CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids
Open accessAbstract
Background Disruption of the circadian system may be causal for manifestations of the metabolic syndrome (MetS).Objective The objective was to study the associations of 5 CLOCK polymorphisms with MetS features by analyzing fatty acid (FA) composition from dietary and red blood cell (RBC) membrane sources.Design Participants (n = 1100) in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study were included. Dietary intake was estimated with a validated questionnaire. Anthropometric and biochemical measurements and genotypes were determined. Postprandial lipids and the FA composition of RBC membranes were analyzed.Results CLOCK single nucleotide polymorphisms were significantly associated with obesity and individual components of MetS. For single nucleotide polymorphism rs4580704, minor allele carriers had a 46% lower risk of hypertension than did noncarriers. The monounsaturated fatty acid (MUFA) content of RBC membranes, particularly oleic acid, changed according to CLOCK genetic variants (P < 0.05). We identified significant gene-diet interactions associated with MetS at the CLOCK locus. By dichotomizing MUFA intake, we found different effects across rs4580704 genotypes for glucose (P = 0.020) and insulin resistance (P = 0.026). The protective effect of the minor allele on insulin sensitivity was only present when MUFA intake was >13.2% of energy. We also found different effects across CLOCK 3111T-->C genotypes for saturated fatty acid intake (% of energy) (P = 0.017). The deleterious effect of gene variants on waist circumference was only found with high saturated fatty acid intakes (>11.8%).Conclusions CLOCK polymorphisms interact with FAs to modulate MetS traits. The dietary source and membrane content of MUFAs are implicated in the relations between alterations in the circadian system and MetS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The protective effect of the minor allele at rs4580704 on insulin sensitivity was only present when MUFA intake was above the median (>13.2% of energy in the GOLDN population).
“However, when we investigated further the potential modulating effect of diet, we observed that the protective effect of the minor allele on insulin sensitivity was only present when MUFA intake was above the median (>13.2% of energy in this population).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
Significant associations were observed between CLOCK variants and markers of chronic inflammation, specifically IL-6.
“Finally, we also observed significant associations with markers of chronic inflammation (i.e., IL-6).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
The MUFA content of red blood cell membranes, particularly oleic acid, was significantly different according to CLOCK genetic variants.
“Another finding came from the analysis of the MUFA content of red blood cell membranes, particularly oleic acid, which was significantly different according to CLOCK genetic variants.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
In the GOLDN study, 3 of 5 selected CLOCK single-nucleotide polymorphisms (rs4580704, rs1801260, and rs3749474) yielded statistically significant associations with BMI, blood pressure, glycemic traits, and markers of dietary intake.
“We investigated 5 selected CLOCK single-nucleotide polymorphisms (SNPs) (rs 4864548, rs4580704, rs1464490, rs1801260, and rs3749474), of which 3 (rs4580704, rs1801260, and rs3749474) yielded statistically significant associations with BMI (in kg/m 2 ), blood pressure, glycemic traits, and markers of dietary intake (red blood cell membrane fatty acids).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
The detrimental effect of the minor allele at rs1801260 on waist circumference was only found with SFA intakes above the median (>11.8% of energy in GOLDN).
“Conversely, the detrimental effect of the minor allele at the rs1801260 SNP on waist circumference was only found with SFA intakes above the median (>11.8% of energy in GOLDN).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
The CLOCK rs4580704 SNP appeared protective; minor allele carriers had a 46% lower risk of hypertension than noncarriers.
