Cited by 361Sexual Differentiation and DisordersSteroid Chemistry and BiochemistryAdrenal Hormones and Disorders

The DOI matches its Crossref record; 188 of the 203 references it cites were found in a registry or an index.

The role of 17 beta-hydroxysteroid dehydrogenases

Mindnich, R, Möller, G, Adamski, J·2004·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2003.12.006

Open this paper in CoChat — free account

Abstract

The biological activity of steroid hormones is regulated at the pre-receptor level by several enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta -HSD). The latter are present in many microorganisms, invertebrates and vertebrates. Dysfunctions in human 17 beta-hydroxysteroid dehydrogenases result in disorders of biology of reproduction and neuronal diseases, the enzymes are also involved in the pathogenesis of various cancers. 17 beta-hydroxysteroid dehydrogenases reveal a remarkable multifunctionality being able to modulate concentrations not only of steroids but as well of fatty and bile acids. Current knowledge on genetics, biochemistry and medical implications is presented in this review.

Integrity signals

Registry

Crossref · 10.1016/j.mce.2003.12.006

Cites

188 of 188 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
Okazaki, Y., Furuno, M., Kasukawa, T., Adachi, J., Bono, H. U., Kondo, S., Nikaido, I., Osato, N., Saito, R., Suzuki, H., et al. (2002) · Nature · doi:10.1038/nature01266 · Cited by 1,660
Short-chain dehydrogenases/reductases (SDR)
Jörnvall, H., Persson, B., Krook, M., Atrian, S., Gonzàlez‐Duarte, R., Jeffery, J., & Ghosh, D. (1995) · Biochemistry · doi:10.1021/bi00018a001 · Cited by 1,241
Hormonal carcinogenesis
Henderson, B. E., & Feigelson, H. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.427 · Cited by 821
Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
PENNING, T. M., BURCZYNSKI, M. E., JEZ, J. M., HUNG, C.-F., LIN, H.-K., MA, H., MOORE, M., PALACKAL, N., & RATNAM, K. (2000) · Biochemical Journal · doi:10.1042/bj3510067 · Cited by 649
Short-chain dehydrogenases/reductases (SDR): the 2002 update
Oppermann, U. C. T., Filling, C., Hult, M., Shafqat, N., Wu, X., Lindh, M., Shafqat, J., Nordling, E., Kallberg, Y., Persson, B., et al. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00164-3 · Cited by 633
Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570
Neurosteroid metabolism in the human brain
Stoffel‐Wagner, B. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450669 · Cited by 546
Oestrogen as a neuroprotective hormone
Behl, C. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn846 · Cited by 489
Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
Wu, L., Einstein, M., Geissler, W. M., Chan, H. K., Elliston, K. O., & Andersson, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31480-7 · Cited by 437
Ligand binding was acquired during evolution of nuclear receptors
Escrivá, H., Safi, R., Hänni, C., Langlois, M., Saumitou‐Laprade, P., Stéhelin, D., Capron, A., Pierce, R. J., & Laudet, V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6803 · Cited by 403

Flagged first, then by citations

Show all 203 references

15 of the 203 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

Brereton, 2001, Pan1b (17betaHSD11): enzymatic activity and distribution in the lung, Mol. Cell Endocrinol., 171/2, 111, 10.1016/S0303-7207(00)00417-2 · DOI
Liu, H., Robert, A., Luu-The, V., 2001. Structure and expression of the gene of a second form of human type 7 17beta-HSD. In: The Endocrine Society 83rd Annual Meeting, Denver, CO, USA, pp. 430.
Mendonca, 1999, 17Beta-hydroxysteroid dehydrogenase 3 deficiency in women, J. Clin. Endocrinol. Metab., 84, 802, 10.1210/jc.84.2.802 · DOI · Paper page
Mindnich, R., Deluca, D., Adamski, J. Identification and characterization of 17beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio, Mol. Cell Endocrinol., in press.
Zhang, Y., Dufort, I., Soucy, P., Labrie, F., Luu-The, V., 1995. Cloning and expression of human type V 17β-hydroxysteroid dehydrogenase. In: Proceedings of the 77th Annual Meeting of the Endocrine Society, Washington, DC, pp. 622.

