Visualising androgen receptor activity in male and female mice
Open accessAbstract
Androgens, required for normal development and fertility of males and females, have vital roles in the reproductive tract, brain, cardiovascular system, smooth muscle and bone. Androgens function via the androgen receptor (AR), a ligand-dependent transcription factor. To assay and localise AR activity in vivo we generated the transgenic "ARE-Luc" mouse, expressing a luciferase reporter gene under the control of activated endogenous AR. In vivo imaging of androgen-mediated luciferase activity revealed several strongly expressing tissues in the male mouse as expected and also in certain female tissues. In males the testes, prostate, seminal vesicles and bone marrow all showed high AR activity. In females, strong activity was seen in the ovaries, uterus, omentum tissue and mammary glands. In both sexes AR expression and activity was also found in salivary glands, the eye (and associated glands), adipose tissue, spleen and, notably, regions of the brain. Luciferase protein expression was found in the same cell layers as androgen receptor expression. Additionally, mouse AR expression and activity correlated well with AR expression in human tissues. The anti-androgen bicalutamide reduced luciferase signal in all tissues. Our model demonstrates that androgens can act in these tissues directly via AR, rather than exclusively via androgen aromatisation to estrogens and activation of the estrogen receptor. Additionally, it visually demonstrates the fundamental importance of AR signalling outside the normal role in the reproductive organs. This model represents an important tool for physiological and developmental analysis of androgen signalling, and for characterization of known and novel androgenic or antiandrogenic compounds.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In adults, AR is expressed across the cerebral cortex, including associative cortex, in both sexes in rodents and humans.
“In adults AR is expressed across the cerebral cortex, including associative cortex, in both sexes in rodents (Clancy et al., 1992; Dart et al., 2013; DonCarlos et al., 2006; Feng et al., 2010; Kritzer, 2004; Simerly et al., 1990; Young and Chang, 1998), and humans (Bezdickova et al., 2007; Puy et al., 1995; Sarrieau et al., 1990).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Dart et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Normal Sexual Dimorphism of the Adult Human Brain Assessed by In Vivo Magnetic Resonance Imaging
Goldstein, J. M. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.490 · Cited by 1,021 · see citing works
Origin of Murine B Cell Lineages
Kantor, A. B., & Herzenberg, L. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.002441 · Cited by 578 · see citing works
Expression of Sry , the mouse sex determining gene
Hacker, A., Capel, B., Goodfellow, P. N., & Lovell-Badge, R. H. (1995) · Development · doi:10.1242/dev.121.6.1603 · Cited by 571 · see citing works
Transepithelial Transport of Immunoglobulins
Mostov, K. E. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.000431 · Cited by 457 · see citing works
Bachmann, G., Bancroft, J., Braunstein, G., Burger, H., Davis, S., Dennerstein, L., Goldstein, I., Guay, A., Leiblum, S., Lobo, R., et al. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02969-2 · Cited by 444 · see citing works
Estrogen: Consequences and Implications of Human Mutations in Synthesis and Action
Grumbach, M. M., & Auchus, R. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.12.6290 · Cited by 412 · see citing works
Ogawa, S., Chan, J. S. W., Chester, A. E., Gustafsson, J.-Α., Korach, K. S., & Pfaff, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12887 · Cited by 399 · see citing works
He, B., Kemppainen, J., Voegel, J. J., Gronemeyer, H., & Wilson, E. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37219 · Cited by 372 · see citing works
SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors.
Sekido, R., Bar, I., Narváez, V., Penny, G. D., & Lovell-Badge, R. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.07.011 · Cited by 362 · see citing works
Androgen Receptor: An Overview
Chang, C., Saltzman, A. G., Yeh, S., Young, W.-J., Keller, E. T., Lee, H., Wang, C., & Mizokami, A. (1995) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v5.i2.10 · Cited by 334 · see citing works
Premature ovarian failure in androgen receptor-deficient mice
Shiina, H., Μatsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., METZGER, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506736102 · Cited by 332 · see citing works
Rennie, P. S., Bruchovsky, N., Leco, K. J., Sheppard, P. C., McQueen, S. A., Cheng, H., Snoek, R., Hamel, A. L., Bock, M. E., MacDonald, B. S., et al. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.1.8446105 · Cited by 323 · see citing works
Sen, A., & Hammes, S. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0006 · Cited by 313 · see citing works
DNA regulatory elements for steroid hormones
Beato, M., Chalepakis, G., Schauer, M., & Slater, E. P. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90521-9 · Cited by 304 · see citing works
Brain masculinization requires androgen receptor function
Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K.-I., Krust, A., Yamada, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305303101 · Cited by 303 · see citing works
In vivo imaging of transcriptionally active estrogen receptors
Ciana, P., Raviscioni, M., Mussi, P., Vegeto, E., Que, I., Parker, M. G., Löwik, C. W. G. M., & Maggi, A. C. (2002) · Nature Medicine · doi:10.1038/nm809 · Cited by 286 · see citing works
Takeda, H., Chodak, G. W., Mutchnik, S., Nakamoto, T., & Chang, C. (1990) · Journal of Endocrinology · doi:10.1677/joe.0.1260017 · Cited by 243 · see citing works
The role of the androgen receptor in the development and progression of prostate cancer.