“One of these SNPs, rs4580704, appeared to be protective; minor allele carriers had a 46% lower risk of hypertension than did noncarriers.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Littell, R. C. (1996) · Medical Entomology and Zoology · Cited by 10,345 · see citing works
Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005 · see citing works
Gruber, A. R., Lorenz, R., Bernhart, S. H., Neuböck, R., & Hofacker, I. L. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn188 · Cited by 2,717 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · see citing works
Efficiency and power in genetic association studies
de Bakker, P. I. W., Yelensky, R., Pe’er, I., Gabriel, S., Daly, M. J., & Altshuler, D. (2005) · Nature Genetics · doi:10.1038/ng1669 · Cited by 1,678 · see citing works
Subar, A. F., Thompson, F. E., Kipnis, V., Midthune, D., Hurwitz, P. E., McNutt, S., McIntosh, A., & Rosenfeld, S. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.12.1089 · Cited by 1,401 · see citing works
Allelic discrimination using fluorogenic probes and the 5′ nuclease assay
Livak, K. J. (1999) · Genetic Analysis Biomolecular Engineering · doi:10.1016/s1050-3862(98)00019-9 · Cited by 1,383 · see citing works
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
Patsch, J. R., Miesenböck, G., Hopferwieser, T., Mühlberger, V, Knapp, E., Dunn, J. K., Gotto, A. M., & Patsch, W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.11.1336 · Cited by 1,122 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works
Allelic discrimination using fluorogenic probes and the 5' nuclease assay
Foitzi, T. (1999) · Medical Entomology and Zoology · Cited by 783 · see citing works
Harmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 674 · see citing works
Sleep Duration and Biomarkers of Inflammation
Patel, S. R., Zhu, X., Storfer-Isser, A., Mehra, R., Jenny, N. S., Tracy, R., & Redline, S. (2009) · Sleep · doi:10.1093/sleep/32.2.200 · Cited by 615 · see citing works
Dietary fats and membrane function: implications for metabolism and disease
Hulbert, A. J., Turner, N. A., Storlien, L. H., & Else, P. L. (2005) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793104006578 · Cited by 406 · see citing works
Canaple, L., Rambaud, J., Dkhissi‐Benyahya, O., Rayet, B., Tan, N. S., Michalik, L., Delaunay, F., Wahli, W., & Laudet, V. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0052 · Cited by 353 · see citing works
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 344 · see citing works
IL-6 and its circadian secretion in humans
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338 · see citing works
A Daily Rhythm in Glucose Tolerance
la Fleur, S. E., Kalsbeek, A., Wortel, J., Fekkes, M. L., & Buijs, R. M. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1237 · Cited by 337 · see citing works
Lemberger, T., Saladin, R., Vázquez‐Carrera, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., & Auwerx, J. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1764 · Cited by 329 · see citing works
Biochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329 · see citing works
The relationship between nutrition and circadian rhythms in mammals
Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 286 · see citing works
Thompson, F. E., Subar, A. F., Brown, C., Smith, A. F., Sharbaugh, C., Jobe, J. B., Mittl, B., Gibson, J. T., & Ziegler, R. G. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90050-7 · Cited by 282 · see citing works
Reed, C. F., Swisher, S. N., Marinetti, G. V., & Enen, E. G. (1960) · PubMed · Cited by 281 · see citing works
NHLBI Family Heart Study: Objectives and Design
HIGGINS, M. W., Province, M. A., HEISS, G. M., Eckfeldt, J. H., Ellison, R. C., Folsom, A. R., Rao, D. C., Sprafka, J. M., & Williams, R. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008709 · Cited by 269 · see citing works
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262 · see citing works
Differential Rescue of Light- and Food-Entrainable Circadian Rhythms
Fuller, P. M., Lü, J., & Saper, C. B. (2008) · Science · doi:10.1126/science.1153277 · Cited by 260 · see citing works
Warensjö, E., Öhrvall, M., & Vessby, B. O. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.06.001 · Cited by 255 · see citing works
A sense of time: how molecular clocks organize metabolism
Kohsaka, A., & Bass, J. T. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.005 · Cited by 233 · see citing works
High-fat feeding alters the clock synchronization to light
Mendoza, J., Pévet, P., & Challet, E. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159566 · Cited by 213 · see citing works
Garaulet, M., Pérez‐Llamas, F., Perez‐Ayala, M., Martı́nez, P., de Medina, F. S., Tébar, F. J., & Zamora, S. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.5.585 · Cited by 211 · see citing works
Self-citationMarinescu, V. D., Kohane, I. S., & Riva, A. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-79 · Cited by 194 · see citing works
Lai, C.-Q., Demissie, S., Cupples, L. A., Zhu, Y., Adiconis, X., Parnell, L. D., Corella, D., & Ordovas, J. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400192-jlr200 · Cited by 163 · see citing works
Self-citationClock genes are implicated in the human metabolic syndrome
Gómez-Abellán, P., Morante, J. J. H., Luján, J., Madrid, J. A., & Garaulet, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803689 · Cited by 160 · see citing works