Sorted by citations

Items 201–300 of 361

Age and Diet Affect Gene Expression Profile in Canine Skeletal Muscle
Middelbos, I. S., Vester, B. M., Karr‐Lilienthal, L. K., Schook, L. B., & Swanson, K. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004481 · Cited by 18
11β-Hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17β-Hydroxysteroid dehydrogenase-type 2
Baker, M. E., & Baker, M. E. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.057 · Cited by 17
Cinnamates and cinnamamides inhibit fungal 17β-hydroxysteroid dehydrogenase
Kristan, K., Starčević, Š., Brunskole, M., Rižner, T. L., & Gobec, S. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.010 · Cited by 17
Gene regulation in Aspergillus oryzae promotes hyphal growth and flavor formation in soy sauce koji
Zhao, G., Yao, Y., Hao, G., Fang, D., Yin, B., Cao, X., & Chen, W. (2015) · RSC Advances · doi:10.1039/c4ra16819d · Cited by 17
Immunoexpression of aromatase cytochrome P450 and 17β-hydroxysteroid dehydrogenase in women’s ovaries after menopause
Brodowska, A., Brodowski, J., Laszczyńska, M., Słuczanowska-Głąbowska, S., Rumianowski, B., Rotter, I., Starczewski, A., & Ratajczak, M. Z. (2014) · Journal of Ovarian Research · doi:10.1186/1757-2215-7-52 · Cited by 17
Effects of 4-nonylphenol on the steroidogenesis of human adrenocarcinoma cell line (NCI-H295R)
Bistáková, J., Forgács, Z., Bartos, Z., Rácz, M., Jambor, T., Kňažická, Z., Tvrdá, E., Libova, L., Goc, Z., Massányi, P., et al. (2016) · Journal of Environmental Science and Health Part A · doi:10.1080/10934529.2016.1246936 · Cited by 17
The Concept of Male Reproductive Anatomy
Obukohwo, O. M., Kingsley, N. E., Rotu, R. A., & Emojevwe, V. O. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99742 · Cited by 16
The Comparative Survey of Coordinated Regulation of Steroidogenic Pathway in Japanese Flounder (Paralichthys olivaceus) and Chinese Tongue Sole (Cynoglossus semilaevis)
Yang, F., Wang, Y., Lu, W., Zong, W., Zhu, Q. J., & Cheng, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105520 · Cited by 16
The origin of peroxisomes: The possibility of an actinobacterial symbiosis
Duhita, N., Le, T. A. H., Saruhashi, S., Kazuo, H., Miyata, D., & Shinozawa, T. (2009) · Gene · doi:10.1016/j.gene.2009.09.014 · Cited by 16
Transcriptional regulation of the human type 8 17β-hydroxysteroid dehydrogenase gene by C/EBPβ
Villar, J., Celay, J., Alonso, M. M., Rotinen, M., de Miguel, C., Migliaccio, M., & Encı́o, I. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.106 · Cited by 16
Circulating Antiandrogenic Activity in Children with Congenital Adrenal Hyperplasia during Peroral Flutamide Treatment
Hero, M. T., Jänne, O. A., Näntö‐Salonen, K., Dunkel, L., & Raivio, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0324 · Cited by 16
Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1
Brožič, P., Cesar, J., Kovač, A., Davies, M., Johnson, A. P., Fishwick, C. W. G., Rižner, T. L., & Gobec, S. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.019 · Cited by 16
Presence of Sex Steroid‐Metabolizing Enzymes in the Olfactory Mucosa of Rats
Horie, S., Yamaki, A., & Takami, S. (2016) · The Anatomical Record · doi:10.1002/ar.23497 · Cited by 15
Seasonal regulation of steroidogenic enzyme expression within the green anole lizard (Anolis carolinensis) brain and gonad
Peek, C., & Cohen, R. E. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.08.005 · Cited by 15
Enhancing production of 9α-hydroxy-androst-4-ene-3,17-dione (9-OHAD) from phytosterols by metabolic pathway engineering of mycobacteria
Sun, H. L., Yang, J., He, K., Wang, Y., & Song, H. (2020) · Chemical Engineering Science · doi:10.1016/j.ces.2020.116195 · Cited by 15
Cloning, characterization and functional expression of Taenia solium 17 beta-hydroxysteroid dehydrogenase
