Interactions between gut bacteria and bile in health and disease

Inference of Macromolecular Assemblies from Crystalline State

Krissinel, E., & Henrick, K. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.05.022 · Cited by 10,007

Richness of human gut microbiome correlates with metabolic markers

Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314

Gut metagenome in European women with normal, impaired and diabetic glucose control

Karlsson, F. H., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., & Bäckhed, F. (2013) · Nature · doi:10.1038/nature12198 · Cited by 3,115

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219

Gut microbiota in irritable bowel syndrome: a narrative review of mechanisms and microbiome-based therapies

Li, X.-M., Yuan, Q., Huang, H., & Wang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1695321 · Cited by 35

A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study

Guerrero-Bonmatty, R., Fernández, G. G., Rodríguez-Velasco, F. J., & Espadaler, J. (2021) · Nutrients · doi:10.3390/nu13041206 · Cited by 30

Effects of sublethal concentration of metamifop on hepatic lipid metabolism in adult zebrafish (Danio rerio)

Zhao, F., Zhang, M., Guo, M., Duan, M., Zheng, J., Chen, X., Liu, Y., & Qiu, L. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105938 · Cited by 28

Comprehensive Analysis of Gut Microbiota and Fecal Bile Acid Profiles in Children With Biliary Atresia

Yang, T., Shen, Y., Zhao, J., Wang, P., Li, S., Jin, Y., Liu, Z., Zhang, X., Zhang, Y., Zhao, Y. M., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.914247 · Cited by 28

Deletion of luxS gene mediated by λRed gene recombination technology reduces biofilm formation and stress resistance of Lactobacillus fermentum

Zhang, Y., Gu, Y., Zheng, Y., Wang, Y., Nie, L., Qiao, R., & Yin-feng, H. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101892 · Cited by 28

Diet as a modifiable factor in tumorigenesis: Focus on microbiome-derived bile acid metabolites and short-chain fatty acids

Ahmad, F., Saha, P., Singh, V., Wahid, M., Mandal, R. K., Mishra, B. N., Fagoonee, S., & Haque, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135320 · Cited by 31

Integrated multi-omics analyses reveal effects of empagliflozin on intestinal homeostasis in high-fat-diet mice

Shi, J., Qiu, H., Xu, Q., Ma, Y., Ye, T., Kuang, Z., Qu, N., Kan, C., Hou, N., Han, F., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105816 · Cited by 27

Isolation and Characterization of Lactic Acid Bacteria With Probiotic Attributes From Different Parts of the Gastrointestinal Tract of Free-living Wild Boars in Hungary

Keresztény, T., Libisch, B., Orbe, S. C., Nagy, T., Kerényi, Z., Kocsis, R., Posta, K., Papp, P., & Olasz, F. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10113-2 · Cited by 29

Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial

Gao, P., Rinott, E., Dong, D., Mei, Z., Wang, F., Liu, Y., Kamer, O., Meir, A. Y., Tuohy, K. M., Blüher, M., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2426610 · Cited by 34

Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection

Xing, J.-H., Niu, T., Yu, T., Zou, B., Shi, C., Wang, Y., Fan, S., Li, M., Bao, M., Sun, Y., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02078-x · Cited by 27

Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro : Focus on P-glycoprotein

Enright, E. F., Govindarajan, K., Darrer, R., MacSharry, J. A., Joyce, S. A., & Gahan, C. G. M. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00875 · Cited by 27

Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice

Miao, Z., Lai, Y., Zhao, Y., Chen, L., Zhou, J., Li, C., & Wang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.710692 · Cited by 27

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

Zhao, W., Wang, T., Zhang, Y., Chen, Q., Wang, Y., Xing, Y., Zheng, J., Duan, C.-C., Chen, L.-J., Zhao, H., et al. (2022) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-022-3522-y · Cited by 27

Understanding and harnessing triple-negative breast cancer-related microbiota in oncology

Devoy, C., Bueso, Y. F., & Tangney, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1020121 · Cited by 29

