Tracking adipogenesis during white adipose tissue development, expansion and regeneration
Open accessAbstract
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.
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eWAT appears to promote de novo adipogenesis through conversion of adipocyte progenitors to committed preadipocytes.
“eWAT appears to promote de novo adipogenesis through conversion of adipocyte progenitors to committed preadipocytes, as demonstrated in a prior study (Wang et al., 2013).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Wang et al., 2013
The Results (‘Cold-induced adipogenesis in epididymal adipose tissue’) and Discussion report new white adipocytes in eWAT after cold exposure or β3-agonist stimulation. The paper does not demonstrate the specific proposed step in which adipocyte progenitors convert to committed preadipocytes; it identifies committed-preadipocyte markers only as background in the Discussion. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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Cites
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works
Self-citationMultilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593 · see citing works
Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms
CARTWRIGHT, M., TCHKONIA, T., & KIRKLAND, J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.003 · Cited by 318 · see citing works
Influence of body fat content and distribution on variation in metabolic risk
Vega, G. L., Adams-Huet, B., Peshock, R., Willett, D., Shah, B., & Grundy, S. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0814 · Cited by 312 · see citing works
Granneman, J. G., Li, P., Zhu, Z., & Lu, Y. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2005 · Cited by 298 · see citing works
Flagged first, then by citations
Research works printed but not linked: 32
- [1]Abate N Garg A Peshock RM Stray-Gundersen J Grundy SM Relationships of generalized and regional adiposity to insulin sensitivity in men J Clin Invest 96 88 98 1995 7615840 PMC185176
- [2]Miyazaki Y DeFronzo R Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type Cardiovasc Diabetol 8 44 2009 19656356 PMC2729732
- [3]McLaughlin T Lamendola C Liu A Abbasi F Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity J Clin Endocrinol Metab 96 E1756 E1760 2011 21865361 PMC3205890
- [5]Kusminski CM MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity Nat Med 18 1539 1549 2012 22961109 PMC3745511
- [6]Sun K Kusminski CM Scherer PE Adipose tissue remodeling and obesity J Clin Invest 121 2094 2101 2011 21633177 PMC3104761
- [7]Prins JB O'Rahilly S Regulation of adipose cell number in man Clin Sci (Lond) 92 3 11 1997 9038586
- [8]Joe AWB Yi L Even Y Vogl AW Rossi FMV Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet Stem Cells 27 2563 2570 2009 19658193
- [9]Jo J Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth PLOS Comput Biol 5 e1000324 2009 19325873 PMC2653640
- [10]Tang W White fat progenitor cells reside in the adipose vasculature Science 322 583 586 2008 18801968 PMC2597101
- [11]Rodeheffer MS Birsoy Kv Friedman JM Identifcation of white adipocyte progenitor cells in vivo Cell 135 240 249 2008 18835024
- [12]Gupta RK Transcriptional control of preadipocyte determination by Zfp423 Nature 464 619 623 2010 20200519 PMC2845731
- [13]Gupta RK Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells Cell Metab 15 230 239 2012 22326224 PMC3366493
- [14]Tran KV The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells Cell Metab 15 222 229 2012 22326223 PMC3278718
- [15]Wu J Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Cell 150 366 376 2012 22796012 PMC3402601
- [16]Lončar D Convertible adipose tissue in mice Cell Tissue Res 266 149 161 1991 1747909
- [17]Loncar D Afzelius BA Cannon B Epididymal white adipose tissue after cold stress in rats. I. Nonmitochondrial changes J Ultrastruct Mol Struct Res 101 109 122 1988 3268608
- [18]van Marken Lichtenbelt WD Cold-activated brown adipose tissue in healthy men N Engl J Med 360 1500 1508 2009 19357405
- [19]Frontini A Cinti S Distribution and development of brown adipocytes in the murine and human adipose organ Cell Metab 11 253 256 2010 20374956
- [21]Lee YH Petkova AP Mottillo EP Granneman JG In vivo identifcation of bipotential adipocyte progenitors recruited by 23-adrenoceptor activation and high-fat feeding Cell Metab 15 480 491 2012 22482730 PMC3322390
- [24]Barbatelli G The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation Am J Physiol Endocrinol Metab 298 E1244 E1253 2010 20354155
- [25]Birsoy K Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis Development 138 4709 4719 2011 21989915 PMC3190384
- [26]Sun K Dichotomous effects of VEGF-A on adipose tissue dysfunction Proc Natl Acad Sci USA 109 5874 5879 2012 22451920 PMC3326476
- [27]Perl AKT Wert SE Nagy A Lobe CG Whitsett JA Early restriction of peripheral and proximal cell lineages during formation of the lung Proc Natl Acad Sci USA 99 10482 10487 2002 12145322 PMC124949
- [28]Soriano P Generalized lacZ expression with the ROSA26 Cre reporter strain Nat Genet 21 70 71 1999 9916792
- [29]Sharp LZ Human BAT possesses molecular signatures that resemble beige/brite cells PLoS ONE 7 e49452 2012 23166672 PMC3500293
- [30]Rosenwald M Perdikari A Rulicke T Wolfrum C Bi-directional interconversion of brite and white adipocytes Nat Cell Biol 15 659 667 2013 23624403
- [32]Miller WH Faust IM Alterations in rat adipose tissue morphology induced by a low-temperature environment Am J Physiol 242 E93 E96 1982 7065129
- [33]Gesta S Tseng YH Kahn CR Developmental origin of fat: tracking obesity to its source Cell 131 242 256 2007 17956727
- [35]Macotela Y Intrinsic differences in adipocyte precursor cells from different white fat depots Diabetes 61 1691 1699 2012 22596050 PMC3379665
- [36]Tchkonia T Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes Am J Physiol Regul Integr Comp Physiol 282 R1286 R1296 2002 11959668
- [37]Baglioni S Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell PLoS ONE 7 e36569 2012 22574183 PMC3344924
- [39]Grundy SM Adams-Huet B Vega GL Variable contributions of fat content and distribution to metabolic syndrome risk factors Metab Syndr Relat Disord 6 281 288 2008 18759660 PMC3190266
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Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.005 · Cited by 100 · see citing works
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- Authors
- Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Scherer, Philipp E
- Venue
- Nature Medicine
- Published
- 2013-09-01
- Volume
- 19
- Issue
- 10
- Pages
- 1338-1344
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC4075943
- OpenAlex
- W2044021940
- Cited by
- 1,262
- References
- 7
- Citations by year
- 2026: 47 · 2025: 65 · 2024: 102 · 2023: 121 · 2022: 105 · 2021: 114 · 2020: 108 · 2019: 99 · 2018: 102 · 2017: 120 · 2016: 103 · 2015: 90 · 2014: 75 · 2013: 7
- FWCI
- 63.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- Searle Scholars Program
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK090120, R01 DK 55758, R01DK055758, R03DK099428, P01DK088761, R01DK099110)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- adipogenesis, white adipose tissue, beige adipocytes, adipocyte turnover, adipose tissue regeneration, high-fat diet, adipocyte hypertrophy, adipose tissue plasticity, fat depots, gonadal fat, subcutaneous adipose tissue, epididymal adipose tissue, adipocyte precursors, beta-adrenergic stimulation
- MeSH terms
- Animals, Adipose Tissue, Brown, Cell Differentiation, Cold Temperature, Dietary Fats, Hyperplasia, Adipogenesis, Mice, Adipose Tissue, White
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