Aceves-Ramos, A., de la Torre, P., Hinojosa, L., Ponce, A., Garcı́a-Villegas, R., Laclette, J. P., Bobes, R. J., & Romano, M. C. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.03.021 · Cited by 15
Lack of association between common polymorphisms in the 17β-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche
Petry, C. J., Ong, K. K., Wingate, D. L., de Zegher, F., Ibáñez, L., & Dunger, D. B. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.01.004 · Cited by 15
Localization of type 5 17β-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
Pelletier, G., Luu-The, V., Li, S., & Labrie, F. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-1105-9 · Cited by 15
Mutation analysis and characterization of HSD17B2 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer
Plourde, M., Manhès, C., Leblanc, G., Durocher, F., Dumont, M., Sinilnikova, O. M., Brcas, I., & Simard, J. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0101 · Cited by 15
Characterization of eight types of 17β-hydroxysteroid dehydrogenases from the Japanese sardine Sardinops melanostictus: The probable role of type 12a in ovarian estradiol synthesis
Nyuji, M., Hongo, Y., Kazeto, Y., & Yoneda, M. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114423 · Cited by 14
Yucca schidigera extract can promote rabbit fecundity and ovarian progesterone release
Štochmaľová, A., Földešiová, M., Baláži, A., Kádasi, A., Großmann, R., Alexa, R., Chrenek, P., & Sirotkin, A. V. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.04.024 · Cited by 14
Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) – an in silico approach
Ebert, B., Kisiela, M., & Maser, E. (2016) · Drug Metabolism Reviews · doi:10.3109/03602532.2016.1167902 · Cited by 14
Ovarian and Adrenal Androgen Biosynthesis and Metabolism
Miller, W. L., Geller, D. H., & Rosen, M. P. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-179-6_2 · Cited by 15
Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver
Becker, C., Riedmaier, I., Reiter, M., Tichopád, A., Pfaffl, M. W., & Meyer, H. H. D. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.029 · Cited by 14
The effect of organotin compounds on gender specific androstenedione metabolism in the freshwater ramshorn snail Marisa cornuarietis
Janer, G., Bachmann, J., Oehlmann, J., Schulte‐Oehlmann, U., & Porte, C. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.12.003 · Cited by 14
Crystallization, X-ray diffraction analysis and phasing of 17β-hydroxysteroid dehydrogenase from the fungusCochliobolus lunatus
Cassetta, A., Büdefeld, T., Rižner, T. L., Kristan, K., Stojan, J., & Lamba, D. (2005) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309105034949 · Cited by 14
Chemical synthesis and in vitro biological evaluation of a phosphorylated bisubstrate inhibitor of type 3 17β-hydroxysteroid dehydrogenase
Bérubé, M., & Poirier, D. (2007) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360601051423 · Cited by 14
Custom microarray construction and analysis for determining potential biomarkers of subchronic androgen exposure in the Eastern Mosquitofish (Gambusia holbrooki)
Brockmeier, E. K., Yu, F., Amador, D. M., Bargar, T. A., & Denslow, N. D. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-660 · Cited by 14
Genetic variation in the HSD17B1 gene and risk of prostate cancer
Kraft, P., Hayes, R. B., Pharoah, P. D. P., Chanock, S. J., Albanes, D., Kolonel, L. N., Altshuler, D., Andriole, G. L., Berg, C., Boeing, H., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010068.eor · Cited by 14
Identification of an important function of CYP123: Role in the monooxygenase activity in a novel estradiol degradation pathway in bacteria
Ye, X., Peng, T., Li, Y., Huang, T., Wang, H., & Hu, Z. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.106025 · Cited by 13
