The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Pro-resolving mediators in the regulation of periodontal disease
Open accessAbstract
Periodontitis is an inflammatory disease of the supporting structures of the dentition that is initiated by bacterial that form a biofilm on the surface of the teeth. The pathogenesis of the disease is a result of complex interactions between the biofilm and the host response that results in dysbiosis of the microbiome and dysregulation of the inflammatory response. Current data suggest that the excess inflammation associated with periodontitis is due to a failure of resolution of inflammation pathways. In this review, the relationship between inflammation and microbial dysbiosis is examined in the context of pro-inflammation and pro-resolution mediators and their ability to modify the course of disease. The impact of local oral inflammation on systemic inflammation and the relationship of periodontitis to other inflammatory diseases, including type 2 diabetes and cardiovascular disease is reviewed. Active resolvers of inflammation, including the lipoxins and resolvins, show great promise as therapeutics for the treatment of periodontitis and other inflammatory diseases.
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Cites
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Cited by
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“Furthermore, Van Dyke suggested that the immunoinflammatory response drives the composition of the bacterial biofilm and the emergence of pathogens [30].”
Background
Metadata
- Authors
- Van Dyke, T. E.
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 58
- Pages
- 21-36
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2615308276
- Cited by
- 168
- References
- 13
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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