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Acute kidney injury in patients hospitalized with COVID-19
Open accessAbstract
The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and April 5, 2020, at 13 academic and community hospitals in metropolitan New York. Patients younger than 18 years of age, with end stage kidney disease or with a kidney transplant were excluded. AKI was defined according to KDIGO criteria. Of 5,449 patients admitted with Covid-19, AKI developed in 1,993 (36.6%). The peak stages of AKI were stage 1 in 46.5%, stage 2 in 22.4% and stage 3 in 31.1%. Of these, 14.3% required renal replacement therapy (RRT). AKI was primarily seen in Covid-19 patients with respiratory failure, with 89.7% of patients on mechanical ventilation developing AKI compared to 21.7% of non-ventilated patients. 276/285 (96.8%) of patients requiring RRT were on ventilators. Of patients who required ventilation and developed AKI, 52.2% had the onset of AKI within 24 hours of intubation. Risk factors for AKI included older age, diabetes mellitus, cardiovascular disease, black race, hypertension and need for ventilation and vasopressor medications. Among patients with AKI, 694 died (35%), 519 (26%) were discharged and 780 (39%) were still hospitalized. AKI occurs frequently among patients with Covid-19 disease. It occurs early and in temporal association with respiratory failure and is associated with a poor prognosis.
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“According to studies, the incidence of AKI ranges between 46 percent and 71 percent; however, most deaths occur within the AKI sample [87, 88].”
From A comprehensive survey on federated learning techniques for healthcare informatics (2023) · cites this paper as [88]
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Metadata
- Authors
- Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., Barnett, R. L., Hazzan, A. D., Fishbane, S., Jhaveri, K. D., Abate, M., Andrade, H. P., Barnett, R. L., Bellucci, A., Bhaskaran, M. C., Corona, A. G., Chang, B. F., Finger, M., Fishbane, S., Gitman, M., Halinski, C., Hasan, S., Hazzan, A. D., Hirsch, J. S., Hong, S., Jhaveri, K. D., Khanin, Y., Kuan, A., Madireddy, V., Malieckal, D., Muzib, A., Nair, G., Nair, V. V., Ng, J. H., Parikh, R., Ross, D. W., Sakhiya, V., Sachdeva, M., Schwarz, R., Shah, H. H., Sharma, P., Singhal, P. C., Uppal, N. N., Wanchoo, R., Chang, B. S. F., & Ng, J. H.
- Affiliations
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- ORCID
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 98
- Issue
- 1
- Pages
- 209-218
- ISSN
- 0085-2538 (ISSN-L)
- PMC
- PMC7229463
- OpenAlex
- W3025305522
- Cited by
- 1,523
- References
- 31
- Citations by year
- 2026: 37 · 2025: 65 · 2024: 120 · 2023: 203 · 2022: 341 · 2021: 462 · 2020: 288
- FWCI
- 204.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK118017)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- acute kidney injury, COVID-19 pandemic, hospitalized patients, risk factors, mechanical ventilation, respiratory failure, renal replacement therapy, AKI staging, mortality, diabetes mellitus, vasopressors, racial disparities
- MeSH terms
- COVID-19, Aged, Female, Humans, Inpatients, Male, Middle Aged, New York City, Pneumonia, Viral, Respiratory Insufficiency, Retrospective Studies, Coronavirus Infections, Acute Kidney Injury, Pandemics
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