Structure, function, and post–translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

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Many cuts to ruin: a comprehensive update of caspase substrates

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Oxidative stress and regulation of glutathione in lung inflammation

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Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-κB and pro-inflammatory gene expression

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Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

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Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence

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Glutathione, Stress Responses, and Redox Signaling in Lung Inflammation

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Fluorescence-based microtiter plate assay for glutamate–cysteine ligase activity

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Hepatic mitochondrial glutathione: transport and role in disease and toxicity

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Glutathione is required for intestinal function.

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Genetically altered mice to evaluate glutathione homeostasis in health and disease

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Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(−/−) Knockout Mouse

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The Enzymes of Glutathione Synthesis: γ‐Glutamylcysteine Synthetase

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Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins

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Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous

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Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene

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Glutamate Cysteine Ligase Catalysis

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Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

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S-Glutathionylation: Indicator of Cell Stress and Regulator of the Unfolded Protein Response

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Functional Roles for Fatty Acylated Amino-terminal Domains in Subcellular Localization

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Ubiquitin-mediated Degradation of the Proapoptotic Active Form of Bid

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Regulation ofγ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defenses

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Non-oxidative Loss of Glutathione in Apoptosis via GSH Extrusion

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Glutamate Cysteine Ligase Modifier Subunit Deficiency and Gender as Determinants of Acetaminophen-Induced Hepatotoxicity in Mice

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Role of p53 family members in apoptosis

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Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.

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Thiol-Based Regulation of Redox-Active Glutamate-Cysteine Ligase from Arabidopsis thaliana

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l-γ-Glutamyl-l-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)?

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Polymorphism in the 5′-Flanking Region of Human Glutamate-Cysteine Ligase Modifier Subunit Gene Is Associated With Myocardial Infarction

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Transforming Growth Factor-β1 Is a Potent Inhibitor of Glutathione Synthesis in the Lung Epithelial Cell Line A549: Transcriptional Effect on the GSH Rate-limiting Enzyme γ-Glutamylcysteine Synthetase

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GSH extrusion and the mitochondrial pathway of apoptotic signalling

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Glutathione Levels Discriminate between Oxidative Stress and Transforming Growth Factor-β Signaling in Activated Rat Hepatic Stellate Cells

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Arabidopsis thaliana Glutamate-Cysteine Ligase

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Increased Transcription of the Regulatory Subunit of γ-Glutamylcysteine Synthetase in Rat Lung Epithelial L2 Cells Exposed to Oxidative Stress or Glutathione Depletion

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Hepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure†

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Inhibition of γ-Glutamylcysteine Synthetase by l-Methionine-S-sulfoximine

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Partial Reactions Catalyzed by γ-Glutamylcysteine Synthetase and Evidence for an Activated Glutamate Intermediate

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Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction

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Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress

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Glutathione Synthesis in Streptococcus agalactiae

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Differential regulation of γ-glutamylcysteine synthetase heavy and light subunit gene expression

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SLCO/OATP-like Transport of Glutathione in FasL-induced Apoptosis

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Genetic Influences on the Retention of Inorganic Mercury

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Characterization of γ-Glutamylcysteine Synthetase, an Essential Enzyme in the Biosynthesis of Trypanothione (Diglutathionylspermidine)

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The redox switch of γ‐glutamylcysteine ligase via a reversible monomer–dimer transition is a mechanism unique to plants

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Acetaminophen-induced Liver Injury Is Attenuated in Male Glutamate-cysteine Ligase Transgenic Mice

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Polymorphism in Glutamate-Cysteine Ligase Modifier Subunit Gene Is Associated With Impairment of Nitric Oxide–Mediated Coronary Vasomotor Function

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Characterization of the Bifunctional γ-Glutamate-cysteine Ligase/Glutathione Synthetase (GshF) of Pasteurella multocida

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The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

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Evidence for Functionally Significant Polymorphism of Human Glutamate Cysteine Ligase Catalytic Subunit: Association with Glutathione Levels and Drug Resistance in the National Cancer Institute Tumor Cell Line Panel

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Mapping of the Glutamate-Cysteine Ligase Catalytic Subunit Gene (GLCLC) to Human Chromosome 6p12 and Mouse Chromosome 9D-E and of the Regulatory Subunit Gene (GLCLR) to Human Chromosome 1p21-p22 and Mouse Chromosome 3H1-3

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Inhibition of the 26S Proteasome Induces Expression of GLCLC, the Catalytic Subunit for γ-Glutamylcysteine Synthetase

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A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia.