Jenster, G. W. (1999) · PubMed · Cited by 239 · see citing works
Zuloaga, D. G., Puts, D. A., Jordan, C. L., & Breedlove, S. M. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.01.013 · Cited by 236 · cited 1× · see citing works
“the sexually dimorphic nucleus of the preoptic area and the anteroventral periventricular nucleus [38].”
BackgroundAnatomical Patterning of Visceral Adipose Tissue: Race, Sex, and Age Variation
Demerath, E. W., Sun, S. S., Rogers, N. L., Lee, M., Reed, D., Choh, A. C., Couch, W. P., Czerwinski, S. A., Chumlea, W. C., Siervogel, R. M., et al. (2007) · Obesity · doi:10.1038/oby.2007.356 · Cited by 229 · see citing works
Imperato‐McGinley, J., Gautier, T., Cai, L., Yee, B., Epstein, J., & Pochi, P. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8381804 · Cited by 220 · see citing works
Testosterone influences libido and well being in women
Davis, S. R., & Tran, J. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00333-7 · Cited by 184 · see citing works
Engineering of a Mouse for the in Vivo Profiling of Estrogen Receptor Activity
Ciana, P., Luccio, G. D., Belcredito, S., Pollio, G., Vegeto, E., Tatangelo, L., Tiveron, C., & Maggi, A. C. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0658 · Cited by 181 · see citing works
A Frameshift Mutation Destabilizes Androgen Receptor Messenger RNA in theTfmMouse
Charest, N. J., Zhou, Z.-X., Lubahn, D. B., Olsen, K. L., Wilson, E., & French, F. S. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-4-573 · Cited by 175 · see citing works
Hodgins, M. B., SPIKE, R. C., MacKie, R. M., & MacLean, A. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10056.x · Cited by 164 · see citing works
Selective androgen receptor modulators in preclinical and clinical development
Narayanan, R., Mohler, M. L., Bohl, C. E., Miller, D. D., & Dalton, J. T. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06010 · Cited by 159 · see citing works
Schoenmakers, E., Alen, P., Verrijdt, G., Peeters, B., Verhoeven, G., Rombauts, W., & Claessens, F. (1999) · Biochemical Journal · doi:10.1042/bj3410515 · Cited by 158 · see citing works
The Rules of DNA Recognition by the Androgen Receptor
Denayer, S., Helsen, C., Thorrez, L., Haelens, A., & Claessens, F. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0310 · Cited by 149 · see citing works
Grad, J. M., Dai, J. L., Wu, S., & Burnstein, K. L. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.11.0369 · Cited by 135 · see citing works
Castration alters peripheral immune function in normal male mice.
Viselli, S. M., Stanziale, S. F., Shults, K., Kovacs, W. J., & Olsen, N. J. (1995) · PubMed Central · Cited by 134 · see citing works
Schauwaers, K., Gendt, K. D., Saunders, P. T. K., Atanassova, N. N., Haelens, A., Callewaert, L., Moehren, U., Swinnen, J. V., Verhoeven, G., Verrijdt, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610814104 · Cited by 116 · see citing works
Poduslo, J. F., Curran, G. L., Kumar, A. R., Frangione, B., & Soto, C. A. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19990605)39:3 · Cited by 114 · see citing works
Up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids
Menard, C. S., & Harlan, R. E. (1993) · Brain Research · doi:10.1016/0006-8993(93)90823-6 · Cited by 114 · see citing works
Janssen, P. J. A., Brinkmann, A. O., Boersma, W. J., & van der Kwast, T. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.8.8027537 · Cited by 102 · see citing works
Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice
Ellis, T. M., Moser, M. T., Le, P. T., Flanigan, R. C., & Kwon, E. D. (2001) · International Immunology · doi:10.1093/intimm/13.4.553 · Cited by 98 · see citing works
Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate.
