The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance — A review
Abstract
Linoleic acid (LA) (n-6) and α-linolenic acid (ALA) (n-3) are essential fatty acids (EFAs) as they cannot be synthesized by humans or other higher animals. In the human body, these fatty acids (FAs) give rise to arachidonic acid (ARA, n-6), eicosapentaenoic acid (EPA, n-3), and docosahexaenoic acid (DHA, n-3) that play key roles in regulating body homeostasis. Locally acting bioactive signaling lipids called eicosanoids derived from these FAs also regulate diverse homeostatic processes. In general, ARA gives rise to pro-inflammatory eicosanoids whereas EPA and DHA give rise to anti-inflammatory eicosanoids. Thus, a proportionally higher consumption of n-3 PUFAs can protect us against inflammatory diseases, cancer, cardiovascular diseases, and other chronic diseases. The present review summarizes major sources, intake, and global consumption of n-3 and n-6 PUFAs. Their metabolism to biosynthesize long-chain PUFAs and eicosanoids and their roles in brain metabolism, cardiovascular disease, obesity, cancer, and bone health are also discussed.
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Cites
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Eicosanoid storm in infection and inflammation
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The Opposing Effects of N-3 and n-6 Fatty Acids
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Fish and Omega-3 Fatty Acid Intake and Risk of Coronary Heart Disease in Women
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Mechanisms of action of docosahexaenoic acid in the nervous system
Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919 · cited 1×
“important role as extra- and intracellular signaling molecules [62].”
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Cited by
The science of plant‐based foods: Constructing next‐generation meat, fish, milk, and egg analogs
McClements, D. J., & Grossmann, L. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12771 · Cited by 600
Advances in Lipid Extraction Methods—A Review
Saini, R. K., Prasad, P., Shang, X., & Keum, Y.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413643 · Cited by 479
Self-citationDietary Polyunsaturated Fatty Acids (PUFAs): Uses and Potential Health Benefits
Kapoor, B., Kapoor, D., Gautam, S., Singh, R., & Bhardwaj, S. (2021) · Current Nutrition Reports · doi:10.1007/s13668-021-00363-3 · Cited by 418
Balić, A., Vlašić, D., Žužul, K., Marinović, B., & Bukvić Mokos, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030741 · Cited by 400
Mariamenatu, A. H., & Abdu, E. M. (2021) · Journal of Lipids · doi:10.1155/2021/8848161 · Cited by 346
Metadata
- Authors
- Saini, R. K., & Keum, Y.-S.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 203
- Pages
- 255-267
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2801960867
- Cited by
- 1,281
- References
- 13
- FWCI
- 68.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saini, R. K., & Keum, Y.-S. (2018). Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance — A review. Life Sciences. https://doi.org/10.1016/j.lfs.2018.04.049
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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