Differential View on the Bile Acid Stress Response of Clostridioides difficile

Sievers, S., Metzendorf, N. G., Dittmann, S., Troitzsch, D., Gast, V., Tröger, S. M., Wolff, C., Zühlke, D., Hirschfeld, C., Schlüter, R., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00258 · Cited by 26

Effect of microbiota metabolites on the progression of chronic hepatitis B virus infection

Sun, X. L., Pan, C. Q., & Xing, H. (2021) · Hepatology International · doi:10.1007/s12072-021-10230-6 · Cited by 26

The probiotic and immunomodulation effects of Limosilactobacillus reuteri RGW1 isolated from calf feces

Huang, K., Shi, W., Yang, B., & Wang, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1086861 · Cited by 26

Bile acids and FXR in functional gastrointestinal disorders

Mosińska, P., Szczepaniak, A., & Fichna, J. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.05.016 · Cited by 30

Impact of bile salts on coevolutionary dynamics between the gut bacterium Escherichia coli and its lytic phage PP01

Scanlan, J., Hall, A. R., & Scanlan, P. D. (2019) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2019.05.021 · Cited by 25

The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the liver-gut axis in mice

Hu, L., Wang, X., Bao, Z., Xu, Q., Qian, M., & Jin, Y. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.136141 · Cited by 25

Gut Microbiota, Obesity and Bariatric Surgery: Current Knowledge and Future Perspectives

Cătoi, A. F., Vodnar, D. C., Corina, A., Nikolić, D., Citarrella, R., Pérez‐Martínez, P., & Rizzo, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190708190437 · Cited by 26

Eimeria: Navigating complex intestinal ecosystems

Weng, S., Tian, E., Gao, M., Zhang, S., Yang, G., & Zhou, B.-H. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012689 · Cited by 30

The Fecal Microbiome in Infants With Biliary Atresia Associates With Bile Flow After Kasai Portoenterostomy

Tessier, M. E. M., Cavallo, L., Yeh, J., Harpavat, S., Hoffman, K. L., Petrosino, J. F., & Shneider, B. L. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002686 · Cited by 24

Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system

Geng, W., Long, S. L., Chang, Y., Saxton, A. M., Joyce, S. A., & Lin, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-61723-7 · Cited by 24

Bile acid–gut microbiota crosstalk in irritable bowel syndrome

Gu, Y., Li, L., Yang, M., Liu, T., Song, X., Qin, X., Xu, X. J., Liu, J., Wang, B., & Cao, H. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2058353 · Cited by 26

Dietary polyphenols maintain homeostasis via regulating bile acid metabolism: a review of possible mechanisms

Liu, Y., Huang, K., Zhang, Y., Cao, H., & Guan, X. (2023) · Food & Function · doi:10.1039/d3fo02471g · Cited by 23

An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics

Chikindas, M. L., Roopchand, D. E., Tiwari, S. K., Sichel, L. S., Karwe, M. V., Nitin, N., Fagundes, V. L., Popov, I. V., Tagg, J. R., Lu, X., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70326 · Cited by 26

Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals – A randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study

Kapoor, M. P., Koido, M., Kawaguchi, M., Timm, D. A., Ozeki, M., Yamada, M., Mitsuya, T., & Ōkubo, T. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104067 · Cited by 23

A combination of three plasma bile acids as a putative biomarker for schizophrenia

Tao, Y., Zheng, F., Cui, D., Huang, F., & Wu, X. (2020) · Acta Neuropsychiatrica · doi:10.1017/neu.2020.42 · Cited by 23

Microbial transformations of bile acids and their receptors in the regulation of metabolic dysfunction-associated steatotic liver disease

Gao, Y., Lin, J., Ye, C., Guo, S., & Jiang, C. (2023) · Liver Research · doi:10.1016/j.livres.2023.09.002 · Cited by 26

Gut–Liver Axis in Nonalcoholic Fatty Liver Disease: the Impact of the Metagenome, End Products, and the Epithelial and Vascular Barriers

