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Cited by 30Hormonal and reproductive studiesSexual function and dysfunction studiesSperm and Testicular Function

A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM)

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Leitão, Alice Erwig, Vieira, Melissa Carvalho de Souza, Pelegrini, Andreia, da Silva, Edson Luiz, Guimarães, Adriana Coutinho de Azevedo·2021·Maturitas
DOI 10.1016/j.maturitas.2020.12.002
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Abstract

Background Androgen deficiency of aging males (ADAM) largely manifests as sexual symptoms. Erectile dysfunction is one of the most common symptoms of ADAM.Aim To ascertain the effect of concurrent training and supplementation with Eurycoma longifolia on erectile function and testosterone levels in men with ADAM, and the association of erectile function with levels of total testosterone.Methods 6-month, randomized, double-blind, placebo-controlled four-arm clinical. 45 men (47.38 ± 5.03 years) were randomized into 4 groups (G1: control + placebo; G2: control + Eurycoma longifolia; G3: concurrent training + placebo; G4: concurrent training + Eurycoma longifolia). 22 received a 200 mg supplement of Eurycoma longifolia and 23 underwent the intervention with concurrent training, 3 times a week for 60 min at progressive intensity.Outcomes International Index of Erectile Function (IIEF-5), Aging Male Scale (AMS) and total testosterone.Results Erectile function demonstrated improvements in both interventions; however, the most significant results were obtained by men allocated to concurrent training + Eurycoma longifolia.Clinical implications A 200 mg supplement of Eurycoma longifolia and the practice of concurrent training for 6 months significantly improved the erectile function of men with ADAM.Strengths & limitations The study's design stands out as a strength, in addition to the six-month intervention. The main limitation is the study not having groups that used only Eurycoma longifolia and only concurrent training.Conclusion The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.

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Authors
Leitão, A. E., Vieira, M. C. D. S., Pelegrini, A., da Silva, E. L., & Guimarães, A. C. D. A.
Affiliations
Universidade do Estado de Santa Catarina (BR)
Corresponding author
Leitão, Alice Erwig
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
2021-03
Volume
145
Pages
78-85
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/j.maturitas.2020.12.002
OpenAlex
W3112781355
Cited by
30
References
41
Citations by year
2026: 5 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 1
FWCI
2.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Funders
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
Eurycoma longifolia, erectile dysfunction, testosterone, concurrent training, exercise supplementation, male sexual health, older men
MeSH terms
Adult, Aging, Androgens, Double-Blind Method, Humans, Erectile Dysfunction, Male, Phytotherapy, Middle Aged, Plant Extracts, Testosterone, Exercise, Eurycoma

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