Aromatase, breast cancer and obesity: a complex interaction
Open accessAbstract
Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, increased local estrogen production, and predisposition to breast hyperplasia and cancer. Increased adiposity in postmenopausal women may trigger signaling pathways that induce aromatase expression. In breast adipose fibroblasts, increased TNF production may induce the distal aromatase promoter, whereas increased local PGE(2) production may induce the proximal promoter region. We review here the mechanisms that control aromatase gene expression in breast adipose tissue, and the paracrine interactions between malignant breast epithelial cells and the surrounding adipose fibroblasts. Systematic characterization of these signaling pathways will facilitate the identification of potential drug targets to selectively reduce aromatase expression and excessive estrogen production, with therapeutic benefit.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated aromatase expression in breast white adipose tissue increases local E2 production, which may contribute to estrogen receptor-positive breast cancer pathogenesis.
“Elevated aromatase expression in breast WAT increases local E2 production, which may contribute to estrogen receptor-positive (ER+) breast cancer pathogenesis (135, 195, 196).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [196]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
Baum, M., Budzar, A. U., Cuzick, J. M., Forbes, J., Houghton, J., Klijn, J. G. M., & Sahmoud, T. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09088-8 · Cited by 1,958 · see citing works
Goss, P. E., Ingle, J. N., Martino, S., Robert, N. J., Muss, H. B., Piccart, M. J., Castiglione, M., Tu, D., Shepherd, L. E., Pritchard, K. I., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa032312 · Cited by 1,795 · see citing works
Haagenson, C. (1971) · Cited by 1,767 · see citing works
Coleman, R. A., Smith, W. L., & Narumiya, S. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06784-5 · Cited by 1,747 · see citing works
Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*
SIMPSON, E. R., Mahendroo, M., Means, G., Kilgore, M. W., Hinshelwood, M. M., Graham-Lorence, S. E., Amarneh, B., Ito, Y., Fisher, C. R., Michael, M. D., et al. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-342 · Cited by 1,534 · see citing works
Self-citationBody mass index, serum sex hormones, and breast cancer risk in postmenopausal women
Endogenous Hormones Breast Cancer Collaborative Group (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg022 · Cited by 1,093 · see citing works
Mouridsen, H. T., Gershanovich, M., Sun, Y., Pérez-Carrión, R., Boni, C., Monnier, A., Apffelstaedt, J., Smith, R., Sleeboom, H. P., Jänicke, F., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.10.2596 · Cited by 1,015 · see citing works
Dual Effects of Weight and Weight Gain on Breast Cancer Risk
Huang, Z., Hankinson, S. E., Colditz, G. A., Stampfer, M. J., Hunter, D. J., Manson, J. E., Hennekens, C. H., ROSNER, B. A., Speizer, F. E., & Willett, W. C. (1997) · JAMA · doi:10.1001/jama.1997.03550170037029 · Cited by 948 · see citing works
Sources of estrogen and their importance
Simpson, E. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00360-1 · Cited by 936 · cited 1× · see citing works
“Although similar promoter regions of aroma-tase may be activated in normal and pathological tissues, the cellular and transcriptional regulatory mechanisms are extremely diverse and cell-specific [9,37].”
BackgroundThe ATAC (Arimidex, T. A. O. I. C. T. G. (2003) · Cancer · doi:10.1002/cncr.11745 · Cited by 861 · see citing works
Bonneterre, J. M., Thurlimann, B. J. K., Robertson, J. F. R., Krzakowski, M. J., Mauriac, L., Koralewski, P., Vergote, I. B., Webster, A., Steinberg, M., & von Euler, M. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.22.3748 · Cited by 839 · see citing works
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson, S. E., Willett, W. C., Manson, J. E., Colditz, G. A., Hunter, D. J., Spiegelman, D. L., Barbieri, R. L., & Speizer, F. E. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.17.1292 · Cited by 687 · see citing works
Morimoto, L. M., White, E., Chen, Z., Chlebowski, R. T., Hays-Grudo, J., Kuller, L. H., López, A. M., Manson, J. E., Margolis, K. L., Muti, P. C., et al. (2002) · Cancer Causes & Control · doi:10.1023/a:1020239211145 · Cited by 568 · see citing works
Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in Postmenopausal Women
Chlebowski, R. T., Anderson, G. L., Gass, M. L. S., Lane, D. S., Aragaki, A. K., Kuller, L. H., Manson, J. E., Stefanick, M. L., Ockene, J. K., Sarto, G. E., et al. (2010) · JAMA · doi:10.1001/jama.2010.1500 · Cited by 565 · see citing works