Gil‐Gómez, A., Brescia, P., Rescigno, M., & Romero‐Gómez, M. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1723752 · Cited by 24

Gut–X Axis and Its Role in Poultry Bone Health: A Review

Yanan, L., Yue, T.-J., Ding, W., Xu, B., Li, J., & Huang, S. (2025) · Microorganisms · doi:10.3390/microorganisms13040757 · Cited by 22

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Qiao, X., Zhang, K., Li, X., Lv, Z., Wei, W., Zhou, R., Yan, L., Pan, Y., Yang, S., Sun, X., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1018897 · Cited by 22

Metabolomics analysis of Pulsatilla decoction on treatment of wetness‐heat‐induced diarrhea in rats based on UPLC–Q/TOF–MS/MS

Hua, Y., Ma, Q., Li, W., Zhang, X., Cheng, X., Jia, Y., Peng, X., Yao, W., Ji, P., Hu, J., et al. (2019) · Biomedical Chromatography · doi:10.1002/bmc.4629 · Cited by 22

Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease

Kelly, J., Al-Rammahi, M. A., Daly, K., Flanagan, P. K., Urs, A. N., Cohen, M. C., Stefano, G. D., Bijvelds, M. J. C., Sheppard, D. N., de Jonge, H. R., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10328-3 · Cited by 23

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders

Darmanto, A. G., Yen, T., Jan, J., Linh, T. T. D., Taliyan, R., Yang, C. H., & Sheu, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107564 · Cited by 23

Metabolism, bioenergetics and thermal physiology: influences of the human intestinal microbiota

Armstrong, L. E., Casa, D. J., & Belval, L. N. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422419000076 · Cited by 21

The Role of the Microbiota in Regeneration-Associated Processes

Díaz-Díaz, L. M., Rodríguez-Villafañe, A., & García‐Arrarás, J. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.768783 · Cited by 19

Antarctic krill peptide alleviates liver fibrosis via downregulating the secondary bile acid mediated NLRP3 signaling pathway

Yue, H., Li, Y., Cai, W., Bai, X., Dong, P., & Wang, J. (2022) · Food & Function · doi:10.1039/d1fo04241f · Cited by 22

In-depth investigation of the therapeutic effect of Tribulus terrestris L. on type 2 diabetes based on intestinal microbiota and feces metabolomics

Meng, X., Shi, M., Guo, G., Xing, J., Liu, Z., Song, F., & Liu, S. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117815 · Cited by 21

Characteristics of Gut Microbiota in Children With Biliary Atresia After Liver Transplantation

Song, W., Sun, L., Zhu, Z., Wei, L., Qu, W., Zeng, Z., & Yang, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.704313 · Cited by 20

Nuclear receptors and liver disease: summary of the 2017 basic research symposium

Tran, M., Liu, Y., Huang, W., & Wang, L. (2018) · Hepatology Communications · doi:10.1002/hep4.1203 · Cited by 20

Enhancement of bile resistance by maltodextrin supplementation in Lactobacillus plantarum Lp‐115

Zhou, Y., Wang, J. ‐., Hu, C., Ren, L., Wang, D.-F., & Ye, B. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14229 · Cited by 20

Duodenal microbiome in patients with or without Helicobacter pylori infection

Suárez‐Jaramillo, A., Baldeon, M. E., Prado, B., Fornasini, M., Cohen, H., Flores, N., Salvador, I., Cargua, O., Realpe, J. L., & Cárdenas, P. (2020) · Helicobacter · doi:10.1111/hel.12753 · Cited by 20

ALZHEIMER’S DISEASE AND ITS RELATIONSHIP WITH THE MICROBIOTA-GUT-BRAIN AXIS

Faulin, T. D. E. S., & Estadella, D. (2023) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202301000-17 · Cited by 25

Growth performance, bile acid profile, fecal microbiome and serum metabolomics of growing-finishing pigs fed diets with bile acids supplementation

Zhou, P., Yan, H., Zhang, Y., Qi, R., Zhang, H., & Liu, J. (2023) · Journal of Animal Science · doi:10.1093/jas/skad393 · Cited by 20

