The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Alcohol and Cardiovascular Health: The Dose Makes the Poison…or the Remedy
Abstract
Habitual light to moderate alcohol intake (up to 1 drink per day for women and 1 or 2 drinks per day for men) is associated with decreased risks for total mortality, coronary artery disease, diabetes mellitus, congestive heart failure, and stroke. However, higher levels of alcohol consumption are associated with increased cardiovascular risk. Indeed, behind only smoking and obesity, excessive alcohol consumption is the third leading cause of premature death in the United States. Heavy alcohol use (1) is one of the most common causes of reversible hypertension, (2) accounts for about one-third of all cases of nonischemic dilated cardiomyopathy, (3) is a frequent cause of atrial fibrillation, and (4) markedly increases risks of stroke-both ischemic and hemorrhagic. The risk-to-benefit ratio of drinking appears higher in younger individuals, who also have higher rates of excessive or binge drinking and more frequently have adverse consequences of acute intoxication (for example, accidents, violence, and social strife). In fact, among males aged 15 to 59 years, alcohol abuse is the leading risk factor for premature death. Of the various drinking patterns, daily low- to moderate-dose alcohol intake, ideally red wine before or during the evening meal, is associated with the strongest reduction in adverse cardiovascular outcomes. Health care professionals should not recommend alcohol to nondrinkers because of the paucity of randomized outcome data and the potential for problem drinking even among individuals at apparently low risk. The findings in this review were based on a literature search of PubMed for the 15-year period 1997 through 2012 using the search terms alcohol, ethanol, cardiovascular disease, coronary artery disease, heart failure, hypertension, stroke, and mortality. Studies were considered if they were deemed to be of high quality, objective, and methodologically sound.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The relationship between alcohol use and cardiovascular disease outcomes is complex, as different dimensions play a role for different outcomes 238, 239, 240.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [239]
Citations
Cites
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026
Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870
Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., Finkelstein, E. A., Hong, Y., Johnston, S. C., Khera, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820a55f5 · Cited by 3,208
Ronksley, P. E., Brien, S. E., Turner, B. J., Mukamal, K. J., & Ghali, W. A. (2011) · BMJ · doi:10.1136/bmj.d671 · Cited by 1,610
Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack
Furie, K. L., Kasner, S. E., Adams, R. J., Albers, G. W., Bush, R. L., Fagan, S. C., Halperin, J. L., Johnston, S. C., Katzan, I. L., Kernan, W. N., et al. (2010) · Stroke · doi:10.1161/str.0b013e3181f7d043 · Cited by 1,497
Di Castelnuovo, A. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2437 · Cited by 930
Alcohol as a Risk Factor for Type 2 Diabetes
Baliunas, D. O., Taylor, B. J., Irving, H., Roerecke, M., Patra, J., Mohapatra, S., & Rehm, J. (2009) · Diabetes Care · doi:10.2337/dc09-0227 · Cited by 703
Moderate Alcohol Consumption Lowers the Risk of Type 2 Diabetes
Koppes, L. L. J., Dekker, J. M., Hendriks, H. F. J., Bouter, L. M., & Heine, R. J. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.719 · Cited by 671
Arrhythmias and the “Holiday Heart”: Alcoholassociated cardiac rhythm disorders
Ettinger, P. O., Wu, C. F., Cruz, C. D. L., Weisse, A. B., Ahmed, S., & Regan, T. J. (1978) · American Heart Journal · doi:10.1016/0002-8703(78)90296-x · Cited by 609
Flagged first, then by citations
Cited by
Sorted by citations
The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204
Alcohol Consumption and Obesity: An Update
Traversy, G., & Chaput, J.-P. (2015) · Current Obesity Reports · doi:10.1007/s13679-014-0129-4 · Cited by 629
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
Malhotra, N., Lee, J., Liman, R. A. D., Ruallo, J. M. S., Villaflores, O. B., Ger, T.-R., & Hsiao, C. (2020) · Molecules · doi:10.3390/molecules25143159 · Cited by 491
Connor, J. P., Haber, P. S., & Hall, W. D. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00122-1 · Cited by 389
Cardiovascular risks and benefits of moderate and heavy alcohol consumption
Fernández‐Solà, J. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.91 · Cited by 370
Running as a Key Lifestyle Medicine for Longevity
Lee, D.-C., Brellenthin, A. G., Thompson, P. D., Sui, X., Lee, I.-M. M., & Lavie, C. J. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.03.005 · Cited by 364
“Runners also tend to engage in other healthy behaviors that contribute to their increased longevity such as maintaining a normal body weight, not smoking, and consuming light-tomoderate amounts of alcohol.(24) Most studies have adjusted their models to account for these confounders.”