Self-citationChronobiology, genetics and metabolic syndrome
Garaulet, M., & Madrid, J. A. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283292399 · Cited by 157 · see citing works
Self-citationMutation screening of the human Clock gene in circadian rhythm sleep disorders
Iwase, T., Kajimura, N., Uchiyama, M., Ebisawa, T., Yoshimura, K., Kamei, Y., Shibui, K., Kim, K., Kudo, Y., Katoh, M., et al. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00006-9 · Cited by 149 · see citing works
Barnea, M., Madar, Z., & Froy, O. (2009) · Endocrinology · doi:10.1210/en.2008-0944 · Cited by 138 · see citing works
Young, M. E., & Bray, M. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.010 · Cited by 129 · see citing works
Sickness behavior, its mechanisms and significance
Tizard, I. R. (2008) · Animal Health Research Reviews · doi:10.1017/s1466252308001448 · Cited by 129 · see citing works
Corella, D., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Peacock, J. M., Hixson, J. E., Straka, R. J., Province, M. A., Lai, C., Parnell, L. D., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084863 · Cited by 121 · see citing works
Self-citationPrather, A. A., Marsland, A. L., Hall, M., Neumann, S. A., Muldoon, M. F., & Manuck, S. B. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.008 · Cited by 106 · see citing works
Lavialle, M., Champeil‐Potokar, G., Alessandri, J. M. J. M., Balasse, L., Guesnet, P., Papillon, C., Pévet, P., Vancassel, S., VIVIEN‐ROELS, B., & Denis, I. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1719 · Cited by 99 · see citing works
Effect of influenza vaccine on markers of inflammation and lipid profile
Tsai, M. Y., Hanson, N. Q., Straka, R. J., Hoke, T. R., Ordovas, J. M., Peacock, J. M., Arends, V. L., & Arnett, D. K. (2005) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2005.03.009 · Cited by 93 · see citing works
Self-citationSleep and energy balance: interactive homeostatic systems
VanItallie, T. B. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.010 · Cited by 89 · see citing works
Adiponectin, the controversial hormone
Garaulet, M., Morante, J. J. H., de Heredia, F. P., & Tébar, F. J. (2007) · Public Health Nutrition · doi:10.1017/s1368980007000638 · Cited by 89 · see citing works
Self-citationPoppitt, S. D., Kilmartin, P. A., Butler, P. A. G., & Keogh, G. F. (2005) · Lipids in Health and Disease · doi:10.1186/1476-511x-4-30 · Cited by 88 · see citing works
Sleep–wake behavior and responses of interleukin-6-deficient mice to sleep deprivation
Morrow, J. D., & Opp, M. R. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.02.003 · Cited by 85 · see citing works
Monteleone, P., Tortorella, A. A. V., Docimo, L., Maldonato, M. N., Canestrelli, B., Luca, L. D., & Maj, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.003 · Cited by 77 · see citing works
Shen, J., Arnett, D. K., Peacock, J. M., Parnell, L. D., Kraja, A. T., Hixson, J. E., Tsai, M. Y., Lai, C., Kabagambe, E. K., Straka, R. J., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1846 · Cited by 69 · see citing works
Self-citationBakan, E., Yıldırım, A., Kurtul, N., Polat, M., Dursun, H., & Cayir, K. (2006) · Acta Diabetologica · doi:10.1007/s00592-007-0224-4 · Cited by 63 · see citing works
Kabagambe, E. K., Tsai, M. Y., Hopkins, P. N., Ordovás, J. M., Peacock, J. M., Borecki, I. B., & Arnett, D. K. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.095059 · Cited by 63 · see citing works
Self-citationCircadian variation of postprandial lipemia
Romon, M., Fur, C. L., Lebel, P., Edmé, J.-L., Fruchart, J., & Dallongeville, J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.934 · Cited by 63 · see citing works
Pérez‐Martínez, P., Ordovás, J. M., López‐Miranda, J., Gómez, P., Marı́n, C., Moreno, J. A., Fuentes, F. J., de la Puebla, R. Á. F., & Pérez‐Jiménez, F. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.809 · Cited by 57 · see citing works
Prediabetes is associated with abnormal circadian blood pressure variability
Gupta, A., Greenway, F. L., Cornélissen, G., Pan, W., & Franz Halberg, A. (2008) · Journal of Human Hypertension · doi:10.1038/jhh.2008.32 · Cited by 50 · see citing works
Nakamura, K.-I., Inoue, I., Takahashi, S., Komoda, T., & Katayama, S. (2008) · PPAR Research · doi:10.1155/2008/348610 · Cited by 33 · see citing works
Food entrainment of circadian gene expression altered in PPARα−/− brown fat and heart
Goh, B. C. K., Wu, X., Evans, A. E., Johnson, M. L., Hill, M., & Gimble, J. M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.136 · Cited by 27 · see citing works
Hamada, T., Murata, T., Narita, K., Takahashi, T., Wada, Y., Kimura, H., & Yoshida, H. (2008) · Blood Pressure · doi:10.1080/08037050802162839 · Cited by 16 · see citing works
N‐6 From Different Sources Protect From Metabolic Alterations to Obese Patients: A Factor Analysis
Morante, J. J. H., Larqué, E., Luján, J., Zamora, S., & Garaulet, M. (2008) · Obesity · doi:10.1038/oby.2008.466 · Cited by 15 · see citing works
Self-citationAdiposity and dietary intake in cardiovascular risk in an obese population from a Mediterranean area
Garaulet, M., Marín, C. R., Pérez‐Llamas, F., Canteras, M., Tébar, F. J., & Zamora, S. (2004) · Journal of Physiology and Biochemistry · doi:10.1007/bf03168219 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Garaulet M, Herna ´ndez-Morante JJ, de Heredia FP, Te ´bar FJ. Adipo- nectin, the controversial hormone. Public Health Nutr 2007;10:1145-50.