Powell, S. M., Christiaens, V., Voulgaraki, D., Waxman, J., Claessens, F., & Bevan, C. L. (2004) · Endocrine Related Cancer · doi:10.1677/erc.0.0110117 · Cited by 90 · see citing works
Molecular Mechanisms of Androgen Action – A Historical Perspective
Brinkmann, A. O. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-243-4_1 · Cited by 86 · see citing works
Verrijdt, G., Schoenmakers, E., Alen, P., Haelens, A., Peeters, B., Rombauts, W., & Claessens, F. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0347 · Cited by 85 · see citing works
SRY: A transcriptional activator of mammalian testis determination
Sekido, R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.12.005 · Cited by 83 · see citing works
Berman, J. R., de Almeida, F. G., Jolin, J. A., Raz, S., Chaudhuri, G., & González-Cadavid, N. F. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04923-3 · Cited by 82 · see citing works
Platell, C., Cooper, D., Papadimitriou, J. M., et al. (2000) · PubMed · doi:10.3748/wjg.v6.i2.169 · Cited by 74 · see citing works
Androgen insufficiency in women: summary of critical issues
Braunstein, G. D. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02962-x · Cited by 71 · see citing works
B cells express intracellular but not surface receptors for testosterone and estradiol
Benten, W. P. M., Stephan, C., & Wunderlich, F. T. (2002) · Steroids · doi:10.1016/s0039-128x(02)00013-2 · Cited by 69 · see citing works
Dodd, J. G., Sheppard, P. C., & Matusik, R. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44517-0 · Cited by 66 · see citing works
Evidence for DNA-Binding Domain–Ligand-Binding Domain Communications in the Androgen Receptor
Helsen, C., Dubois, V., Verfaillie, A., Young, J., Trekels, M., Vancraenenbroeck, R., Maeyer, M. D., & Claessens, F. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00151-12 · Cited by 63 · see citing works
Validity of a new automated software program for visceral adipose tissue estimation
Demerath, E. W., Ritter, K. J., Couch, W. P., Rogers, N. L., Moreno, G. J., Choh, A. C., Lee, M., Remsberg, K. E., Czerwiński, S., Chumlea, W. C., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803409 · Cited by 63 · see citing works
The Phytoestrogen Genistein Is a Tissue-Specific Androgen Receptor Modulator
Pihlajamaa, P., Zhang, F., Saarinen, L., Mikkonen, L., Hautaniemi, S., & Jänne, O. A. (2011) · Endocrinology · doi:10.1210/en.2011-0221 · Cited by 57 · see citing works
Noninvasive Bioluminescence Imaging of Normal and Spontaneously Transformed Prostate Tissue in Mice
Lyons, S. K., Lim, E., Clermont, A. O., Dusich, J., Zhu, L., Campbell, K. D., Coffee, R. J., Grass, D., Hunter, J., Purchio, T. F., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3598 · Cited by 56 · see citing works
Pfaffl, M. W., Lange, I. G., & MEYER, H. H. D. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00025-6 · Cited by 55 · see citing works
Dart, D. A., Spencer‐Dene, B., Gamble, S. C., Waxman, J., & Bevan, C. L. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0028 · Cited by 53 · see citing works
Ye, X.-C., Han, S. J., Tsai, S. Y., DeMayo, F. J., Xu, J., Tsai, M., & O’Malley, B. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503577102 · Cited by 50 · see citing works
Carrière, R. (1966) · The Anatomical Record · doi:10.1002/ar.1091560406 · Cited by 50 · see citing works
MacLean, H. E., Moore, A., Sastra, S. A., Morris, H. A., Ghasemzadeh, A., Rana, K., Axell, A.-M., Notini, A. J., Handelsman, D. J., Seeman, E., et al. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0026 · Cited by 45 · see citing works
Tuohimaa, P., & Niemi, M. (1968) · European Journal of Endocrinology · doi:10.1530/acta.0.0580696 · Cited by 39 · see citing works
Identification and Hormonal Control of Sex Steroid Receptors in the Eye
Wickham, L. A., Rocha, E. M., Gao, J., Krenzer, K. L., da Silveira, L. A., Toda, I., & Sullivan, D. A. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5359-5_12 · Cited by 36 · see citing works
Transgenic Mouse Model for Rapid Pharmacodynamic Evaluation of Antiandrogens
Ellwood‐Yen, K., Wongvipat, J., & Sawyers, C. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1397 · Cited by 36 · see citing works
Androgen receptor immunohistochemistry on paraffin-embedded tissue.
Loda, M. F., Fogt, F., French, F. S., Posner, M., Cukor, B., Aretz, H. T., & Alsaigh, N. (1994) · PubMed · Cited by 33 · see citing works
Seethammagari, M. R., Xie, X., Greenberg, N. M., & Spencer, D. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3954 · Cited by 26 · see citing works
Expression of androgen receptor in mouse eye tissues.
