(-)-Linalool inhibits in vitro NO formation. Probable involvement in the antinociceptive activity of this monoterpene compound
Abstract
Recent studies performed in our laboratory have shown that (-)-linalool, the natural occurring enantiomer in essential oils, possesses anti-inflammatory, antihyperalgesic and antinociceptive effects in different animal models. The antinociceptive and antihyperalgesic effect of (-)-linalool has been ascribed to the stimulation of the cholinergic, opioidergic and dopaminergic systems, to its local anaesthetic activity and to the blockade of N-Methyl-d-aspartate receptors (NMDA). Since nitric oxide (NO) and prostaglandin E(2) (PGE(2)) play an important role in oedema formation and hyperalgesia and nociception development, to investigate the mechanism of these actions of the (-)-linalool, we examined the effects of this compound on lipopolysaccharide (LPS)-induced responses in macrophage cell line J774.A1. Exposure of LPS-stimulated cells to (-)-linalool significantly inhibited nitrite accumulation in the culture medium without inhibiting the LPS-stimulated increase of inducible nitric oxide synthase (iNOS) expression, suggesting that the inhibitory activity of (-)-linalool is mainly due to the iNOS enzyme activity. In contrast, exposure of LPS-stimulated cells to (-)-linalool failed, if not at the highest concentration, both in inhibiting PGE(2) release and in inhibiting increase of inducible cyclooxygenase-2 (COX(2)) expression in the culture medium. Collectively, these results indicate that the reduction of NO production/release is responsible, at least partially, for the molecular mechanisms of (-)-linalool antinociceptive effect, probably through mechanisms where cholinergic and glutamatergic systems are involved.
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PGE2 and COX-2 expression are inhibited in LPS-stimulated J774.A1 macrophages only when treated with high concentrations of (-)-linalool; linalool inhibits NO release but not iNOS expression, indicating its inhibitory activity is mainly attributed to iNOS enzyme activity.
“PGE2 was only inhibited by LPS-stimulated macrophages J774.A1 cells when treated with high concentrations of (-)-linalool. The same was observed for the COX-2 expression. The same monoterpene inhibited NO release but did not inhibit the increase of iNOS expression indicating that the inhibitory activity of linalool was mainly attributed to the iNOS enzyme activity [142].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [142]
Cites
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,089 · see citing works
Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils
Peana, A. T., D’Aquila, P. S., Panin, F., Serra, G., Pippia, P., & Moretti, M. D. L. (2002) · Phytomedicine · doi:10.1078/094471102321621322 · Cited by 587 · see citing works
Self-citationHaley, J. E., & Dickenson, A. H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.001 · Cited by 511 · see citing works
Haley, J. E., Sullivan, A. F., & Dickenson, A. H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90975-h · Cited by 463 · see citing works
Eide, P. K., Stubhaug, A., & Stenehjem, A. E. (1995) · Neurosurgery · doi:10.1227/00006123-199512000-00007 · Cited by 235 · see citing works
Nitric Oxide: A Novel Mediator of Inflammation
Clancy, R. M., & Abramson, S. B. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-210-43927aa · Cited by 235 · see citing works
(−)-Linalool produces antinociception in two experimental models of pain
Peana, A. T., D’Aquila, P. S., Chessa, M., Moretti, M. D. L., Serra, G., & Pippia, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02856-x · Cited by 220 · see citing works
Self-citationAnticonvulsant properties of linalool in glutamate-related seizure models
Elisabetsky, E., Brum, L. F. S., & Souza, D. O. (1999) · Phytomedicine · doi:10.1016/s0944-7113(99)80044-0 · Cited by 219 · see citing works
Inflammation-induced changes in peripheral glutamate receptor populations
Carlton, S. M., & Coggeshall, R. E. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01328-6 · Cited by 215 · see citing works
Local Anaesthetic Activity of the Essential Oil of Lavandula angustifolia