Cited by
Sorted by citations
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733 · see citing works
Timing of food intake predicts weight loss effectiveness
Garaulet, M., Gómez-Abellán, P., Alburquerque-Béjar, J. J., Lee, Y.-C., Ordovás, J. M., & Scheer, F. A. J. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.229 · Cited by 639 · see citing works
Self-citationSaturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations
Astrup, A. V., Magkos, F., Bier, D. M., Brenna, J. T., Otto, M. C. D. O., Hill, J. O., King, J. C., Mente, A., Ordovás, J. M., Volek, J. S., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.05.077 · Cited by 561 · see citing works
Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 449 · see citing works
Garaulet, M., Ortega, F. B., Ruiz, J. R., Rey-López, J. P., Béghin, L., Μanios, Y., Cuenca‐García, M., Plada, M., Diethelm, K., Kafatos, A., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.149 · Cited by 423 · see citing works
Self-citationTiming of food intake and obesity: a novel association
Garaulet, M., & Gómez-Abellán, P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.001 · Cited by 362 · see citing works
Self-citationCircadian control of glucose metabolism
Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338 · see citing works
Circadian Clocks and Metabolism
Marcheva, B., Ramsey, K. M., Peek, C. B., Affinati, A., Maury, E., & Bass, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25950-0_6 · Cited by 282 · see citing works
The chronobiology, etiology and pathophysiology of obesity
Garaulet, M., Ordovás, J. M., & Madrid, J. A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.118 · Cited by 279 · see citing works
Self-citationCircadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258 · see citing works
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235 · see citing works
Milagro, F. I., Gómez-Abellán, P., Campión, J., Martínez, J. A., Ordovás, J. M., & Garaulet, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.719967 · Cited by 194 · see citing works
Self-citationSato-Mito, N., Sasaki, S., Murakami, K., Okubo, H., Takahashi, Y., Shibata, S., Yamada, K., & Sato, K. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.09.012 · Cited by 191 · see citing works
Circadian regulation of lipid metabolism
Gooley, J. J. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 186 · see citing works
Chronobiological aspects of nutrition, metabolic syndrome and obesity
Garaulet, M., & Madrid, J. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.005 · Cited by 177 · see citing works
Self-citationChrono-Nutrition: Circadian Rhythm and Personalized Nutrition
Franzago, M., Alessandrelli, E., Notarangelo, S., Stuppia, L., & Vitacolonna, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032571 · Cited by 172 · see citing works
Bo, S., Musso, G., Beccuti, G., Fadda, M., Fedele, D., Gambino, R., Gentile, L., Durazzo, M., Ghigo, E., & Cassader, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108467 · Cited by 170 · see citing works
Corella, D., Asensio, E. M., Coltell, O., Sorlí, J. V., Estruch, R., Martínez-González, M. Á., Salas-Salvadó, J., Castañer, O., Arós, F., Lapetra, J., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0327-8 · Cited by 165 · see citing works
Metspalu, M., Romero, I. G., Yunusbayev, B., Chaubey, G., Mallick, C. B., Hudjashov, G., Nelis, M., Mägi, R., Metspalu, E., Remm, M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.010 · Cited by 165 · see citing works
The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects
Froy, O., & Garaulet, M. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00193 · Cited by 148 · see citing works
Self-citationCircadian gene variants in cancer
Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147 · see citing works
Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_2 · Cited by 144 · see citing works
Ribas‐Latre, A., & Eckel‐Mahan, K. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.006 · Cited by 133 · see citing works
Circadian disruption in the pathogenesis of metabolic syndrome
Maury, E., Hong, H. K., & Bass, J. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.12.005 · Cited by 132 · see citing works
Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss
Garaulet, M., Sánchez-Moreno, C., Smith, C. E., Lee, Y.-C., Nicolás, F., & Ordovás, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017435 · Cited by 132 · see citing works
Self-citationNutrition and Cardiovascular Disease: Finding the Perfect Recipe for Cardiovascular Health