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter, M. J., Hoover, D. R., Yu, H., Wassertheil-Smoller, S. W., Rohan, T. E., Manson, J. E., Li, J., Ho, G. Y. F., Xue, X., Anderson, G. L., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn415 · Cited by 561 · see citing works
LaCroix, A. Z. (2011) · JAMA · doi:10.1001/jama.2011.382 · Cited by 538 · see citing works
Bulun, S. E., Lin, Z., Imir, G., Amin, S., Demura, M., Yilmaz, B., Martin, R., Utsunomiya, H., Thung, S., Gurates, B., et al. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.3.6 · Cited by 531 · see citing works
Self-citationvan Landeghem, A. A. J., Poortman, J., Nabuurs, M., & Thijssen, J. H. H. (1985) · PubMed · Cited by 448 · see citing works
Haagensen, C. D. (1957) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195708000-00030 · Cited by 442 · see citing works
Zhao, Y. D., Agarwal, V. R., Mendelson, C. R., & Simpson, E. R. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940410 · Cited by 434 · see citing works
Krylova, I. N., Sablin, E. P., Moore, J. M. R., Xu, R. X., Waitt, G. M., MacKay, J. A., JUZUMIENE, D. I., Bynum, J. M., Madauss, K. P., Montana, V. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.024 · Cited by 405 · see citing works
Aromatization of Androstenedione by Human Adipose Tissue Stromal Cells in Monolayer Culture*
Ackerman, G. E., Smith, M. E., Mendelson, C. R., MacDonald, P. C., & Simpson, E. R. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-2-412 · Cited by 392 · see citing works
Harada, N., Utsumi, T., & Takagi, Y. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11312 · Cited by 361 · see citing works
Bulun, S. E., Price, T. M., Aitken, R. J., Mahendroo, M., & Simpson, E. R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8117355 · Cited by 334 · see citing works
Self-citationChetrite, G. S., Cortés-Prieto, J., Philippe, J.-C., Wright, F., & Pasqualini, J. R. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00040-6 · Cited by 278 · see citing works
Agarwal, V. R., Bulun, S. E., Leitch, M. E., Rohrich, R. J., & Simpson, E. R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923826 · Cited by 258 · see citing works
Self-citationGonzález, R. R., Cherfils, S., Escobar, M., Yoo, J. H., Cariño, C., Styer, A. K., Sullivan, B. T., Sakamoto, H., Olawaiye, A., Serikawa, T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601991200 · Cited by 242 · see citing works
Liver Receptor Homologue-1 (LRH-1) Regulates Expression of Aromatase in Preadipocytes
Clyne, C. D., Speed, C. J., Zhou, J., & Simpson, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201117200 · Cited by 233 · see citing works
Paridaens, R., Dirix, L. Y., Lohrisch, C. A., Beex, L. V. A. M., Nooij, M. A., Cameron, D., Biganzoli, L., Čufer, T., Duchateau, L., Hamilton, A. L., et al. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg362 · Cited by 230 · see citing works
Aromatase activity in adipose tissue from breast quadrants: a link with tumour site
O'Neill, J. S., Elton, R. A., & Miller, W. R. (1988) · BMJ · doi:10.1136/bmj.296.6624.741 · Cited by 213 · see citing works
Of mice and men: the evolving phenotype of aromatase deficiency
Jones, M. E. E., Chin Boon, W., Proietto, J., & Simpson, E. R. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.01.004 · Cited by 193 · see citing works
Zhao, Y., Nichols, J. E., Valdez, R., Mendelson, C. R., & Simpson, E. R. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923461 · Cited by 189 · see citing works
Relative Weight, Weight Change, Height, and Breast Cancer Risk in Asian-American Women
Ziegler, R. G., Hoover, R. N., Nomura, A. M. Y., West, D. W., Wu, A. H., Pike, M. C., Lake, A. J., Horn‐Ross, P. L., Kolonel, L. N., Siiteri, P. K., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.10.650 · Cited by 185 · see citing works
Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-catenin
Boyle, T. P., Hernandez, J. A., Grammer, J. C., Weck, J., Hunzicker-Dunn, M. E., Zeleznik, A. J., & Nilson, J. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603006103 · Cited by 184 · see citing works
Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders
Sasano, H., Nagura, H., Harada, N., Goukon, Y., & Kimura, M. (1994) · Human Pathology · doi:10.1016/0046-8177(94)90127-9 · Cited by 173 · see citing works
Bulun, S. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.6.1622 · Cited by 172 · see citing works
Self-citationLi, M., Zhou, J., Sasano, H., Suzuki, T., Zeitoun, K. M., & Bulun, S. E. (2001) · PubMed · Cited by 169 · see citing works
Self-citationde Waard, F., Halewijn, E., & Huizinga, J. G. (1964) · Cancer · doi:10.1002/1097-0142(196402)17:2 · Cited by 169 · see citing works
Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma.
