Lemongrass effects on IL-1β and IL-6 production by macrophages
Abstract
Cymbopogon citratus has been widely recognised for its ethnobotanical and medicinal usefulness. Its insecticidal, antimicrobial and therapeutic properties have been reported, but little is known about its effect on the immune system. This work aimed to investigate the in vivo effect of a water extract of lemongrass on pro-inflammatory cytokine (IL-1beta and IL-6) production by macrophages of BALB/c mice. The action of lemongrass essential oil on cytokine production by macrophages was also analysed in vitro. The chemical composition of the extract and the oil was also investigated. Treatment of mice with water extract of lemongrass inhibited macrophages to produce IL-1beta but induced IL-6 production by these cells. Lemongrass essential oil inhibited the cytokine production in vitro. Linalool oxide and epoxy-linalool oxide were found to be the major components of lemongrass water extract, and neral and geranial were the major compounds of its essential oil. Taken together, these data suggest an anti-inflammatory action of this natural product.
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Cymbopogon citratus essential oil suppresses IL-1β and IL-6 in LPS-stimulated peritoneal macrophages of normal mice.
“This essential oil revealed to be capable to suppress IL-1β and IL-6 in LPS-stimulated peritoneal macrophages of normal mice [117].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [117]
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“In other work, Lin et al.”
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- Authors
- Sforcin, J. M., Amaral, J. T., Fernandes, A., Sousa, J. P. B., & Bastos, J. K.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Sforcin, J.M.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2009-08-15
- Volume
- 23
- Issue
- 12
- Pages
- 1151-1159
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2034221198
- Cited by
- 51
- References
- 35
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Cymbopogon citratus, macrophages, IL-1β, interleukin-6, inflammatory cytokines, anti-inflammatory activity, essential oils, aqueous extract, linalool oxide, neral, geranial, chemical composition, immunomodulation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cells, Cultured, Chromatography, Gas, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Male, Mice, Inbred BALB C, Plant Extracts, Interleukin-6, Macrophages, Peritoneal, Cymbopogon, Mice, Interleukin-1beta
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