Cited by 393Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchNutritional Studies and Diet

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Flavonols and cardiovascular disease

Perez-Vizcaino, Francisco, Duarte, Juan·2010·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2010.09.002

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Abstract

Flavonols, and specially quercetin, are widely distributed in plants and are present in considerable amounts in fruits and vegetables. In addition to their anti-oxidant effect, flavonols interfere with a large number of biochemical signaling pathways and, therefore, physiological and pathological processes. There is solid evidence that, in vitro, quercetin and related flavonols exert endothelium-independent vasodilator effects, protective effect on nitric oxide and endothelial function under conditions of oxidative stress, platelet antiaggregant effects, inhibition of LDL oxidation, reduction of adhesion molecules and other inflammatory markers and prevention of neuronal oxidative and inflammatory damage. The metabolites of quercetin show partial protective effects on endothelial function and LDL oxidation. Quercetin produces undisputed antihypertensive and antiatherogenic effects, prevents endothelial dysfunction and protects the myocardium from ischemic damage. It has no clear effects on serum lipid profile and on insulin resistance. Human intervention trials with isolated flavonols demonstrate an antihypertensive effect. The meta-analysis of epidemiological studies show an inverse association between flavonol (together with flavone) intake and coronary heart disease and stroke. Therefore, although there is no solid proof yet, a substantial body of evidence suggests that quercetin may prevent the most common forms of cardiovascular disease contributing to the protective effects afforded by fruits and vegetables.

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Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
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Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,589
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(2003) · The Lancet · doi:10.1016/s0140-6736(03)14739-3 · Cited by 2,402
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Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924
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Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,765
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765
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Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 1×
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Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652