Sasano, H., Frost, A. R., Saitoh, R., Harada, N., Poutanen, M., Vihko, R., Bulun, S. E., Silverberg, S. G., & Nagura, H. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923858 · Cited by 167 · see citing works
Self-citationStructural Basis for Ligand-Independent Activation of the Orphan Nuclear Receptor LRH-1
Sablin, E. P., Krylova, I. N., Fletterick, R. J., & Ingraham, H. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00236-3 · Cited by 164 · see citing works
Estrogen Excess Associated with Novel Gain-of-Function Mutations Affecting the Aromatase Gene
Shozu, M., Sebastian, S., Takayama, K., Hsu, W.-T., Schultz, R. A., Neely, K., Bryant, M., & Bulun, S. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021559 · Cited by 158 · see citing works
Self-citationStromal spindle cells contain aromatase in human breast tumors
Santen, R. J., Martel, J., Hoagland, M. S., Naftolin, F. N., Roa, L., Harada, N., Hafer, L. J., Zaino, R. J., & Santner, S. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045987 · Cited by 153 · see citing works
Hinshelwood, M. M., Repa, J. J., Shelton, J. M., Richardson, J. A., Mangelsdorf, D. J., & Mendelson, C. R. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00257-0 · Cited by 148 · see citing works
Milla-Santos, A., Milla, L., Portella, J., Rallo, L., Pons, M., Rodes, E., Casanovas, J., & Puig-Gali, M. (2003) · American Journal of Clinical Oncology · doi:10.1097/01.coc.0000047126.10522.f9 · Cited by 142 · see citing works
Zhou, C., Zhou, D., López-Jamar, J. M. E., Murai, J. T., Siiteri, P. K., Wilczynski, S. P., & Chen, S. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00100-8 · Cited by 133 · see citing works
Krause, S., Maffini, M. V., Soto, A. M., & Sonnenschein, C. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-263 · Cited by 124 · see citing works
Presence of alternatively spliced transcripts of aromatase gene in human breast cancer
Utsumi, T., Harada, N., MARUTA, M., & Takagi, Y. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.6.8964875 · Cited by 113 · see citing works
Control of aromatase activity in breast cancer cells: The role of cytokines and growth factors
Reed, M. J., Topping, L., Coldham, N. G., Purohit, A., Ghilchik, M. W., & James, V. H. T. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90264-w · Cited by 111 · see citing works
Brown, K. A., McInnes, K. J., Hunger, N. I., Oakhill, J. S., Steinberg, G. R., & Simpson, E. R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0108 · Cited by 108 · see citing works
Zhou, J. N., Gürateş, B., Yang, S., Sebastian, S., & Bulun, S. E. (2001) · PubMed · Cited by 106 · see citing works
Self-citationIrahara, N., Miyoshi, Y., Taguchi, T., Tamaki, Y., & Noguchi, S. (2005) · International Journal of Cancer · doi:10.1002/ijc.21562 · Cited by 97 · see citing works
Lin, Z., Reierstad, S., Huang, C.-C., & Bulun, S. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3696 · Cited by 93 · see citing works
Self-citationGeisler, J., Berntsen, H., & Lønning, P. E. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00036-4 · Cited by 92 · see citing works
Sutton-Tyrrell, K., Zhao, X., Santoro, N. F., Lasley, B. L., Sowers, M., Johnston, J. M., Mackey, R. H., & Matthews, K. A. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq049 · Cited by 90 · see citing works
Phosphorylation of the Hinge Domain of the Nuclear Hormone Receptor LRH-1 Stimulates Transactivation
Lee, Y., Choi, Y., Chua, S. S., Park, Y. J., & Moore, D. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509115200 · Cited by 89 · see citing works
Aromatase activity of membrane fractions of human adipose tissue stromal cells and adipocytes
CLELAND, W. H., MENDELSON, C. R., & SIMPSON, E. R. (1983) · Endocrinology · doi:10.1210/endo-113-6-2155 · Cited by 86 · see citing works
Sebastian, S., Takayama, K., Shozu, M., & Bulun, S. E. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0123 · Cited by 85 · see citing works
Self-citationChen, D., Reierstad, S., Lin, Z., Lü, M., Brooks, C., Li, N., Innes, J. E., & Bulun, S. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4751 · Cited by 80 · see citing works
Self-citationPrice, T. M., AITKEN, J. W., Head, J., Mahendroo, M., Means, G. D., & Simpson, E. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.6.1592866 · Cited by 78 · see citing works
Aromatase and cyclooxygenases: enzymes in breast cancer
Brueggemeier, R. W., Richards, J. A., & Petrel, T. A. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00380-7 · Cited by 73 · see citing works
Safi, R., Kovacic, A., Gaillard, S. L., Murata, Y., Simpson, E. R., McDonnell, D. P., & Clyne, C. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2792 · Cited by 70 · see citing works
Lin, Z., Yin, P., Reierstad, S., O'Halloran, M., Coon, J. S., Pearson, E. K., Mutlu, G. M., & Bulun, S. E. (2009) · Oncogene · doi:10.1038/onc.2009.409 · Cited by 69 · see citing works
Self-citationDemura, M., Martin, R. M., Shozu, M., Sebastian, S., Takayama, K., Hsu, W.-T., Schultz, R. A., Neely, K., Bryant, M., Mendonca, B. B., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm145 · Cited by 68 · see citing works
Self-citationTEKMAL, R. R., Kirma, N. B., Gill, K., & Fowler, K. A. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060307 · Cited by 66 · see citing works
Tissue‐Specific Estrogen Biosynthesis and Metabolism
