Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
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) is a potent cytoprotective agent promoting antioxidant, anti-inflammatory, antiglycative, and antimicrobial effects in in vitro and in vivo experimental models. Mitochondria are the major site of adenosine triphosphate (ATP) production due to the work of the oxidative phosphorylation (OXPHOS) system. They are also the main site of reactive oxygen species (ROS) production in nucleated human cells. Mitochondrial impairment is central in several human diseases, including neurodegeneration and metabolic disorders. In this paper, we describe and discuss the effects and mechanisms of action by which SFN modulates mitochondrial function and dynamics in mammalian cells. Mitochondria-related pro-apoptotic effects promoted by SFN in tumor cells are also discussed. SFN may be considered a cytoprotective agent, at least in part, because of the effects this organosulfur agent induces in mitochondria. Nonetheless, there are certain points that should be addressed in further experiments, indicated here as future directions, which may help researchers in this field of research.
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Sulforaphane is an antioxidant, anti-inflammatory, and mitochondrial protective agent that has been studied in several animal models and humans with neurodegenerative and neurodevelopmental disorders.
“Sulforaphane is an antioxidant, anti-inflammatory, and mitochondrial protective agent that has been studied in several animal models and humans with neurodegenerative and neurodevelopmental disorders [66].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [66]
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An Update on Psychopharmacological Treatment of Autism Spectrum Disorder
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- Authors
- Jardim, F. R., de Almeida, F. J. S., Luckachaki, M. D., & de Oliveira, M. R.
- Affiliations
- Universidade Federal de Mato Grosso (BR)
- Venue
- Journal of Zhejiang University SCIENCE B
- Publisher
- Zhejiang University Press
- Published
- 2020-04
- Volume
- 21
- Issue
- 4
- Pages
- 263-279
- ISSN
- 1673-1581 (ISSN-L)
- 1862-1783
- PMC
- PMC7183447
- OpenAlex
- W3015110163
- Cited by
- 26
- References
- 136
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Zhejiang University SCIENCE B (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the National Council for Scientific and Technological Development (CNPq), Brazil (301273/2018-9)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- sulforaphane, brain mitochondria, mitochondrial dynamics, oxidative phosphorylation, reactive oxygen species, neuroprotection, neurodegeneration, apoptosis, cancer cells, organosulfur compounds, cytoprotection
- MeSH terms
- Animals, Antioxidants, Brain, Carbon Monoxide Poisoning, Humans, Mitochondria, Sulfoxides, Apoptosis, Isothiocyanates, Cytoprotection, Membrane Potential, Mitochondrial
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