Cited by 150Mesenchymal stem cell researchMultiple Sclerosis Research StudiesExtracellular vesicles in disease

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Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases

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Staff, Nathan P., Jones, David T., Singer, Wolfgang·2019·Mayo Clinic Proceedings

DOI 10.1016/j.mayocp.2019.01.001PMC PMC6643282

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Abstract

Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of medical conditions. Over the past decade, there has been considerable excitement about using MSCs to treat neurodegenerative diseases, which are diseases that are typically fatal and without other robust therapies. In this review, we discuss the proposed MSC mechanisms of action in neurodegenerative diseases, which include growth factor secretion, exosome secretion, and attenuation of neuroinflammation. We then provide a summary of preclinical and early clinical work on MSC therapies in amyotrophic lateral sclerosis, multiple system atrophy, Parkinson disease, and Alzheimer disease. Continued rigorous and controlled studies of MSC therapies will be critical in order to establish efficacy and protect patients from possible untoward effects.

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Authors: Staff, N. P., Jones, D. T., & Singer, W.
Affiliations: Mayo Clinic (US)
Corresponding author: Staff, Nathan P.
ORCID: Staff, Nathan P.
Jones, David T.
Singer, Wolfgang
Venue: Mayo Clinic Proceedings
Publisher: Elsevier BV
Published: 2019-05
Volume: 94
Issue: 5
Pages: 892-905
ISSN: 0025-6196 (ISSN-L)
DOI: 10.1016/j.mayocp.2019.01.001
PMC: PMC6643282
OpenAlex: W2943517835
Cited by: 150
References: 193
Citations by year: 2026: 10 · 2025: 7 · 2024: 18 · 2023: 38 · 2022: 26 · 2021: 26 · 2020: 23 · 2019: 2
FWCI: 2.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 365 d)
Locations: Mayo Clinic Proceedings (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Food and Drug Administration (R01 FD004789)
National Cancer Institute (R01CA211887)
National Institute of Neurological Disorders and Stroke (U54NS065736, R01NS092625)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: mesenchymal stem cells, neurodegenerative diseases, amyotrophic lateral sclerosis, multiple system atrophy, Parkinson's disease, Alzheimer's disease, growth factor secretion, exosomes, neuroinflammation
MeSH terms: Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Clinical Trials as Topic, Humans, Parkinson Disease, Multiple System Atrophy, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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