SIMPSON, E. R., Clyne, C. D., Speed, C. J., RUBIN, G., & Bulun, S. E. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb04002.x · Cited by 65 · see citing works
Self-citationAgarwal, V. R., Ashanullah, C. I., Simpson, E. R., & Bulun, S. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3655 · Cited by 60 · see citing works
Self-citationDistribution of aromatase P450 transcripts and adipose fibroblasts in the human breast
Bulun, S. E., Sharda, G., Rink, J., Sharma, S., & Simpson, E. R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772611 · Cited by 59 · see citing works
Self-citationAromatase expression in the human breast
Brodie, A. M. H., Long, B. J., & Lü, Q. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006029612990 · Cited by 55 · see citing works
To Block Estrogen's Synthesis or Action: That Is the Question
Santen, R. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8589 · Cited by 54 · see citing works
Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models
Dressing, G. E., Hagan, C. R., Knutson, T. P., Daniel, A. R., & Lange, C. A. (2009) · Endocrine Related Cancer · doi:10.1677/erc-08-0281 · Cited by 50 · see citing works
Deb, S., Zhou, J., Amin, S. A., Imir, A. G., Yılmaz, M. B., Lin, Z., & Bulun, S. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508498200 · Cited by 46 · see citing works
Self-citationValidation of new aromatase monoclonal antibodies for immunohistochemistry: progress report
Sasano, H., Edwards, D. P., Anderson, T. J., Silverberg, S. G., Evans, D. B., Santen, R. J., Ramage, P., Simpson, E. R., Bhatnagar, A. S., & Miller, W. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00363-7 · Cited by 45 · see citing works
Agarwal, V. R. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.1.70 · Cited by 43 · see citing works
Chand, A. L., Herridge, K. A., Howard, T. L., Simpson, E. R., & Clyne, C. D. (2011) · Steroids · doi:10.1016/j.steroids.2011.02.024 · Cited by 39 · see citing works
Buzdar, A. U., Vergote, I. B., & Sainsbury, R. (2004) · The Breast Journal · doi:10.1111/j.1075-122x.2004.21320.x · Cited by 35 · see citing works
Aromatase activity in adipose tissue from breast quadrants
O'Neill, J. S., & Boo-Chai, K. (1989) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198902000-00074 · Cited by 31 · see citing works
Chen, D., Reierstad, S., Fang, F., & Bulun, S. E. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0368 · Cited by 28 · see citing works
Self-citationRegulatedCYP19Aromatase Transcription in Breast Stromal Fibroblasts1
Pauley, R. J., Santner, S. J., Tait, L. R., Bright, R. K., & Santen, R. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6345 · Cited by 28 · see citing works
Ghosh, S., Choudary, A., Ghosh, S., Musi, N., Hu, Y., & Li, R. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0468 · Cited by 20 · see citing works
Regulated CYP19 Aromatase Transcription in Breast Stromal Fibroblasts
Pauley, R. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.837 · Cited by 20 · see citing works
Paracrine-stimulated gene expression profile favors estradiol production in breast tumors
Amin, S. A., Huang, C., Reierstad, S., Lin, Z., Arbieva, Z. H., Wiley, E. L., Saborian, H., Haynes, B. P., Cotterill, H., Dowsett, M., et al. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.029 · Cited by 15 · see citing works
Self-citationLessons learned from the WHI: HRT requires a cautious and individualized approach.
Aubuchon, M., & Santoro, N. (2004) · PubMed · Cited by 11 · see citing works
相原, 智., & 高塚, 雄. (2004) · Mebio oncology · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 88 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [68]Meng L TNFalpha and IL-11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively downregulating C/EBPalpha and PPARgamma: mechanism of desmoplastic reaction Cancer Res 2001 61 2250 2255 11280794
Cited by
Sorted by citations
Obesity and cancer—mechanisms underlying tumour progression and recurrence
Park, J., Morley, T. S., Kim, M. G., Clegg, D. J., & Scherer, P. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.94 · Cited by 792 · see citing works
Global patterns in excess body weight and the associated cancer burden
Sung, H., Siegel, R. L., Torre, L. A., Pearson‐Stuttard, J., Islami, F., Fedewa, S. A., Sauer, A. G., Shuval, K., Gapstur, S. M., Jacobs, E. J., et al. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21499 · Cited by 551 · see citing works
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
Kim, J. J., Kurita, T., & Bulun, S. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1043 · Cited by 520 · see citing works
Self-citationSex, body mass index, and dietary fiber intake influence the human gut microbiome
Dominianni, C., Sinha, R., Goedert, J. J., Pei, Z., Yang, L., Hayes, R. B., & Ahn, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124599 · Cited by 468 · see citing works
Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis
Pierobon, M., & Frankenfeld, C. L. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2339-3 · Cited by 357 · see citing works
Obesity, Diabetes, and Increased Cancer Progression
Kim, D.-S., & Scherer, P. E. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0077 · Cited by 312 · see citing works
Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331 · see citing works
Is there a causal relationship between obesity and puberty?