Lifelong exposure to pyrethroid insecticide cypermethrin at environmentally relevant doses causes primary ovarian insufficiency in female mice
Ma, X., Zhang, W., Song, J., Li, F., & Liu, J. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.118839 · Cited by 13
Phytoestrogens as inhibitors of fungal 17β-hydroxysteroid dehydrogenase
Kristan, K., Krajnc, K., Konc, J., Gobec, S., Stojan, J., & Rižner, T. L. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.022 · Cited by 13
Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach
Cassetta, A., Krastanova, I. B., Kristan, K., Brunskole, M., Lamba, D., Rižner, T. L., & Stojan, J. (2011) · Biochemical Journal · doi:10.1042/bj20110567 · Cited by 12
Genomewide association analysis of sow lactation performance traits in lines of Yorkshire pigs divergently selected for residual feed intake during grow–finish phase1
Thekkoot, D. M., Young, J. M., Rothschild, M. F., & Dekkers, J. C. M. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-0258 · Cited by 15
Does estrogen regulate vitellogenin synthesis in corals?
Tan, E. S., Hamazato, H., Ishii, T., Taira, K., Takeuchi, Y., Takekata, H., Isomura, N., & Takemura, A. (2021) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2021.110910 · Cited by 12
Synthesis and Biological Evaluation of Spiro-δ-lactones as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2)
Xu, K., Wetzel, M., Hartmann, R. W., & Marchais‐Oberwinkler, S. (2011) · Letters in Drug Design & Discovery · doi:10.2174/157018011795514230 · Cited by 12
In vivo mouse model for analysis of hydroxysteroid (17β) dehydrogenase 1 inhibitors
Lamminen, T., Saloniemi, T., Huhtinen, K., Koskimies, P., Messinger, J., Husen, B., Thole, H., & POUTANEN, M. H. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.034 · Cited by 12
Characterization of 17β-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells
Nagayoshi, Y., Ohba, T., Yamamoto, H., Miyahara, Y., Tashiro, H., Katabuchi, H., & Okamura, H. (2005) · Molecular Human Reproduction · doi:10.1093/molehr/gah215 · Cited by 12
Systemic Estrone Production and Injury-Induced Sex Hormone Steroidogenesis after Severe Traumatic Brain Injury: A Prognostic Indicator of Traumatic Brain Injury-Related Mortality
Rakholia, M. V., Kumar, R. G., Oh, B., Ranganathan, P. R., Berga, S., Kochanek, P., & Wagner, A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5782 · Cited by 13
Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase
Mindnich, R., & Adamski, J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.013 · Cited by 12
Self-citation
Type 2 17-β Hydroxysteroid Dehydrogenase as a Novel Target for the Treatment of Osteoporosis
Soubhye, J., Alard, I. C., Antwerpen, P. V., & Dufrasne, F. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.74 · Cited by 11
Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated with 46, XY Disorders of Sex Development in Egyptian Patients
Engeli, R. T., Tsachaki, M., Hassan, H. A., Sager, C. P., Essawi, M. L., Gad, Y. Z., Kamel, A. K., Mazen, I., & Odermatt, A. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2017.07.006 · Cited by 11
Longitudinal Phenotypes Improve Genotype Association for Hyperketonemia in Dairy Cattle
Yepes, F. A. L., Nydam, D. V., Mann, S., Caixeta, L. S., McArt, J. A. A., Overton, T. R., Wakshlag, J. J., & Huson, H. J. (2019) · Animals · doi:10.3390/ani9121059 · Cited by 11
Combined Lipidomics and Network Pharmacology Study of Protective Effects of Salvia miltiorrhiza against Blood Stasis Syndrome
Jin, Y., Xie, Z., Li, S., Zeng, X., Wang, L., Hu, P., Zhang, H., & Xiao, X. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5526778 · Cited by 11
Steroid hormone bioavailability is controlled by the lymphatic system
