Vascular Inflammation in Aging

Ungvari, Zoltan; Csiszar, Anna; Kaley, Gabor

doi:10.1007/s00059-004-2625-x

Cited by 75Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Vascular Inflammation in Aging

Ungvari, Zoltan, Csiszar, Anna, Kaley, Gabor·2004·Herz

DOI 10.1007/s00059-004-2625-x

Open this paper in CoChat — free account

Abstract

Although epidemiologic studies have revealed that high plasma cholesterol or high homocysteine levels, as well as diabetes, hypertension and smoking are important risk factors for atherosclerotic vascular disease, the deleterious effects of these conditions can be delayed or significantly attenuated by therapeutic interventions. Since the population in the Western world is aging, advancing age itself became one of the most significant risk factors for the development of atherosclerosis. Atherosclerosis is a chronic inflammatory disease, however, the mechanisms by which advanced age per se promotes vascular inflammation are not well understood. In the present review the authors propose a model for age-related alterations in cytokine expression, increased oxidative stress and decreased bioavailability of NO that underlie a pro-inflammatory phenotype of aged vessels promoting the development of atherosclerosis in the elderly.

Integrity signals

Registry

Crossref · 10.1007/s00059-004-2625-x

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chronic low-grade inflammation develops in arteries with aging.
“Chronic low-grade inflammation develops in arteries with aging (44, 180)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [180]

Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
Libermann, T. A., & Baltimore, D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2327 · Cited by 1,372 · see citing works
Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264 · see citing works
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,220 · cited 1× · see citing works
“Role of Altered Stress Resistance in Vascular Inflammation in Aging There is increasing evidence that expression of pro-inflammatory cytokines, including that of TNF-α and IL-6, may be induced by stress [20, 71].”
Background
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,086 · see citing works
Inflammatory Cytokines and Postmyocardial Infarction Remodeling
Nian, M., Lee, P. C., Khaper, N., & Liu, P. J. (2004) · Circulation Research · doi:10.1161/01.res.0000130526.20854.fa · Cited by 1,031 · see citing works
Aging and proinflammatory cytokines
Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.
Zeiher, A. M., Drexler, H., Saurbier, B., & Just, H. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116634 · Cited by 671 · see citing works
The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
Hajra, L., Evans, A. I., Chen, M., Hyduk, S. J., Collins, T., & Cybulsky, M. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9052 · Cited by 569 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
Self-citation
IL-1 stimulates IL-6 production in endothelial cells.
Sironi, M., Breviario, F., Proserpio, P., Biondi, A., Vecchi, A., Damme, J. V., Dejana, E., & Mantovani, A. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.2.549 · Cited by 522 · see citing works
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
Berkowitz, D. E., White, R., Li, D., Minhas, K. M., Cernetich, A., Kim, S., Burke, S., Shoukas, A. A., Nyhan, D., Champion, H. C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000092948.04444.c7 · Cited by 486 · see citing works
Interleukin‐6: A Cytokine for Gerontolgists
Ershler, W. B. (1993) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb02054.x · Cited by 480 · see citing works
Superoxide Excess in Hypertension and Aging
Hamilton, C., Brosnan, M. J., McIntyre, M., Graham, D., & Dominiczak, A. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.529 · Cited by 438 · see citing works
Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women
Volpato, S., Guralnik, J. M., Ferrucci, L., Balfour, J. L., Chaves, P. H. M., Fried, L. P., & Harris, T. B. (2001) · Circulation · doi:10.1161/01.cir.103.7.947 · Cited by 434 · see citing works
Anti-Inflammatory Mechanisms in the Vascular Wall
Tedgui, A., & Mallat, Z. (2001) · Circulation Research · doi:10.1161/hh0901.090440 · Cited by 418 · see citing works
Ageing, tumour necrosis factor-alpha (TNF- α ) and atherosclerosis
Brüünsgaard, H., Skinhøj, P., Pedersen, B. K., Schroll, M., & Pedersen, B. K. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01281.x · Cited by 402 · see citing works
Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging.
Kirstein, M., Brett, J., Radoff, S., Ogawa, S., Stern, D., & Vlassara, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.9010 · Cited by 364 · see citing works
Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli
Hoffmann, J., Haendeler, J., Aicher, A., Rössig, L., Vasa‐Nicotera, M., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh2001.097796 · Cited by 355 · see citing works
Expression of Constitutive and Inducible Nitric Oxide Synthases in the Vascular Wall of Young and Aging Rats
Cernadas, M. R., de Miguel, L. S., Garcı́a-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, A. P., de Frutos, T., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.3.279 · Cited by 310 · see citing works
The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction
Chung, H. Y., Kim, H. J., Kim, J. W., & Yu, B. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05662.x · Cited by 305 · see citing works
eNOS Activity Is Reduced in Senescent Human Endothelial Cells
Matsushita, H., Chang, E., Glassford, A. J., Cooke, J. P., Chiu, C., & Tsao, P. S. (2001) · Circulation Research · doi:10.1161/hh2101.098443 · Cited by 302 · see citing works
Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction
Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 297 · see citing works
Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
Grammas, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00276-7 · Cited by 292 · see citing works
Increased Superoxide Production in Coronary Arteries in Hyperhomocysteinemia
Ungvari, Z. I., Csiszár, A., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Kaley, G., & Koller, Á. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000061735.85377.40 · Cited by 267 · see citing works
Self-citation
Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries
Csiszár, A., Ungvari, Z. I., Koller, Á., Edwards, J. G., & Kaley, G. (2003) · The FASEB Journal · doi:10.1096/fj.02-1049fje · Cited by 266 · see citing works
Self-citation
Interleukin-6 Induction by Tumor Necrosis Factor and Interleukin-1 in Human Fibroblasts Involves Activation of a Nuclear Factor Binding to a κΒ-Like Sequence
Zhang, Y., Lin, J., & Vilček, J. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3818-3823.1990 · Cited by 264 · see citing works
Aging Increases Aortic MMP-2 Activity and Angiotensin II in Nonhuman Primates
Wang, M., Takagi, G., Asai, K., Resuello, R. G., Natividad, F. F., Vatner, D. E., Vatner, S. F., & Lakatta, E. G. (2003) · Hypertension · doi:10.1161/01.hyp.0000073843.56046.45 · Cited by 235 · see citing works
Serum From Patients With Severe Heart Failure Downregulates eNOS and Is Proapoptotic