Reinehr, T., & Roth, C. L. (2018) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(18)30306-7 · Cited by 272 · see citing works
Vemuri, R., Sylvia, K. E., Klein, S. L., Forster, S. C., Plebanski, M., Eri, R., & Flanagan, K. L. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-018-0716-7 · Cited by 265 · see citing works
Aromatase expression and regulation in breast and endometrial cancer
Zhao, H., Zhou, L., Shangguan, A. J., & Bulun, S. E. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0310 · Cited by 219 · see citing works
Self-citationObesity, Leptin and Breast Cancer: Epidemiological Evidence and Proposed Mechanisms
Andò, S., Gelsomino, L., Panza, S., Giordano, C., Bonofiglio, D., Barone, I., & Catalano, S. (2019) · Cancers · doi:10.3390/cancers11010062 · Cited by 212 · see citing works
Abdominal Obesity, Adipokines and Non-communicable Diseases
Dhawan, D., & Sharma, S. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105737 · Cited by 206 · see citing works
The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression
Rose, D. P., & Vona-Davis, L. C. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0203 · Cited by 167 · see citing works
Gérard, C., & Brown, K. A. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.014 · Cited by 136 · see citing works
Steroid biosynthesis in adipose tissue
Li, J., Papadopoulos, V., & Vihma, V. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.016 · Cited by 130 · see citing works
Obesity as potential breast cancer risk factor for postmenopausal women
Mohanty, S. S., & Mohanty, P. K. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.09.006 · Cited by 132 · see citing works
Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention
Hefetz-Sela, S., & Scherer, P. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.008 · Cited by 126 · see citing works
Emerging Concepts Linking Obesity with the Hallmarks of Cancer
Donohoe, C. L., Lysaght, J., O'Sullivan, J. N., & Reynolds, J. V. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.08.004 · Cited by 116 · see citing works
The Role of Adipokines in Breast Cancer: Current Evidence and Perspectives
Christodoulatos, G. S., Spyrou, N., Kadillari, J., Psallida, S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00364-y · Cited by 107 · see citing works
Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis
Borin, T. F., Angara, K., Rashid, M. H., Achyut, B. R., & Arbab, A. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122661 · Cited by 104 · see citing works
Hert, M. A. F. D., Peuskens, J., Sabbe, T., Mitchell, A. J., Stubbs, B., Neven, P., Wildiers, H. P. M. W., & Detraux, J. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12459 · Cited by 98 · see citing works
The Many Faces of Obesity and Its Influence on Breast Cancer Risk
Agurs‐Collins, T., Ross, S. A., & Dunn, B. K. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00765 · Cited by 97 · see citing works
Caron-Beaudoin, É., Denison, M. S., & Sanderson, J. T. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv220 · Cited by 81 · see citing works
Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers
Chen, K., Zhang, J., Beeraka, N. M., Tang, C., Babayeva, Y. V., Sinelnikov, M. Y., Zhang, X., Zhang, J., Liu, J., Reshetov, I. V., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.820968 · Cited by 79 · see citing works
Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells (Review)
Liu, T., Huang, Y., & Lin, H. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4906 · Cited by 79 · see citing works
Epidemiological profile of women with endometriosis: a retrospective descriptive study
Cardoso, J. V., Machado, D. E., da Silva, M. C., Berardo, P. T., Ferrari, R., Abrão, M. S., & Perini, J. A. (2020) · Revista Brasileira de Saúde Materno Infantil · doi:10.1590/1806-93042020000400008 · Cited by 77 · see citing works
Body mass index and prognosis of breast cancer
Sun, L., Zhu, Y., Qian, Q., & Tang, L. (2018) · Medicine · doi:10.1097/md.0000000000011220 · Cited by 76 · see citing works
Carter, J. M., Hoskin, T. L., Pena, M.-C., Brahmbhatt, R. A., Winham, S. J., Frost, M. H., Stallings‐Mann, M. L., Radisky, D. C., Knutson, K. L., Visscher, D. W., et al. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-17-0245 · Cited by 70 · see citing works
Adipocytokines, Inflammation, and Breast Cancer Risk in Postmenopausal Women: A Prospective Study
Gross, A. L., Newschaffer, C. J., Hoffman–Bolton, J., Rifai, N., & Visvanathan, K. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-1444 · Cited by 70 · see citing works
The Obesity-Inflammation-Eicosanoid Axis in Breast Cancer
Vona-Davis, L. C., & Rose, D. P. (2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-013-9299-z · Cited by 70 · see citing works
Fortner, R. T., Katzke, V. A., Kuhn, T. E., & Kaaks, R. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42542-9_3 · Cited by 62 · see citing works
Mechanisms linking the renin-angiotensin system, obesity, and breast cancer
Rasha, F. A., Ramalingam, L., Gollahon, L., Rahman, R. L., Rahman, S. M., Menikdiwela, K. R., & Moustaïd‐Moussa, N. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0314 · Cited by 62 · see citing works
Aromatase inhibitors in the breast cancer clinic: focus on exemestane
Asten, K. V., Neven, P., Lintermans, A., Wildiers, H. P. M. W., & Paridaens, R. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0269 · Cited by 62 · see citing works