Klossner, R., Groessl, M., Schumacher, N., Fux, M., Escher, G., Verouti, S. N., Jamin, H., Vogt, B., Mohaupt, M. G., & Gennari‐Moser, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-88508-w · Cited by 11
His164 regulates accessibility to the active site in fungal 17β-hydroxysteroid dehydrogenase
Kristan, K., Adamski, J., Rižner, T. L., & Stojan, J. (2006) · Biochimie · doi:10.1016/j.biochi.2006.09.004 · Cited by 11
Self-citation
Effect of γ-oryzanol on testicular degeneration induced by scrotal insulation in rams
Escobar, E., Lopes, S., Malavolta, C., Ramalho, J. B., Missio, D., Pinto, H. F., Soares, M. B., Leivas, F. G., Brum, D. D. S., & Cibin, F. W. S. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.01.041 · Cited by 11
Cloning and characterization of a novel β-ketoacyl-ACP reductase from Comamonas testosteroni
Zhang, H., Ji, Y., Wang, Y., Zhang, X., & Yu, Y. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.01.003 · Cited by 11
Genes in the HLA region indicative for head and neck squamous cell carcinoma
Reinders, J., Rozemuller, E. H., VANDERWEIDE, P., OKA, A., Slootweg, P. J., INOKO, H., & Tilanus, M. G. J. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.04.003 · Cited by 11
Sex Steroid-Dependent and -Independent Action of Hydroxysteroid (17β) Dehydrogenase 2: Evidence from Transgenic Female Mice
Shen, Z., Saloniemi, T., Rönnblad, A., Järvensivu, P., Pakarinen, P., & Poutanen, M. (2009) · Endocrinology · doi:10.1210/en.2009-0670 · Cited by 10
Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue
Straume, A. H., Knappskog, S., & Lønning, P. E. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.02.003 · Cited by 10
Butyrate Induces Expression of 17β-Hydroxysteroid Dehydrogenase Type 1 in HT29 and SW707 Colorectal Cancer Cells
Rawłuszko-Wieczorek, A. A., Krokowicz, P., & Jagodziński, P. P. (2011) · DNA and Cell Biology · doi:10.1089/dna.2010.1192 · Cited by 10
Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats
Izaguirry, A. P., Pavin, N. F., Soares, M. B., Spiazzi, C. C., Araújo, F. A., Michels, L. R., Leivas, F. G., Brum, D. D. S., Haas, S. E., & Cibin, F. W. S. (2016) · Toxicology Research · doi:10.1039/c6tx00203j · Cited by 10
Molecular cloning and characterization of a steroidogenic enzyme, 17β-hydroxysteroid dehydrogenase type 14, from the stony coral Euphyllia ancora (Cnidaria, Anthozoa)
Shikina, S., Chung, Y.-J., Chiu, Y., Huang, Y., Lee, Y., & Chang, C. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.02.006 · Cited by 10
Improved Homogeneous Proximity-Based Screening Assay of Potential Inhibitors of 17 β -Hydroxysteroid Dehydrogenases
Kokko, L., Jaakohuhta, S., Lindroos, P., & Soukka, T. (2006) · Assay and Drug Development Technologies · doi:10.1089/adt.2006.4.671 · Cited by 10
Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792)
Priyatha, C. V., Jeena, N. S., Abdulkhadar, S. K., Siva Prasad, M. S., & Chidambaran, C. K. (2024) · Toxicology and Industrial Health · doi:10.1177/07482337241242510 · Cited by 9
In silico Northern blot, an automated method to determine expression patterns from EST databases, reveals tissue specificity of murine 17beta-hydroxysteroid dehydrogenase type 11
Keller, B., Grote, K., & Adamski, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.033 · Cited by 9
Self-citation
An intact eight‐membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity
Wuxiuer, Y., Morgunova, E. Y., Cols, N., Popov, A. N., Karshikoff, A., Sylte, I., Gonzàlez‐Duarte, R., Ladenstein, R., & Winberg, J. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08675.x · Cited by 9
3β-Alkyl-androsterones as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines
Ngatcha, B. T., Laplante, Y., Labrie, F., Luu-The, V., & Poirier, D. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.023 · Cited by 9
How experimental competition changes ovarian gene activity in free-living birds: Implications for steroidogenesis, maternal effects, and beyond