BackgroundSelf-citationKutlu, M. G., & Gould, T. J. (2016) · Learning & Memory · doi:10.1101/lm.042192.116 · Cited by 345
“…showing that light to moderate alcohol intake (1–2 drinks per day) may decrease the risk of cardiovascular mortality, coronary heart disease, and stroke in humans (Fagrell et al. 1999; O’Keefe et al. 2014), which suggests that lower doses of ethanol may have some beneficial effects on human health.”
BackgroundYun, J.-S., & Ko, S.-H. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154838 · Cited by 292
Alcohol and Atrial Fibrillation
Voskoboinik, A., Prabhu, S., Ling, L., Kalman, J. M., & Kistler, P. M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.08.074 · Cited by 288
“More than 100 nonrandomized studies have demonstrated that lightmoderate intake (especially 7 standard drinks/week for women and 14 standard drinks/week for men) may decrease the risk of new-onset coronary artery disease, angina, myocardial infarction, and cardiovascular mortality (70) in nearly one-third of drinkers.”
BackgroundMetabolic Methanol: Molecular Pathways and Physiological Roles
Dorokhov, Y. L., Shindyapina, A. V., Sheshukova, E. V., & Komarova, T. V. (2015) · Physiological Reviews · doi:10.1152/physrev.00034.2014 · Cited by 235
Contribution of Red Wine Consumption to Human Health Protection
Snopek, L., Mlček, J., Sochorová, L., Baroň, M., Hlaváčová, I., Juríková, T., Kizek, R., Sedláčková, E., & Sochor, J. (2018) · Molecules · doi:10.3390/molecules23071684 · Cited by 224
3D-printed epifluidic electronic skin for machine learning–powered multimodal health surveillance
Song, Y., Tay, R. Y., Li, J., Xu, C., Min, J., Sani, E. S., Kim, G., Heng, W., Kim, I. H., & Gao, W. F. (2023) · Science Advances · doi:10.1126/sciadv.adi6492 · Cited by 228
Gibbs, B. B., Hivert, M., Jerome, G. J., Kraus, W. E., Rosenkranz, S. K., Schorr, E. N., Spartano, N. L., & Lobelo, F. (2021) · Hypertension · doi:10.1161/hyp.0000000000000196 · Cited by 224
Morin, D. P., Bernard, M. L., Madias, C. A., Rogers, P. A., Thihalolipavan, S., & Estes, N. A. M. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.08.022 · Cited by 201
Alcohol and CV Health: Jekyll and Hyde J-Curves
O’Keefe, E. L., DiNicolantonio, J. J., O’Keefe, J. H., & Lavie, C. J. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.02.001 · Cited by 194
Self-citationThe Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy
Fernández‐Solà, J. (2020) · Nutrients · doi:10.3390/nu12020572 · Cited by 182
“However, there is a clear personal susceptibility of this effect that creates a wide variability range and supposes significant inter-individual differences [50,66].”
