Cited by 393Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchNutritional Studies and Diet

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Flavonols and cardiovascular disease

Perez-Vizcaino, Francisco, Duarte, Juan·2010·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2010.09.002

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Abstract

Flavonols, and specially quercetin, are widely distributed in plants and are present in considerable amounts in fruits and vegetables. In addition to their anti-oxidant effect, flavonols interfere with a large number of biochemical signaling pathways and, therefore, physiological and pathological processes. There is solid evidence that, in vitro, quercetin and related flavonols exert endothelium-independent vasodilator effects, protective effect on nitric oxide and endothelial function under conditions of oxidative stress, platelet antiaggregant effects, inhibition of LDL oxidation, reduction of adhesion molecules and other inflammatory markers and prevention of neuronal oxidative and inflammatory damage. The metabolites of quercetin show partial protective effects on endothelial function and LDL oxidation. Quercetin produces undisputed antihypertensive and antiatherogenic effects, prevents endothelial dysfunction and protects the myocardium from ischemic damage. It has no clear effects on serum lipid profile and on insulin resistance. Human intervention trials with isolated flavonols demonstrate an antihypertensive effect. The meta-analysis of epidemiological studies show an inverse association between flavonol (together with flavone) intake and coronary heart disease and stroke. Therefore, although there is no solid proof yet, a substantial body of evidence suggests that quercetin may prevent the most common forms of cardiovascular disease contributing to the protective effects afforded by fruits and vegetables.

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Guo, N., Zhu, Y., Tian, D., Zhao, Y., Zhang, C., Mu, C., Han, C., Zhu, R., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.19862388
Additional file 4 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Guo, N., Zhu, Y., Tian, D., Zhao, Y., Zhang, C., Mu, C., Han, C., Zhu, R., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.19862397
Additional file 3 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Guo, N., Zhu, Y., Tian, D., Zhao, Y., Zhang, C., Mu, C., Han, C., Zhu, R., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.19862394
Additional file 2 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Guo, N., Zhu, Y., Tian, D., Zhao, Y., Zhang, C., Mu, C., Han, C., Zhu, R., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.19862391
Additional file 1 of A flavonol synthase (FLS) gene, GhFLS1, was screened out increasing salt resistance in cotton
Han, M., Cui, R., Cui, Y., Wang, J., Wang, S., Jiang, T., Huang, H., Lei, Y., Liu, X., Rui, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26590581
Additional file 5 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Guo, N., Zhu, Y., Tian, D., Zhao, Y., Zhang, C., Mu, C., Han, C., Zhu, R., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.19862400
Additional file 6 of Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Guo, N., Zhu, Y., Tian, D., Zhao, Y., Zhang, C., Mu, C., Han, C., Zhu, R., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.19862403
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Natural bioactive compounds: Properties and health advantages against numerous medical conditions with a special focus on endometriosis management
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“These are multifunctional natural active molecules, with their core effects stemming from potent antioxidant and anti-inflammatory mechanisms (Chen et al. 2018; Kim and Park 2016; Nabavi et al. 2015; Perez-Vizcaino and Duarte 2010).”
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Authors: Perez-Vizcaino, F., & Duarte, J.
Affiliations: Universidad de Granada (ES)
ORCID: Duarte, Juan
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2010-12
Volume: 31
Issue: 6
Pages: 478-494
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2010.09.002
OpenAlex: W2088383365
Cited by: 393
References: 164
Citations by year: 2026: 11 · 2025: 23 · 2024: 23 · 2023: 21 · 2022: 33 · 2021: 26 · 2020: 18 · 2019: 20 · 2018: 29 · 2017: 16 · 2016: 32 · 2015: 34 · 2014: 30 · 2013: 30 · 2012: 31
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Spanish Ministerio de Ciencia y Tecnología (AGL2007-66108, SAF2008-03948, Red HERACLES RD06/0009)
Junta de Andalucía (P06-CTS-01555)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: flavonols, quercetin, cardiovascular disease, endothelial function, nitric oxide, oxidative stress, platelet aggregation, LDL oxidation, inflammation, antihypertensive effect, atherosclerosis, coronary artery disease, stroke, flavonoid metabolites, fruits and vegetables, antioxidant activity
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Endothelium, Vascular, Humans, Muscle, Smooth, Vascular, Quercetin, Oxidative Stress, Flavonols

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