Bentz, A. B., Empson, T. A., George, E., Rusch, D. B., Buechlein, A. M., & Rosvall, K. A. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105171 · Cited by 9
Transcriptome analysis during 4-vinylcyclohexene diepoxide exposure-induced premature ovarian insufficiency in mice
Li, Y., He, R., Qin, X. Y., Zhu, Q., Ma, L., & Liang, X. (2024) · PeerJ · doi:10.7717/peerj.17251 · Cited by 8
Synthesis and characterization of targeted 17β-hydroxysteroid dehydrogenase type 7 inhibitors
Sancéau, J., Maltais, R., Zhou, M., Lin, S., & Poirier, D. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106544 · Cited by 7
Enhancing production and purity of 9‐OH‐AD from phytosterols by balancing metabolic flux of the side‐chain degradation and 9‐position hydroxylation in Mycobacterium neoaurum
Zhu, X., Wang, X. X., Zhang, J., & Wang, X. (2023) · Biotechnology Journal · doi:10.1002/biot.202300439 · Cited by 7
Relationships between the transcriptome and physiological indicators of reproduction in female rainbow trout over an annual cycle
Hook, S. E., Nagler, J. J., Cavileer, T., Verducci, J. S., Liu, Y., Hayton, W. L., & Schultz, I. R. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.407 · Cited by 7
Reproductive performance is associated with seasonal plasma reproductive hormone levels, steroidogenic enzymes and sex hormone receptor expression levels in cultured Asian yellow pond turtles (Mauremys mutica)
Wang, Y., Liu, X., Li, W., Zhao, J., Liu, H., Yu, L., & Zhu, X. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110566 · Cited by 7
17β-hydroxysteroid dehydrogenase type 1 improves survival in serous epithelial ovarian tumors
Pedernera, E. A., Morales-Vásquez, F., Gómora, M. J., Almaraz, M. Á., Mena, E., Pérez‐Montiel, D., Rendón, E., López-Basave, H. N., Maldonado-Cubas, J., & Méndez, C. (2023) · Endocrine Connections · doi:10.1530/ec-23-0315 · Cited by 7
Genomic evidence sheds light on the genetic mechanisms of musk secretion in muskrats
Zhou, C., Zhang, Y., Qiu, S., Yu, H., Tu, H., Wen, Q., James, J. G., Meng, Y., Wu, Y., Yang, N., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.045 · Cited by 7
Effect of selected natural and synthetic substances on rabbit reproduction–A mini review
Svoradová, A., Baláži, A., & Chrenek, P. (2021) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13641 · Cited by 7
Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer
Plourde, M., Samson, C., Durocher, F., Sinilnokova, O., & Simard, J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.10.004 · Cited by 7
Three types of 17β-hydroxysteroid dehydrogenases involved in Japanese eel ovarian steroidogenesis
Suzuki, H., Ito, R., Ozaki, Y., & Kazeto, Y. (2025) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2025.114697 · Cited by 6
Sequence of pig 17β-hydroxysteroid dehydrogenase Type3 cDNA and its expression in mammalian cells
Ohno, S., Honda, Y., Nakajima, Y., & Nakajin, S. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.06.012 · Cited by 6
Immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma
Motohara, K.-I., Tashiro, H., Taura, Y., Ohba, T., & Katabuchi, H. (2010) · Medical Molecular Morphology · doi:10.1007/s00795-009-0490-7 · Cited by 6
Peripheral Testosterone Metabolism
Sherbet, D. P., & Auchus, R. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-453-7_12 · Cited by 6
Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis
Vuorinen, A., Engeli, R. T., Leugger, S., Kreutz, C., Schuster, D., Odermatt, A., & Matuszczak, B. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.05.005 · Cited by 6
Physiologic Roles of Hepatic Lipid Droplets and Involvement of Peroxisome Proliferator-Activated Receptor .ALPHA. in Their Dynamism
Aishan, H., Horiguchi, Y., & Motojima, K. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.351 · Cited by 6