Ghelardini, C., Galeotti, N., Salvatore, G., & Mazzanti, G. (1999) · Planta Medica · doi:10.1055/s-1999-14045 · Cited by 193 · see citing works
Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats
Jackson, D. L., Graff, C. B., Richardson, J. D., & Hargreaves, K. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00449-u · Cited by 188 · see citing works
The Role of Nitric Oxide in Inflammation
Lyons, C. R. (1995) · Advances in immunology · doi:10.1016/s0065-2776(08)60589-1 · Cited by 169 · see citing works
Iwamoto, E. T., & Marion, L. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38297-2 · Cited by 145 · see citing works
Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages
Marcinkiewicz, J., Grabowska, A. K., & Chain, B. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250414 · Cited by 142 · see citing works
Modulation by nitric oxide of prostaglandin biosynthesis in the rat
Sautebin, L., Ialenti, A., Ianaro, A., & Rosa, M. D. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13230.x · Cited by 141 · see citing works
Coderre, T. J., & Empel, I. V. (1994) · Pain · doi:10.1016/0304-3959(94)90020-5 · Cited by 133 · see citing works
Effects of Linalool on Glutamate Release and Uptake in Mouse Cortical Synaptosomes
Brum, L. F. S., Emanuelli, T., Souza, D. O., & Elisabetsky, E. (2001) · Neurochemical Research · doi:10.1023/a:1010904214482 · Cited by 131 · see citing works
Effects of Linalool on [3H] MK801 and [3H] Muscimol Binding in Mouse Cortical Membranes
Brum, L. F. S., Elisabetsky, E., & Souza, D. O. (2001) · Phytotherapy Research · doi:10.1002/ptr.973 · Cited by 123 · see citing works
Peripheral nitric oxide in carrageenan-induced inflammation
Omote, K., Hazama, K., Kawamata, T., Kawamata, M., Nakayaka, Y., Toriyabe, M., & Namiki, A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02733-0 · Cited by 113 · see citing works
Çeli̇k, S., & Özkaya, A. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.6.547 · Cited by 95 · see citing works
Profile of spinal and supra-spinal antinociception of (−)-linalool
Peana, A. T., Montis, M. G. D., Nieddu, E., Spano, M. T., D’Aquila, P. S., & Pippia, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.066 · Cited by 92 · see citing works
Self-citationPeana, A. T., Montis, M. G. D., Sechi, S., Sircana, G., D’Aquila, P. S., & Pippia, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.06.006 · Cited by 68 · see citing works
Self-citationIwamoto, E. T., & Marion, L. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23806-x · Cited by 59 · see citing works
Chizh, B. A., Reißmüller, E., Schlütz, H., Scheede, M., Haase, G., & Englberger, W. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00148-9 · Cited by 50 · see citing works
The role of CNS NMDA receptors and nitric oxide in visceral hyperalgesia
Coutinho, S. V., Urban, M. O., & Gebhart, G. F. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01331-0 · Cited by 31 · see citing works
Rivot, J. P., Montagne-Clavel, J., & Besson, J. (2002) · European Journal of Pain · doi:10.1053/eujp.2001.0268 · Cited by 30 · see citing works
Kawabata, A., Kawao, N., Itoh, H., Shimada, C., Takebe, K., Kuroda, R., Masuko, T., Kataoka, K., & Ogawa, S. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00702-4 · Cited by 27 · see citing works
Dudhgaonkar, S. P., Kumar, D., Naik, A., Devi, A. R., Bawankule, D. U., & Tandan, S. K. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.03.021 · Cited by 19 · see citing works
Nitric oxide synthase inhibitors enhance the antinociceptive effects of oxotremorine in mice.
Pavone, F., Capone, F. T., Populin, R., & Przewłocka, B. (1997) · PubMed · Cited by 13 · see citing works
Machelska, H., Pavone, F., Capone, F. T., & Przewłocka, B. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)00028-5 · Cited by 12 · see citing works
Smith, J. B. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01820-x · Cited by 6 · see citing works
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933 · see citing works
“The same monoterpene inhibited NO release but did not inhibit the increase of iNOS expression indicating that the inhibitory activity of linalool was mainly attributed to the iNOS enzyme activity [142] .”