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“[49], to function as a chemopreventive agent [50], to have anti-proliferative and growth-suppressing effects [51], to induce senescence and autophagy [52, 53], and to have anti-inflammatory and anti-angiogenic activities [54, 55].”
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Background
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Background
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Background
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Background
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“Oxidative stress (OS), the imbalance between antioxidants and pro-oxidants, has been linked to CVD in many papers [1,4–10].”
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Background
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Zhao, J., Quan, X., Xie, Z., Zhang, L., & Ding, Z. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107048 · Cited by 11
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Guan, Q., Tang, L.-H., Xu, M., Zhang, L., Huang, L., & Khan, M. S. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105213 · Cited by 10
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“For example, after the ingestion of PP-rich foods such as berries, cocoa, or tea, peak plasma concentrations of flavonoids and phenolic acids are usually observed within 1–2 h and the concentration is generally below 5 µM [ 6 ].”
Influential
Microwave-assisted extraction in dry fruit of andean species Vaccinium meridionale: Experimental conditions on the recovery of total polyphenols
Espinosa, W. E., Garzón, L. C. A., & Medina, O. J. (2017) · Ciência e Agrotecnologia · doi:10.1590/1413-70542017416016117 · Cited by 10
Quercetin affects uterine smooth muscle contractile activity in gilts
Zygmuntowicz, A., Markiewicz, W., Grabowski, T., Burmańczuk, A., Vyniarska, A., & JAROSZEWSKI, J. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252438 · Cited by 9
“In vitro studies have been demonstrated that quercetin exerts endothelium-independent vasodilator effects, protective effect on nitric oxide and endothelial function under conditions of oxidative stress, platelet antiaggregant effects, inhibition of LDL oxidation, reduction of adhesion molecules and other inflammatory…”
Background
Fermentation Process Effects on Fermented McIntosh Apple Ciders
Wang, Z., Svyantek, A. W., Miller, Z., & Watrelot, A. A. (2024) · Fermentation · doi:10.3390/fermentation10030115 · Cited by 9
Local Administration of the Phytochemical, Quercetin, Attenuates the Hyperexcitability of Rat Nociceptive Primary Sensory Neurons Following Inflammation Comparable to lidocaine
Sashide, Y., Toyota, R., & Takeda, M. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.10.004 · Cited by 9
Vasodilatory effects of mulberry (Morus spp.) leaf extract on porcine cerebral arteries in vitro: Possible underlying mechanisms
Pothinuch, P., Miyamoto, A., Nguyen, H. T. T., & Tongchitpakdee, S. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.09.010 · Cited by 9
Practical application of flavonoid-poor menu meals to the study of the bioavailability of bilberry anthocyanins in human subjects
Sakakibara, H., Ichikawa, Y., Tajima, S., Makino, Y., Wakasugi, Y., Shimoi, K., Kobayashi, S., Kumazawa, S., & Goda, T. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.932667 · Cited by 9
Propolis and its constituent chrysin inhibit plasminogen activator inhibitor 1 production induced by tumour necrosis factor-α and lipopolysaccharide
Ohkura, N., Takata, Y., Ando, K., Kanai, S., Watanabe, E., Nohira, T., & Atsumi, G. (2012) · Journal of Apicultural Research · doi:10.3896/ibra.1.51.2.06 · Cited by 9
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols
Istıflı, E. S., Tepe, A. S., Netz, P. A., Sarıkürkçü, C., Kılıç, İ. H., & Tepe, B. (2021) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-2104-51 · Cited by 9
“Thus, the glycosidic forms of flavonols are more effective biological/pharmacological agents than aglycon forms (Dávalos et al., 2006; Perez-Vizcaino and Duarte 2010).”
Background
Changes in Biochemical Composition and Nutrient Materials in Apocynum pictum Honey During Storage
Jiang, L., Gong, Y., Zhao, Y., Dong, W., Guo, L., Ju, J., & Su, N. (2024) · Foods · doi:10.3390/foods13233790 · Cited by 8
Excited state deactivation in phytochemical flavonoids: astragalin and kaempferol
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The vasodilatory effect of Apium graveolens L (celery) seed in isolated rat aorta: The roles of endothelium, calcium and potassium channels.
Sohrabi, F., Niazmand, S., Mahmoudabady, M., & Niazmand, M. J. (2021) · PubMed Central · doi:10.22038/ajp.2020.15697 · Cited by 8
Chronic effects of different quercetin doses in penicillin-induced focal seizure model
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A high-performance liquid chromatography method for quality control of complex substances: analysis of marker alkaloids and flavonoids of the herb Herba leonuri (Yimucao)
Wang, Y., Li, B., Ni, Y., & Serge Kokot, A. (2013) · Analytical Methods · doi:10.1039/c3ay40985f · Cited by 8
Polyphenols in Foods
Yang, J., Dwyer, J. T., & Peterson, J. J. (2016) · Nutrition Today · doi:10.1097/nt.0000000000000183 · Cited by 8
“with flavonol intakes, others have not, and results from human studies are less consistent than those from in vitro studies.(24,25) However, a recent systematic review and meta-analysis of 7 randomized controlled trials (587 patients) found that quercetin supplementation of greater than 500 mg/d was effective in reduc…”