Agnoletti, L., Curello, S., Bachetti, T., Malacarne, F., Gaia, G., Comini, L., Volterrani, M., Bonetti, P., Parrinello, G., Cadei, M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.19.1983 · Cited by 233 · see citing works
The IL-6-Soluble IL-6Rα Autocrine Loop of Endothelial Activation as an Intermediate Between Acute and Chronic Inflammation: an Experimental Model Involving Thrombin
Marin, V., Montero-Julian, F., Grès, S., Boulay, V., Bongrand, P., Farnarier, C., & Kaplanski, G. (2001) · Journal of Immunology · doi:10.4049/jimmunol.167.6.3435 · Cited by 227 · see citing works
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice
Spaulding, C. C., Walford, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01824-6 · Cited by 224 · see citing works
Aging-induced Up-regulation of Nuclear Binding Activities of Oxidative Stress Responsive NF-kB Transcription Factor in Mouse Cardiac Muscle
Helenius, M. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0045 · Cited by 217 · see citing works
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
Csiszár, A., Ungvari, Z. I., Koller, Á., Edwards, J. G., & Kaley, G. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2003 · Cited by 217 · see citing works
Self-citation
Ras Induces Vascular Smooth Muscle Cell Senescence and Inflammation in Human Atherosclerosis
Minamino, T., Yoshida, T., Tateno, K., Miyauchi, H., Zou, Y., Toko, H., & Komuro, I. (2003) · Circulation · doi:10.1161/01.cir.0000093274.82929.22 · Cited by 208 · see citing works
Increased Expression of Matrix Metalloproteinase-2 in the Thickened Intima of Aged Rats
Li, Z., Froehlich, J. P., Galis, Z. S., & Lakatta, E. G. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.116 · Cited by 203 · see citing works
Hyperhomocysteinemia Activates Nuclear Factor-κB in Endothelial Cells via Oxidative Stress
Au-Yeung, K. K. W., Woo, C. W., Sung, F. L., Yip, J. C. W., Siow, Y. L., & Karmin, O. (2003) · Circulation Research · doi:10.1161/01.res.0000108264.67601.2c · Cited by 198 · see citing works
Inflammation-mediated rheumatic diseases and atherosclerosis
MANZI, S., WASKO, M. C. M., & MANZI, S. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.5.321 · Cited by 195 · see citing works
Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats
Sun, D., Huang, A., Yan, E. H., Wu, Z., Yan, C., Kaminski, P. M., Oury, T. D., Wolin, M. S., & Kaley, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2003 · Cited by 167 · see citing works
Self-citation
Modulation of redox-sensitive transcription factors by calorie restriction during aging
Kim, H. J., Jung, K. J., Yu, B. P., Cho, C. G., Choi, J. S., & Chung, H. Y. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00094-5 · Cited by 166 · see citing works
Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals
Yamamoto, K., Takeshita, K., Shimokawa, T., Yi, H., Isobe, K., Loskutoff, D. J., & Saito, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022608799 · Cited by 163 · see citing works
Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians
Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., et al. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00195-0 · Cited by 162 · see citing works
TNF-α inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
Kim, F., Gallis, B. M., & Corson, M. A. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.5.c1057 · Cited by 143 · see citing works
Age-Related Endothelial Dysfunction with Respect to Nitric Oxide, Endothelium-Derived Hyperpolarizing Factor and Cyclooxygenase Products
Matz, R. L., Schott, C., Stoclet, J. C., & Andriantsitohaina, R. (2000) · Physiological Research · doi:10.33549/physiolres.930000.49.11 · Cited by 143 · see citing works
Vascular bed heterogeneity in age‐related endothelial dysfunction with respect to NO and eicosanoids
Matz, R. L., de Sotomayor, M. Á., Schott, C., et al. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703568 · Cited by 130 · see citing works
Exercise training improves ageing‐induced decrease in eNOS expression of the aorta
Tanabe, T., Maeda, S., Miyauchi, T., Iemitsu, M., Takanashi, M., Irukayama‐Tomobe, Y., Yokota, T., Ohmori, H., & Matsuda, M. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01100.x · Cited by 122 · see citing works
Increase in Circulating Levels of Monocyte Chemoattractant Protein-1 with Aging
Inadera, H., Egashira, K., Takemoto, M., Ouchi, Y., & Matsushima, K. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313127 · Cited by 120 · see citing works
Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries
Woodman, C. R., Price, E. M., & Laughlin, M. H. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00461.2002 · Cited by 119 · see citing works
The process of aging changes the interplay of the immune, endocrine and nervous systems
Straub, R. H., Cutolo, M., Zietz, B., & Schölmerich, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00289-5 · Cited by 110 · see citing works
Aging-Related Expression of Inducible Nitric Oxide Synthase and Markers of Tissue Damage in the Rat Penis1
Ferrini, M. G., Magee, T. R., Vernet, D. A., Rajfer, J., & González-Cadavid, N. F. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.3.974 · Cited by 108 · see citing works
Circulating and cellular markers of endothelial dysfunction with aging in rats
Challah, M., Nadaud, S., Philippe, M., Battle, T., Soubrier, F., Corman, B., & Michel, J. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1941 · Cited by 104 · see citing works
Cyclo‐oxygenase‐1 and −2 contribution to endothelial dysfunction in ageing