Testosterone concentration and aromatisation efficiency at different stages of gonad development: a case study with Mytilus edulis trossulus
Goździk, P., Smolarz, K., Konieczna, L., & Hallmann, A. (2023) · Invertebrate Reproduction & Development · doi:10.1080/07924259.2023.2231868 · Cited by 5
Functional assignment of gene AAC16202.1 from Rhodobacter capsulatus SB1003: New insights into the bacterial SDR sorbitol dehydrogenases family
Sola-Carvajal, A., García-García, M. I., Sánchez-Carrón, G., García‐Carmona, F., & Sánchez‐Ferrer, Á. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.018 · Cited by 5
Altered Transcription Profiles of Key-Enzymes of Androgen Biosynthesis in Genital Skin Fibroblasts from Patients with 46,XY Disorders of Sex Development (DSD)
Hoppe, U., Wünsch, L., Holterhus, P., Jocham, D., Richter-Unruh, A., & Hiort, O. (2007) · Sexual Development · doi:10.1159/000104773 · Cited by 5
Biotransformation of Steroids: History, Current Status, and Future Prospects
El-Menoufy, H. A., Elkhateeb, W. A., & Daba, G. M. (2024) · Springer eBooks · doi:10.1007/978-981-99-5696-8_25 · Cited by 5
Whole-Genome Analysis of Mycobacterium neoaurum DSM 1381 and the Validation of Two Key Enzymes Affecting C22 Steroid Intermediates in Sterol Metabolism
Zhang, J., Zhang, R., Song, S., Su, Z., Shi, J., Cao, H., & Zhang, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076148 · Cited by 4
Reduced expression of steroid sulfatase in primary colorectal cancer
Rawłuszko-Wieczorek, A. A., Antoniucci, M., Horbacka, K., Lianeri, M., Krokowicz, P., & Jagodziński, P. P. (2013) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2013.04.007 · Cited by 4
The Influence of Bovine Milk High or Low in Isoflavones on Hepatic Gene Expression in Mice
Skaanild, M. T., & Nielsen, T. S. (2010) · Journal of Toxicology · doi:10.1155/2010/423179 · Cited by 4
Transgenerational expression profiles of a sex related and an epigenetic control gene in the rotifer Brachionus plicatilis in relation to environmental predictability
Colinas, N., Montero‐Pau, J., Carmona, M. J., Sabatino, R., Cesare, A. D., Eckert, E. M., & García-Roger, E. M. (2023) · Hydrobiologia · doi:10.1007/s10750-023-05316-1 · Cited by 4
Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1
Keller, B., Ohnesorg, T., Mindnich, R., Gloeckner, C. J., Rainer Breitling, A., Scharfe, M., Moeller, G., Blöcker, H., & Adamski, J. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.014 · Cited by 4
Self-citation
THE EFFECT OF GREEN TEA EXTRACT - EPIGALLOCATECHIN GALLATE (EGCG) ON PORCINE OVARIAN GRANULOSA CELL
Kádasi, A., Kolesárová, A., Maruniaková, N., Großmann, R., Štochmaľová, A., Alexa, R., & Sirotkin, A. V. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 4
The characterisation of the catalytic activity of human steroid 5α-reductase towards novel C19 substrates
Quanson, J. L. (2015) · SUNScholar (Stellenbosch University) · Cited by 4
A useful cell system for studying the regulation of 17HSD/KSR type 2 activity and expression in ovarian epithelial cancer
Provost, P. R., Lima, P. H., Tremblay, Y., & Blomquist, C. H. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.06.008 · Cited by 3
Japanese eel retinol dehydrogenases 11/12-like are 17-ketosteroid reductases involved in sex steroid synthesis
Suzuki, H., Ozaki, Y., Gen, K., & Kazeto, Y. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113685 · Cited by 3
High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway.
Zhang, N., Wang, Y., Sun, C., Shi, Y., Hou, L., Yao, M., Hu, M., Wang, X., Ma, P.-P., Li, W., et al. (2023) · PubMed Central · Cited by 3
Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis
Heikelä, H., Mairinoja, L., Ruohonen, S. T., Rytkönen, K. T., de Brot, S., Laiho, A., Koskinen, S., Suomi, T., Elo, L. L., Strauss, L., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400333rr · Cited by 3