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

Fiebig, A., Schnizlein, M. K., Pena-Rivera, S., Trigodet, F., Dubey, A. A., Hennessy, M., Basu, A., Pott, S., Dalal, S., Rubin, D., et al. (2023) · mBio · doi:10.1128/mbio.02830-23 · Cited by 20

Isotopic dilution method for bile acid profiling reveals new sulfate glycine-conjugated dihydroxy bile acids and glucuronide bile acids in serum

Ulaszewska, M., Mancini, A., Garcia‐Aloy, M., BUBBA, M. D., Tuohy, K. M., & Vrhovšek, U. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.05.002 · Cited by 20

Short‐chain fatty acids and bile acids in human faeces are associated with the intestinal cholesterol conversion status

Matysik, S., Krautbauer, S., Liebisch, G., Schött, H.-F., Kjølbæk, L., Astrup, A. V., Blachier, F., Beaumont, M., Nieuwdorp, M., Hartstra, A. V., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15440 · Cited by 20

Integrative Analysis of Colonic Biopsies from Inflammatory Bowel Disease Patients Identifies an Interaction Between Microbial Bile Acid-inducible Gene Abundance and Human Angiopoietin-like 4 Gene Expression

Hernández-Rocha, C., Borowski, K., Turpin, W., Filice, M., Nayeri, S., Garay, J. A. R., Stempak, J. M., & Silverberg, M. S. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab096 · Cited by 20

Impact of supplementary Lactobacillus casei K17 on growth and gut health of largemouth bass Micropterus salmoides

Wang, J., Zhu, Z., Li, R., Wang, X., Leng, X., & Chen, L. (2021) · Aquaculture Reports · doi:10.1016/j.aqrep.2021.100734 · Cited by 20

Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow

Marzano, M., Fosso, B., Colliva, C., Notario, E., Passeri, D., Intranuovo, M., Gioiello, A., Adorini, L., Pesole, G., Pellicciari, R., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113380 · Cited by 21

Effects of bile acid metabolism on intestinal health of livestock and poultry

Jia, H., & Dong, N. (2024) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13969 · Cited by 19

Metabolic Analysis of Regionally Distinct Gut Microbial Communities Using an In Vitro Platform

Firrman, J., Liu, L., Tanes, C., Friedman, E. S., Bittinger, K. L., Daniel, S. G., den Abbeele, P. V., & Evans, B. S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05202 · Cited by 19

Assessment of Lactobacillus casei rhamnosus (LGG) therapy in children with biliary atresia – Randomized placebo controlled trial

Orłowska, E., Czubkowski, P., Wołochowska, K., Jarzębicka, D., Motyl, I., & Socha, P. (2021) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2021.101753 · Cited by 19

Akkermansia and its metabolites play key roles in the treatment of campylobacteriosis in mice

Jiang, L., Yuan, C., Ye, W., Huang, Q., Chen, Z., Wu, W., & Qian, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1061627 · Cited by 19

Alterations and clinical relevance of gut microbiota in patients with Peutz–Jeghers syndrome: A prospective study

Wang, Y. X., Huang, H. B., Dong, Y. H., Li, Z., Liu, F., & Du, Y. (2023) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13175 · Cited by 19

Ethanol extract of Pueraria lobata improve acute myocardial infarction in rats via regulating gut microbiota and bile acid metabolism

Zhang, P., Fang, Z., Zhao, M., Yi, B., Huang, Y., Yang, H., Guo, N., & Zhao, C. (2023) · Phytotherapy Research · doi:10.1002/ptr.8005 · Cited by 19

Potential contribution of the gut microbiota to the development of portal vein thrombosis in liver cirrhosis

Huang, X., Zhang, Y.-H., Yi, S.-Y., Lei, L., Ma, T., Huang, R., Yang, L., Li, Z.-M., & Zhang, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1217338 · Cited by 19

Nutrient acquisition of gut microbiota: Implications for tumor immunity

Wang, Y., Huang, J., Tong, H., Jiang, Y., Yu, J., & Ma, X. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.003 · Cited by 19

Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer’s Disease

Muraleedharan, A., & Ray, S. K. (2024) · Brain Sciences · doi:10.3390/brainsci14010096 · Cited by 20

The microbiome: a link between obesity and breast cancer risk

Gaber, M. K., Arnone, A. A., Vidi, P., & Cook, K. L. (2024) · Frontiers in Microbiomes · doi:10.3389/frmbi.2024.1394719 · Cited by 21

The human gut microbiome – a new and exciting avenue in cardiovascular drug discovery

Du, Y., Li, X., Su, C., Wang, L., Jiang, J., & Hong, B. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1638909 · Cited by 20

Xyloglucan compounded inulin or arabinoxylan against glycometabolism disorder via different metabolic pathways: Gut microbiota and bile acid receptor effects

Chen, H., Zhou, S., Li, J., Huang, X., Cheng, J., Jiang, X., Qin, W., Liu, Y., Liu, A., Zhang, Q. R., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104162 · Cited by 18

The Impact of Fermented Milk Products on Gut Microbiota‐Derived Metabolites in Obesity: A Narrative Review

Mukarromah, T. A., Rustanti, N., Mahati, E., Suparmi, S., & Ayustaningwarno, F. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70301 · Cited by 19

New insights into the interplay between intestinal flora and bile acids in inflammatory bowel disease

Zheng, L. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i30.10823 · Cited by 17

Microbial metabolites as modulators of host physiology

Joyce, S. A., & Clarke, D. J. (2024) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2023.12.001 · Cited by 20

Dietary-Induced Bacterial Metabolites Reduce Inflammation and Inflammation-Associated Cancer via Vitamin D Pathway

O’Mahony, C., Clooney, A. G., Clarke, S. F., Aguilera, M., Gavin, A. M., Simnica, D., Ahern, M., Fanning, A., Stanley, M., Cabrera‐Rubio, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031864 · Cited by 18

The interplay between tissue‐resident microbiome and host proteins by integrated multi‐omics during progression of colorectal adenoma to carcinoma

Wu, D., Wang, A., Bu, D., Sun, Y., Li, C., Hong, Y.-M., Zhang, S., Chen, S., Zhou, J., Zhang, T., et al. (2025) · iMeta · doi:10.1002/imt2.70090 · Cited by 16

Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

Aydın, Ö. Ç., Aydın, S., & Barun, S. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i1.65 · Cited by 16

Creep Feeding and Weaning Influence the Postnatal Evolution of the Plasma Metabolome in Neonatal Piglets

Metzler-Zebeli, B. U., Lerch, F., Yosi, F., Vötterl, J. C., Koger, S., Aigensberger, M., Rennhofer, P. M., Berthiller, F., & Schwartz, H. (2023) · Metabolites · doi:10.3390/metabo13020214 · Cited by 16

Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice

Zhai, T., Wang, J., & Chen, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-42358-w · Cited by 18

Oatmeal induced gut microbiota alteration and its relationship with improved lipid profiles: a secondary analysis of a randomized clinical trial

Ye, M., Sun, J., Chen, Y., Ren, Q., Li, Z., Zhao, Y., Pan, Y., & Xue, H. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00505-4 · Cited by 17

Programming gene expression in multicellular organisms for physiology modulation through engineered bacteria

Gao, B., & Sun, Q. H. (2021) · Nature Communications · doi:10.1038/s41467-021-22894-7 · Cited by 16

Drug Metabolism for the Identification of Clinical Biomarkers in Breast Cancer

Costa, B., & Vale, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063181 · Cited by 16

Changes of intestinal microbiota and microbiota-based treatments in IBD

Li, Q., Zhou, S., Wang, Y., & Cong, J. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03069-4 · Cited by 16

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed Streptococcus thermophilus MN-ZLW-002

Luo, Y., Cheng, R., Liang, H., Miao, Z., Wang, J., Zhou, Q., Chen, J., He, F., & Shen, X. P. (2022) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.21-0182 · Cited by 15

