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Cited by 73Skin Protection and AgingTea Polyphenols and EffectsAntioxidants, Aging, Portulaca oleracea

Anti-skin-aging effect of epigallocatechin gallate by regulating epidermal growth factor receptor pathway on aging mouse model induced by d -Galactose

Chen, Jiming, Li, Yifan, Zhu, Qiangqiang, Li, Tong, Lu, Hao, Wei, Nan, Huang, Yewei, Shi, Ruoyu +3 more·2017·Mechanisms of Ageing and Development
DOI 10.1016/j.mad.2017.03.007
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Abstract

Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty-five male mice were divided into 5 groups and treated with different dose of EGCG, Vitamin C (VitC) to mice as a positive control. All groups except vehicle were established aging model induced by d-galactose (200mg/kg/day) that was subcutaneously injected to mice for 8 weeks. Two weeks after injection of d-galactose, EGCG and Vit C groups were simultaneously administered once a day by subcutaneously inject after 5h for injecting d-galactose. The results show that EGCG can be absorbed by the skin. Overall, the conditions of the skin of EGCG-treatment groups were improved, the whole structure of skin were better than control groups, and the levels of oxidative stress and the expression of relate with EGFR proteins were significantly higher than control group after EGCG treatment. All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.

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  • Chronological aging and photoaging activate the same oxidative stress-related pathways.

    “During the last decade, different studies demonstrated that chronological aging and photoaging activate the same oxidative stress-related pathways.”

    From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [60]

  • Antioxidants inhibit damages induced by oxidation caused by ROS.

    “In this context, antioxidants are known to inhibit damages induced by oxidation, caused by ROS, as described in this review in paragraph 5 [54, 59, 60].”

    From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [60]

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Authors
Chen, J., Li, Y., Zhu, Q., Li, T., Lu, H., Wei, N., Huang, Y., Shi, R., Ma, X., Wang, X., & Sheng, J.
Affiliations
Yunnan Agricultural University (CN)
Corresponding author
  • Ma, Xiao
  • Wang, Xuanjun
  • Sheng, Jun
ORCID
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2017-06
Volume
164
Pages
1-7
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/j.mad.2017.03.007
OpenAlex
W2600630333
Cited by
73
References
29
Citations by year
2026: 5 · 2025: 16 · 2024: 12 · 2023: 5 · 2022: 11 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 2
FWCI
5.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Key Laboratory of Puer Tea Science
  • Ministry of Education, Yunnan Agricultural University
  • Project-sponsored by SRF for ROCS
  • SEM
  • Biological industry development special Foundation of Yunnan province
  • science and technology Foundation of Pu-erh tea institute
  • YNAU Young Scientists Found
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
epigallocatechin gallate, skin aging, epidermal growth factor receptor, D-galactose-induced aging, oxidative stress, tea catechins, vitamin C, EGFR signaling, skin rejuvenation
MeSH terms
Animals, Catechin, Galactose, Male, Models, Biological, Signal Transduction, Skin Aging, Mice, ErbB Receptors

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