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Glutamate Cysteine Ligase Catalytic Subunit Promoter Polymorphisms and Associations with Type 1 Diabetes Age-at-onset and GAD65 Autoantibody Levels

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Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

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Epigallocatechin-3-gallate Inhibits Growth of Activated Hepatic Stellate Cells by Enhancing the Capacity of Glutathione Synthesis

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Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia

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Variants in the Glutamate-Cysteine-Ligase Gene Are Associated with Cystic Fibrosis Lung Disease

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Knock Down of γ-Glutamylcysteine Synthetase in Rat Causes Acetaminophen-induced Hepatotoxicity

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Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase

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Molecular Mechanism(s) for UV-B Irradiation–Induced Glutathione Depletion in Cultured Human Keratinocytes¶

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Cystamine-Sepharose. A probe for the active site of gamma-glutamylcysteine synthetase.

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Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers

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Assignment of the gene (GLCLC) that encodes the heavy subunit of γ-glutamylcysteine synthetase to human chromosome 6

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Trypanosoma brucei γ-Glutamylcysteine Synthetase

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Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of γ-glutamylcysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5’ untranslated region

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Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress

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γ-Glutamylcysteine Synthetase−Glutathione Synthetase: Domain Structure and Identification of Residues Important in Substrate and Glutathione Binding

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Specific Efflux of Glutathione from the Basolateral Membrance Domain in Polarized MDCK Cells during Ricin-Induced Apoptosis

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Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol

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Menadione causes increases in the level of glutathione and in the activity of γ-glutamylcysteine synthetase in cultured Chinese hamster V79 cells

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Protein N-myristoylation: Critical Role in Apoptosis and Salt Tolerance

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YbdK is a carboxylate‐amine ligase with a γ‐glutamyl:Cysteine ligase activity: Crystal structure and enzymatic assays

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Overexpression of the regulatory subunit of γ-glutamylcysteine synthetase in HeLa cells increases γ-glutamylcysteine synthetase activity and confers drug resistance

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The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility

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Role of the Proteasome in TGF-β Signaling in Lens Epithelial Cells

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Polymorphisms and Vascular Cognitive Impairment After Ischemic Stroke

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Glutamate-cysteine ligase polymorphism, hypertension, and male sex are associated with cardiovascular events. Biochemical and genetic characterization of Italian subpopulation

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Structure-Based Identification of Novel Human γ-Glutamylcysteine Synthetase Inhibitors

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Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of γ-glutamylcysteine ligase

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Novel substrate specificity of glutathione synthesis enzymes from Streptococcus agalactiae and Clostridium acetobutylicum

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Chronic non-spherocytic hemolytic anemia associated with severe neurological disease due to -glutamylcysteine synthetase deficiency in a patient of Moroccan origin

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Association study between polymorphisms in glutathione‐related genes and methamphetamine use disorder in a Japanese population

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Chronic Beryllium Disease and Glutathione Biosynthesis Genes

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Activation of the Nrf2 pathway, but decreased γ-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of primary mouse hepatocytes to diphenylarsinic acid

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Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries

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Autophosphorylation Inhibits the Activity of γ-Glutamylcysteine Synthetase

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C–588T polymorphism of the human glutamate-cysteine ligase modifier subunit gene is not associated with the risk and extent of ischemic heart disease in a German cohort

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Glutathione: overview of its protective roles, measurement, and biosynthesis

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Role of Glutathione in Cancer: From Mechanisms to Therapies

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Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

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Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

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Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

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Glutathione Metabolism of the Brain—The Role of Astrocytes

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Differential Induction of Reactive Oxygen Species and Expression of Antioxidant Enzymes in Human Melanocytes Correlate with Melanin Content: Implications on the Response to Solar UV and Melanoma Susceptibility

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Control of angiogenesis dictated by picomolar superoxide levels

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Effects of sulforaphane on brain mitochondria: mechanistic view and future directions

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Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress

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Aging Impairs the Expression of the Catalytic Subunit of Glutamate Cysteine Ligase in Soleus Muscle Under Stress

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Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers

Neurohr, C., Lenz, A., Ding, I., Leuchte, H. H., Kolbe, T., & Behr, J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00080403 · Cited by 38 · see citing works

Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase

Yang, Y., Chen, Y., Johansson, E., Schneider, S. N., Shertzer, H. G., Nebert, D. W., & Dalton, T. P. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.02.003 · Cited by 40 · see citing works

c- Jun -N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury

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