Neurokinin B signalling in the human reproductive axis

Topaloglu, A. Kemal; Semple, Robert K.

doi:10.1016/j.mce.2011.07.014

Cited by 41Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

Neurokinin B signalling in the human reproductive axis

Topaloglu, A. Kemal, Semple, Robert K.·2011·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2011.07.014

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Abstract

Recent human genetic studies have established that neurokinin B (NKB) signalling via the neurokinin 3 receptor (NK3R) is required for normal developmental activation of pulsatile GnRH secretion from the hypothalamus. As increasing numbers of patients with loss-of-function mutations have been described, evidence has emerged that peripheral NKB is not necessary for normal pregnancy despite high placental expression and high plasma levels of NKB in late gestation. Nevertheless many key questions about the role of NKB in the function of the GnRH pulse generator remain to be answered. Differences in requirement for NKB/NK3R for hypothalamic-pituitary-gonadal (HPG) maturation amongst different species, and their varied responses to stimulation with NKB represent a challenge for higher resolution studies. Neuroanatomical investigation has, however, identified key "KNDy" (Kisspeptin, Neurokinin B, Dynorphin) arcuate neurones that are conserved amongst different species and that are intimately connected both to each other and to the GnRH nerve termini. Several lines of evidence suggest that these may be the core of the GnRH pulse generator, and with experimental tools now in place in humans, monkeys and other experimental animals to pursue the function of these interconnected neurones and the functional hierarchy of their neuroendocrine inputs, understanding of the enigmatic GnRH pulse generator may at last be within reach.

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Two of the most important excitatory components of the GnRH network were identified with the demonstration that the genetic loss of such inputs results in failure to initiate the GnRH pulse generator at the expected time of puberty, resulting in isolated hypogonadotropic hypogonadism.
“Two of the most important excitatory components of the GnRH network were identified with the demonstration that the genetic loss of such inputs results in failure to initiate the GnRH pulse generator at the expected time of puberty, resulting in isolated hypogonadotropic hypogonadism.42–45”
From Pubertal development and regulation (2016) · cites this paper as [45]
Other studies did not show a similar frequency of reversibility, and it is still not definitively known whether the NKB system is essential for the excitatory GnRH regulatory network after pubertal development.
“However, other studies did not show a similar frequency of reversibility,45 and it is still not definitively known whether the NKB system is essential for the excitatory GnRH regulatory network after pubertal development.”
From Pubertal development and regulation (2016) · cites this paper as [45]

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Authors: Topaloglu, A. K., & Semple, R. K.
Affiliations: Cukurova University (TR)
University of Cambridge (GB)
Corresponding author: Topaloglu, A. Kemal
ORCID: Topaloglu, A. Kemal
Semple, Robert K.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2011-10
Volume: 346
Issue: 1-2
Pages: 57-64
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2011.07.014
OpenAlex: W2061423925
Cited by: 41
References: 81
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 3
FWCI: 0.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (080952/Z/06/Z)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: neurokinin B, neurokinin-3 receptor, GnRH pulse generator, pulsatile GnRH secretion, hypothalamic-pituitary-gonadal axis, kisspeptin, dynorphin, hypothalamus, pregnancy, loss-of-function mutations, neuroendocrine regulation
MeSH terms: Animals, Humans, Gonadotropin-Releasing Hormone, Neurons, Neurosecretory Systems, Reproduction, Neurokinin B, Receptors, Neurokinin-3

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Neurokinin B signalling in the human reproductive axis

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