Ravera, A., Carubelli, V., Sciatti, E., Bonadei, I., Gorga, E., Cani, D., Vizzardi, E., Metra, M., & Lombardi, C. (2016) · Nutrients · doi:10.3390/nu8060363 · Cited by 131 · see citing works
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
Liang, C., Liu, Z., Song, M., Li, W., Wu, Z., Wang, Z., Wang, Q., Wang, S., Yan, K., Sun, L., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0385-7 · Cited by 117 · see citing works
Circadian rhythms, food timing and obesity
Lopez-Minguez, J., Gómez-Abellán, P., & Garaulet, M. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s0029665116000628 · Cited by 113 · see citing works
Self-citationCedernaes, J., Schiöth, H. B., & Benedict, C. (2015) · Diabetes · doi:10.2337/db14-1475 · Cited by 103 · see citing works
Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology
Bolshette, N. B., Ibrahim, H., Reinke, H., & Asher, G. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00792-1 · Cited by 99 · see citing works
Garaulet, M., Esteban Tardido, A., Lee, Y.-C., Smith, C. E., Parnell, L. D., & Ordovás, J. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.270 · Cited by 98 · see citing works
Self-citationCircadian Clocks, Food Intake, and Metabolism
Challet, É. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00005-1 · Cited by 97 · see citing works
Ruiz-Lozano, T., Vidal, J., de Hollanda, A., Canteras, M., Garaulet, M., & Izquierdo-Pulido, M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.116 · Cited by 96 · see citing works
Self-citationContribution of evening macronutrient intake to total caloric intake and body mass index
Baron, K. G., Reid, K. J., Horn, L. V., & Zee, P. C. (2012) · Appetite · doi:10.1016/j.appet.2012.09.026 · Cited by 94 · see citing works
Nutrigenomics and Personalized Diets: What Will They Mean for Food?
German, J. B., Zivkovic, A. M., Dallas, D. C., & Smilowitz, J. T. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.102308.124147 · Cited by 90 · see citing works
Casas‐Agustench, P., Arnett, D. K., Smith, C. E., Lai, C., Parnell, L. D., Borecki, I. B., Wood, A. C., Allison, M., Chen, Y.-D. I., Taylor, K. D., et al. (2014) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2014.03.014 · Cited by 82 · see citing works
Self-citationDashti, H. S., Smith, C. E., Lee, Y., Parnell, L. D., Lai, C., Arnett, D. K., Ordovás, J. M., & Garaulet, M. (2014) · Chronobiology International · doi:10.3109/07420528.2014.886587 · Cited by 80 · see citing works
Self-citationGarcía‐Ríos, A., Gómez-Delgado, F., Garaulet, M., Alcala-Diaz, J. F., Delgado‐Lista, J., Marı́n, C., Rangel-Zúñiga, O. A., Rodríguez-Cantalejo, F., Gómez-Luna, P., Ordovás, J. M., et al. (2013) · Chronobiology International · doi:10.3109/07420528.2013.864300 · Cited by 73 · see citing works
Self-citationEffects of Olive Oil on Blood Pressure: Epidemiological, Clinical, and Mechanistic Evidence
Massaro, M., Scoditti, E., Carluccio, M. A., Calabriso, N., Santarpino, G., Verri, T., & Caterina, R. D. (2020) · Nutrients · doi:10.3390/nu12061548 · Cited by 71 · see citing works
Chrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 72 · see citing works
Bandín, C., Martínez-Nicolás, A., Ordovás, J. M., Ros, J. A., Castell, P. F., Silvente, T., Madrid, J. A., & Garaulet, M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.180 · Cited by 68 · see citing works
Self-citationClock genes, pancreatic function, and diabetes
Vieira, E. C., Burris, T. P., & Quesada, I. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.10.007 · Cited by 68 · see citing works
Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity‐Related Genes
Hammad, S. S., & Jones, P. J. H. (2017) · Lipids · doi:10.1007/s11745-017-4291-9 · Cited by 65 · see citing works
Clock genes alterations and endocrine disorders
Angelousi, A. G., Kassi, E. N., Ansari, N. N., Weickert, M. O., Randeva, H. S., & Kaltsas, G. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12927 · Cited by 65 · see citing works
Gene-environment interactions of circadian-related genes for cardiometabolic traits
Dashti, H. S., Follis, J. L., Smith, C. E., Tanaka, T., Garaulet, M., Gottlieb, D. J., Hruby, A., Jacques, P. F., Kiefte-de Jong, J. C., Lamon-Fava, S., et al. (2015) · Diabetes Care · doi:10.2337/dc14-2709 · Cited by 64 · see citing works
Self-citationCircadian rhythms and pancreas physiology: A review
Chan, K., Wong, F. S., & Pearson, J. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.920261 · Cited by 61 · see citing works
Association between genetic variants of the clock gene and obesity and sleep duration