Heymes, C., Habib, A., Yang, D., Mathieu, E., Marotte, F., Samuel, J., & Boulanger, C. M. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703632 · Cited by 103 · see citing works
NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2consumption by NO in old Fischer 344 rats
Adler, A., Messina, E. J., Sherman, B., Wang, Z., Huang, H., Linke, A., & Hintze, T. H. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01047.2002 · Cited by 100 · see citing works
Increased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats
Belmin, J., Bernard, C., Corman, B., Merval, R., Esposito, B., & Tedgui, A. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.6.h2288 · Cited by 93 · see citing works
Inhibition of Renin-Angiotensin System Ameliorates Endothelial Dysfunction Associated With Aging in Rats
Mukai, Y., Shimokawa, H., Higashi, M., Morikawa, K., Matoba, T., Hiroki, J., Kunihiro, I., Hassan, T. M. A., & Takeshita, A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000029121.63691.ce · Cited by 92 · see citing works
Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase‐2 in brain endothelial cells and also upregulate their receptors
Cao, C., Matsumura, K., Shirakawa, N., Maeda, M., Jikihara, I., Kobayashi, S., & Watanabe, Y. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01551.x · Cited by 90 · see citing works
Comparative Studies on Vascular Endothelium in vitro
Klein, C. L., Köhler, H., Bittinger, F., Wagner, M., Hermanns, I., Grant, K., Lewis, J. C., & Kirkpatrick, C. J. (2008) · Pathobiology · doi:10.1159/000163911 · Cited by 84 · see citing works
Circulating Vascular Cell Adhesion Molecules VCAM-1, ICAM-1, and E-Selectin in Dependence on Aging
Richter, V., Rassoul, F., Purschwitz, K., Hentschel, B., Reuter, W., & Kuntze, T. (2003) · Gerontology · doi:10.1159/000071710 · Cited by 81 · see citing works
Post-transcriptional regulation of interleukin 1 alphain various strains of young and senescent human umbilical vein endothelialcells.
Garfinkel, S., Brown, S., Wessendorf, J., & Maciag, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1559 · Cited by 75 · see citing works
Augmented Expression of Inducible NO Synthase in Vascular Smooth Muscle Cells During Aging Is Associated With Enhanced NF-κB Activation
Yan, Z.-Q., Sirsjö, A., Bochaton‐Piallat, M., et al. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.12.2854 · Cited by 73 · see citing works
Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress
Saitō, H., & Papaconstantinou, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103740200 · Cited by 69 · see citing works
Age-related changes in the signaling and function of vascular smooth muscle cells
Lundberg, M. S., & Crow, M. T. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00036-4 · Cited by 54 · see citing works
Expression of IFN-gamma in Cerebrovascular Endothelial Cells from Aged Mice
Wei, Y., Kita, M., Shinmura, K., Yan, X.-Q., Fukuyama, R., Fushiki, S., & Imanishi, J. (2000) · Journal of Interferon & Cytokine Research · doi:10.1089/107999000312342 · Cited by 52 · see citing works
Effect of losartan in aging-related endothelial impairment
Rajagopalan, S., Brook, R. D., Mehta, R. H., Supiano, M. A., & Pitt, B. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02297-4 · Cited by 51 · see citing works
Comparative Studies on Vascular Endothelium in vitro
Klein, C. L., Bittinger, F., Köhler, H., Wagner, M., Otto, M., Hermanns, I., & Kirkpatrick, C. J. (2008) · Pathobiology · doi:10.1159/000163938 · Cited by 51 · see citing works
Pressure-Induced Vascular Activation of Nuclear Factor-κB
Lemarié, C. A., Esposito, B., Tedgui, A., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000086942.13523.88 · Cited by 47 · see citing works
Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats.
Sirén, A., Liu, Y., FEUERSTEIN, G. Z., & Hallenbeck, J. M. (1993) · Stroke · doi:10.1161/01.str.24.6.880 · Cited by 41 · see citing works
Impact of aging and life‐long calorie restriction on expression of apoptosis‐related genes in male F344 rat liver
Ando, K., Higami, Y., Tsuchiya, T., Kanematsu, T., & Shimokawa, I. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10207 · Cited by 41 · see citing works
Lower extremity arterial occlusions in young patients with Crohn's colitis and premature atherosclerosis: report of six cases.
Levy, P. J., Tabares, A. H., & Olin, J. W. (1997) · PubMed · Cited by 37 · see citing works
Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse
Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D. J., & Saito, H. (2002) · Blood · doi:10.1182/blood-2002-03-0945 · Cited by 37 · see citing works
In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging
Zhang, J., Dai, J., Lu, Y. H., Yao, Z., O’Brien, C. A., Murtha, J., Qi, W., Hall, D. E., Manolagas, S. C., Ershler, W. B., et al. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.024 · Cited by 33 · see citing works
Unique Sensitivities to Cytokine Regulated Expression of Adhesion Molecules in Human Heart-Derived Endothelial Cells
McDouall, R. M., Farrar, M. W., Khan, S., Yacoub, M. H., & Allen, S. P. (2001) · Endothelium · doi:10.3109/10623320109063155 · Cited by 20 · see citing works
Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway
Bachschmid, M. M., van der Loo, B., Schüler, K., Labugger, R., Thurau, S., Eto, M., Kilo, J., Hölz, R., Lüscher, T. F., & Ullrich, V. (2003) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2003.09.006 · Cited by 18 · see citing works
Biological and social predictors of immune senescence in the aged primate
Coe, C. L. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.11.011 · Cited by 15 · see citing works