BackgroundPromoting Successful Cognitive Aging: A Ten-Year Update
Krivanek, T. J., Gale, S. A., McFeeley, B. M., Nicastri, C. M., & Daffner, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201462 · Cited by 189
Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease
Caruana, M., Cauchi, R. J., & Vassallo, N. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00031 · Cited by 164
Alcohol’s Impact on the Cardiovascular System
Roerecke, M. (2021) · Nutrients · doi:10.3390/nu13103419 · Cited by 170
Capítulo 1 - Conceituação, Epidemiologia e Prevenção Primária
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160151 · Cited by 152
Impact of age, clinical conditions, and lifestyle on routine semen parameters and sperm kinematics
Verón, G. L., Tissera, A. D., Bello, R., Beltramone, F., Estofan, G. M., Molina, R. I., & Vazquez-Levin, M. H. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.03.016 · Cited by 126
Kabwama, S. N., Ndyanabangi, S., Mutungi, G. N., Wesonga, R., Bahendeka, S., & Guwatudde, D. (2016) · Global Health Action · doi:10.3402/gha.v9.31302 · Cited by 118
Alcoholic cardiomyopathy: What is known and what is not known
Mirijello, A., Tarli, C., Vassallo, G. A., Sestito, L., Antonelli, M., D’Angelo, C., Ferrulli, A., Cosmo, S. D., Gasbarrini, A., & Addolorato, G. (2017) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2017.06.014 · Cited by 116
Cardiovascular effects of alcohol consumption
Rehm, J. T., & Roerecke, M. (2017) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2017.06.002 · Cited by 113
Lifestyle Medicine and the Management of Cardiovascular Disease
Doughty, K. N., Pilar, N. X. D., Audette, A., & Katz, D. L. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0925-z · Cited by 109
Alcohol Effects on Cardiac Function
Gardner, J. D., & Mouton, A. J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140046 · Cited by 102
Toxicology and the biological role of methanol and ethanol: Current view
Pohanka, M. (2015) · Biomedical Papers · doi:10.5507/bp.2015.023 · Cited by 95
Draijer, R., de Graaf, Y., Slettenaar, M., de Groot, E., & Wright, C. (2015) · Nutrients · doi:10.3390/nu7053138 · Cited by 95
Quantifying the contribution of alcohol to cardiomyopathy: A systematic review
Rehm, J., Hasan, O. S. M., Imtiaz, S., & Neufeld, M. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.011 · Cited by 92
Saha, B., Bruneau, J. C., Kodys, K., & Szabó, G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402190 · Cited by 93
“Low- to moderate-dose alcohol consumption is associated with reduced risk of coronary heart disease (2, 3).”
BackgroundA Clinician’s Guide for Trending Cardiovascular Nutrition Controversies
Freeman, A. M., Morris, P. B., Aspry, K. E., Gordon, N. F., Barnard, N. D., Esselstyn, C. B., Ros, E., Devries, S. R., O’Keefe, J. H., Miller, M. J., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.030 · Cited by 93
“However, heavy and binge alcohol consumption are associated with increased risks of atrial fibrillation and ventricular arrhythmias, sudden cardiac death, impaired diastolic and systolic left ventricular function, alcohol-induced cardiomyopathy, heart failure, hemorrhagic and ischemic stroke, arterial hypertension, DM…”
BackgroundSelf-citationChang, K. J., Thach, M. L., & Olsen, J. E. (2016) · Wine Economics and Policy · doi:10.1016/j.wep.2016.09.001 · Cited by 80
Comportamentos em saúde e o controle da hipertensão arterial: resultados do ELSI-BRASIL
Firmo, J. O. A., Peixoto, S. V., Filho, A. I. D. L., Júnior, P. R. B. D. S., de Andrade, F. B., Lima‐Costa, M. F., & Mambrini, J. V. D. M. (2019) · Cadernos de Saúde Pública · doi:10.1590/0102-311x00091018 · Cited by 72
André, S., Andreozzi, F., Overstraeten, C. V., Youssef, S. B., Bold, I., Carlier, S., Gruwez, A., Bruyneel, A.-V., & Bruyneel, M. (2020) · Respiratory Research · doi:10.1186/s12931-020-1284-7 · Cited by 76