Tachibana, M., Kobayashi, Y., Kasukabe, T., Kawajiri, K., & Matsushima, Y. (2000) · PubMed · Cited by 21 · see citing works
Carmena, M. J., Recio, M. N., & Prieto, J. C. (1988) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(88)90091-2 · Cited by 21 · see citing works
Androgens are powerful non-genomic inducers of calcium sensitization in visceral smooth muscle
González-Montelongo, M. D. C., Marín, R., Gómez, T., & Díaz, M. L. (2009) · Steroids · doi:10.1016/j.steroids.2009.09.012 · Cited by 21 · see citing works
Evaluation of steroid hormone receptor protein expression in intact cells using flow cytometry
Butts, C. L., Shukair, S. A., Duncan, K. M., Harris, C. W., Belyavskaya, E., & Sternberg, E. M. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05007 · Cited by 16 · see citing works
Expression of estrogen and androgen receptor in the bovine gastrointestinal tract.
Sauerwein, H., Pfaffl, M. W., Hagen‐Mann, K., Malucelli, A., & Meyer, H. H. (1995) · PubMed · Cited by 16 · see citing works
Feldman, S. R. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70231-4 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz‐Zagrosek, V., & Kararigas, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 738 · see citing works
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175 · see citing works
Multiplexed imaging for diagnosis and therapy
Heinzmann, K., Carter, L. M., Lewis, J. S., & Aboagye, E. O. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0131-8 · Cited by 168 · see citing works
Androgen actions in the ovary: balance is key
Prizant, H., Gleicher, N., & Sen, A. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0296 · Cited by 136 · see citing works
The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health
Alemany, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911952 · Cited by 140 · see citing works
Androgens and endometrium: new insights and new targets
Simitsidellis, I., Saunders, P. T. K., & Gibson, D. A. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.022 · Cited by 107 · see citing works
Sex differences in autophagy-mediated diseases: toward precision medicine
Shang, D., Wang, L., Klionsky, D. J., Cheng, H., & Zhou, R. (2020) · Autophagy · doi:10.1080/15548627.2020.1752511 · Cited by 92 · see citing works
Leach, D. A., Mohr, A., Giotis, E. S., Cil, E., Isac, A. M., Yates, L. L., Barclay, W., Zwacka, R. M., Bevan, C. L., & Brooke, G. N. (2021) · Nature Communications · doi:10.1038/s41467-021-24342-y · Cited by 87 · see citing works
Brock, O., Mees, C. D., & Bakker, J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12258 · Cited by 88 · see citing works
Ayaz, O., & Howlett, S. E. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0027-9 · Cited by 85 · see citing works
Evidence of androgen action in endometrial and ovarian cancers
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2014) · Endocrine-Related Cancer · doi:10.1530/erc-13-0551 · Cited by 73 · see citing works
Uncovering sex-specific mechanisms of action of testosterone and redox balance
Cruz‐Topete, D., Dominic, P. S., & Stokes, K. Y. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101490 · Cited by 77 · see citing works
Duong, P., Tenkorang, M. A. A., Trieu, J., McCuiston, C., Rybalchenko, N., & Cunningham, R. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-0283-1 · Cited by 74 · see citing works
Flexible clock systems: adjusting the temporal programme
van der Veen, D. R., Riede, S., Heideman, P., Hau, M., van der Vinne, V., & Hut, R. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0254 · Cited by 62 · see citing works
Suprachiasmatic nucleus as the site of androgen action on circadian rhythms
Model, Z., Butler, M. P., LeSauter, J., & Silver, R. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.007 · Cited by 68 · see citing works
Associations Among Estrogens, the Gut Microbiome and Osteoporosis
Kverka, M., & Stepan, J. J. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00896-w · Cited by 63 · see citing works
Cox, M. J., Edwards, M. C., Paris, V. R., Aflatounian, A., Ledger, W. J., Gilchrist, R. B., Padmanabhan, V., Handelsman, D. J., & Walters, K. A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa061 · Cited by 59 · see citing works
The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis
Walters, K. A., Edwards, M. C., Tesic, D., Caldwell, A. S. L., Jimenez, M., Smith, J. T., & Handelsman, D. J. (2018) · Neuroendocrinology · doi:10.1159/000487762 · Cited by 56 · see citing works
Sex steroids and the kidney: role in renal calcium and phosphate handling
Khalil, R., Kim, N. R., Jardi, F., Vanderschueren, D., Claessens, F., & Decallonne, B. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.11.011 · Cited by 53 · see citing works
A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus
Simitsidellis, I., Gibson, D. A., Cousins, F. L., Esnal‐Zufiaurre, A., & Saunders, P. T. K. (2016) · Endocrinology · doi:10.1210/en.2015-2032 · Cited by 49 · see citing works
Tissue control of androgen action: The ups and downs of androgen receptor expression
Hunter, I., Hay, C. W., Eßwein, B., Watt, K., & McEwan, I. J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.002 · Cited by 49 · see citing works
Tulsulkar, J., Glueck, B., Hinds, T. D., & Shah, Z. A. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0433-7 · Cited by 48 · see citing works
Blanquart, E., Mandonnet, A., Mars, M., Cénac, C., Anesi, N., Mercier, P., Audouard, C., Roga, S., de Almeida, G. S., Bevan, C. L., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.04.029 · Cited by 48 · see citing works
Rastelli, D., Robinson, A., Lagomarsino, V. N., Matthews, L. T., Hassan, R., Perez, K., Dan, W., Yim, P. D., Mixer, M., Prochera, A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci150789 · Cited by 45 · see citing works
Lynch, S. E., Boyett, J. E., Smith, M. R., & Giordano‐Mooga, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.610516 · Cited by 44 · see citing works
Rapid Fluorescent Detection of (Anti)androgens with spiggin-gfp Medaka
Sébillot, A., Damdimopoulou, P., Ogino, Y., Špirhanzlová, P., Miyagawa, S., Pasquier, D. D., Mouatassim, N., Iguchi, T., Lemkine, G. F., DEMENEIX, B. A., et al. (2014) · Environmental Science & Technology · doi:10.1021/es5030977 · Cited by 44 · see citing works
Resistance to Antiandrogens in Prostate Cancer: Is It Inevitable, Intrinsic or Induced?
Maitland, N. J. (2021) · Cancers · doi:10.3390/cancers13020327 · Cited by 44 · see citing works
Androgens as double-edged swords: Induction and suppression of follicular development
Pan, J., Zhang, J., Ke, Z.-H., Wang, F., Barry, J. A., Hardiman, P. J., & Qu, F. (2015) · HORMONES · doi:10.14310/horm.2002.1580 · Cited by 41 · see citing works
Androgen Physiology: Receptor and Metabolic Disorders
McEwan, I. J., & Brinkmann, A. O. (2016) · Cited by 42 · see citing works
Regulation of androgen action during establishment of pregnancy
Gibson, D. A., Simitsidellis, I., & Saunders, P. T. K. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0027 · Cited by 42 · see citing works
Sex Hormone Decline and Amyloid β Synthesis, Transport and Clearance in the Brain
Duarte, A. C., Hrynchak, M. V., Gonçalves, I., Quintela, T., & Santos, C. R. A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12432 · Cited by 40 · see citing works
Sebastian, R., & Raghavan, S. C. (2015) · Cell Death Discovery · doi:10.1038/cddiscovery.2015.20 · Cited by 40 · see citing works
The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance
Cronin, R., Brooke, G. N., & Prischi, F. (2021) · Oncogene · doi:10.1038/s41388-021-01810-9 · Cited by 32 · see citing works
Gholami, K., Loh, S. Y., Salleh, N., Lam, S. K., & Hoe, S.-Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176368 · Cited by 33 · see citing works
Davey, R. A., Clarke, M. V., Russell, P. K., Rana, K., Seto, J. T., Roeszler, K. N., How, J. M. Y., Chia, L. Y., North, K. N., & Zajac, J. D. (2017) · Endocrinology · doi:10.1210/en.2017-00470 · Cited by 31 · see citing works
Ayaz, O., Banga, S., Heinze-Milne, S., Rose, R. A., Pyle, W. G., & Howlett, S. E. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00471.2018 · Cited by 31 · see citing works
Influence of Aromatase Inhibition on the Bone-Protective Effects of Testosterone
Beck, D. T., Yarrow, J. F., Beggs, L. A., Otzel, D. M., Ye, F., Conover, C. F., Miller, J. R., Balaez, A., Combs, S. M., Leeper, A. M., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2265 · Cited by 28 · see citing works
Progesterone receptor activation regulates seizure susceptibility
Shiono, S., Williamson, J., Kapur, J., & Joshi, S. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50830 · Cited by 27 · see citing works
Molecular Characterisation of Canine Osteosarcoma in High Risk Breeds