Flagged first, then by citations

Sorted by citations

Inflammation and endothelial dysfunction during aging: role of NF-κB
Csiszar, A., Wang, M., Lakatta, E. G., & Ungvari, Z. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90470.2008 · Cited by 441 · see citing works
Self-citation
Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency
Ungvari, Z., Krasnikov, B. F., Csiszar, A., Labinskyy, N., Mukhopadhyay, P., Pacher, P., Cooper, A. J. L., Podlutskaya, N., Austad, S. N., & Podlutsky, A. (2008) · AGE · doi:10.1007/s11357-008-9059-y · Cited by 56 · see citing works
Self-citation
The aging kidney: role of endothelial oxidative stress and inflammation
Csiszar, A., Toth, J., Peti-Peterdi, J., & Ungvari, Z. (2007) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.94.2007.1-2.10 · Cited by 43 · see citing works
Self-citation

Homocysteine and Endothelial Dysfunction: A Link with Cardiovascular Disease
McDowell, I., & Lang, D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.369s · Cited by 135 · see citing works
Endothelial Function and Oxidative Stress
Ogita, H., & Liao, J. K. (2004) · Endothelium · doi:10.1080/10623320490482664 · Cited by 188 · see citing works
Anti-inflammatory strategies for homocysteine-related cardiovascular disease
Lin, C. P. (2009) · Frontiers in bioscience · doi:10.2741/3492 · Cited by 22 · see citing works
Homocysteine as a Risk Factor for Peripheral Vascular Disease
Abou‐Zamzam, A. M., Moneta, G. L., Porter, J. M., et al. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-94-017-1789-2_9 · Cited by 3 · see citing works
Homocysteine Hypothesis for Atherothrombotic Cardiovascular Disease
Kaul, S., Zadeh, A. A., & Shah, P. K. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.04.086 · Cited by 175 · see citing works

Authors: Ungvari, Z., Csiszar, A., & Kaley, G.
Affiliations: New York Medical College (US)
Corresponding author: Kaley, Gabor
ORCID: Ungvari, Zoltan
Venue: Herz
Publisher: Springer Science and Business Media LLC
Published: 2004-12
Volume: 29
Issue: 8
Pages: 733-740
ISSN: 0340-9937 (ISSN-L)
1615-6692
DOI: 10.1007/s00059-004-2625-x
OpenAlex: W119636436
Cited by: 75
References: 77
Citations by year: 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 7
FWCI: 1.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Herz (publishedVersion)
PubMed (publishedVersion)
Funders: American Health Assistance Foundation
American Heart Association
American Foundation for Aging Research
National Institutes of Health
National Heart, Lung, and Blood Institute (P01HL043023, P01 HL 43023)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: vascular inflammation, aging, atherosclerosis, cytokine expression, oxidative stress, nitric oxide bioavailability, pro-inflammatory phenotype, older adults, vascular aging
MeSH terms: Aging, Animals, Humans, Nitric Oxide, Vasculitis, Cytokines, Oxidative Stress, Models, Immunological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vascular Inflammation in Aging

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks