250
Cited by: 811
References: 184
Citations by year: 2026: 58 · 2025: 75 · 2024: 90 · 2023: 80 · 2022: 100 · 2021: 103 · 2020: 88 · 2019: 65 · 2018: 50 · 2017: 57 · 2016: 37 · 2015: 6
FWCI: 17.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Value in Health (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
Keywords: cost-effectiveness analysis, clinical trials, economic evaluation, trial design, health care utilization, health utility, intention-to-treat analysis, subgroup analysis, uncertainty characterization, reporting guidelines, reimbursement decisions, healthcare resource allocation
MeSH terms: Cost-Benefit Analysis, Health Policy, Health Services Research, Humans, Randomized Controlled Trials as Topic, Advisory Committees, Research Report

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Cost-Effectiveness Analysis Alongside Clinical Trials II—An ISPOR Good Research Practices Task Force Report

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