BackgroundLinalool: a review on a key odorant molecule with valuable biological properties
Aprotosoaie, A. C., Hăncianu, M., Costache, I. I., & Miron, A. (2014) · Flavour and Fragrance Journal · doi:10.1002/ffj.3197 · Cited by 343 · see citing works
Monoterpenes with Analgesic Activity—A Systematic Review
Guimarães, A. G., Quintans, J. D. S. S., & Quintans‐Júnior, L. J. (2012) · Phytotherapy Research · doi:10.1002/ptr.4686 · Cited by 292 · see citing works
Linalool bioactive properties and potential applicability in drug delivery systems
Pereira, I., Severino, P. B., Paiva‐Santos, A. C., Silva, A. M., & Souto, E. B. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.08.001 · Cited by 267 · see citing works
Baron, E. P. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13345 · Cited by 256 · see citing works
Linalool – a Review of a Biologically Active Compound of Commercial Importance
Kamatou, G., & Viljoen, A. M. (2008) · Natural Product Communications · doi:10.1177/1934578x0800300727 · Cited by 242 · see citing works
Analgesic-like Activity of Essential Oils Constituents
de Sousa, D. P. (2011) · Molecules · doi:10.3390/molecules16032233 · Cited by 196 · see citing works
Hajiali, H., Summa, M., Russo, D., Armirotti, A., Brunetti, V., Bertorelli, R., Athanassiou, A., & Mele, E. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02174j · Cited by 196 · see citing works
Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil
da Silva, G. L., Luft, C., Lunardelli, A., Amaral, R. H., Melo, D. A. D. S., Donadio, M. V. F., Nunes, F. B., de Azambuja, M. S., Santana, J. C. B., de Moraes, C. M. B., et al. (2015) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201520150056 · Cited by 194 · see citing works
Baron, E. P., Lucas, P., Eades, J., & Hogue, O. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0862-2 · Cited by 182 · see citing works
Sabogal-Guáqueta, A. M., Hobbie, F., Keerthi, A., Oun, A., Kortholt, A., Boddeke, E., & Dolga, A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109295 · Cited by 154 · see citing works
Batista, P. A., Werner, M. F. D. P., Oliveira, E. C., Burgos, L., Pereira, P., Brum, L. F. D. S., Story, G. M., & Santos, A. R. S. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.02.022 · Cited by 143 · see citing works
Antinociceptive properties of diphenyl diselenide: Evidences for the mechanism of action
Savegnago, L., Pinto, L. G., Jessé, C. R., Alves, D. A. C., da Rocha, J. B. T., Nogueira, C. W., & Zeni, G. R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.003 · Cited by 129 · see citing works
Silva, F. V., Guimarães, A. G., Silva, E. R. S., Neto, B. P. D. S., Machado, F. D. F., Quintans‐Júnior, L. J., Arcanjo, D. D. R., Oliveira, F. D. A., & Oliveira, R. C. M. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0102 · Cited by 124 · see citing works
Batista, P. A., Werner, M. F. D. P., Oliveira, E. C., Burgos, L., Pereira, P., Brum, L. F. D. S., & Santos, A. R. S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.092 · Cited by 117 · see citing works
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Mączka, W. K., Duda-Madej, A., Grabarczyk, M., & Wińska, K. (2022) · Molecules · doi:10.3390/molecules27206928 · Cited by 119 · see citing works
Okoh, S. O., Asekun, O. T., Familoni, O. B., & Afolayan, A. J. (2014) · Antioxidants · doi:10.3390/antiox3020278 · Cited by 99 · see citing works
Terpenoids as Important Bioactive Constituents of Essential Oils
Stéphane, F. F. Y., & Bankeu, J. J. K. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91426 · Cited by 94 · see citing works
Chemical composition of stinging nettle leaves obtained by different analytical approaches
