The DOI matches its Crossref record; 304 of the 304 references it cites were found in a registry or an index.
The hallmarks of fibroblast ageing
Abstract
Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage accumulation and (mal-)adaptation, thus constituting a powerful indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of ageing (Lopez-Otin et al., 2013, Cell 153) to categorise the available knowledge regarding dermal fibroblast ageing. We discriminate processes inducible in culture from phenomena apparent in skin biopsies or primary cells from old donors, coming to the following conclusions: (i) Fibroblasts aged in culture exhibit most of the established, ubiquitous hallmarks of ageing. (ii) Not all of these hallmarks have been detected or investigated in fibroblasts aged in situ (in the skin). (iii) Dermal fibroblasts aged in vitro and in vivo exhibit additional features currently not considered ubiquitous hallmarks of ageing. (iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“UV-A also inhibits the synthesis of hyaluronic acid (HA) by down-regulating the synthesis of hyaluronic acid synthase, thereby changing the composition of skin proteoglycans [20].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [20]
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“The same endpoint is also reached along the p53 and p16INK4a pathway following activation of ras oncogene (oncogeneinduced premature senescence) (Serrano et al., 1997).”
BackgroundThe senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 231
A dynamical systems model for the measurement of cellular senescence
Galvis, D., Walsh, D. A., Harries, L. W., Latorre, E., & Rankin, J. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0311 · Cited by 22
Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies
Schiavi, A., Strappazzon, F., & Ventura, N. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111252 · Cited by 22
Self-citationDietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan
Brinkmann, V., Schiavi, A., Shaik, A., Puchta, D. R., & Ventura, N. (2020) · Aging · doi:10.18632/aging.202316 · Cited by 22
Self-citationYu, Z., Smith, M. J., Siow, R. C. M., & Liu, K. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.118972 · Cited by 20
Cellular Senescence and Aging in Myotonic Dystrophy
Hasuike, Y., Mochizuki, H., & Nakamori, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042339 · Cited by 22
Epigenetics in Skin Homeostasis and Ageing
Dermitzakis, I., Kyriakoudi, S. A., Chatzianagnosti, S., Chatzi, D., Vakirlis, E., Meditskou, S., Μanthou, M. E., & Theotokis, P. (2025) · Epigenomes · doi:10.3390/epigenomes9010003 · Cited by 23
The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence
Magalhães, S., Almeida, I., Pereira, C. D., Rebelo, S., Goodfellow, B. J., & Nunes, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105830 · Cited by 21
Human placental extract activates a wide array of gene expressions related to skin functions
Chang, P. Y., Chin, L.-C., Kimura, K., & Nakahata, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-15270-y · Cited by 18
Naughton, G. K., Jiang, L. I., Makino, E. T., Chung, R., Nguyen, A., Cheng, T., Kadoya, K., & Mehta, R. (2022) · Dermatology and Therapy · doi:10.1007/s13555-022-00839-2 · Cited by 18
Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy
Liu, X., Yang, C., Deng, Y., Liu, P., Yang, H., Du, X., & Du, Y. (2021) · BioMed Research International · doi:10.1155/2021/5847153 · Cited by 17
Aging-related increase in store-operated Ca2+ influx in human ventricular fibroblasts
Mohis, M., Kroboth, S., Ryan, S., Rizvi, F., Tajik, A. J., Jahangir, A., & Ross, G. R. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00588.2017 · Cited by 18
Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts
Yalamanchili, N., Kriete, A., Alfego, D., Danowski, K. M., Kari, C., & Rodeck, U. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00171 · Cited by 17
Chen, M., Chang, C.-C., Wu, C.-L., Chiang, P., Yeh, C.-C., Chen, Y., & Sheu, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136311 · Cited by 16
Wounding Therapies for Prevention of Photocarcinogenesis
Frommeyer, T. C., Rohan, C. A., Spandau, D. F., Kemp, M. G., Wanner, M. A., Tanzi, E. L., & Travers, J. B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.813132 · Cited by 17
Li, J., Liu, Y., Zhang, R., Yang, Q., Xiong, W., He, Y., & Ye, Q. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03774-5 · Cited by 20
Alterations in the Genomic Distribution of 5hmC in In Vivo Aged Human Skin Fibroblasts
Kołodziej, P., Borkowska, J., Wicik, Z., Domaszewska-Szostek, A., Połosak, J., Cakala, M., Bujanowska, O., & Puzianowska‐Kuźnicka, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010078 · Cited by 16
Sarandy, M. M., Gonçalves, R. V., & Valacchi, G. (2024) · Biomedicines · doi:10.3390/biomedicines12020348 · Cited by 16
Chen, P., Zhang, Q., Zhang, H., Gao, Y., Zhou, Y., Chen, Y., Guan, L., Jiao, T., Zhao, Y.-Y., Huang, M., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29906 · Cited by 14
Kim, Y., Ji, H., Cho, E., Park, N. H., Hwang, K., Park, W.-S., Lee, K.-S., Park, D., & Jung, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413673 · Cited by 16
Gudenschwager, C., Chavez, I., Cárdenas, C., & González-Billault, C. E. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5586052 · Cited by 12
da Cruz, I. B. M., Bonotto, N. C. D. A., Turra, B. O., Teixeira, C. F., Azzolin, V. F., Ribeiro, E. A. M., Piccoli, J. D. C. E., & Barbisan, F. (2023) · Toxicology in Vitro · doi:10.1016/j.tiv.2023.105637 · Cited by 15
Therapeutic Potential of Stem Cell-Derived Exosomes in Skin Wound Healing
Jo, C., Choi, Y. J., & Lee, T. (2025) · Biomimetics · doi:10.3390/biomimetics10080546 · Cited by 16
Wang, Y., Shen, X., Song, S., Chen, Y., Wang, Y., Liao, J., Chen, N., & Zeng, L. (2023) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12910 · Cited by 14
Kim, W. S., Seo, J. H., Lee, J. I., Ko, E.-S., Cho, S.-M., Kang, J.-R., Jeong, J.-H., Jeong, Y. J., Kim, C. Y., Cha, J., et al. (2021) · Plants · doi:10.3390/plants10040659 · Cited by 14
Hyaluronan: Structure, Metabolism, and Biological Properties
Passi, A. G., & Vigetti, D. (2019) · Biologically-inspired systems · doi:10.1007/978-3-030-12919-4_4 · Cited by 14
Enhanced Type I Collagen Synthesis in Fibroblasts by Dermal Stem/Progenitor Cell-Derived Exosomes
Sanada, A., Yamada, T., Hasegawa, S., Ishii, Y., Hasebe, Y., Iwata, Y., Arima, M., Sugiura, K., & Akamatsu, H. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-01084 · Cited by 14
The role of sirtuins in dermal fibroblast function
Gilbert, M. M., Mathes, S. C., Mahajan, A. S., Rohan, C. A., Travers, J. B., & Thyagarajan‐Sahu, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1021908 · Cited by 15
AP2A1 modulates cell states between senescence and rejuvenation
Chantachotikul, P., Liu, S., Furukawa, K. T., & Deguchi, S. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111616 · Cited by 13
Leal, E. C., Moura, L. I. F., Pirzgalska, R. M., Marques‐da‐Silva, D., Ledent, C. A., Köfalvi, A., & Carvalho, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111528 · Cited by 12
IRescue: uncertainty-aware quantification of transposable elements expression at single cell level
Polimeni, B., Marasca, F., Ranzani, V., & Bodega, B. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae793 · Cited by 11
Gregory, A., Humphrey, S. D., Chunharas, C., Ogilvie, P., & Fabi, S. G. (2019) · Dermatologic Surgery · doi:10.1097/dss.0000000000002086 · Cited by 11
Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin
Kawagishi‐Hotta, M., Hasegawa, S., Inoue, Y., Hasebe, Y., Arima, M., Iwata, Y., Sugiura, K., & Akamatsu, H. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.06.007 · Cited by 11
Lim, J., Lim, C. J., Kim, S., Nam, G., Chang, M., Park, K., Park, K., Kim, H. J., Ahn, J. K., & Jeong, S. (2018) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12530 · Cited by 11
Wirtz, L., Möckel, M., & Knebel-Mörsdorf, D. (2019) · Journal of Virology · doi:10.1128/jvi.02046-19 · Cited by 11
Pérez-Davó, A., Truchuelo, M. T., Vitale, M., & González-Castro, J. (2019) · PubMed Central · Cited by 11
Sengstack, J., Zheng, J., Aghayev, T., Bieri, G., Mobaraki, M., Lin, J., Deng, C., Villeda, S., & Li, H. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2515183123 · Cited by 12
Effect of Selected Antioxidants on the In Vitro Aging of Human Fibroblasts
Bartosz, G., Pieńkowska, N., & Sadowska‐Bartosz, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031529 · Cited by 11
Predicting Chronological Age via the Skin Volatile Profile
Finnegan, M., Fitzgerald, S., Duroux, R., Attia, J., Markey, E., O’Connor, D. J., & Morrin, A. (2024) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.3c00315 · Cited by 10
Boismal, F., Peltier, S., So, S. L. K., Chevreux, G., Blondel, L., Serror, K., Setterblab, N., Zuelgaray, E., Boccara, D., Mimoun, M., et al. (2024) · Aging · doi:10.18632/aging.206055 · Cited by 11
Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells
Low, J., Chan, B., & Tay, A. K. P. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107990 · Cited by 11
Benoit, I., Burty-Valin, E., & Radman, M. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s397751 · Cited by 11
Georgakopoulou, E. A., Valsamidi, C., Veroutis, D., & Havaki, S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111409 · Cited by 12
Nuryana, C. T., Haryana, S. M., Wirohadidjojo, Y. W., & Arfian, N. (2020) · Journal of Stem Cells and Regenerative Medicine · doi:10.46582/jsrm.1601005 · Cited by 10
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., & Meevassana, J. (2023) · Biomedical Reports · doi:10.3892/br.2023.1693 · Cited by 9
Hsu, W., Lin, B., Leu, J., Lo, P., Yu, H.-Y., Chen, C.-T., Tu, Y.-H., Lin, Y., & Lee, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-76797-6 · Cited by 9
Voghera Sweet Pepper: A Potential Ally against Oxidative Stress and Aging
Gola, F., Gaiaschi, L., Roda, E., Luca, F. D., Ferulli, F., Vicini, R., Rossi, P., & Bottone, M. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043782 · Cited by 10
Sulistyoningrum, E., Rosmelia, R., Hamid, M., & Nuraini, W. S. T. (2019) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2019.90904 · Cited by 8
ΔNp63α-mediated epigenetic regulation in keratinocyte senescence
Kuang, L., & Li, C. (2023) · Epigenetics · doi:10.1080/15592294.2023.2173931 · Cited by 8
Espada, L., Dakhovnik, A., Chaudhari, P., Martirosyan, A., Miek, L., Poliezhaieva, T., Schaub, Y., Nair, A., Döring, N., Rahnis, N., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/863357 · Cited by 8
Hymecromone Promotes Longevity and Insulin Sensitivity in Mice
Nagy, N., Czepiel, K. S., Kaber, G., Stefanovski, D., Hargil, A., Pennetzdorfer, N., Targ, R. W., Reghupaty, S. C., Wight, T. N., Vernon, R. B., et al. (2024) · Cells · doi:10.3390/cells13201727 · Cited by 7
Wang, X., Wang, W., Yao, R., Liu, Z., & Wang, Q. (2026) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2026.102064 · Cited by 8
Niyogi, U., Jara, C. P., & Carlson, M. A. (2023) · Wound Repair and Regeneration · doi:10.1111/wrr.13106 · Cited by 8
Steinberg, T., Dieterle, M. P., Ramminger, I., Klein, C., Brossette, J., Husari, A., & Tomakidi, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612677 · Cited by 7
Rasbach, L., Caliskan, A., Saderi, F., Dandekar, T., & Breitenbach, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302045 · Cited by 7
How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling
Krbanjevic, A., Travers, J. B., & Spandau, D. F. (2016) · Current Dermatology Reports · doi:10.1007/s13671-016-0143-8 · Cited by 8
Association of Biological Age with Tumor Microenvironment in Patients with Esophageal Adenocarcinoma
Ravensbergen, C. J., van Holstein, Y., Hagenaars, S. C., Crobach, A. S. L. P., Trompet, S., Portielje, J. E. A., de Glas, N. A., van Heemst, D., van den Bos, F., Tollenaar, R. A. �. �., et al. (2024) · Gerontology · doi:10.1159/000536471 · Cited by 6
Downregulated SPESP1‐driven fibroblast senescence decreases wound healing in aged mice
Zhong, Y., Zhou, L., Guo, Y., Wang, F., He, F., Cheng, Y., Meng, X., Xie, H., Zhang, Y., & Li, J. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1660 · Cited by 5
Badi, I. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz012 · Cited by 7
Ming, X., Zhu, B., & Zhang, Z. (2021) · Nature Protocols · doi:10.1038/s41596-020-00488-9 · Cited by 6
Ng, H. Y., Wu, Y. S., Biswas, M., & Sim, M. S. (2025) · Biogerontology · doi:10.1007/s10522-025-10296-x · Cited by 6
Soft Polymer-Based Technique for Cellular Force Sensing
Yu, Z., & Liu, K. (2021) · Polymers · doi:10.3390/polym13162672 · Cited by 5
Metabolomics to Study Human Aging: A Review
Martins, C., Magalhães, S., Almeida, I., Neto, V., Rebelo, S., & Nunes, A. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230407123727 · Cited by 6
Bramwell, L. R., Frankum, R., & Harries, L. W. (2024) · Cells · doi:10.3390/cells13060517 · Cited by 4
Role of Prion protein in premature senescence of human fibroblasts
Boilan, E., Winant, V., Dumortier, E., Elmoualij, B., Quatresooz, P., Osiewacz, H. D., Debacq‐Chainiaux, F., & Toussaint, O. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.002 · Cited by 5
Sengstack, J., Zheng, J., Mobaraki, M., Lin, J., Deng, C., & Li, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.20.517270 · Cited by 6
Liao, L., Zheng, S., Meng, J., Hu, Y., & Shi, W. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-025-04222-x · Cited by 4
Ageing alters zinc, magnesium, and interleukin-8 levels in human dermal fibroblasts
Zakaria, N., Smith, M. J., Messenger, D. J., Bhogal, R. K., Siow, R. C. M., & Maret, W. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127673 · Cited by 4
Reǐter, L., Niehoff, N., Weiland, D., Helbig, D., Eming, S. A., Krieg, T., Etich, J., Brachvogel, B., Wiesner, R., & Knuever, J. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.07.002 · Cited by 4
Jerdan, K., & Fabi, S. G. (2016) · Current Dermatology Reports · doi:10.1007/s13671-016-0150-9 · Cited by 4
Optimizing skin pharmacotherapy for older patients: the future is at hand but are we ready for it?
Hausmann, C., Vogt, A., Kerscher, M. J., Ghoreschi, K., Schäfer‐Korting, M., & Zoschke, C. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.01.011 · Cited by 4
Wu, B., Wang, Y., Chang, C., Juang, T., Chiang, H., Tu, Y., Siew, J., & Fan, S. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70069 · Cited by 3
Zhou, Y., Chen, Y., Zhu, L., Li, H., Gao, Y., Xian, T., Zhao, P., Fan, S., Casals, N., Huang, M., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108154 · Cited by 3
Hao, Y., Wang, Z., & Qu, L. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4579 · Cited by 3
Podgórska, A., Kicman, A., Wacewicz-Muczyńska, M., Konończuk, T., & Niczyporuk, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237439 · Cited by 3
CHARACTERISATION OF AN IN VITRO AGED CELL CULTURE MODEL
Bunc, M. (2019) · FARMACIA · doi:10.31925/farmacia.2019.2.7 · Cited by 3
Dermal niche signaling and epidermal stem cells
Frech, S., Forsthuber, A., Korosec, A., & Lichtenberger, B. M. (2019) · Advances in stem cells and their niches · doi:10.1016/bs.asn.2019.04.004 · Cited by 3
Single Modality Approach to Rejuvenate the Aging Face and Body
Fabi, S. G., & Carruthers, J. B. (2016) · Dermatologic Surgery · doi:10.1097/dss.0000000000000682 · Cited by 3
Mazini, L., Rochette, L., & Malka, G. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91233 · Cited by 4
Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
Uhler, C., & Shivashankar, G. V. (2020) · Current Opinion in Solid State and Materials Science · doi:10.1016/j.cossms.2020.100874 · Cited by 3
To, Q. M., Tran, N. D., Pham, P. T.-K., Ho, M. T.-N., Lai, B. D., Le, T. Q., Long, L. T., & Sơn, H. N. (2021) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-030-75506-5_54 · Cited by 3
Hall, S. R., Reid, A., Eng, J., McKeown, B. T., St‐Onge, M., & Goralski, K. B. (2020) · Journal of Natural Health Product Research · doi:10.33211/jnhpr.10 · Cited by 1
Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age
Brodeau, C., Joly, C., Chekroun, A., Nakhle, J., Blase, V., Espagnolle, N., Dray, C., Yart, A., Planat‐Benard, V., Tertrais, M., et al. (2025) · Aging Cell · doi:10.1111/acel.70153 · Cited by 5
Molecular Basis of Progeroid Diseases
García‐Aguirre, I., Monterrubio-Ledezma, F., Alamillo‐Iniesta, A., Castro‐Obregón, S., & Cisneros, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-40955-5_10 · Cited by 2
