Cited by 13Muscle Physiology and DisordersAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats

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Bueno, P.G., Bassi, D., Contrera, D.G., Carnielli, H.M., Silva, R.N., Nonaka, K.O., Selistre-de-Araújo, H.S., Leal, A.M.O.·2011·Molecular and Cellular Endocrinology

Abstract

We evaluated the expression of MSTN and ActRIIB mRNA in muscle and adipose tissue in diet-induced obesity and insulin resistance in rats subjected to exercise. There was no difference in the expression of MSTN between exercised and sedentary high-fat fed rats in muscle after swimming training. The expression of ActRIIB mRNA in muscle was not significantly different among the groups. In BAT, MSTN mRNA expression was higher in exercised high-fat fed group (EHF) compared with sedentary high-fat fed group (SHF). ActRIIB mRNA expression in BAT was higher in EHF compared with SHF. In mesenteric fat, MSTN mRNA was lower in EHF compared with SHF and ActRIIB mRNA was lower in EHF compared with SHF. In conclusion, the results demonstrate that the expression of MSTN and ActRIIB mRNA changes in both adipose tissue and skeletal muscle in diet-induced obese and exercised rats and suggest the participation of MSTN in energy homeostasis.

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Crossref · 10.1016/j.mce.2011.04.006

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Authors
Bueno, P. G., Bassi, D., Contrera, D. G., Carnielli, H. M., Silva, R. N., Nonaka, K. O., Selistre-de-Araújo, H. S., & Leal, A. M. O.
Affiliations
Universidade Federal de São Carlos (BR)
Corresponding author
Leal, A.M.O.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2011-06
Volume
339
Issue
1-2
Pages
159-164
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2059967767
Cited by
13
References
51
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 1 · 2014: 2 · 2012: 3
FWCI
0.65
Type
journal article
Language
en
Open access
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
myostatin, ActRIIB, insulin resistance, diet-induced obesity, physical activity, swimming training, skeletal muscle, brown adipose tissue, mesenteric fat, energy homeostasis, high-fat diet, gene expression
MeSH terms
Animals, Body Weight, Adipose Tissue, Brown, Dietary Fats, Epididymis, Glucose Tolerance Test, Insulin Resistance, Male, Mesenteric Arteries, Obesity, Physical Conditioning, Animal, Gene Expression, Rats, Wistar, Muscle, Skeletal, Area Under Curve, Activin Receptors, Type II, Intra-Abdominal Fat, Adiposity, Rats, Myostatin

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