Đurović, S. D., Pavlić, B., Šorgić, S., Popov, S., Savic, S. R., Petronijević, M., Radojković, M., Cvetanović, A. D., & Zeković, Z. P. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.02.019 · Cited by 92 · see citing works
Yamasaki, Y., Kunoh, H., Yamamoto, H., & Akimitsu, K. (2007) · Journal of General Plant Pathology · doi:10.1007/s10327-007-0013-0 · Cited by 88 · see citing works
Denner, S. S. (2009) · Holistic Nursing Practice · doi:10.1097/01.hnp.0000343210.56710.fc · Cited by 86 · see citing works
Sakurada, T., Mizoguchi, H., Kuwahata, H., Katsuyama, S., Komatsu, T., Morrone, L. A., Corasaniti, M. T., Bagetta, G., & Sakurada, S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.09.020 · Cited by 86 · see citing works
Beier, R. C., Byrd, J. A., Kubena, L. F., Hume, M. E., McReynolds, J. L., Anderson, R. C., & Nisbet, D. J. (2014) · Poultry Science · doi:10.3382/ps.2013-03254 · Cited by 86 · see citing works
Vila, R., Santana, A. I., Pérez-Rosés, R., Valderrama, A., Castelli, M. V., Mendonça, S., Zacchino, S. A., Gupta, M. P., & Cañigueral, S. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.11.021 · Cited by 84 · see citing works
Lee, S.-C., Xu, W., Lin, L.-Y., Yang, J.-J., & Liu, C. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf401039z · Cited by 82 · see citing works
Salehi, M., Niyakan, M., Ehterami, A., Haghi‐Daredeh, S., Nazarnezhad, S., Abbaszadeh‐Goudarzi, G., Vaez, A., Hashemi, S. F., Rezaei, N., & Mousavi, S. R. (2019) · Biomedical Engineering Letters · doi:10.1007/s13534-019-00138-4 · Cited by 78 · see citing works
Analgesic-Like Activity of Essential Oil Constituents: An Update
Sá, R. D. C. D. S. E., Lima, T. C., da Nóbrega, F. R., Brito, A. D., & de Sousa, D. P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122392 · Cited by 77 · see citing works
Mohamed, M. E., Abduldaium, Y. S., & Younis, N. S. (2020) · Biomolecules · doi:10.3390/biom10111488 · Cited by 76 · see citing works
Baker, D. H. A., Amarowicz, R., Kandeil, A., Ali, M. A., & Ibrahim, E. A. (2021) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2021.100135 · Cited by 76 · see citing works
Izuegbuna, O., Otunola, G. A., & Bradley, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209682 · Cited by 72 · see citing works
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Quintans‐Júnior, L. J., da Rocha, R. F., Caregnato, F. F., Moreira, J. C. F., da Silva, F. A., Araújo, A. A. D. S., dos Santos, J. P. A., Seabra, M. S. D. M., de Sousa, D. P., Bonjardim, L. R., et al. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0125 · Cited by 68 · see citing works
Sanna, M. D., Les, F., López, V., & Galeotti, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00472 · Cited by 69 · see citing works
Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide
Maior, F. N. S., da Fonsêca, D. V., Salgado, P. R. R., Monte, L. D. O., de Sousa, D. P., & de Almeida, R. N. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1228682 · Cited by 58 · see citing works
Chapter 18 Intraplantar Injection Of Bergamot Essential Oil Into The Mouse Hindpaw
Sakurada, T., Kuwahata, H., Katsuyama, S., Komatsu, T., Morrone, L. A., Corasaniti, M. T., Bagetta, G., & Sakurada, S. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85018-6 · Cited by 56 · see citing works
Li, J., Zhang, X., & Huang, H. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.10.001 · Cited by 55 · see citing works
Yuan, C., Shin, M., Park, Y., Choi, B., Jang, S., Lim, C., Yun, H. S., Lee, I., Won, S.-Y., & Cho, K. S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8887716 · Cited by 55 · see citing works
p-Cymene reduces orofacial nociceptive response in mice