Valladares, M., Obregón, A. M., & Chaput, J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0447-3 · Cited by 61 · see citing works
Personalized Nutrition and Cardiovascular Disease Prevention: From Framingham to PREDIMED
Konstantinidou, V., Daimiel, L., & Ordovás, J. M. (2014) · Advances in Nutrition · doi:10.3945/an.113.005686 · Cited by 61 · see citing works
Diversity of Human Clock Genotypes and Consequences
Zhang, L., Ptáček, L. J., & Fu, Y. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00003-8 · Cited by 57 · see citing works
López‐Guimerà, G., Dashti, H. S., Smith, C. E., Sánchez‐Carracedo, D., Ordovás, J. M., & Garaulet, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099152 · Cited by 55 · see citing works
Self-citationRiestra, P., Gebreab, S. Y., Xu, R., Khan, R., Gaye, A., Correa, A., Min, Y., Sims, M., & Davis, S. (2017) · BMC Genetics · doi:10.1186/s12863-017-0522-6 · Cited by 53 · see citing works
Role of the Immune System and the Circadian Rhythm in the Pathogenesis of Chronic Pancreatitis
Kessler, A., Weksler‐Zangen, S., & Ilan, Y. (2020) · Pancreas · doi:10.1097/mpa.0000000000001626 · Cited by 53 · see citing works
Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism
Grosjean, E., Simonneaux, V., & Challet, É. (2023) · Biology · doi:10.3390/biology12040539 · Cited by 50 · see citing works
Garaulet, M., Smith, C. E., Gómez-Abellán, P., Ordovás‐Montañés, M., Lee, Y., Parnell, L. D., Arnett, D. K., & Ordovás, J. M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300361 · Cited by 50 · see citing works
Self-citationGlucocorticoids Affect 24 h Clock Genes Expression in Human Adipose Tissue Explant Cultures
Gómez-Abellán, P., Dı́ez-Noguera, A., Madrid, J. A., Luján, J., Ordovás, J. M., & Garaulet, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050435 · Cited by 50 · see citing works
Self-citationFigueiredo, P. S., Inada, A. C., Fernandes, M. R., Arakaki, D. G., Freitas, K. D. C., Guimarães, R. D. C. A., do Nascimento, V. A., & Hiane, P. A. (2018) · Molecules · doi:10.3390/molecules23040877 · Cited by 48 · see citing works
Gómez-Delgado, F., García‐Ríos, A., Alcala-Diaz, J. F., Rangel-Zúñiga, O. A., Delgado‐Lista, J., Yubero‐Serrano, E. M., López-Moreno, J., Tinahones, F. J., Ordovás, J. M., Garaulet, M., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500375 · Cited by 47 · see citing works
Self-citationGaraulet, M., Martínez-Nicolás, A., Ruiz, J. R., Konstabel, K., Labayen, I., González‐Gross, M., Marcos, A., Molnár, D., Widhalm, K., Casajús, J. A., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.026 · Cited by 43 · see citing works
Self-citationShanmugam, V., Wafi, A., Al-Taweel, N., & Büsselberg, D. (2013) · Journal of Local and Global Health Science · doi:10.5339/jlghs.2013.3 · Cited by 41 · see citing works
Aspectos cronobiológicos de la obesidad y el síndrome metabólico
Gómez-Abellán, P., Madrid, J. A., Ordovás, J. M., & Garaulet, M. (2011) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2011.08.002 · Cited by 40 · see citing works
Self-citationCRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome
Kovanen, L., Donner, K. M., Kaunisto, M. A., & Partonen, T. (2014) · Hypertension Research · doi:10.1038/hr.2014.157 · Cited by 40 · see citing works
Circadian clock gene polymorphisms implicated in human pathologies
Janoski, J. R., Aiello, I., Lundberg, C. W., & Finkielstein, C. V. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.05.006 · Cited by 39 · see citing works
REV-ERB ALPHA Polymorphism Is Associated with Obesity in the Spanish Obese Male Population
Ruano, E. G., Canivell, S., & Vieira, E. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104065 · Cited by 39 · see citing works
Plasma phospholipids n‐3 polyunsaturated fatty acid is associated with metabolic syndrome
Huang, T., Bhulaidok, S., Cai, Z., Xu, T., Xu, F., Wahlqvist, M. L., & Li, D. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000025 · Cited by 38 · see citing works
Chalfant, J. M., Howatt, D. A., Tannock, L. R., Daugherty, A., & Pendergast, J. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-66834-9 · Cited by 38 · see citing works
Plasticity of circadian clocks and consequences for metabolism
Coomans, C. P., Lucassen, E. A., Kooijman, S., Fifel, K., Deboer, T., Rensen, P. C. N., Michel, S. H., & Meijer, J. H. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12513 · Cited by 37 · see citing works
Samblas, M., Milagro, F. I., Gómez-Abellán, P., Martínez, J. A., & Garaulet, M. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416629247 · Cited by 37 · see citing works