Simpson, S., Dunning, M., de Brot, S., Alibhai, A. A., Bailey, C., Woodcock, C. L., Mestas, M., Akhtar, S., Jeyapalan, J. N., Lothion‐Roy, J. H., et al. (2020) · Cancers · doi:10.3390/cancers12092405 · Cited by 26 · see citing works
Androgen action in female reproductive physiology
Walters, K. A., Simanainen, U., & Gibson, D. A. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000246 · Cited by 24 · see citing works
The effects of hormone replacement therapy on the microbiomes of postmenopausal women
Dothard, M. I., Allard, S. M., & Gilbert, J. A. (2023) · Climacteric · doi:10.1080/13697137.2023.2173568 · Cited by 25 · see citing works
Analysis of androgen receptor expression and activity in the mouse brain
Dart, D. A., Bevan, C. L., Uysal-Onganer, P., & Jiang, W.-G. (2024) · Scientific Reports · doi:10.1038/s41598-024-61733-9 · Cited by 21 · see citing works
Rastelli, D., Robinson, A. F., Lagomarsino, V. N., Matthews, L., Hassan, R., Perez, K., Dan, W., Yim, P. D., Mixer, M., Prochera, A., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 24 · see citing works
Yu, Y., Wei, S., Weiss, R. M., & Felder, R. B. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00499.2018 · Cited by 24 · see citing works
Xiong, T., Paris, V. R., Edwards, M. C., Hu, Y., Cochran, B. J., Rye, K., Ledger, W. J., Padmanabhan, V., Handelsman, D. J., Gilchrist, R. B., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00418.2021 · Cited by 23 · see citing works
Xu, J., Li, M., Zhang, L., Xiong, H., Lai, L., Guo, M., Zong, T., Zhang, D., Yang, B., Wu, L., et al. (2015) · Molecular Reproduction and Development · doi:10.1002/mrd.22532 · Cited by 21 · see citing works
Androgen-induced alterations in endometrial proteins crucial in recurrent miscarriages
Rahman, T. U., Ullah, K., Guo, M., Pan, H., Liu, J., Ren, J. T., Jin, L., Zhou, Y.-Z., Cheng, Y., Sheng, J., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24821 · Cited by 21 · see citing works
Shen, J.-S., Meng, X., Wight‐Carter, M., Day, T. S., Goetsch, S. C., Forni, S., Schneider, J. W., Liu, Z.-P., & Schiffmann, R. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv070 · Cited by 20 · see citing works
Genetics of Aggression in Alzheimer’s Disease (AD)
Lukiw, W. J., & Rogaev, E. I. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00087 · Cited by 20 · see citing works
Contreras-Zarate, M. J., & Cittelly, D. M. (2020) · Cancer Reports · doi:10.1002/cnr2.1241 · Cited by 20 · see citing works
Han, X., Ren, X., Zeng, Y., Zhou, Y.-Q., Song, T., Cao, X., Du, X., Meng, F., Tan, Y., Liu, Y., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.06.011 · Cited by 20 · see citing works
Mokhtar, M. H., Giribabu, N., Kassim, N. M., Muniandy, S., & Salleh, N. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.007 · Cited by 19 · see citing works
Ruetten, H. M., Wegner, K. A., Zhang, H. L., Wang, P., Sandhu, J., Sandhu, S. K., Mueller, B., Wang, Z., Macoska, J. A., Peterson, R. E., et al. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00270.2019 · Cited by 19 · see citing works
Zhao, G., Zhao, X., Song, Y., Haire, A., Dilixiati, A., Liu, Z., Zhao, S., Aihemaiti, A., Fu, X., & Wusiman, A. (2022) · Reproduction in Domestic Animals · doi:10.1111/rda.14111 · Cited by 18 · see citing works
Barsky, S. T., & Monks, D. A. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00707-6 · Cited by 19 · see citing works
Chronic high‐dose testosterone treatment: impact on rat cardiac contractile biology
Wadthaisong, M., Witayavanitkul, N., Bupha‐Intr, T., Wattanapermpool, J., & de Tombe, P. P. (2019) · Physiological Reports · doi:10.14814/phy2.14192 · Cited by 18 · see citing works
Hamid, F. A., Abu, M., Karim, A. K. A., Ahmad, M., Aziz, N. A., Kamal, D. A. M., & Mokhtar, M. H. (2022) · Biomedicines · doi:10.3390/biomedicines10071705 · Cited by 17 · see citing works
Sex mechanisms as nonbinary influences on cognitive diversity
Grissom, N. M., Glewwe, N., Chen, C. Y.-H., & Giglio, E. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105544 · Cited by 18 · see citing works
Differential Growth of the Reproductive Organs during the Peripubertal Period in Male Rats
Han, S. H., & Lee, S.-H. (2013) · Development & Reproduction · doi:10.12717/dr.2013.17.4.469 · Cited by 16 · see citing works
Kavarthapu, R., & Dufau, M. L. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1198 · Cited by 16 · see citing works