de Santana, M. F., Quintans‐Júnior, L. J., Cavalcanti, S. C. H., de Oliveira, M. G. B., Guimarães, A. G., Cunha, E. S., Seabra, M. S. D. M., dos Santos, M. R. V., Araújo, A. A. D. S., & Bonjardim, L. R. (2011) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2011005000156 · Cited by 52 · see citing works
Lemongrass effects on IL-1β and IL-6 production by macrophages
Sforcin, J. M., Amaral, J. T., Fernandes, A., Sousa, J. P. B., & Bastos, J. K. (2009) · Natural Product Research · doi:10.1080/14786410902800681 · Cited by 51 · see citing works
Venâncio, A. M., Marchioro, M., Estevam, C. D. S., Seabra, M. S. D. M., de Santana, M. T., Onofre, A. S. C., Guimarães, A. G., de Oliveira, M. G. B., Alves, P. B., Pimentel, H. D. C., et al. (2011) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2011005000147 · Cited by 49 · see citing works
Katsuyama, S., Otowa, A., Kamio, S., Kazuma, S. A. T. O., Yagi, T., Kishikawa, Y., Komatsu, T., Bagetta, G., Sakurada, T., & Nakamura, H. (2015) · Biomedical Research · doi:10.2220/biomedres.36.47 · Cited by 48 · see citing works
Sabogal-Guáqueta, A. M., Posada‐Duque, R., Cortés, N., Arias-Londoño, J. D., & Cardona‐Gómez, G. P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.015 · Cited by 48 · see citing works
Antinociceptive effect of inhalation of the essential oil of bergamot in mice
Scuteri, D., Crudo, M., Rombolà, L., Watanabe, C., Mizoguchi, H., Sakurada, S., Sakurada, T., Greco, R., Corasaniti, M. T., Morrone, L. A., et al. (2018) · Fitoterapia · doi:10.1016/j.fitote.2018.06.007 · Cited by 48 · see citing works
Wang, X., Wu, J., Chen, J., Xiao, L., Zhang, Y., Wang, F., & Li, X. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03664 · Cited by 48 · see citing works
Effect of Linalool on Morphine Tolerance and Dependence in Mice
Hosseinzadeh, H., Imenshahidi, M., Hosseini, M., & Razavi, B. M. (2012) · Phytotherapy Research · doi:10.1002/ptr.3736 · Cited by 47 · see citing works
Kozuharova, E. K., Simeonov, V., Batovska, D. I., Stoycheva, C., Valchev, H., & Benbassat, N. (2023) · Pharmacia · doi:10.3897/pharmacia.70.e104404 · Cited by 44 · see citing works
Linalool in essential plant oils: pharmacological effects.
Peana, A. T., & Moretti, M. D. L. (2008) · CABI Publishing eBooks · doi:10.1079/9781845934132.0716 · Cited by 44 · see citing works
Self-citationMohammadi, A., Mohammad‐Alizadeh‐Charandabi, S., Mirghafourvand, M., Javadzadeh, Y., Fardiazar, Z., & Effati-Daryani, F. (2014) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(14)60025-x · Cited by 44 · see citing works
Anti-neuroinflammatory effects of geranium oil in microglial cells
Elmann, A., Mordechay, S., Rindner, M., & Ravid, U. (2010) · Journal of Functional Foods · doi:10.1016/j.jff.2009.12.001 · Cited by 44 · see citing works
Rosewood oil induces sedation and inhibits compound action potential in rodents
de Almeida, R. N., Araújo, D. A. M., Gonçalves, J. C. R., Montenegro, F. C., de Sousa, D. P., Leite, J. R., Mattei, R., Benedito, M. A. C., de Carvalho, J. G. B., Cruz, J. S., et al. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.05.044 · Cited by 41 · see citing works
Nikolova, G., Karamalakova, Y. D., Kovacheva, N., Stanev, S., Zheleva, A. M., & Gadjeva, V. G. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.06.024 · Cited by 39 · see citing works
Camargo, S. B., Simões, L. O., Medeiros, C. F. D. A., Jesus, A. D. M., Fregoneze, J. B., Evangelista, A. F., Villarreal, C. F., Araújo, A. A. D. S., Quintans‐Júnior, L. J., & Silva, D. F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.014 · Cited by 39 · see citing works
History repeats itself: Role of characterizing flavors on nicotine use and abuse