Self-citationGalbete, C., Contreras, R., Martínez, J. A., Martínez‐González, M. Á., Guillén‐Grima, F., & Martí, A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.728657 · Cited by 35 · see citing works
Climie, R. E., Grace, M. S., Larsen, R. N., Dempsey, P. C., Oberoi, J., Cohen, N. D., Owen, N. G., Kingwell, B. A., & Dunstan, D. W. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.05.009 · Cited by 34 · see citing works
Guevara‐Cruz, M., Lai, C., Richardson, K., Parnell, L. D., Lee, Y., Tovar, A. R., Ordovás, J. M., & Torres, N. (2013) · Gene · doi:10.1016/j.gene.2013.09.055 · Cited by 33 · see citing works
Self-citationMisalignment of Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_2 · Cited by 33 · see citing works
Metabolic syndrome: Evidences for a personalized nutrition
Pérez‐Martínez, P., Garcia‐Rios, A., Delgado‐Lista, J., Pérez‐Jiménez, F., & López‐Miranda, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100531 · Cited by 33 · see citing works
Chen, Q., Huang, C.-Q., Hu, X., Li, S., & Zhang, X. (2013) · Journal of International Medical Research · doi:10.1177/0300060513476430 · Cited by 32 · see citing works
Garaulet, M., & Gómez-Abellán, P. (2013) · PubMed · doi:10.3305/nh.2013.28.sup5.6926 · Cited by 32 · see citing works
Self-citationPolymorphism in the CLOCK gene may influence the effect of fat intake reduction on weight loss
Loria‐Kohen, V., Espinosa‐Salinas, I., Marcos-Pasero, H., Lourenço-Nogueira, T., Herránz, J., Molina, S., Reglero, G., & de Molina, A. R. (2015) · Nutrition · doi:10.1016/j.nut.2015.10.013 · Cited by 31 · see citing works
Chronobiological aspects of obesity and metabolic syndrome
Gómez-Abellán, P., Madrid, J. A., Ordovás, J. M., & Garaulet, M. (2012) · Endocrinología y Nutrición (English Edition) · doi:10.1016/j.endoen.2011.08.002 · Cited by 31 · see citing works
Self-citationA genomics perspective of personalized prevention and management of obesity
Gkouskou, K. K., Grammatikopoulou, M. G., Lazou, E., Vasilogiannakopoulou, T., Sanoudou, D., & Eliopoulos, A. G. (2024) · Human Genomics · doi:10.1186/s40246-024-00570-3 · Cited by 30 · see citing works
Sookoian, S. C., Gianotti, T. F., Burgueño, A. L., & Pirola, C. J. (2010) · Chronobiology International · doi:10.3109/07420528.2010.496913 · Cited by 30 · see citing works
Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome
Hashinaga, T., Wada, N., Otabe, S., Yuan, X., Kurita, Y., Kakino, S., Tanaka, K., Sato, T., Kojima, M., Ohki, T., et al. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0305 · Cited by 30 · see citing works
Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health
Micó, V., Díez-Ricote, L., & Daimiel, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030299 · Cited by 30 · see citing works
García‐Ríos, A., Pérez‐Martínez, P., Delgado‐Lista, J., Phillips, C. M., Gjelstad, I. M. F., Wright, J. W., Karlström, B., Kieć‐Wilk, B., van Hees, A. M. J., Helal, O., et al. (2012) · Journal of Nutrition · doi:10.3945/jn.111.156968 · Cited by 29 · see citing works
Glucagon‐like peptide‐1: The missing link in the metabolic clock?
Brubaker, P. L., & Gil‐Lozano, M. (2016) · Journal of Diabetes Investigation · doi:10.1111/jdi.12477 · Cited by 29 · see citing works
The circadian rhythm: an influential soundtrack in the diabetes story
Hariri, A., Mirian, M., Zarrabi, A., Kohandel, M., Amini-Pozveh, M., Aref, A. R., Tabatabaee, A., Prabhakar, P. K., & Sivakumar, P. M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156757 · Cited by 28 · see citing works
Associations of polymorphisms in circadian genes with abdominal obesity in Chinese adult population
Ye, D., Cai, S., Jiang, X., Ye, D., Chen, K., Fan, C., & Jin, M. (2016) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2016.02.002 · Cited by 26 · see citing works
Morante, J. J. H., Gómez‐Santos, C., Margareto, J., Formiguera, X., Martínez, C. M., González, R., Martínez‐Augustin, O., Madrid, J. A., Ordovás, J. M., & Garaulet, M. (2011) · AGE · doi:10.1007/s11357-011-9309-2 · Cited by 25 · see citing works
Self-citationMurube, M. C., Borregon-Rivilla, E., Colmenarejo, G., Aguilar-Aguilar, E., Martínez, J. A., de Molina, A. R., Reglero, G., & Loria‐Kohen, V. (2020) · Nutrients · doi:10.3390/nu12041142 · Cited by 23 · see citing works
Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease
Reitz, C. J., Alibhai, F. J., Seolin, B. G. D. L., Nemec-Bakk, A. S., Khaper, N., & Martino, T. A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00462.2020 · Cited by 23 · see citing works
Chronotype: A Tool to Screen Eating Habits in Polycystic Ovary Syndrome?
