The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
Open accessAbstract
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of medical conditions. Over the past decade, there has been considerable excitement about using MSCs to treat neurodegenerative diseases, which are diseases that are typically fatal and without other robust therapies. In this review, we discuss the proposed MSC mechanisms of action in neurodegenerative diseases, which include growth factor secretion, exosome secretion, and attenuation of neuroinflammation. We then provide a summary of preclinical and early clinical work on MSC therapies in amyotrophic lateral sclerosis, multiple system atrophy, Parkinson disease, and Alzheimer disease. Continued rigorous and controlled studies of MSC therapies will be critical in order to establish efficacy and protect patients from possible untoward effects.
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“Meanwhile, mesenchymal stem cell transplantation for Parkinson’s disease can significantly improve the daily activities and motor functions of Parkinson’s disease patients without side effects, as well as being safe and reliable.363,364”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [364]
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2 retracted
Batelli, S., Albani, D., Rametta, R., Polito, L., Prato, F., Pesaresi, M., Negro, A., & Forloni, G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001884 · Cited by 130
RetractedYan, M., Sun, M., Zhou, Y., Wang, W., He, Z., Tang, D., Lu, S., Wang, X., Li, S., Wang, W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064000 · Cited by 76
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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164
A perivascular origin for mesenchymal stem cells in multiple human organs
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Second consensus statement on the diagnosis of multiple system atrophy
Gilman, S., Wenning, G. K., Low, P. A., Brooks, D. J., Mathias, C. J., Trojanowski, J. Q., Wood, N. W., Colosimo, C., Dürr, A., Fowler, C. J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000324625.00404.15 · Cited by 3,140
Cited by
Sorted by citations
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
“Meanwhile, mesenchymal stem cell transplantation for Parkinson’s disease can significantly improve the daily activities and motor functions of Parkinson’s disease patients without side effects, as well as being safe and reliable.(363,364) In addition, HSC transplantation is a very rapidly and effective clinical treatm…”
BackgroundA Brief Overview of Global Trends in MSC-Based Cell Therapy
Jovic, D., Yu, Y., Wang, D., Wang, K., Li, H., Xu, F., Liu, C., Liu, J., & Luo, Y. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10369-1 · Cited by 305
Wang, S., Lei, B., Zhang, E., Gong, P., Gu, J., He, L., Han, L., & Yuan, Z. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s355366 · Cited by 180
Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy
Zhou, X., Deng, X., Liu, M., He, M., Long, W., Xu, Z., Zhang, K., Liu, T., So, K., Fu, Q., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.033 · Cited by 160
Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis
Wei, H., Xu, Y., Chen, Q., Chen, H., Zhu, X., & Li, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2490-4 · Cited by 152
Metadata
- Authors
- Staff, N. P., Jones, D. T., & Singer, W.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Staff, Nathan P.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 94
- Issue
- 5
- Pages
- 892-905
- ISSN
- 0025-6196 (ISSN-L)
- PMC
- PMC6643282
- OpenAlex
- W2943517835
- Cited by
- 150
- References
- 193
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 18 · 2023: 38 · 2022: 26 · 2021: 26 · 2020: 23 · 2019: 2
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mayo Clinic Proceedings (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Food and Drug Administration (R01 FD004789)
- National Cancer Institute (R01CA211887)
- National Institute of Neurological Disorders and Stroke (U54NS065736, R01NS092625)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- mesenchymal stem cells, neurodegenerative diseases, amyotrophic lateral sclerosis, multiple system atrophy, Parkinson's disease, Alzheimer's disease, growth factor secretion, exosomes, neuroinflammation
- MeSH terms
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Clinical Trials as Topic, Humans, Parkinson Disease, Multiple System Atrophy, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells
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