Patten, T., & Biasi, M. D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108162 · Cited by 39 · see citing works
Boukhatem, M. N., Darwish, N. H. E., Sudha, T., Bahlouli, S., Kellou, D., Benelmouffok, A. B., Chader, H., Rajabi, M., Benali, Y., & Mousa, S. A. (2020) · Scientia Pharmaceutica · doi:10.3390/scipharm88030033 · Cited by 41 · see citing works
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Passos, F. F. B., Lopes, E. M., de Araújo, J. M., de Sousa, D. P., Véras, L. M. C., Leite, J. R. S. A., & Almeida, F. R. D. C. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/829414 · Cited by 38 · see citing works
Heidari, B., Sajjadi, S. E., & Minaiyan, M. (2016) · PubMed Central · Cited by 38 · see citing works
Neurobehavioral and genotoxic evaluation of (−)-linalool in mice
Coelho, V., Mazzardo‐Martins, L., Martins, D. F., Santos, A. R. S., Brum, L. F. D. S., Picada, J. N., & Pereira, P. (2013) · Journal of Natural Medicines · doi:10.1007/s11418-013-0751-6 · Cited by 38 · see citing works
Genčić, M. S., Aksić, J. M., Stošić, M. Z. Ž., Randjelović, P. J., Stojanović, N. M., Stojanović-Radić, Z. Z., & Radulović, N. S. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112666 · Cited by 38 · see citing works
Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil
Abdelli, W., Bahri, F., Romane, A., Höferl, M., Wanner, J., Schmidt, E., & Jirovetz, L. (2017) · Natural Product Communications · doi:10.1177/1934578x1701200435 · Cited by 37 · see citing works
Kharraf, S. E., Faleiro, M. L., Farah, A., El‐Guendouz, S., Hadrami, E. M. E., & Miguel, M. G. (2021) · Molecules · doi:10.3390/molecules26185452 · Cited by 37 · see citing works
Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis
But, V. M., Bulboacă, A. E., Rus, V., Ilyés, T., Gherman, L.-M., & Bolboaca, S. D. (2023) · Thrombosis Journal · doi:10.1186/s12959-023-00516-0 · Cited by 34 · see citing works
Kaka, G., Yaghoobi, K., Davoodi, S., Hosseini, S. R., Sadraie, S. H., & Mansouri, K. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00025 · Cited by 34 · see citing works
Coelho, V. R., Gianesini, J., Borowski, R. G. V., Mazzardo‐Martins, L., Martins, D. F., Picada, J. N., Santos, A. R. S., Brum, L. F. S., & Pereira, P. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.02.010 · Cited by 34 · see citing works
Hassani, F. V., Hashemzaei, M., Akbari, E., Imenshahidi, M., & Hosseinzadeh, H. (2016) · PubMed Central · doi:10.22038/ajp.2016.15567.1615 · Cited by 32 · see citing works
Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice
Katsuyama, S., Kuwahata, H., Yagi, T., Kishikawa, Y., Komatsu, T., Sakurada, T., & Nakamura, H. (2012) · Biomedical Research · doi:10.2220/biomedres.33.175 · Cited by 31 · see citing works
Souri, F., Rakhshan, K., Erfani, S., Azizi, Y., Maleki, S. N., & Aboutaleb, N. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0520-y · Cited by 29 · see citing works
In vitro and In vivo Antibacterial and Anti-inflammatory Properties of Linalool
Varia, R. D., Patel, J. H., Modi, F. D., Vihol, P. D., & Bhavsar, S. K. (2020) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2020.909.187 · Cited by 28 · see citing works
Teles, A. M., Silva‐Silva, J. V., Fernandes, J. M. P., Calabrese, K. D. S., Abreu‐Silva, A. L., Marinho, S. C., Mouchrek, A. N., Filho, V. E. M., & Almeida-Souza, F. (2020) · Antibiotics · doi:10.3390/antibiotics10010024 · Cited by 28 · see citing works
Phytochemistry, Bioactivities and Traditional Uses of Michelia × alba
Cheng, K., Nadri, M. H., Othman, N. Z., Rashid, S. N. A. A., Lim, Y.-C., & Leong, H.-Y. (2022) · Molecules · doi:10.3390/molecules27113450 · Cited by 28 · see citing works
Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells
Maeda, H., Yamazaki, M., & Katagata, Y. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120692 · Cited by 28 · see citing works
Kang, P., & Seol, G. H. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12359 · Cited by 27 · see citing works
Zhang, N., Bian, Y., & Yao, L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050966 · Cited by 26 · see citing works
Haghparast, A., Shams, J., Khatibi, A., Alizadeh, A.-M., & Kamalinejad, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.060 · Cited by 25 · see citing works
Neuroprotective effect of (R)-(-)-linalool on oxidative stress in PC12 cells
Migheli, R., Lostia, G., Galleri, G., Rocchitta, G., Serra, P. A., Bassareo, V., Acquas, E., & Peana, A. T. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100073 · Cited by 24 · see citing works
Self-citationMedeiros, M. A. M. B., Silva, M. G. E., Barbosa, J. D. M., de Lavor, É. M., Ribeiro, T. F., Macêdo, C. A. F., Filho, L. A. M. D. S. D., Feitosa, T. A., Silva, J. D. J., Fokoue, H. H., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258094 · Cited by 24 · see citing works
HPTLC Fingerprint Profile Of Some Cinnamomum Species
Saraswathy, A., Ramachandran, S., & Sunilkumar, K. (2010) · Pharmacognosy Journal · doi:10.1016/s0975-3575(10)80095-1 · Cited by 23 · see citing works
Therapeutic innovation: Inflammatory-reactive astrocytes as targets of inflammation
Hansson, E., Werner, T., Björklund, U., & Skiöldebrand, E. (2016) · IBRO Reports · doi:10.1016/j.ibror.2016.06.001 · Cited by 23 · see citing works
Essential oils and their bioactive molecules in healthcare
Yeshi, K., & Wangchuk, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85852-6.00006-8 · Cited by 21 · see citing works
Próspero, D. F. A., Filho, A. C. D. R., Piauilino, C. A., Lopes, E. M., de Sousa, D. P., & Almeida, F. R. D. C. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.07.019 · Cited by 21 · see citing works
Maheswari, J. U. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26274 · Cited by 20 · see citing works
Effect of Cuminum cyminum L. Seed Extracts on Pain and Inflammation
Bhat, S. P., Rizvi, W., & Kumar, A. (2014) · Journal of Natural Remedies · doi:10.18311/jnr/2014/81 · Cited by 20 · see citing works
Atividades biológicas de Linalol: conceitos atuais e possibilidades futuras deste monoterpeno
Camargo, S. B., & Silva, D. F. (2015) · Revista de Ciências Médicas e Biológicas · doi:10.9771/cmbio.v13i3.12949 · Cited by 19 · see citing works
Antinociceptive and Anti-Inflammatory Activities ofTeucrium persicumBoiss. Extract in Mice
Miri, A., Sharifi‐Rad, J., Tabrizian, K., & Nasiri, A. A. (2015) · Scientifica · doi:10.1155/2015/972827 · Cited by 19 · see citing works
Romero, T. R. L., Galdino, G. S., da Silva, G. C., Resende, L. C., Perez, A. C., Côrtes, S. F., & Duarte, I. D. G. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22797 · Cited by 19 · see citing works
Rungqu, P., Oyedeji, O. O., Gondwe, M. M., & Oyedeji, A. O. (2023) · Molecules · doi:10.3390/molecules28145294 · Cited by 17 · see citing works
Antifungal and anti-inflammatory potential of the endangered aromatic plant Thymus albicans
Roxo, M., Zuzarte, M., Gonçalves, M. J., Alves-Silva, J. M., Cavaleiro, C., Cruz, M. T., & Salgueiro, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-75244-w · Cited by 18 · see citing works
Li, P., Shih, Y.-J., Lu, W., Huang, P., & Wang, C.-C. R. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104873 · Cited by 16 · see citing works
Hashimoto, M., Takahashi, K., & Ohta, T. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101468 · Cited by 15 · see citing works
Kawata, J., Kameda, M., & Miyazawa, M. (2008) · Journal of Natural Medicines · doi:10.1007/s11418-007-0221-0 · Cited by 15 · see citing works
