Cited by 93Influenza Virus Research StudiesAdipokines, Inflammation, and Metabolic DiseasesImmune responses and vaccinations

Effect of influenza vaccine on markers of inflammation and lipid profile

Tsai, Michael Y., Hanson, Naomi Q., Straka, Robert J., Hoke, Tracy R., Ordovas, Jose M., Peacock, James M., Arends, Valerie L., Arnett, Donna K.·2005·Journal of Laboratory and Clinical Medicine

Abstract

Despite wide use of the influenza vaccine, relatively little is known about its effect on the measurement of inflammatory markers. Because inflammatory markers such as C-reactive protein (CRP) are increasingly being used in conjunction with lipids for the clinical assessment of cardiovascular disease and in epidemiologic studies, we evaluated the effect of influenza vaccination on markers of inflammation and plasma lipid concentrations. We drew blood from 22 healthy individuals 1 to 6 hours before they were given an influenza vaccination and 1, 3, and 7 days after the vaccination. Plasma CRP, interleukin (IL)-6, monocyte chemotactic protein 1, tumor necrosis factor alpha, IL-2 soluble receptor alpha, and serum amyloid A were measured, and differences in mean concentrations of absolute and normalized values on days 1, 3, and 7 were compared with mean baseline values. There was a significant increase in mean IL-6 (P < .01 absolute values, P < .001 normalized values) on day 1 after receiving the influenza vaccine. The mean increases in normalized high sensitivity CRP values were significant on day 1 (P < .01) and day 3 (P = .05), whereas the mean increase in normalized serum amyloid A was significant only on day 1 (P < .05). No significant changes were seen in mean concentrations of IL-2 soluble receptor alpha, monocyte chemotactic protein-1, or tumor necrosis factor-alpha. Of the lipids, significant decreases in mean concentrations of normalized triglyceride values were seen on days 1 (P < .05), 3 (P < .001), and 7 (P < .05) after vaccination. Our findings show that the influenza vaccination causes transient changes in select markers of inflammation and lipids. Consequently, clinical and epidemiologic interpretation of the biomarkers affected should take into account the possible effects of influenza vaccination.

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Crossref · 10.1016/j.lab.2005.03.009

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Authors
Tsai, M. Y., Hanson, N. Q., Straka, R. J., Hoke, T. R., Ordovas, J. M., Peacock, J. M., Arends, V. L., & Arnett, D. K.
Affiliations
  • University of Minnesota (US)
  • National Heart, Lung, and Blood Institute (US)
  • University of Alabama at Birmingham (US)
Venue
Journal of Laboratory and Clinical Medicine
Publisher
Elsevier BV
Published
2005-06
Volume
145
Issue
6
Pages
323-327
ISSN
0022-2143 (ISSN-L)
OpenAlex
W2087802416
Cited by
93
References
16
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 11 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 5
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Laboratory and Clinical Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL72524-02, HL72524-03, U01HL072524, HL72524-04, U01 HL72524-01)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
influenza vaccination, inflammatory markers, C-reactive protein, interleukin-6, serum amyloid A, triglycerides, lipid profile, MCP-1, TNF-α, vaccine-induced immune response, cardiovascular biomarkers
MeSH terms
Adult, Hypolipidemic Agents, C-Reactive Protein, Female, Humans, Influenza, Human, Influenza Vaccines, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Fenofibrate, Risk Factors, Triglycerides, Biomarkers, Interleukin-6

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