Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats
Open accessAbstract
We evaluated the expression of MSTN and ActRIIB mRNA in muscle and adipose tissue in diet-induced obesity and insulin resistance in rats subjected to exercise. There was no difference in the expression of MSTN between exercised and sedentary high-fat fed rats in muscle after swimming training. The expression of ActRIIB mRNA in muscle was not significantly different among the groups. In BAT, MSTN mRNA expression was higher in exercised high-fat fed group (EHF) compared with sedentary high-fat fed group (SHF). ActRIIB mRNA expression in BAT was higher in EHF compared with SHF. In mesenteric fat, MSTN mRNA was lower in EHF compared with SHF and ActRIIB mRNA was lower in EHF compared with SHF. In conclusion, the results demonstrate that the expression of MSTN and ActRIIB mRNA changes in both adipose tissue and skeletal muscle in diet-induced obese and exercised rats and suggest the participation of MSTN in energy homeostasis.
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In obese insulin-resistant rats that practiced swimming training, no change was found in myostatin expression in skeletal muscle of trained animals compared to control.
“No change was found in myostatin expression in the SkM of trained animals compared to the control group.”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bueno et al., 2011
In obese insulin-resistant rats that practiced swimming training, myostatin and ACTRIIb expression was increased in brown adipose tissue of trained obese animals compared to sedentary obese, while it was reduced in mesenteric adipose tissue.
“However, in the BAT the expression of myostatin and ACTRIIb was increased in the trained obese animals compared to the sedentary obese, while in the mesenteric adipose tissue (meAT) they were reduced (Table 1).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Bueno et al., 2011
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“The authors suggest that these changes are due to the ability of myostatin tomodulate energetic homeostasis in exercise and obesity, since no change was observed in non-obese animals (Bueno et al., 2011).”
BackgroundMyostatin: more than just a regulator of muscle mass
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- Authors
- Bueno, P. G., Bassi, D., Contrera, D. G., Carnielli, H. M., Silva, R. N., Nonaka, K. O., Selistre-de-Araújo, H. S., & Leal, A. M. O.
- Affiliations
- Universidade Federal de São Carlos (BR)
- Corresponding author
- Leal, A.M.O.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 339
- Issue
- 1-2
- Pages
- 159-164
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2059967767
- Cited by
- 13
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 1 · 2014: 2 · 2012: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- myostatin, ActRIIB, insulin resistance, diet-induced obesity, physical activity, swimming training, skeletal muscle, brown adipose tissue, mesenteric fat, energy homeostasis, high-fat diet, gene expression
- MeSH terms
- Animals, Body Weight, Adipose Tissue, Brown, Dietary Fats, Epididymis, Glucose Tolerance Test, Insulin Resistance, Male, Mesenteric Arteries, Obesity, Physical Conditioning, Animal, Gene Expression, Rats, Wistar, Muscle, Skeletal, Area Under Curve, Activin Receptors, Type II, Intra-Abdominal Fat, Adiposity, Rats, Myostatin
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