Anuka, E., Gal, M., Stocco, D. M., & Orly, J. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.02.003 · Cited by 60 · see citing works
Glaser, R. L., & Dimitrakakis, C. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.08.002 · Cited by 58 · see citing works
Targeting obesity-related dysfunction in hormonally driven cancers
Rubinstein, M. M. Z., Brown, K. A., & Iyengar, N. M. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01393-y · Cited by 60 · see citing works
Zhang, M., Hu, R., Huang, Y., Zhou, F., Li, F., Liu, Z., Geng, Y., Dong, H., Ma, W., Song, K., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.933110 · Cited by 57 · see citing works
Obesity and endocrine therapy resistance in breast cancer: Mechanistic insights and perspectives
Barone, I., Caruso, A., Gelsomino, L., Giordano, C., Bonofiglio, D., Catalano, S., & Andò, S. (2021) · Obesity Reviews · doi:10.1111/obr.13358 · Cited by 54 · see citing works
Pellikaan, K., Rosenberg, A. G. W., Kattentidt‐Mouravieva, A. A., Kersseboom, R., Bos‐Roubos, A. G., Veen-Roelofs, J. M. C., Wieringen, N. V. A.-V., Hoekstra, F. M. E., van den Berg, S. A. A., van der Lely, A. J., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa621 · Cited by 56 · see citing works
Bhardwaj, P., & Brown, K. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638918 · Cited by 54 · see citing works
Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses
Shay, D. A., Vieira‐Potter, V. J., & Rosenfeld, C. S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00374 · Cited by 51 · see citing works
Fortner, R. T., Poole, E. M., Wentzensen, N., Trabert, B. L., White, E., Arslan, A. A., Patel, A. V., Setiawan, V. W., Visvanathan, K., Weiderpass, E., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32075 · Cited by 49 · see citing works
Liu, X., McMurphy, T. B., Xiao, R., Slater, A., Huang, W., & Cao, L. (2014) · Molecular Therapy · doi:10.1038/mt.2014.45 · Cited by 46 · see citing works
Monk, J. M., Turk, H. F., Liddle, D. M., Boer, A. D., Power, K. A., David, W. L., & Robinson, L. E. (2014) · Nutrients · doi:10.3390/nu6114760 · Cited by 45 · see citing works
Multiple roles of COUP-TFII in cancer initiation and progression
Litchfield, L. M., & Klinge, C. M. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0144 · Cited by 45 · see citing works
The Role of Pediatric Nutrition as a Modifiable Risk Factor for Precocious Puberty
Calcaterra, V., Verduci, E., Magenes, V. C., Pascuzzi, M. C., Rossi, V., Sangiorgio, A., Bosetti, A., Zuccotti, G., & Mameli, C. (2021) · Life · doi:10.3390/life11121353 · Cited by 45 · see citing works
Kwon, Y. (2022) · Cancers · doi:10.3390/cancers14123021 · Cited by 43 · see citing works
Wang, J., Zhang, W.-F., Liu, C., Wang, L., Wu, J., Sun, C.-G., & Wu, Q.-B. (2024) · International Journal on Biological Sciences · doi:10.7150/ijbs.92125 · Cited by 47 · see citing works
Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER
Zekas, E., & Prossnitz, E. R. (2015) · BMC Cancer · doi:10.1186/s12885-015-1699-6 · Cited by 44 · see citing works
Breast Adipose Tissue Estrogen Metabolism in Postmenopausal Women With or Without Breast Cancer
Savolainen-Peltonen, H. M., Vihma, V., Leidenius, M., Wang, F., Turpeinen, U., Hämäläinen, E. K., Tikkanen, M. J., & Mikkola, T. S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2550 · Cited by 41 · see citing works
Cardiometabolic Risk Factors and Benign Gynecologic Disorders
AlAshqar, A., Patzkowsky, K. E., Afrin, S., Wild, R. A., Taylor, H. S., & Borahay, M. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000718 · Cited by 41 · see citing works
Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers
Manna, P. R., Molehin, D., & Ahmed, A. U. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.10.002 · Cited by 40 · see citing works
Anwar, S. L., Cahyono, R., Prabowo, D., Avanti, W. S., Choridah, L., Dwianingsih, E. K., Harahap, W. A., & Aryandono, T. (2021) · BMC Cancer · doi:10.1186/s12885-021-08343-0 · Cited by 40 · see citing works
Obesity, cancer risk, and time-restricted eating
Das, M., & Webster, N. J. G. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10061-3 · Cited by 42 · see citing works
Polari, L., Yatkin, E., Martínez Chacón, M. G., Ahotupa, M., Smeds, A., Strauss, L., Zhang, F., Poutanen, M., Saarinen, N., & Mäkelä, S. I. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.002 · Cited by 38 · see citing works
Ho, P. J., Lau, H. S. H., Ho, W.-K., Wong, F. Y., Yang, Q., Tan, K. W., Tan, M., Chay, W. Y., Chia, K. S., Hartman, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-57341-7 · Cited by 38 · see citing works
Ingle, J. N., Cairns, J., Suman, V. J., Shepherd, L. E., Fasching, P. A., Hoskin, T. L., Singh, R. J., Desta, Z., Kalari, K. R., Ellis, M. J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3091 · Cited by 38 · see citing works
Adeyemi, O. J., Gill, T. L., Paul, R., & Huber, L. R. B. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260481 · Cited by 38 · see citing works
Krishnan, K., Baglietto, L., Apicella, C., Stone, J., Southey, M. C., English, D. R., Giles, G. G., & Hopper, J. L. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0722-4 · Cited by 36 · see citing works
Vitamin D deficiency: a potential risk factor for cancer in obesity?
