Testosterone concentrations in young pubertal and post-pubertal obese males
Open accessAbstract
OBJECTIVE: Obesity in adult males is associated with hypogonadotropic hypogonadism. We evaluated the effect of obesity on plasma testosterone concentrations in pubertal and post-pubertal young males. DESIGN AND METHODS: Morning fasting blood samples were obtained from 25 obese [body mass index (BMI) ≥95th percentile] and 25 lean (BMI <85th percentile) males between the ages 14-20 years with Tanner staging ≥4. Total (TT) and free testosterone (FT) and estradiol concentrations were measured by liquid chromatography tandem mass spectrometry and equilibrium dialysis. Free testosterone was also calculated using SHBG and albumin. C-reactive protein (CRP), insulin and glucose concentrations were measured and homoeostasis model of insulin resistance (HOMA-IR) was calculated. RESULTS: After controlling for age and Tanner staging, obese males had a significantly lower total testosterone (10·5 vs 21·44 nmol/l), free testosterone (0·22 vs 0·39 nmol/l) and calculated free testosterone (0·26 vs 0·44 nmol/l) concentrations as compared to lean males (P < 0·001 for all). Obese males had higher CRP concentrations (2·8 vs 0·8 mg/l; P < 0·001), and HOMA-IR (3·8 vs 1·1; P < 0·001) than lean males. Free testosterone concentrations were positively related to age and negatively to BMI, HOMA-IR and CRP concentrations. Total and free estradiol concentrations were significantly lower in males with subnormal testosterone concentrations. CONCLUSION: Testosterone concentrations of young obese pubertal and post-pubertal males are 40-50% lower than those with normal BMI. Obesity in young males is associated with low testosterone concentrations, which are not secondary to an increase in estradiol concentrations. Our results need to be confirmed in a larger number of subjects.
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Diabetes, hypertension, cardiovascular/renal/hepatic complications, hypogonadotropic hypogonadism, bronchial asthma, and Alzheimer's disease are associated with obesity.
“Several comorbidities such as diabetes, hypertension, cardiovascular/renal/hepatic complications, hypogonadotropic hypogonadism, bronchial asthma, and Alzheimer’s disease are associated with obesity [10-13].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [11]
In obese adolescent males, testosterone concentrations are approximately 50% lower than those of normal males.
“In obese, adolescent males, testosterone concentrations are approximately 50% lower than those of normal males [11, 63].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [11]
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Hoai, B. N., Pham, Q. M., Nguyen, A. B. Q., Nguyen, A. P., Nguyen, V. B. D., Sansone, A., & Jannini, E. A. (2025) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdaf184 · Cited by 1 · see citing works
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WOOD BIOCHEMICALS FOR THE PROTECTION OF HEALTH FOCUS ON HEMICELLULOSE, STILBENOIDS AND LIGNANS
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Functional Hypogonadism: Diabetes Mellitus, Obesity, Metabolic Syndrome, and Testosterone
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Effect of Aerobic Treadmill Training on Level of Testosterone Hormone and Obesity in Male Children
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Self-citation
- Authors
- Mogri, M., Dhindsa, S., Quattrin, T., Ghanim, H., & Dandona, P.
- Affiliations
- State University of New York (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Dandona, Paresh
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2013-03-12
- Volume
- 78
- Issue
- 4
- Pages
- 593-599
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- PMC
- PMC3524388
- OpenAlex
- W2057336778
- Cited by
- 79
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 14 · 2014: 4 · 2013: 3
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Abbott Laboratories
- Sanofi
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075877)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- obesity, testosterone, free testosterone, hypogonadotropic hypogonadism, insulin resistance, C-reactive protein, estradiol, body mass index, adolescent boys
- MeSH terms
- Adolescent, Adult, Age Factors, Cross-Sectional Studies, Humans, Male, Obesity, Puberty, Testosterone, Thinness, Body Mass Index, Case-Control Studies, Young Adult
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