Passaglia, P., Ceron, C. S., Mecawi, A. S., Antunes‐Rodrigues, J., Coelho, E. B., & Tirapelli, C. R. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.04.002 · Cited by 68
Risk of cardiovascular diseases in relation to substance use disorders
Gan, W., Buxton, J. A., Scheuermeyer, F. X., Palis, H., Zhao, B., Desai, R., Janjua, N. Z., & Slaunwhite, A. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.109132 · Cited by 64
Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy
Wang, S., & Ren, J. T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.016 · Cited by 64
Rehm, J. T., Shield, K. D., Roerecke, M., & Gmel, G. E. (2016) · BMC Public Health · doi:10.1186/s12889-016-3026-9 · Cited by 64
Moderate Beer Intake and Cardiovascular Health in Overweight Individuals
Padró, T., Muñoz‐García, N., Vilahur, G., Chagas, P., Deyà, A., Antonijoan, R. M., & Badimón, L. (2018) · Nutrients · doi:10.3390/nu10091237 · Cited by 63
“Excessive alcohol intake has been associated with hypertension and atrial fibrillation [41].”
BackgroundSasot, G., Martínez‐Huélamo, M., Vallverdú‐Queralt, A., Mercader-Martí, M., Estruch, R., & Lamuela-Raventós, R. M. (2017) · Food Research International · doi:10.1016/j.foodres.2017.01.020 · Cited by 61
Klaming, R., Annese, J., Veltman, D. J., & Comijs, H. C. (2017) · Aging, Neuropsychology, and Cognition · doi:10.1080/13825585.2016.1226746 · Cited by 59
“Light-to-moderate alcohol intake has beneficial effects on cardiovascular health, such as reduced risks of stroke and congestive heart failure (O’Keefe et al., 2014), promoting brain health (Deng et al., 2006).”
BackgroundHealth Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate
Lombardo, M., Feraco, A., Camajani, E., Caprio, M., & Armani, A. (2023) · Nutrients · doi:10.3390/nu15081921 · Cited by 59
Joo, Y. S., Koh, H. B., Nam, K. H., Lee, S., Kim, J., Lee, C., Yun, H., Park, J. T., Kang, E. W., Chang, T. I., et al. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.06.014 · Cited by 59
Zheng, Q., Lin, W., Liu, C.-G., Zhou, Y., Chen, T.-H., Zhang, L.-Q., Zhang, X.-H., Yu, S., Wu, Q., Jin, Z., et al. (2020) · BMC Public Health · doi:10.1186/s12889-020-08630-8 · Cited by 46
A scoping review on consumer behaviour related to wine and health
Deroover, K., Siegrist, M., Brain, K., McIntyre, J., & Bucher, T. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.057 · Cited by 61
Effects of Age Discrimination on Self-perceptions of Aging and Cancer Risk Behaviors
Hooker, K. A., Mejía, S. T., Phibbs, S. C., Tan, E. J., & Stevens, J. (2019) · The Gerontologist · doi:10.1093/geront/gny183 · Cited by 55
Wallach, J. D., Serghiou, S., Chu, L., Egilman, A. C., Vasiliou, V., Ross, J. S., & Ioannidis, J. P. A. (2020) · BMC Medical Research Methodology · doi:10.1186/s12874-020-0914-6 · Cited by 55
Huang, C., Zhan, J., Liu, Y., Li, D., Wang, S.-Q., & He, Q. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.05.014 · Cited by 56
He, Y., Qiu, H., Wang, W., Lin, Y., & Ho, K. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170639 · Cited by 51
Jorge, E., Lopez‐Valeiras, E., & Sánchez, M. B. G. (2020) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2020.120601 · Cited by 56
The Association of Alcohol Consumption with Glaucoma and Related Traits
Stuart, K. V., Luben, R., Warwick, A., Madjedi, K. M., Patel, P. J., Biradar, M. I., Sun, Z., Chia, M. A., Pasquale, L. R., Wiggs, J. L., et al. (2022) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2022.11.008 · Cited by 54
“61,62 Although all associations were noted to attenuate after adjustment for systolic blood pressure in our analyses, this did not account for a signi fi cant difference in the overall results, and results were materially unchanged when restricting analyses to participants without hypertension.”
