Cited by 26Genomics, phytochemicals, and oxidative stressMitochondrial Function and PathologySulfur Compounds in Biology

Effects of sulforaphane on brain mitochondria: mechanistic view and future directions

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Jardim, Fernanda Rafaela, de Almeida, Fhelipe Joiner Souza, Luckachaki, Matheus Dargesso, de Oliveira, Marcos Roberto·2020·Journal of Zhejiang University SCIENCE B

Abstract

) is a potent cytoprotective agent promoting antioxidant, anti-inflammatory, antiglycative, and antimicrobial effects in in vitro and in vivo experimental models. Mitochondria are the major site of adenosine triphosphate (ATP) production due to the work of the oxidative phosphorylation (OXPHOS) system. They are also the main site of reactive oxygen species (ROS) production in nucleated human cells. Mitochondrial impairment is central in several human diseases, including neurodegeneration and metabolic disorders. In this paper, we describe and discuss the effects and mechanisms of action by which SFN modulates mitochondrial function and dynamics in mammalian cells. Mitochondria-related pro-apoptotic effects promoted by SFN in tumor cells are also discussed. SFN may be considered a cytoprotective agent, at least in part, because of the effects this organosulfur agent induces in mitochondria. Nonetheless, there are certain points that should be addressed in further experiments, indicated here as future directions, which may help researchers in this field of research.

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Crossref · 10.1631/jzus.b1900614

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  • Sulforaphane is an antioxidant, anti-inflammatory, and mitochondrial protective agent that has been studied in several animal models and humans with neurodegenerative and neurodevelopmental disorders.

    “Sulforaphane is an antioxidant, anti-inflammatory, and mitochondrial protective agent that has been studied in several animal models and humans with neurodegenerative and neurodevelopmental disorders [66].”

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Authors
Jardim, F. R., de Almeida, F. J. S., Luckachaki, M. D., & de Oliveira, M. R.
Affiliations
Universidade Federal de Mato Grosso (BR)
Venue
Journal of Zhejiang University SCIENCE B
Published
2020-04
Volume
21
Issue
4
Pages
263-279
ISSN
  • 1673-1581 (ISSN-L)
  • 1862-1783
OpenAlex
W3015110163
Cited by
26
References
136
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 1
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Zhejiang University SCIENCE B (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
the National Council for Scientific and Technological Development (CNPq), Brazil (301273/2018-9)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Keywords
sulforaphane, brain mitochondria, mitochondrial dynamics, oxidative phosphorylation, reactive oxygen species, neuroprotection, neurodegeneration, apoptosis, cancer cells, organosulfur compounds, cytoprotection
MeSH terms
Animals, Antioxidants, Brain, Carbon Monoxide Poisoning, Humans, Mitochondria, Sulfoxides, Apoptosis, Isothiocyanates, Cytoprotection, Membrane Potential, Mitochondrial

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