Barrea, L., Verde, L., Vetrani, C., Savastano, S., Colao, A., & Muscogiuri, G. (2022) · Nutrients · doi:10.3390/nu14050955 · Cited by 20 · see citing works
“Based on these findings, several studies investigated gene-behavior interactions and showed that interactions between diet and clock gene mutations affect fasting plasma glucose [30], IR [31], body weight [32], and type 2 diabetes [27].”
BackgroundChronobiology and obesity: the orchestra out of tune
Garaulet, M., Gómez-Abellán, P., & Madrid, J. A. (2010) · Clinical Lipidology · doi:10.2217/clp.10.18 · Cited by 20 · see citing works
Self-citationEpigenetics of Insulin Resistance: An Emerging Field in Translational Medicine
Sookoian, S., & Pirola, C. J. (2013) · Current Diabetes Reports · doi:10.1007/s11892-012-0361-9 · Cited by 19 · see citing works
Kovač, U., Jasper, E. A., Smith, C. J., Baer, R. J., Bedell, B. A., Donovan, B. M., Weathers, N., Zmrzljak, U. P., Jelliffe‐Pawlowski, L. L., Rozman, D., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00540 · Cited by 19 · see citing works
Gkouskou, K. K., Lazou, E., Skoufas, E., & Eliopoulos, A. G. (2021) · Nutrients · doi:10.3390/nu13020355 · Cited by 18 · see citing works
Kim, K., Yang, Y. J., Kim, K., & Kim, M. K. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.022749 · Cited by 18 · see citing works
Barragán, R., Fernández-Carrión, R., Asensio, E. M., Ortega‐Azorín, C., Álvarez‐Sala, A., Fidalgo, J. A. P., Sorlí, J. V., Portolés, O., Gonzalez-Monje, I., St‐Onge, M., et al. (2023) · Nutrients · doi:10.3390/nu15030708 · Cited by 17 · see citing works
Genetic control of circadian rhythms and aging
Solovev, I. A., Dobrovolskaya, E., & Moskalev, A. (2016) · Russian Journal of Genetics · doi:10.1134/s1022795416040104 · Cited by 17 · see citing works
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children
Meng, Y., Lohse, B., & Cunningham-Sabo, L. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236991 · Cited by 15 · see citing works
Shon, J., Han, Y., & Park, Y. J. (2022) · Nutrients · doi:10.3390/nu14030478 · Cited by 15 · see citing works
Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects
Chang, Y., Chiu, Y., Liu, P., Hee, S., Chang, T., Jiang, Y., Lee, W.-J., Lee, P., Kao, H., Hwang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069622 · Cited by 15 · see citing works
Gálvez, J. F., Sanches, M., Bauer, I. E., Sharma, A. N., Hamilton, J. E., Mwangi, B., Quevedo, J., Zunta‐Soares, G. B., & Soares, J. C. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.01.016 · Cited by 15 · see citing works
Adaptive genetic variation and heart disease risk
Parnell, L. D., Lee, Y., & Lai, C. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283378e42 · Cited by 14 · see citing works
Self-citation
- Authors
- Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M.
- Affiliations
- Tufts University (US)
- Corresponding author
- Garaulet, Marta
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 90
- Issue
- 6
- Pages
- 1466-1475
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC2777463
- OpenAlex
- W2119294761
- Cited by
- 172
- References
- 59
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 15 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 15 · 2015: 14 · 2014: 16 · 2013: 16 · 2012: 12
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Seneca Foundation (02934/PI/05)
- NIH (1R21AR055228-01A1, U01 HL72524, HL54776, DK075030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- clock genes, circadian rhythm, metabolic syndrome, monounsaturated fatty acids, oleic acid, red blood cell membrane fatty acids, dietary fatty acid intake, saturated fatty acids, insulin resistance, hypertension, obesity, gene-diet interaction
- MeSH terms
- Adult, Aged, Erythrocyte Membrane, Fatty Acids, Monounsaturated, Female, Genotype, Haplotypes, Humans, Insulin Resistance, Male, Middle Aged, Risk, Body Mass Index, Polymorphism, Single Nucleotide, Metabolic Syndrome, CLOCK Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