Moderate alcohol consumption and atherosclerosis
Huang, Y., Li, Y., Zheng, S., Yang, X., Wang, T., & Zeng, J. (2017) · Wiener klinische Wochenschrift · doi:10.1007/s00508-017-1235-6 · Cited by 49
Degerud, E., Ariansen, I., Ystrøm, E., Graff‐Iversen, S., Høiseth, G., Mørland, J. G., Smith, G. D., & Næss, Ø. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002476 · Cited by 48
“We observed higher CVD, IHD, and all-cause mortality among current drinkers who were frequent binge drinkers compared with current drinkers who did not binge drink during the last year, possibly mediated by increased blood pressure [19,47], cardiomyopathy, cardiac arrhythmias, and disturbances in blood electrolyte sta…”
BackgroundHealth Lifestyles in Late Middle Age
Cockerham, W. C., Wolfe, J. D., & Bauldry, S. (2019) · Research on Aging · doi:10.1177/0164027519884760 · Cited by 47
“We use this to create an indicator variable for any occurrence of binge drinking in the past month, which is associated with cirrhosis, seizures, stroke, and cancer (O’Keefe et al., 2014).”
MethodShen, C., Wang, C., Han, S., Wang, Z., Dong, Z., Zhao, X., Wang, P., Zhu, H., Sun, X., Ma, X., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.016 · Cited by 47
D'Alessandro, A., Lampignano, L., & Pergola, G. D. (2019) · Nutrients · doi:10.3390/nu11061296 · Cited by 55
“The cardio-metabolic protective effects of light to moderate alcohol intake depend on an increase of HDL cholesterol and of adiponectin, a reduction of the low-grade inflammation, an improvement of insulin sensitivity, and endothelial function (reviewed in [118]).”
BackgroundNutrición y salud cardiovascular
Berciano, S., & Ordovás, J. M. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2014.05.003 · Cited by 48
Risk of cardiac death among cancer survivors in the United States: a SEER database analysis
Abdel-Rahman, O. M. (2017) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2017.1344099 · Cited by 44
Manolis, T. A., Manolis, A. S., & Manolis, A. S. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.08.011 · Cited by 45
Brellenthin, A. G., & Lee, D.-C. (2018) · Progress in Preventive Medicine · doi:10.1097/pp9.0000000000000018 · Cited by 46
“protective against premature mortality compared with abstinence or heavy drinking.[12] It is crucial to determine how physical activity”
BackgroundPoppitt, S. D. (2015) · Nutrients · doi:10.3390/nu7085304 · Cited by 44
Temporal Trends in Substance Use and Cardiovascular Disease–Related Mortality in the United States
Minhas, A. M. K., Kewcharoen, J., Hall, M. E., Warraich, H. J., Greene, S. J., Shapiro, M. D., Michos, E. D., Sauer, A. J., & Abramov, D. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.030969 · Cited by 41
Using Physical Activity to Enhance Health Outcomes Across the Life Span
Roychowdhury, D. (2020) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk5010002 · Cited by 47
Gomes, J. M. G., Fabrini, S. P., & Alfenas, R. D. C. G. (2016) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000206 · Cited by 39
“The exclusion criteria were tobacco use, consumption of > 50 g/day of alcohol (14), pregnancy or lactation, menopause or postmenopause, regular use of hormones, antiinflammatory medications or other medications that might interfere with outcome measures, recent change (in the previous three months) in the level of phy…”
BackgroundAlcohol Consumption and Risk of Incident Frailty: The English Longitudinal Study of Aging
Kojima, G., Jivraj, S., Iliffe, S., Falcaro, M., Liljas, A. E. M., & Walters, K. R. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.10.011 · Cited by 39
“Although the mechanisms underlying this potential beneficial effect of low alcohol consumption are not clear, it has been suggested that light-to-moderate alcohol intake may improve insulin sensitivity, increase high-density lipoprotein cholesterol, decrease inflammation and increase adiponectin.(21) However, this app…”
BackgroundRichard, E., Kritz‐Silverstein, D. C., Laughlin, G. A., Fung, T. T., Barrett-Connor, E. L., & McEvoy, L. K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161153 · Cited by 39
Capítulo 3 - Avaliação Clínica e Complementar
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160153 · Cited by 38
Sexual Dysfunction in Heart Failure Patients
Jaarsma, T., Fridlund, B., & Mårtensson, J. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0202-z · Cited by 36
Barr, T., Girke, T., Sureshchandra, S., Nguyen, C., Grant, K. A., & Messaoudi, I. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501527 · Cited by 37
Rehm, J. T., Anderson, P., Prieto, J. A. A., Armstrong, I. J., Aubin, H., Bachmann, M., Bastús, N. B., Brotons, C., Burton, R., Cardoso, M., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0934-1 · Cited by 38
“As indicated by the potential threshold, the dose-response relationship is not linear over the full range of alcohol consumption, but for both sexes there is a monotonic dose-response relationship for higher levels of consumption [20, 22, 24], and thus hazardous/ harmful drinking and AUDs are closely associated with R…”
BackgroundAlcohol Intake and Arterial Hypertension: Retelling of a Multifaceted Story
Vacca, A., Bulfone, L., Cicco, S., Brosolo, G., Porto, A. D., Soardo, G., Catena, C., & Sechi, L. A. (2023) · Nutrients · doi:10.3390/nu15040958 · Cited by 38
Low Vs. High Alcohol: Central Benefits Vs. Detriments
Tizabi, Y., Getachew, B., Ferguson, C. L., Csoka, A. B., Thompson, K. M., Gómez-Paz, A., Kučerová, J., & Taylor, R. E. (2018) · Neurotoxicity Research · doi:10.1007/s12640-017-9859-x · Cited by 35
“, 10 mg% or lower) various beneficial effects of alcohol, particularly on cardiovascular function have been noted (O’Keefe et al. 2014; de Gaetano et al. 2016).”
Prevalence of Lebanese stroke survivors: A comparative pilot study
Lahoud, N., Salameh, P., Saleh, N., & Hosseini, H. (2015) · Journal of Epidemiology and Global Health · doi:10.1016/j.jegh.2015.10.001 · Cited by 33
Logue, M. W., Miller, M. W., Sherva, R., Zhang, R., Harrington, K. M., Fonda, J. R., Merritt, V. C., Panizzon, M. S., Hauger, R. L., Wolf, E. J., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12870 · Cited by 35
Yang, Q., He, Y., Cai, D.-P., Yang, X., & Xu, H. (2016) · Scientific Reports · doi:10.1038/srep35463 · Cited by 32
Kawasoe, S., Kubozono, T., Yoshifuku, S., Ojima, S., Miyata, M., Miyahara, H., Maenohara, S., & Ohishi, M. (2018) · Circulation Journal · doi:10.1253/circj.cj-18-0508 · Cited by 32
Are Sustainable Consumers Health Conscious? A Segmentation Study of Wine Consumers
Ghvanidze, S., Velikova, N., Dodd, T. H., & Oldewage-Theron, W. H. (2019) · Journal of Food Products Marketing · doi:10.1080/10454446.2019.1640160 · Cited by 33
Georgescu, O. Ş., Martin, L., Târtea, G. C., Rotaru-Zăvăleanu, A. D., Dinescu, S. N., Vasile, R. C., Greșiță, A., Gheorman, V., Aldea, M., & Dinescu, V. C. (2024) · Life · doi:10.3390/life14091134 · Cited by 46
“Understanding the impact of alcohol consumption on cardiovascular health requires clear definitions of drinking patterns, as you can see in Table 2 [36].”