Migliaccio, S., Nisio, A. D., Magno, S., Romano, F., Barrea, L., Colao, A. M. L., Muscogiuri, G., & Savastano, S. (2022) · International Journal of Obesity · doi:10.1038/s41366-021-01045-4 · Cited by 37 · see citing works
Bonsang‐Kitzis, H., Chaltier, L., Belin, L., Savignoni, A., Rouzier, R., Sablin, M., Lerebours, F., Bidard, F., Cottu, P. H., Sastre‐Garau, X., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144359 · Cited by 36 · see citing works
Lønning, P. E., Haynes, B. P., & Dowsett, M. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.01.007 · Cited by 34 · see citing works
AMP-activated protein kinase and energy balance in breast cancer.
Zhao, H., Orhan, Y. C., Zha, X., Esencan, E., Chatterton, R. T., & Bulun, S. E. (2017) · Europe PMC (PubMed Central) · Cited by 34 · see citing works
Self-citationEffect of Weight Loss on Puberty Onset in Overweight Children
Reinehr, T., Bosse, C., Lass, N., Rothermel, J., Knop, C., & Roth, C. L. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.01.066 · Cited by 34 · see citing works
Manna, P. R., Ahmed, A. U., Molehin, D., Narasimhan, M., Pruitt, K., & Reddy, P. H. (2022) · Biomedicines · doi:10.3390/biomedicines10061313 · Cited by 33 · see citing works
Iwasa, A., Arakaki, R., Honma, N., Ushio, A., Yamada, A., Kondo, T., Kurosawa, E., Kujiraoka, S., Tsunematsu, T., Kudo, Y., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.006 · Cited by 32 · see citing works
Byun, D., Hong, S., Ryu, S., Nam, Y., Jang, H., Cho, Y., Keum, N., & Oh, H. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01625-1 · Cited by 32 · see citing works
Aromatase Inhibitors: Development and Current Perspectives
Sayyad, N., Sabale, P., Umare, M. D., & Bajaj, K. K. (2022) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.56.2.51 · Cited by 32 · see citing works
Weight change in adulthood and risk of postmenopausal breast cancer: the HUNT study of Norway
Alsaker, M. D., Janszky, I., Opdahl, S., VATTEN, L. J., & Romundstad, P. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.403 · Cited by 32 · see citing works
Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors
Lim, H., Im, K.-S., Kim, N. H., Kim, H. W., Shin, J.-I., & Sur, J. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.01.005 · Cited by 32 · see citing works
Detecting Disease Specific Pathway Substructures through an Integrated Systems Biology Approach
Alaimo, S., Marceca, G. P., Ferro, A., & Pulvirenti, A. (2017) · Non-Coding RNA · doi:10.3390/ncrna3020020 · Cited by 30 · see citing works
Morgan, M. M., Arendt, L. M., Alarid, E. T., Beebe, D. J., & Johnson, B. P. (2019) · The FASEB Journal · doi:10.1096/fj.201802347rrr · Cited by 30 · see citing works
Kakugawa, Y., Tada, H., Kawai, M., Suzuki, T., Nishino, Y., Kanemura, S., Ishida, T., Ohuchi, N., & Minami, Y. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-4094-3 · Cited by 30 · see citing works
Toward reproducible, scalable, and robust data analysis across multiplex tissue imaging platforms
Burlingame, E. A., Eng, J. R., Thibault, G., Chin, K., Gray, J. W., & Chang, Y. H. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100053 · Cited by 29 · see citing works
Pellikaan, K., Brahim, Y. B., Rosenberg, A. G. W., Davidse, K., Poitou, C., Coupaye, M., Goldstone, A. P., Höybye, C., Markovic, T., Grugni, G., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245781 · Cited by 30 · see citing works
Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots
Bernasochi, G. B., Bell, J. R., Simpson, E. R., Delbridge, L. M. D., & Boon, W. C. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180009 · Cited by 33 · see citing works
Health of adipose tissue: oestrogen matters
Vieira‐Potter, V. J., Mishra, G., & Townsend, K. L. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01180-2 · Cited by 27 · see citing works
Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells
Kim, H. G., Jin, S. W., Kim, Y.-A., Khanal, T., Lee, G. H., Kim, S., Rhee, S. D., Chung, Y., Hwang, Y. J., Jeong, T. C., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.058 · Cited by 27 · see citing works
Targeting sex steroid biosynthesis for breast and prostate cancer therapy
POUTANEN, M. H., Thulin, M. H., & Härkönen, P. L. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00609-y · Cited by 28 · see citing works
Adenomyosis: genetics of estrogen metabolism
Артымук, Н. В., Zotova, O. A., & Gulyaeva, L. F. (2019) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0069 · Cited by 26 · see citing works
Lee, A. A., & Den Hartigh, L. J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1682231 · Cited by 32 · see citing works
Şendur, M. A. N., Aksoy, S., Zengin, N., & Altundağ, K. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.473 · Cited by 25 · see citing works
