CoChat
Sign Up
Cited by 406Alcohol Consumption and Health EffectsSubstance Abuse Treatment and OutcomesCoffee research and impacts

The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.

Alcohol and Cardiovascular Health: The Dose Makes the Poison…or the Remedy

O’Keefe, James H., Bhatti, Salman K., Bajwa, Ata, DiNicolantonio, James J., Lavie, Carl J.·2014·Mayo Clinic Proceedings
DOI 10.1016/j.mayocp.2013.11.005
Open this paper in CoChat — free account

Abstract

Habitual light to moderate alcohol intake (up to 1 drink per day for women and 1 or 2 drinks per day for men) is associated with decreased risks for total mortality, coronary artery disease, diabetes mellitus, congestive heart failure, and stroke. However, higher levels of alcohol consumption are associated with increased cardiovascular risk. Indeed, behind only smoking and obesity, excessive alcohol consumption is the third leading cause of premature death in the United States. Heavy alcohol use (1) is one of the most common causes of reversible hypertension, (2) accounts for about one-third of all cases of nonischemic dilated cardiomyopathy, (3) is a frequent cause of atrial fibrillation, and (4) markedly increases risks of stroke-both ischemic and hemorrhagic. The risk-to-benefit ratio of drinking appears higher in younger individuals, who also have higher rates of excessive or binge drinking and more frequently have adverse consequences of acute intoxication (for example, accidents, violence, and social strife). In fact, among males aged 15 to 59 years, alcohol abuse is the leading risk factor for premature death. Of the various drinking patterns, daily low- to moderate-dose alcohol intake, ideally red wine before or during the evening meal, is associated with the strongest reduction in adverse cardiovascular outcomes. Health care professionals should not recommend alcohol to nondrinkers because of the paucity of randomized outcome data and the potential for problem drinking even among individuals at apparently low risk. The findings in this review were based on a literature search of PubMed for the 15-year period 1997 through 2012 using the search terms alcohol, ethanol, cardiovascular disease, coronary artery disease, heart failure, hypertension, stroke, and mortality. Studies were considered if they were deemed to be of high quality, objective, and methodologically sound.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.mayocp.2013.11.005

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

See all 406

Related

See all

Metadata

Authors
O’Keefe, J. H., Bhatti, S. K., Bajwa, A., DiNicolantonio, J. J., & Lavie, C. J.
Affiliations
  • Saint Luke's Hospital (US)
  • The University of Queensland (AU)
Corresponding author
O’Keefe, James H.
ORCID
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2014-03
Volume
89
Issue
3
Pages
382-393
ISSN
0025-6196 (ISSN-L)
DOI
10.1016/j.mayocp.2013.11.005
OpenAlex
W2042273266
Semantic Scholar
fb99861a75849bf01ecd526f770d9df083ecff23
Cited by
406
References
96
Citations by year
2026: 20 · 2025: 20 · 2024: 27 · 2023: 41 · 2022: 31 · 2021: 33 · 2020: 43 · 2019: 22 · 2018: 39 · 2017: 35 · 2016: 40 · 2015: 42 · 2014: 13
FWCI
6.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords
alcohol consumption, cardiovascular health, moderate drinking, heavy drinking, binge drinking, coronary artery disease, stroke, hypertension, congestive heart failure, diabetes mellitus, premature mortality, red wine, atrial fibrillation, non-ischemic dilated cardiomyopathy, risk-benefit ratio
MeSH terms
Alcohol Drinking, Ethanol, Alcoholic Beverages, Cardiotonic Agents, Cardiovascular Diseases, Dose-Response Relationship, Drug, Humans, Primary Prevention, Risk Factors, United States, Health Behavior, Secondary Prevention

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review