Liver Microenvironment Response to Prostate Cancer Metastasis and Hormonal Therapy
Buxton, A. K., Abbasova, S., Bevan, C. L., & Leach, D. A. (2022) · Cancers · doi:10.3390/cancers14246189 · Cited by 16 · see citing works
Hua, Y., Azeem, W., Shen, Y., Zhang, S., Olsen, J. R., Oyan, A. M., Ke, X., Zhang, W., & Kalland, K. (2018) · Pharmacology Research & Perspectives · doi:10.1002/prp2.437 · Cited by 15 · see citing works
Testosterone and Myelin Regeneration in the Central Nervous System
Schumacher, M., Ghoumari, A. M., Mattern, C., Bougneres, P. F., & Traiffort, É. (2021) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2021.0023 · Cited by 12 · see citing works
Androgen Inhibition of Reproductive Neuroendocrine Function in Females and Transgender Males
Kauffman, A. S. (2024) · Endocrinology · doi:10.1210/endocr/bqae113 · Cited by 12 · see citing works
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice
Banga, S., Heinze-Milne, S., Godin, J., & Howlett, S. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111523 · Cited by 12 · see citing works
In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice
Yasuda, K., Cline, C., Lin, Y. S., Scheib, R., Ganguly, S., Thirumaran, R. K., Chaudhry, A. S., Kim, R. B., & Schuetz, E. G. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.065078 · Cited by 12 · see citing works
Dart, D. A., Kandil, S., Tommasini-Ghelfi, S., de Almeida, G. S., Bevan, C. L., Jiang, W. G., & Westwell, A. D. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0037 · Cited by 11 · see citing works
Li, Y., Tang, L., Zhao, M., Tang, R., Fang, K., Ge, W., & Du, W. (2024) · Biomedical Chromatography · doi:10.1002/bmc.5870 · Cited by 10 · see citing works
Ren, Y., Wang, Y., Wang, Y., Ning, X., Li, G., & Sang, N. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136855 · Cited by 10 · see citing works
Sex Hormones and Immunosenescence
Gómez, C. R., Nomellini, V., & Kovacs, E. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_42 · Cited by 10 · see citing works
Silva, S., Bicker, J., Fialho, S., Cunha, S., Falcão, A. C., & Fortuna, A. C. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116184 · Cited by 9 · see citing works
Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients
Giotis, E. S., Cil, E., & Brooke, G. N. (2022) · Viruses · doi:10.3390/v14122728 · Cited by 8 · see citing works
Male and female atria exhibit distinct acute electrophysiological responses to sex steroids
Wells, S. P., O’Shea, C., Hayes, S., Weeks, K. L., Kirchhof, P. F., Delbridge, L. M. D., Pavlović, D., & Bell, J. R. (2024) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2024.100079 · Cited by 8 · see citing works
Leach, D. A., Chatterjee, N., Spahr, K., de Almeida, G. S., Varela‐Carver, A., Shah, T. T., Winkler, M. H., Ahmed, H. U., & Bevan, C. L. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70065 · Cited by 8 · see citing works
Xia, S., Ou, K., Zhang, S., Huang, J. S., Fang, L., Wang, C., & Wang, Q. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113306 · Cited by 7 · see citing works
Ma, Y., Zhao, G., Wang, C., An, M., Ma, C., Liu, Z., Wang, J., & Kailun, Y. (2023) · Animal Production Science · doi:10.1071/an22290 · Cited by 7 · see citing works
Androgen Receptors in the Dermal Glands of Male and Female Ouachita Dusky Salamanders
Gunelson, A. M., Tuong, M. A., & Staub, N. L. (2024) · Integrative Organismal Biology · doi:10.1093/iob/obae001 · Cited by 7 · see citing works
Hendry, W. J., Hariri, H. Y., Alwis, I. D., Gunewardena, S., & Hendry, I. R. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.09.002 · Cited by 7 · see citing works
Ryberg, H., Norlén, A., Landin, A., Johansson, P., Salman, Z., Wallin, A., Svensson, J., & Ohlsson, C. (2023) · Endocrine Connections · doi:10.1530/ec-23-0250 · Cited by 6 · see citing works
Immunohistochemical localization of androgen receptors in female mole rat (Spalax leucodon) tissues
Gür, F. M., & Timurkaan, S. (2016) · Biotechnic & Histochemistry · doi:10.1080/10520295.2016.1230784 · Cited by 6 · see citing works
Lékó, A. H., KUMARI, R. R., Dóra, F., Keller, D. W., Udvari, E. B., Csikós, V., Renner, É., & Dobolyi, Á. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041517 · Cited by 6 · see citing works
Mammary gland development and EDC-driven cancer susceptibility in mesenchymal ERα-knockout mice