Nagaprashantha, L. D., Adhikari, R., Singhal, J., Chikara, S., Awasthi, S., Horne, D. A., & Singhal, S. S. (2017) · International Journal of Cancer · doi:10.1002/ijc.31085 · Cited by 26 · see citing works
Obesity-induced thymic involution and cancer risk
Lagou, M. K., & Karagiannis, G. S. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.04.008 · Cited by 25 · see citing works
Subbaramaiah, K., Howe, L. R., Zhou, X. K., Yang, P., Hudis, C. A., Kopelovich, L., & Dannenberg, A. J. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0201 · Cited by 25 · see citing works
RetractedKumar, A., Sunita, P., Jha, S., & Pattanayak, S. P. (2018) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-018-0608-2 · Cited by 24 · see citing works
Torres, C. G., Iturriaga, M. P., & Cruz, P. (2021) · Animals · doi:10.3390/ani11030608 · Cited by 24 · see citing works
Recurrent CYP2C19 deletion allele is associated with triple-negative breast cancer
Tervasmäki, A., Winqvist, R., Jukkola‐Vuorinen, A., & Pylkäs, K. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-902 · Cited by 24 · see citing works
Aromatase Acetylation Patterns and Altered Activity in Response to Sirtuin Inhibition
Molehin, D., Castro‐Piedras, I., Sharma, M., Sennoune, S. R., Arena, D., Manna, P. R., & Pruitt, K. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0047 · Cited by 24 · see citing works
Testosterone and Secondary Hypertension
Barton, M., Prossnitz, E. R., & Meyer, M. R. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.195149 · Cited by 24 · see citing works
Vihma, V., Wang, F., Savolainen-Peltonen, H., Turpeinen, U., Hämäläinen, E., Leidenius, M., Mikkola, T. S., & Tikkanen, M. J. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.10.004 · Cited by 23 · see citing works
Association of obesity and circulating adipose stromal cells among breast cancer survivors
Ghosh, S., Hughes, D. C., Parma, D. L., Ramírez, A. G., & Li, R. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3146-1 · Cited by 22 · see citing works
Renin angiotensin system inhibition attenuates adipocyte-breast cancer cell interactions
Rasha, F. A., Ramalingam, L., Menikdiwela, K. R., Hernandez, A., Moussa, H. M., Gollahon, L., Rahman, R. L., & Moustaïd‐Moussa, N. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112114 · Cited by 23 · see citing works
Diorio, C., Lemieux, J., Provencher, L., Hogue, J., & Vachon, É. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2278-z · Cited by 23 · see citing works
Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation
Wu, Y., Goodrich, J. M., Dolinoy, D. C., Sánchez, B. N., Ruiz-Narváez, E., Banker, M. M., Cantoral, A., Mercado‐García, A., Téllez‐Rojo, M. M., & Peterson, K. E. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002175 · Cited by 22 · see citing works
CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls
Stueve, T. R., Wolff, M. S., Pajak, A., Teitelbaum, S. L., & Chen, J. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-78 · Cited by 22 · see citing works
Obesity and Breast Cancer: A Complex Relationship
Gershuni, V. M., Ahima, R. S., & Tchou, J. C. (2016) · Current Surgery Reports · doi:10.1007/s40137-016-0134-5 · Cited by 23 · see citing works
Zhao, H., Wang, J., Fang, D., Lee, O., Chatterton, R. T., Stearns, V., Khan, S. A., & Bulun, S. E. (2018) · Hormones and Cancer · doi:10.1007/s12672-018-0329-6 · Cited by 22 · see citing works
Self-citationTralau, T., & Luch, A. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.828692 · Cited by 21 · see citing works
Brooks, S., Hileman, S. M., Chantler, P. D., Milde, S. A., Lemaster, K., Frisbee, S. J., Shoemaker, J. K., Jackson, D. N., & Frisbee, J. C. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00648.2017 · Cited by 21 · see citing works
- Authors
- Bulun, S. E., Chen, D., Moy, I., Brooks, D. C., & Zhao, H.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Bulun, Serdar E.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 23
- Issue
- 2
- Pages
- 83-89
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3428377
- OpenAlex
- W2098876067
- Cited by
- 224
- References
- 88
- Citations by year
- 2026: 13 · 2025: 8 · 2024: 14 · 2023: 11 · 2022: 19 · 2021: 28 · 2020: 15 · 2019: 16 · 2018: 19 · 2017: 16 · 2016: 15 · 2015: 16 · 2014: 13 · 2013: 12 · 2012: 9
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Avon Foundation for Women
- Sage Foundation
- National Cancer Institute (R29CA067167, R01CA067167, CA-67167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- aromatase, breast cancer, obesity, aromatase gene expression, breast adipose tissue, estrogen synthesis, postmenopausal women, TNF signaling, prostaglandin E2, paracrine signaling, breast hyperplasia, therapeutic target
- MeSH terms
- Adipose Tissue, Aromatase, Breast, Breast Neoplasms, Estrogens, Female, Fibroblasts, Humans, Obesity, Signal Transduction, Paracrine Communication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review