Liver cirrhosis and complications from the perspective of dysbiosis

Nie, G., Zhang, H., Xie, D., Yan, J., & Li, X. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2023.1320015 · Cited by 16

Healthy and Unhealthy Aging and the Human Microbiome

Simbirtseva, K., & O’Toole, P. W. (2024) · Annual Review of Medicine · doi:10.1146/annurev-med-042423-042542 · Cited by 16

Predictive Value of a Gastric Microbiota Dysbiosis Test for Stratifying Cancer Risk in Atrophic Gastritis Patients

Zaramella, A., Arcidiacono, D., Duci, M., Benna, C., Pucciarelli, S., Fantin, A., Rosato, A., Re, V. D., Cannizzaro, R., Fassan, M., et al. (2024) · Nutrients · doi:10.3390/nu17010142 · Cited by 15

Ozone-induced changes in the serum metabolome: Role of the microbiome

Cho, Y., Osgood, R. S., Bell, L. N., Karoly, E. D., & Shore, S. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221633 · Cited by 15

Probiotics Administration in Cystic Fibrosis: What Is the Evidence?

Esposito, S., Testa, I., Zani, E. M., Cunico, D., Torelli, L., Grandinetti, R., Fainardi, V., Pisi, G., & Principi, N. (2022) · Nutrients · doi:10.3390/nu14153160 · Cited by 15

The Interplay between Gut Microbiota-Derived Metabolites and Ferroptosis: Implications for Intestinal Health and Disease

Gao, C., Ma, J., Yu, Y., Zhang, L., Pang, Y., Zhang, H., Xue, C., Li, D., Zhao, X., Gantumur, M., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c00130 · Cited by 14

Dietary astaxanthin-rich extract ameliorates atherosclerosis/retinopathy and restructures gut microbiome in apolipoprotein E-deficient mice fed on a high-fat diet

Liu, D., Ji, Y., Cheng, Q., Zhu, Y., Zhang, H., Guo, Y., Cao, X., & Wang, H. (2022) · Food & Function · doi:10.1039/d2fo02102a · Cited by 15

The molecular insights of bile acid homeostasis in host diseases

Zhang, J., Lü, A., & Wang, C. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121919 · Cited by 15

Promoting longevity in aged liver through NLRP3 inflammasome inhibition using tauroursodeoxycholic acid (TUDCA) and SCD probiotics

Baba, B., Ceylani, T., Gurbanov, R., Açıkgöz, E., Keskin, S., Allahverdi, H., Samgane, G., Tombuloğlu, H., & Teker, H. T. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105517 · Cited by 14

Antimicrobial activity, molecular typing and in vitro safety assessment of Lactococcus garvieae isolates from healthy cultured rainbow trout (Oncorhynchus mykiss, Walbaum) and rearing environment

Feito, J. A., Araújo, C., Gómez‐Sala, B., Contente, D., Campanero, C., Arbulu, S., Saralegui, C., Peña, N., Muñoz-Atienza, E., Borrero, J., et al. (2022) · LWT · doi:10.1016/j.lwt.2022.113496 · Cited by 14

Bacillus sp. DU-106 ameliorates type 2 diabetes by modulating gut microbiota in high-fat-fed and streptozotocin-induced mice

Yan, J., Li, J., Xue, Q., Xie, S., Jiang, J., Li, P., & Du, B. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15773 · Cited by 14

Clinical management of autoimmune liver diseases: juncture, opportunities, and challenges ahead

Chen, Y., Chen, R., Li, H., & Shuai, Z. (2025) · Immunologic Research · doi:10.1007/s12026-025-09622-9 · Cited by 14

Effects of Previous Kasai Surgery on Gut Microbiota and Bile Acid in Biliary Atresia With End-Stage Liver Disease

Song, W., Sun, L., & Zhu, Z. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.704328 · Cited by 13

The relative abundance of fecal bacterial species belonging to the Firmicutes and Bacteroidetes phyla is related to plasma levels of bile acids in young adults