Result
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Han, X., Wang, J., Wang, G., Dong, F., Nie, P., & Xue, X. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1187551 · Cited by 7
Interaction between bioactive carbonyl compounds and asparagine and impact on acrylamide
Hamzalıoğlu, A., & Gökmen, V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99119-3.00008-4 · Cited by 7
Abiu-do-Mato (Pouteria caimito, Sapotaceae): A promising Amazonian fruit with rich chemical composition, antioxidant potential, and cytotoxic safety
de Oliveira, A. C., Cruz, J. M. D. A., Mar, J. M., Corrêa, R. F., Rodrigues, J. V. D. S., Mendes, T. A. D. O., Aguiar, J. P. L., Souza, F. D. C. D. A., Neves, K. D. O. G., Santos, A. D. D. C., et al. (2025) · Food Research International · doi:10.1016/j.foodres.2025.115984 · Cited by 10
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Dmello, J. R., Chandekar, L. P., Bavadekar, T. A., Buttar, H. S., & Kaur, G. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-14952-8_23 · Cited by 7
Cranberry Polyphenols: Effects on Cardiovascular Risk Factors
Khoo, C., Falk, M., & Zhang, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813008-7.00009-6 · Cited by 7
Antihypertensive and antioxidant effects of hydroalcoholic extract from the aerial parts of Kelussia odoratissima Mozaff. in dexamethasone-induced hypertensive rats
Safaeian, L., Sajjadi, S. E., Javanmard, S. H., & Gholamzadeh, H. (2016) · Advanced Biomedical Research · doi:10.4103/2277-9175.176342 · Cited by 7
“have vascular protective effect under oxidative stress conditions.[32]”
Background
Chapter 81 – Cranberry Polyphenols: Effects on Cardiovascular Risk Factors
Khoo, C., & Falk, M. L. (2014) · Polyphenols in Human Health and Disease · Cited by 7
Statistical Innovations Improve Prevalence Estimates of Nutrient Risk Populations: Applications in São Paulo, Brazil
Morimoto, J. M., Marchioni, D. M. L., César, C. L. G., & Fisberg, R. M. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.07.003 · Cited by 6
Structure assignment and H/D-exchange behavior of several glycosylated polyphenols
Franz, A. H., Serebnitskaya, I., Gudial, G., & Wallis, C. M. (2014) · ARKIVOC · doi:10.3998/ark.5550190.p008.583 · Cited by 6
Nanoformulations of polyphenols for prevention and treatment of cardiovascular and metabolic disorders
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Campesi, I., Romani, A., Marino, M., & Franconi, F. (2014) · Wiley eBooks · doi:10.1002/9781118329634.ch10 · Cited by 7
Development of the Transgenic Rice Accumulating Flavonoids in Seed by Metabolic Engineering
Ogo, Y., & Takaiwa, F. (2017) · doi:10.1002/9781119079972.ch13 · Cited by 6
Effects of B-ring structures on binding behavior of flavonols with proteins: Experimental and molecular docking approaches
Li, X., Xu, R., & Ni, T. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.135614 · Cited by 5
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Jiang, D., Qian, J., Chen, K., Zhang, B., & Li, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c06227 · Cited by 4
Metabolic variation in sea buckthorn berries during yearly natural fermentation via non-targeted metabolomics
Zhao, L., Zhao, B., Song, K., Lan, Q., Feng, D., Yao, Y., Zhou, J., & Lu, H. (2025) · LWT · doi:10.1016/j.lwt.2025.118154 · Cited by 4
Effects of Onion Peel Water Extract on the Blood Lipid Profiles in Mice Fed a High-Fat Diet
Lee, H. A., Han, S. J., Hong, S., & Kim, O. J. (2014) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2014.22.3.203 · Cited by 4
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Yazdanshenas, R., & Gharib, F. (2016) · Journal of Solution Chemistry · doi:10.1007/s10953-016-0506-6 · Cited by 4
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Kimura, Y., Kato, R., Oyama, K., Kondo, T., & Yoshida, K. (2016) · Natural Product Communications · doi:10.1177/1934578x1601100722 · Cited by 4
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Sajjadi‐Ghotbabadi, H., Javanshir, S., Rostami‐Charati, F., & Sayyed-Alangi, S. Z. (2018) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-018-2297-8 · Cited by 4
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Authors: Perez-Vizcaino, F., & Duarte, J.
Affiliations: Universidad de Granada (ES)
ORCID: Duarte, Juan
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2010-12
Volume: 31
Issue: 6
Pages: 478-494
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2010.09.002
OpenAlex: W2088383365
Cited by: 393
References: 164
Citations by year: 2026: 11 · 2025: 23 · 2024: 23 · 2023: 21 · 2022: 33 · 2021: 26 · 2020: 18 · 2019: 20 · 2018: 29 · 2017: 16 · 2016: 32 · 2015: 34 · 2014: 30 · 2013: 30 · 2012: 31
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Spanish Ministerio de Ciencia y Tecnología (AGL2007-66108, SAF2008-03948, Red HERACLES RD06/0009)
Junta de Andalucía (P06-CTS-01555)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: flavonols, quercetin, cardiovascular disease, endothelial function, nitric oxide, oxidative stress, platelet aggregation, LDL oxidation, inflammation, antihypertensive effect, atherosclerosis, coronary artery disease, stroke, flavonoid metabolites, fruits and vegetables, antioxidant activity
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Endothelium, Vascular, Humans, Muscle, Smooth, Vascular, Quercetin, Oxidative Stress, Flavonols

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