Biological and social predictors of immune senescence in the aged primate
Abstract
The transition to geriatric status occurs at around 20 years of age in monkeys after which there is typically a decline in immune responses. However, the loss in immune vigor may be quite dissociated from chronological age in some of these long-lived animals. The degree to which natural killer (NK) cell activity is sustained in aged monkeys has proven to be a valuable prognostic of ultimate health and longevity. Another useful biomarker of cellular aging in the monkey is interleukin-6 (IL-6) release. For example, when endothelial cell cultures were generated from cerebral blood vessels, those derived from aged donors produced significantly more IL-6 in response to IL-1, LPS, and hypoxia. Despite this evidence of intrinsic aging, we have found that immune responses in old animals are quite responsive to contemporaneous conditions, including changes in housing or the first onset of illness. Indeed, these changes, especially the pathological processes associated with disease, may promote many age-related immune alterations at the end of the life span.
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Natural killer cell and lymphocyte activity, which are reported to diminish with age in monkeys and mice, were further attenuated following restraint stress in aged mice.
“For example, natural killer cell and lymphocyte activity, which are reported to diminish with age in monkeys and mice, were further attenuated following restraint stress in aged mice (Coe, 2004;Padgett, 1998).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Coe, 2004
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Self-citationAge-related pathology and biosenescent markers in captive rhesus macaques
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Self-citationThe proinflammatory cytokine network: interactions in the CNS and blood of rhesus monkeys
Reyes, T. M., & Coe, C. L. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.1.r139 · Cited by 35 · see citing works
Self-citationIntrinsic and environmental influences on immune senescence in the aged monkey
Coe, C. L., & Ershler, W. B. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00491-7 · Cited by 25 · see citing works
Self-citationErshler, W. B., Coe, C. L., Gravenstein, S., et al. (1988) · American Journal of Primatology · doi:10.1002/ajp.1350150210 · Cited by 21 · see citing works
Self-citationPsychosocial Factors and Immune Senescence in the Aged Primatea
Coe, C. L., Ershler, W. B., Champoux, M., et al. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb49136.x · Cited by 11 · see citing works
Self-citationSurgical and Psychological Stressors Differentially Affect Cytolytic Responses in the Rhesus Monkey
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The molecular inflammatory process in aging
Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437 · see citing works
Microglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works
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Vascular Inflammation in Aging
Ungvari, Z., Csiszar, A., & Kaley, G. (2004) · Herz · doi:10.1007/s00059-004-2625-x · Cited by 75 · see citing works
The inflammatory response to social defeat is increased in older mice
Kinsey, S. G., Bailey, M. T., Sheridan, J. F., & Padgett, D. A. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.003 · Cited by 48 · see citing works
The aging kidney: role of endothelial oxidative stress and inflammation
Csiszar, A., Toth, J., Peti-Peterdi, J., & Ungvari, Z. (2007) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.94.2007.1-2.10 · Cited by 43 · see citing works
- Authors
- Coe, C. L.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Coe, Christopher L.
- ORCID
- Coe, Christopher L.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 125
- Issue
- 2
- Pages
- 95-98
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W1975828200
- Cited by
- 15
- References
- 8
- Citations by year
- 2017: 1 · 2016: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI046521, AI46521)
- National Center for Research Resources (RR 000167, P51RR000167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- immunosenescence, aging, non-human primates, rhesus monkeys, natural killer cells, interleukin-6, cellular aging, endothelial cells, social environment, longevity, aging biomarkers
- MeSH terms
- Aging, Animals, Killer Cells, Natural, Predictive Value of Tests, Primates, Social Behavior, Biomarkers, Interleukin-6
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