Waltenberger, B., Schuster, D., Paramapojn, S., Gritsanapan, W., Wolber, G., Rollinger, J. M., & Stuppner, H. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.08.002 · Cited by 15 · see citing works
Naghdi, F., Gholamnezhad, Z., Boskabady, M. H., & Bakhshesh, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.004 · Cited by 15 · see citing works
da Silva, P. R., Pazos, N. D. N., Gonzaga, T. K. S. D. N., Andrade, J., Monteiro, Á. B., Portela, A. C. R., Pires, H. F. O., Maia, M. D. S., da Fonsêca, D. V., Scotti, L., et al. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220505104726 · Cited by 14 · see citing works
Essential Oil of Ocimum basilicum L. and (−)‐Linalool Blocks the Excitability of Rat Sciatic Nerve
Venâncio, A. M., Ferreira‐da‐Silva, F. W., da Silva‐Alves, K. S., Pimentel, H. D. C., Macêdo-Lima, M., de Santana, M. F., Alves, P. B., da Silva, G. B., Leal‐Cardoso, J. H., & Marchioro, M. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/9012605 · Cited by 15 · see citing works
Strong antioxidant activity of carane derivatives
Librowski, T., & Moniczewski, A. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70255-3 · Cited by 14 · see citing works
Yaghoobi, K., Kaka, G., Mansouri, K., Davoodi, S., Sadraie, S. H., & Hosseini, S. R. (2016) · Stem Cells International · doi:10.1155/2016/5328689 · Cited by 13 · see citing works
Stevens, N. S., Dorsett, J., DaBell, A., Eggett, D. L., Han, X., & Parker, T. L. (2017) · Cogent Medicine · doi:10.1080/2331205x.2017.1380871 · Cited by 12 · see citing works
Bioactivity assessment of essential oils of Cymbopogon species using a network pharmacology approach
Bansal, H., Pravallika, V. S. S., Srivastava, G., & Ganjewala, D. (2022) · Biologia Futura · doi:10.1007/s42977-022-00111-w · Cited by 12 · see citing works
Lejeune, V. B. P., Lopes, R. V., Baggio, D. F., Koren, L. D. O., Zanoveli, J. M., & Chichorro, J. G. (2022) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2002-0304 · Cited by 11 · see citing works
Pharmacological, medicinal and toxicological properties of lavender essential oil: A review
Cardia, G. F. E., Silva-Comar, F. M. D. S., da Rocha, E. M. T., Silva-Filho, S. E., Zagoto, M., Uchida, N. S., do Amaral, V., Bersani‐Amado, C. A., & Cuman, R. K. N. (2021) · Research Society and Development · doi:10.33448/rsd-v10i5.14933 · Cited by 11 · see citing works
Asekun, O. T., Okoh, S. O., Familoni, O. B., & Afolayan, A. J. (2013) · Research Journal of Medicinal Plant · doi:10.3923/rjmp.2013.82.91 · Cited by 10 · see citing works
Yunusoğlu, O. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.11.003 · Cited by 9 · see citing works
- Authors
- Peana, A. T., Marzocco, S., Popolo, A., & Pinto, A.
- Affiliations
- University of Sassari (IT)
- University of Salerno (IT)
- Corresponding author
- Peana, Alessandra T.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 78
- Issue
- 7
- Pages
- 719-723
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2073572798
- Cited by
- 160
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- linalool, nitric oxide, inducible nitric oxide synthase, antinociceptive activity, hyperalgesia, prostaglandin E2, cyclooxygenase-2, lipopolysaccharide, macrophages, monoterpenes, cholinergic system, glutamatergic system, anti-inflammatory activity
- MeSH terms
- Acyclic Monoterpenes, Analgesics, Animals, Cell Line, Dose-Response Relationship, Drug, Drug Combinations, Insecticides, Lipopolysaccharides, Macrophages, Nitric Oxide, Nitrites, Dinoprostone, Culture Media, Conditioned, Monoterpenes, Cyclooxygenase 2, Nitric Oxide Synthase Type II
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