Cited by 250Telomeres, Telomerase, and SenescenceSkin Protection and AgingGenetics, Aging, and Longevity in Model Organisms

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The hallmarks of fibroblast ageing

Tigges, Julia, Krutmann, Jean, Fritsche, Ellen, Haendeler, Judith, Schaal, Heiner, Fischer, Jens W., Kalfalah, Faiza, Reinke, Hans, Reifenberger, Guido, Stühler, Kai, Ventura, Natascia, Gundermann, Sabrina, Boukamp, Petra, Boege, Fritz·2014·Mechanisms of Ageing and Development

DOI 10.1016/j.mad.2014.03.004

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Abstract

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly undergoing damage accumulation and (mal-)adaptation, thus constituting a powerful indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of ageing (Lopez-Otin et al., 2013, Cell 153) to categorise the available knowledge regarding dermal fibroblast ageing. We discriminate processes inducible in culture from phenomena apparent in skin biopsies or primary cells from old donors, coming to the following conclusions: (i) Fibroblasts aged in culture exhibit most of the established, ubiquitous hallmarks of ageing. (ii) Not all of these hallmarks have been detected or investigated in fibroblasts aged in situ (in the skin). (iii) Dermal fibroblasts aged in vitro and in vivo exhibit additional features currently not considered ubiquitous hallmarks of ageing. (iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades.

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Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain
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Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury
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Matrix Metalloproteinase-1 is the Major Collagenolytic Enzyme Responsible for Collagen Damage in UV-irradiated Human Skin¶
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A Transcriptional Profile of Aging in the Human Kidney
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Inhibition of Type I Procollagen Synthesis by Damaged Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro
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How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
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Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin
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Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
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Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: “Mitohormesis” for health and vitality
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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
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Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes.
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The Olive Constituent Oleuropein Exhibits Proteasome Stimulatory Properties In Vitro and Confers Life Span Extension of Human Embryonic Fibroblasts
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Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities
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The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine
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The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors
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p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
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Tissue-specific splicing pattern of fibronectin messenger RNA precursor during development and aging in rat.
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Authors: Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., Ventura, N., Gundermann, S., Boukamp, P., & Boege, F.
Affiliations: Leibniz Institute of Environmental Medicine (DE)
Heinrich Heine University Düsseldorf (DE)
German Cancer Research Center (DE)
Corresponding author: Boege, Fritz
ORCID: Tigges, Julia
Krutmann, Jean
Fritsche, Ellen
Haendeler, Judith
Schaal, Heiner
Fischer, Jens W.
Kalfalah, Faiza
Reinke, Hans
Reifenberger, Guido
Stühler, Kai
Ventura, Natascia
Boukamp, Petra
Boege, Fritz
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 2014-06
Volume: 138
Pages: 26-44
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/j.mad.2014.03.004
OpenAlex: W2052101576
Cited by: 250
References: 304
Citations by year: 2026: 12 · 2025: 12 · 2024: 22 · 2023: 27 · 2022: 42 · 2021: 28 · 2020: 28 · 2019: 28 · 2018: 16 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 1
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: dermal fibroblasts, skin aging, hallmarks of aging, extracellular matrix, in vitro aging, damage accumulation, postmitotic cells
MeSH terms: Aging, Extracellular Matrix, Fibroblasts, Humans, Models, Biological, Skin, Skin Physiological Phenomena, Skin Aging, Cellular Senescence, Proteasome Endopeptidase Complex

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The hallmarks of fibroblast ageing

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