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Cited by 111Immune Cell Function and InteractionInfluenza Virus Research Studiesinterferon and immune responses

Characterization of age-related changes in natural killer cells during primary influenza infection in mice

Nogusa, Shoko, Ritz, Barry W., Kassim, Sadik H., Jennings, Stephen R., Gardner, Elizabeth M.·2008·Mechanisms of Ageing and Development
DOI 10.1016/j.mad.2008.01.003
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Abstract

The current investigation examined the importance of natural killer (NK) cells during the innate immune response to primary influenza infection in young and aged mice. Young (6-8 weeks) and aged (22 months) C57BL/6 mice were infected intranasally with influenza A virus, and NK cell-mediated cytotoxicity was determined in lung and spleen during the first 4 days of infection. Aged mice demonstrated both a decrease in influenza-inducible NK activity and a reduction in the percentage and number of NK1.1+ cells in response to primary influenza infection, relative to young mice. In order to further establish a role for NK cells in controlling influenza infection, young mice were depleted of NK cells in vivo by injecting rabbit anit-NK1.1 antibody 2 days and 1 day prior to influenza infection. Young mice depleted of NK cells exhibited increased weight loss and lung virus titers during the course of infection, compared to young mice infected with influenza virus. These data indicate that NK cell function is impaired in response to primary influenza infection in aged mice. More importantly, these results underscore the essential role of NK cells in controlling virus titers in lung during the early course of influenza infection, regardless of age.

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  • Experimental studies have illustrated that altered function and phenotype of NK cells with advanced aged underlies increased susceptibility of older persons to infectious stimuli.

    “Experimental studies have illustrated that altered function and phenotype of NK cells with advanced aged underlies increased susceptibility of older persons to infectious stimuli (127).”

    From Aging and Lung Disease (2020) · cites this paper as [127]

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Authors
Nogusa, S., Ritz, B. W., Kassim, S. H., Jennings, S. R., & Gardner, E. M.
Affiliations
Drexel University (US)
Corresponding author
Gardner, Elizabeth M.
ORCID
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2008-04
Volume
129
Issue
4
Pages
223-230
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/j.mad.2008.01.003
OpenAlex
W2078343139
Cited by
111
References
22
Citations by year
2026: 4 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 10 · 2012: 5
FWCI
2.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
natural killer cells, influenza A virus, aging, innate immunity, NK cell cytotoxicity, NK1.1, NK cell depletion, lung viral titers, age-related immune decline, C57BL/6 mice
MeSH terms
Aging, Animals, Cytotoxicity, Immunologic, Killer Cells, Natural, Kinetics, Male, Mice, Inbred C57BL, Orthomyxoviridae Infections, Pneumonia, RNA, Messenger, Viral Matrix Proteins, Weight Loss, Gene Expression Regulation, Viral, Lymphocyte Count, Mice, Influenza A Virus, H1N1 Subtype

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