Microbial steroid biotransformation: Regio- and stereo selective 17β-reduction by Priestia aryabhattai
Sudhakar, Y., Manasa, R. K., Priyadarshini, D., Dalsaniya, S. C., Sheelu, G., & Kumaraguru, T. (2025) · Steroids · doi:10.1016/j.steroids.2025.109600 · Cited by 3
Analyses of Smooth Endoplasmic Reticulum in Vomeronasal Receptor Cells
Takami, S., Hasegawa, R., Shima, Y., Horie, S., Sato, Y., Koyama, S., Moroi, K., & Yamaki, A. (2009) · 杏林医学会雑誌 · doi:10.11434/kyorinmed.40.24 · Cited by 3
Localization of Five Steroidogenic Enzyme mRNAs in Japanese Black Bear (Ursus thibetanus japonicus) Testes During the Mating Season by In Situ Hybridization
Iibuchi, R., Shimozuru, M., Kamine, A., Nio‐Kobayashi, J., Iwanaga, T., & Tsubota, T. (2010) · Journal of Reproduction and Development · doi:10.1262/jrd.09-188n · Cited by 3
New inhibitors of fungal 17β-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold
Živec, M., Sova, M., Brunskole, M., Lenaršič, R., Rižner, T. L., & Gobec, S. (2007) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360600953819 · Cited by 3
Gender-specific alteration of steroid metabolism and its impact on viral replication in a mouse model of hepatitis B virus infection
Park, E., Won, J., Ahn, S. H., Lee, A. R., Lee, D. H., Moon, J.-Y., Choi, M. H., & Kim, K. (2024) · Animal Cells and Systems · doi:10.1080/19768354.2024.2403569 · Cited by 2
Population Variation in Steroid Hormone‐Related Gene Expression and Sexually Dimorphic Communication in the Electric Fish Apteronotus albifrons
Proffitt, M. R., & Smith, G. T. (2025) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.70011 · Cited by 2
17β-Hydroxysteroid dehydrogenases 1 and 2: potential markers for breast cancer recurrence and tamoxifen resistance among premenopausal women diagnosed with breast cancer in Denmark
Collin, L. J., Woolpert, K. M., Kjærsgaard, A., Ahern, T. P., Goodman, M., McCullough, L. E., Waller, L. A., Christensen, K. B., Damkier, P., Hamilton-Dutoit, S. J., et al. (2025) · Breast Cancer Research · doi:10.1186/s13058-025-02196-2 · Cited by 2
Cell Progression and Survival Functions of Enzymes Secreted in Extracellular Vesicles Associated with Breast and Prostate Cancers
Onyiba, C. I., Kumar, N. K., Scarlett, C. J., & Weidenhofer, J. (2025) · Cells · doi:10.3390/cells14070468 · Cited by 2
Bisphenol A diglycidyl ether-induced DNA methylation abnormalities may disrupt testis development in adult male zebrafish
Lee, E. J., Lee, H., Kang, J., Kim, K., & Yang, Y.-J. (2025) · Environmental Analysis Health and Toxicology · doi:10.5620/eaht.2025s05 · Cited by 2
PPARαas a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds
Ashibe, B., Nakajima, Y., Fukui, Y., & Motojima, K. (2012) · PPAR Research · doi:10.1155/2012/814945 · Cited by 2

Authors: Mindnich, R., Möller, G., & Adamski, J.
Affiliations: Helmholtz Munich (DE)
Corresponding author: Adamski, J
ORCID: Möller, G
Adamski, J
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2004-04
Volume: 218
Issue: 1-2
Pages: 7-20
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2003.12.006
OpenAlex: W2083859759
Cited by: 354
References: 203
Citations by year: 2026: 7 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 14 · 2013: 8 · 2012: 10
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: 17β-hydroxysteroid dehydrogenase, steroid hormone metabolism, steroidogenesis, reproductive disorders, neuronal diseases, carcinogenesis, fatty acid metabolism, bile acid metabolism, enzyme genetics, enzyme biochemistry
MeSH terms: Androgens, Animals, Estrogens, Humans, 17-Hydroxysteroid Dehydrogenases, Molecular Structure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of 17 beta-hydroxysteroid dehydrogenases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks