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The hallmarks of fibroblast ageing
Abstract
Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage accumulation and (mal-)adaptation, thus constituting a powerful indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of ageing (Lopez-Otin et al., 2013, Cell 153) to categorise the available knowledge regarding dermal fibroblast ageing. We discriminate processes inducible in culture from phenomena apparent in skin biopsies or primary cells from old donors, coming to the following conclusions: (i) Fibroblasts aged in culture exhibit most of the established, ubiquitous hallmarks of ageing. (ii) Not all of these hallmarks have been detected or investigated in fibroblasts aged in situ (in the skin). (iii) Dermal fibroblasts aged in vitro and in vivo exhibit additional features currently not considered ubiquitous hallmarks of ageing. (iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades.
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From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [20]
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Metadata
- Authors
- Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., Ventura, N., Gundermann, S., Boukamp, P., & Boege, F.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Heinrich Heine University Düsseldorf (DE)
- German Cancer Research Center (DE)
- Corresponding author
- Boege, Fritz
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 138
- Pages
- 26-44
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2052101576
- Cited by
- 250
- References
- 304
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 22 · 2023: 27 · 2022: 42 · 2021: 28 · 2020: 28 · 2019: 28 · 2018: 16 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 1
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- dermal fibroblasts, skin aging, hallmarks of aging, extracellular matrix, in vitro aging, damage accumulation, postmitotic cells
- MeSH terms
- Aging, Extracellular Matrix, Fibroblasts, Humans, Models, Biological, Skin, Skin Physiological Phenomena, Skin Aging, Cellular Senescence, Proteasome Endopeptidase Complex
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