Osuna‐Prieto, F. J., Xu, H., Ortiz-Alvarez, L., Di, X., Köhler, I., Jurado‐Fasoli, L., Rubio‐López, J., Plaza‐Díaz, J., Vilchez‐Vargas, R., Link, A., et al. (2023) · Metabolomics · doi:10.1007/s11306-023-02016-8 · Cited by 14

Cardiovascular disease: extraintestinal manifestation of inflammatory bowel disease

Lakhanpal, S., Aggarwal, K., Kaur, H., Kanwar, K., Gupta, V., Bhavsar, J., & Jain, R. (2024) · Intestinal Research · doi:10.5217/ir.2023.00104 · Cited by 16

Taurine-conjugated bile acids and their link to hepatic S1PR2 play a significant role in hepatitis C–related liver disease

Ali, R., Haddad, J. A., Quinn, G. M., Zhang, G. Y., Townsend, E. C., Scheuing, L., Hill, K. L., Menkart, M. G., Oringher, J. L., Umarova, R., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000478 · Cited by 13

The probiotic potential of Lactobacillus plantarum strain RW1 isolated from canine faeces

Raheem, A., Wang, M., Zhang, J., Liang, L., Liang, R., Yin, Y., Zhu, Y.-L., Yang, W., Wang, L., Lv, X., et al. (2021) · Journal of Applied Microbiology · doi:10.1111/jam.15341 · Cited by 15

Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant mice

Núñez‐Sánchez, M. Á., Herisson, F. M., Keane, J. M., García-González, N., Rossini, V., Pinhiero, J., Daly, J., Bustamante-Garrido, M., Hueston, C. M., Patel, S. H., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2149023 · Cited by 15

Better living through chemistry: Addressing emerging antibiotic resistance

Coussens, N. P., Molinaro, A. L., Culbertson, K. J., Peryea, T., Zahoránszky-Köhalmi, G., Hall, M. D., & Daines, D. A. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218755659 · Cited by 13

How Gut Microbes Nurture Intestinal Stem Cells: A Drosophila Perspective

Neophytou, C., & Pitsouli, C. (2022) · Metabolites · doi:10.3390/metabo12020169 · Cited by 14

Microbial Metabolites and Cardiovascular Dysfunction: A New Era of Diagnostics and Therapy

Kumar, J. (2025) · Cells · doi:10.3390/cells14161237 · Cited by 14

Identification of Plasma Biomarkers in Drug-Naïve Schizophrenia Using Targeted Metabolomics

Su, Q., Bi, F., Yang, S., Yan, H., Sun, X., Wang, J., Qiu, Y., Li, M., Li, S., & Li, J. (2023) · Psychiatry Investigation · doi:10.30773/pi.2023.0121 · Cited by 12

Gut microbial dysbiosis in the pathogenesis of leukemia: an immune-based perspective

Goswami, M., & Bose, P. D. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104211 · Cited by 13

Microbiota-derived bile acid metabolic enzymes and their impacts on host health

Ma, H., Wang, K., & Jiang, C. (2025) · Cell Insight · doi:10.1016/j.cellin.2025.100265 · Cited by 37

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

Funabashi, M., Grove, T. L., Wang, M., Varma, Y., McFadden, M. E., Brown, L. C., Guo, C., Higginbottom, S., Almo, S. C., & Fischbach, M. A. (2020) · Nature · doi:10.1038/s41586-020-2396-4 · Cited by 590

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

Staley, C. M., Weingarden, A. R., Khoruts, A., & Sadowsky, M. J. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-8006-6 · Cited by 595

Research progress on the relationship between intestinal microbiota and bile acids

Zhang, X., & Wang, Y. (2018) · International journal of pediatrics · doi:10.3760/cma.j.issn.1673-4408.2018.09.011 · Cited by 1

Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease

Mullish, B. H., Pechlivanis, A., Barker, G. F., Thursz, M. R., Marchesi, J. R., & McDonald, J. A. K. (2018) · Methods · doi:10.1016/j.ymeth.2018.04.028 · Cited by 109