Axon pruning: An essential step underlying the developmental plasticity of neuronal connections

Low, Lawrence K; Cheng, Hwai-Jong

doi:10.1098/rstb.2006.1883

Cited by 258Neuroscience and Neuropharmacology ResearchAxon Guidance and Neuronal SignalingNerve injury and regeneration

Axon pruning: An essential step underlying the developmental plasticity of neuronal connections

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Low, Lawrence K, Cheng, Hwai-Jong·2006·Philosophical Transactions of the Royal Society B Biological Sciences

DOI 10.1098/rstb.2006.1883PMC PMC1664669

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Abstract

Regressive events play a key role in modifying neural connectivity in early development. An important regressive event is the pruning of neuronal processes. Pruning is a strategy often used to selectively remove exuberant neuronal branches and connections in the immature nervous system to ensure the proper formation of functional circuitry. In the following review, we discuss our present understanding of the cellular and molecular mechanisms that regulate the pruning of axons during neuronal development as well as in neurological diseases. The evidence suggests that there are several similarities between the mechanisms that are involved in developmental axon pruning and axon elimination in disease. In summary, these findings provide researchers with a unique perspective on how developmental plasticity is achieved and how to develop strategies to treat complex neurological diseases.

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The pruning of synapses and axons during development is affected by synaptic functioning.
“However, the pruning of synapses and axons during development is affected by synaptic functioning (60,61).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [61]

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Authors: Low, L. K., & Cheng, H.-J.
Affiliations: University of California, Davis (US)
ORCID: Cheng, Hwai-Jong
Venue: Philosophical Transactions of the Royal Society B Biological Sciences
Publisher: The Royal Society
Published: 2006-07-28
Volume: 361
Issue: 1473
Pages: 1531-1544
ISSN: 0962-8436 (ISSN-L)
1471-2970
DOI: 10.1098/rstb.2006.1883
PMC: PMC1664669
OpenAlex: W2170112692
Cited by: 258
References: 133
Citations by year: 2026: 2 · 2025: 10 · 2024: 6 · 2023: 15 · 2022: 13 · 2021: 10 · 2020: 41 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 17 · 2014: 13 · 2013: 18 · 2012: 15
FWCI: 0.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
Locations: Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alfred P. Sloan Foundation
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD045757, HD045757)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: axon pruning, developmental plasticity, neuronal connectivity, axon elimination, neuronal development, neurological disorders, synaptic pruning, circuit formation
MeSH terms: Animals, Axons, Nervous System Diseases, Neural Pathways, Synaptic Transmission, Neuronal Plasticity

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Axon pruning: An essential step underlying the developmental plasticity of neuronal connections

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