BackgroundUdo, T., Vásquez, E., & Shaw, B. A. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.10.008 · Cited by 31
Catena, C., Colussi, G., Verheyen, N., Novello, M., Fagotto, V., Soardo, G., & Sechi, L. A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08145 · Cited by 31
Nonpharmacologic management of hypertension
Ozemek, C., Phillips, S. A., Popović, D., Laddu, D., Fancher, I. S., Arena, R. A., & Lavie, C. J. (2017) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000406 · Cited by 31
Self-citationJongenelis, M. I., Pratt, I., Slevin, T. J., Chikritzhs, T. N., Liang, W., & Pettigrew, S. (2018) · Health Education Research · doi:10.1093/her/cyy025 · Cited by 31
Microbiota for production of wine with enhanced functional components
James, A., Yao, T., Ke, H., & Wang, Y. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.02.008 · Cited by 30
Date Fruits as Raw Material for Vinegar and Non-Alcoholic Fermented Beverages
Cantadori, E., Brugnoli, M., Centola, M., Uffredi, E., Colonello, A., & Gullo, M. (2022) · Foods · doi:10.3390/foods11131972 · Cited by 30
Capítulo 14 – Crise Hipertensiva
Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160164 · Cited by 32
Rehm, J. T., Prieto, J. A. A., Beier, M., Duhot, D., Rossi, A., Schulte, B., Zarco, J., Aubin, H., Bachmann, M., Grimm, C. J., et al. (2016) · BMC Family Practice · doi:10.1186/s12875-016-0529-5 · Cited by 30
Justice, M., Ferrugia, A., Beidler, J., Penprase, J. C., Cintora, P., Erwin, D., Medrano, O., Brasser, S. M., & Hong, M. Y. (2018) · Alcohol and Alcoholism · doi:10.1093/alcalc/agy079 · Cited by 29
“An increasing body of evidence continues to validate a J- or U-shaped correlation between alcohol consumption and CVD risk factors (Carnevale and Nocella, 2012; Bergmann et al., 2013; Chiva-Blanch et al., 2013; Wakabayashi, 2013a; Klein et al., 2014; Matsumoto et al., 2014; O’Keefe et al., 2014).”
BackgroundKnapper, J. T., Ghasemzadeh, N., Khayata, M., Patel, S. P., Quyyumi, A. A., Mendis, S., Mensah, G. A., Taubert, K. A., & Sperling, L. S. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.008 · Cited by 33
“associated with numerous positive health outcomes, including lower rates of diabetes mellitus, congestive heart failure, coronary artery disease, stroke, and allcause mortality (71).”
BackgroundDaily alcohol consumption and sickness absence in the GAZEL cohort
Morois, S., Airagnes, G., Lemogne, C., Leclerc, A., Limosin, F., Goldberg, S., Herquelot, É., Goldberg, M., & Zins, M. (2017) · European Journal of Public Health · doi:10.1093/eurpub/ckx012 · Cited by 28
Krauss, M. J., Cavazos‐Rehg, P. A., Plunk, A. D., Bierut, L. J., & Grucza, R. A. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12533 · Cited by 28
“Wine is often perceived as a relatively healthy alcoholic beverage, and epidemiologic studies have shown the health benefits of moderate wine consumption, including decreased risk of cardiovascular disease-related mortality (O’Keefe et al., 2014).”
The Prognostic Factors of Alcoholic Cardiomyopathy
Fang, W., Luo, R., Tang, Y., Hua, W., Fu, M. L. X., Chen, W., Lai, L. F., & Li, X. (2018) · Medicine · doi:10.1097/md.0000000000011744 · Cited by 28
Morales, G. I., Martínez‐González, M. Á., Barbería-Latasa, M., Bes‐Rastrollo, M., & Gea, A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02342-w · Cited by 28
Jung, Y., Lyu, J., & Kim, G. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104533 · Cited by 27
Research trends and hotspots of post-stroke cognitive impairment: a bibliometric analysis
Chi, X., Fan, X., Fu, G.-J., Liu, Y., Zhang, Y., & Shen, W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1184830 · Cited by 29
“Notably, habitual mild-to-moderate alcohol consumption has been linked to reduce the risk, while higher levels of alcohol consumption increase the stroke risk (O’Keefe et al., 2014).”
BackgroundGodfrey, J., Jeanguenin, L., Castro, N., Olney, J. J., Dudley, J., Pipkin, J. A., Walls, S. M., Wang, W., Herr, D. R., Harris, G. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139012 · Cited by 27
Patananan, A. N., Budenholzer, L., Eskin, A., Torres, E. R., & Clarke, S. G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.11.010 · Cited by 25
“Finally, a full understanding of the beneficial effects of ethanol on C. elegansmay provide insights into how consuming small amounts of ethanol may be beneficial to humans (O'Keefe et al., 2014).”
BackgroundInfluentialAlcohol Use and Breast Cancer Survival among Participants in the Women's Health Initiative
Lowry, S., Kapphahn, K., Chlebowski, R. T., & Li, C. I. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0151 · Cited by 25
“Alcohol has been shown to have a protective effect on cardiovascular disease (CVD) mortality (12), but presumably this effect is not immediate.”
BackgroundResult“The Bottle Is My Wife”: Exploring Reasons Why Men Drink Alcohol in Ugandan Fishing Communities
Breuer, C., Bloom, B. E., Miller, A. P., Kigozi, G., Nakyanjo, N., Ddaaki, W. G., Nalugoda, F. K., & Wagman, J. A. (2019) · Social Work in Public Health · doi:10.1080/19371918.2019.1666072 · Cited by 24
Increased Mortality in Hip Fracture Patients Living Alone: A NOREPOS Study
Dahl, C., Holvik, K., Meyer, H. E., Stigum, H., Solbakken, S. M., Schei, B., Søgaard, A. J., & Omsland, T. K. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4212 · Cited by 24
“(46) A high alcohol intake may also be associated with a higher degree of comorbidity, (47) and in the current study the association between living situation and mortality in the youngest male hip fracture patients (50-59 years) was somewhat attenuated when adjusting for comorbidity level.”
BackgroundAlcohol and vascular endothelial function: Biphasic effect highlights the importance of dose
Rajendran, N. K., Liu, W., Cahill, P. A., & Redmond, E. M. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15138 · Cited by 23
Metadata
- Authors
- O’Keefe, J. H., Bhatti, S. K., Bajwa, A., DiNicolantonio, J. J., & Lavie, C. J.
- Affiliations
- Saint Luke's Hospital (US)
- The University of Queensland (AU)
- Corresponding author
- O’Keefe, James H.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 89
- Issue
- 3
- Pages
- 382-393
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2042273266
- Semantic Scholar
- fb99861a75849bf01ecd526f770d9df083ecff23
- Cited by
- 406
- References
- 96
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 27 · 2023: 41 · 2022: 31 · 2021: 33 · 2020: 43 · 2019: 22 · 2018: 39 · 2017: 35 · 2016: 40 · 2015: 42 · 2014: 13
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- alcohol consumption, cardiovascular health, moderate drinking, heavy drinking, binge drinking, coronary artery disease, stroke, hypertension, congestive heart failure, diabetes mellitus, premature mortality, red wine, atrial fibrillation, non-ischemic dilated cardiomyopathy, risk-benefit ratio
- MeSH terms
- Alcohol Drinking, Ethanol, Alcoholic Beverages, Cardiotonic Agents, Cardiovascular Diseases, Dose-Response Relationship, Drug, Humans, Primary Prevention, Risk Factors, United States, Health Behavior, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