Wormsbaecher, C., Cumbia, B. M., Amurgis, E. G., Poska, J. M., Price, M. R., Mo, X. M., Knoblaugh, S. E., Kurita, T., & Burd, C. J. (2023) · Endocrine Related Cancer · doi:10.1530/erc-23-0062 · Cited by 6 · see citing works
Hu, S., Kang, H., Bae, M., Kim, M., Jang, H., Corvino, O., Pham, T. X., Lee, Y., Smyth, J. A., Park, Y., et al. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16856 · Cited by 6 · see citing works
Tian, Y., Qiao, H., Odamah, K., Zhu, L., & Man, H. (2025) · iScience · doi:10.1016/j.isci.2025.111868 · Cited by 5 · see citing works
Peng, H., Ren, J., Zhao, Y., Fang, X., Wang, X., Liu, C., & Wan, Z. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112235 · Cited by 6 · see citing works
Gender differences in expression and localization of the apelin receptor in mice skin
Das, M., Kumar, R. K., Kumar, V., Gurusubramanian, G., & Roy, V. K. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10492-6 · Cited by 5 · see citing works
Morphology and MMP-9, AR and IGFR-1 responses of the seminal vesicle in TRAMP mice model
Pozzo, C. F. S. D., Kido, L. A., Montico, F., Gonçalves, M. P., & Cagnon, V. H. A. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.03.005 · Cited by 5 · see citing works
In Vivo Imaging of Nuclear Receptor Transcriptional Activity
Dart, D. A., & Bevan, C. L. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3724-0_13 · Cited by 5 · see citing works
Sex and Stress Steroid Crosstalk Reviewed: Give Us More
Kroon, J., & Meijer, O. C. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa113 · Cited by 4 · see citing works
Kugler, J., Luch, A., & Oelgeschläger, M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.06.009 · Cited by 4 · see citing works
Alba, E., Castaño, C., Toledano‐Díaz, A., Velázquez, R., Martínez-Madrid, B., Gómez-Crespo, A., Álvarez‐Rodríguez, M., Rodríguez‐Martínez, H., & Santiago‐Moreno, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211972 · Cited by 2 · see citing works
Sex Hormones and Immunosenescence
Gómez, C. R., Nomellini, V., & Kovacs, E. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_42-1 · Cited by 2 · see citing works
Barsky, S. T., & Monks, D. A. (2024) · Endocrinology · doi:10.1210/endocr/bqae012 · Cited by 2 · see citing works
Nolasco-Pérez, T. D. J., Salazar-Castañón, V. H., Cervantes-Candelas, L. A., Buendía-González, F. O., Aguilar-Castro, J., & Legorreta-Herrera, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083898 · Cited by 4 · see citing works
Genetic Mouse Models for Female Reproductive Toxicology Studies
Dávila, J., Li, Q., & Bagchi, I. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95679-4 · Cited by 2 · see citing works
Leach, D. A., Mohr, A., Giotis, E. S., Isac, A. M., Yates, L. L., Barclay, W., Zwacka, R. M., Bevan, C. L., & Brooke, G. N. (2021) · doi:10.21203/rs.3.rs-137931/v1 · Cited by 2 · see citing works
Li, R., & DeMayo, F. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64635-4 · Cited by 1 · see citing works
Cüce Hamsterlerin (Phodopus roborovskii) Genital Dokularında Androjen Reseptör Lokalizasyonu
Gür, F. M., Timurkaan, S., Baygeldi, S. B., Özkan, Z. E., Kanmaz, Y. A., Gür, H. E., İlgün, R., & Tarakçı, B. G. (2018) · Turkish Journal of Agriculture - Food Science and Technology · doi:10.24925/turjaf.v6i4.415-420.1887
- Authors
- Dart, D. A., Waxman, J., Aboagye, E. O., & Bevan, C. L.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Bevan, Charlotte L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-08-07
- Volume
- 8
- Issue
- 8
- Pages
- e71694
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3737126
- OpenAlex
- W2045176719
- Cited by
- 112
- References
- 66
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 11 · 2016: 13 · 2015: 10 · 2014: 7 · 2013: 1
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Funders
- Genesis Research Trust
- Imperial College London
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- androgen receptor, androgen signaling, transgenic mouse model, luciferase reporter, in vivo imaging, bicalutamide, androgen receptor antagonists, estrogen receptor, sex differences
- MeSH terms
- Androgen Antagonists, Anilides, Animals, Chlorocebus aethiops, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Nitriles, Organ Specificity, Receptors, Androgen, Tosyl Compounds, Transcriptional Activation, Genes, Reporter, COS Cells, Luciferases, Firefly, Mice, Mice, 129 Strain, MCF-7 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