Krutmann, J., Grether‐Beck, S., Makrantonaki, E., & Schikowski, T. (2023) · Die Dermatologie · doi:10.1007/s00105-023-05210-w · Cited by 2
Self-citationPotential Roles of Exosomes in Aging and Age-Related Diseases
Hosseini, L., & Abolhasanpour, N. (2023) · International Journal of Aging · doi:10.34172/ija.2023.e22 · Cited by 2
Martins, C., Almeida, I., Rebelo, S., Magalhães, S., & Nunes, A. (2023) · Spectroscopy Journal · doi:10.3390/spectroscj1010004 · Cited by 2
Experimentelle Modelle humaner Hautalterung
Nikolakis, G. D., Zoschke, C., Makrantonaki, E., Hausmann, C., Schäfer‐Korting, M., & Zouboulis, C. C. (2016) · Der Hautarzt · doi:10.1007/s00105-015-3747-1 · Cited by 3
Biomarkers of Replicative Senescence Revisited
Nehlin, J. O. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_12 · Cited by 2
Mitochondrial Longevity Pathways
Schiavi, A., & Ventura, N. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_5 · Cited by 3
Self-citationIn vivo and in vitro ageing results in accumulation of de novo copy number variations in bulls
Révay, T., Oluwole, O. A., Kroetsch, T., & King, W. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-01793-2 · Cited by 2
The accelerated aging skin in rhino‐like SHJHhr mice
Gao, J., Li, Y., Guan, Y., Wei, X., Chen, S., Li, X., Li, Y., Huang, Z., Liu, S., Li, G., et al. (2022) · Experimental Dermatology · doi:10.1111/exd.14632 · Cited by 2
Effects of Lamb Placenta Peptide Powder on Skin Moisturizing and Wrinkle Formation
Lee, E. J., Jang, Y., & Hong, I. K. (2023) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2023.52.10.1013 · Cited by 2
Chantachotikul, P., Liu, S., Furukawa, K. T., & Deguchi, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.19.553998 · Cited by 2
Genetic and Epigenetic Influences on Cutaneous Cellular Senescence
Sarkar, T. J., Hermsmeier, M., Ross, J. L., & Herron, G. S. (2021) · Physiology · doi:10.5772/intechopen.101152 · Cited by 1
Relevance of the Platelet-activating factor system in chemical warfare agents-induced effects
Thyagarajan‐Sahu, A., Travers, J. B., & Sahu, R. P. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.037 · Cited by 1
Aberrant expression of messenger and small noncoding RNAomes in aged skin of rats
Zhao, D., Wang, Y., Wang, C., Xue, Y., Lv, H., Xu, W., Han, D., Sun, Y. H., & Li, Q. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.112022 · Cited by 1
Peptides as Master Keys to Skin Aging
Zhang, Q. X., Liu, Z., Shu, P., Jiang, L., & Ding, W. (2025) · Skin Pharmacology and Physiology · doi:10.1159/000547734 · Cited by 1
Tang, L., Chen, X., Chen, K., Zheng, X., Ye, M., Liu, Z., Li, W., & Liu, X. (2025) · Journal of Ginseng Research · doi:10.1016/j.jgr.2025.11.002 · Cited by 1
Mi, R., Chen, B., Leng, J., Zhao, W., Gao, S., Jiang, J., Lan, J. Q., & Zhou, Z. (2026) · Foods · doi:10.3390/foods15071147 · Cited by 1
Aging of Stem Cells in Skin: What Is Driving the Aging Process?
Gundermann, S., Stark, H., & Boukamp, P. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_8 · Cited by 1
Self-citation
Metadata
- Authors
- Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., Ventura, N., Gundermann, S., Boukamp, P., & Boege, F.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Heinrich Heine University Düsseldorf (DE)
- German Cancer Research Center (DE)
- Corresponding author
- Boege, Fritz
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 138
- Pages
- 26-44
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2052101576
- Cited by
- 250
- References
- 304
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 22 · 2023: 27 · 2022: 42 · 2021: 28 · 2020: 28 · 2019: 28 · 2018: 16 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 1
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- dermal fibroblasts, skin aging, hallmarks of aging, extracellular matrix, in vitro aging, damage accumulation, postmitotic cells
- MeSH terms
- Aging, Extracellular Matrix, Fibroblasts, Humans, Models, Biological, Skin, Skin Physiological Phenomena, Skin Aging, Cellular Senescence, Proteasome Endopeptidase Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
