Cited by 92Alcohol Consumption and Health EffectsSubstance Abuse Treatment and OutcomesCardiovascular Health and Risk Factors

Quantifying the contribution of alcohol to cardiomyopathy: A systematic review

Rehm, Jürgen, Hasan, Omer Syed Muhammad, Imtiaz, Sameer, Neufeld, Maria·2017·Alcohol

Abstract

Alcohol has a direct toxic impact on the heart, and while there is an ICD code for alcoholic cardiomyopathy, the burden of alcohol-attributable cardiomyopathy is not clear. For the usual estimation of this burden via population-attributable fractions, one would need to determine the risk relationships, i.e., average risk associated with different dimensions of alcohol exposure. The most important among these risk relationships is the dose-response relationship with different levels of average alcohol consumption. To establish risk relationships, we systematically searched for all studies on dose-response relationships, directly and indirectly, via reviews. The results did not permit computation of pooled estimates through meta-analyses. There were clear indications that heavy drinking (≥80 g per day) over several years was linked to high risk of cardiomyopathy, with greater lifetime exposure of alcohol linked to higher risks. Some studies indicated potential effects of patterns of drinking as well. As such, the global quantification of alcohol-attributable cardiomyopathy will have to rely on other methods than those used conventionally.

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Crossref · 10.1016/j.alcohol.2017.01.011

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  • Alcoholic cardiomyopathy (I42.6) as a cause of death is available in approximately half of the countries as a cause of death.

    “For example, alcoholic cardiomyopathy (I42.6) as a cause of death is available in approximately half of the countries as a cause of death 39, and thus could be included as part of alcohol attributable mortality in these countries.”

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Authors
Rehm, J., Hasan, O. S. M., Imtiaz, S., & Neufeld, M.
Affiliations
Centre for Addiction and Mental Health (CA)
Corresponding author
Rehm, Jürgen
Venue
Alcohol
Publisher
Elsevier BV
Published
2017-06
Volume
61
Pages
9-15
ISSN
0741-8329 (ISSN-L)
OpenAlex
W2605612208
Cited by
92
References
111
Citations by year
2026: 8 · 2025: 12 · 2024: 10 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 6 · 2019: 11 · 2018: 6 · 2017: 6
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Alcohol (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
alcoholic cardiomyopathy, population attributable fraction, dose-response relationship, heavy drinking, drinking patterns, alcohol consumption, cardiovascular risk
MeSH terms
Adult, Age Factors, Alcohol Drinking, Ethanol, Alcoholism, Dose-Response Relationship, Drug, Ethnicity, Female, Humans, Male, Cardiomyopathies, Risk Factors, Sex Factors, World Health Organization

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