Cited by 34Adipose Tissue and MetabolismFatty Acid Research and HealthLipid metabolism and biosynthesis

Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice

Bargut, Thereza Cristina Lonzetti, Martins, Fabiane Ferreira, Santos, Larissa Pereira, Aguila, Marcia Barbosa, Mandarim-de-Lacerda, Carlos A.·2019·Molecular and Cellular Endocrinology

Abstract

The role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in browning and thermogenesis has not been fully elucidated. Thus, we meant to evaluate the effect of EPA and DHA, administered alone or combined, with the activation of browning markers in subcutaneous white adipose tissue (sWAT), and thermogenic markers in brown adipose tissue (BAT). C57BL/6 adult male mice received a control diet or a high-fructose diet (HFru) for eight weeks, but after the first three weeks, HFru was divided into new groups: HFru, HFru + EPA, HFru + DHA, and HFru-EPA + DHA. EPA and DHA diminished adipocyte hypertrophy, recovered markers of browning in sWAT and thermogenic factors in the BAT, and improved gene expressions linked with mitochondrial biogenesis and lipid metabolism. Importantly, EPA and DHA administrated alone showed stronger results than the combination of EPA + DHA. The results suggest that EPA and DHA might be useful as adjuvant strategies to treat metabolic-associated disorders.

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Crossref · 10.1016/j.mce.2018.12.003

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  • PUFAs such as EPA and DHA stimulate UCP1 expression and adaptive non-shivering or diet-induced thermogenesis in brown adipocytes, as well as browning of WAT in C57BL/6 mice, Sprague-Dawley rats, and overweight humans.

    “PUFAs such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also stimulate UCP1 expression and thus adaptive non-shivering or diet-induced thermogenesis in brown adipocytes, as well as the browning of the white adipose tissue (WAT) in C57BL/6 mice [67,68], Sprague-Dawley rats [69,70], and overweight humans [71].”

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Authors
Bargut, T. C. L., Martins, F. F., Santos, L. P., Aguila, M. B., & Mandarim-de-Lacerda, C. A.
Affiliations
  • Universidade Federal Fluminense (BR)
  • Universidade do Estado do Rio de Janeiro (BR)
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2019-02
Volume
482
Pages
18-27
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2903848597
Cited by
34
References
79
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 2
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • CNPq (302.920/2016-1, 305865/2017-0, 401001/2016-4)
  • FAPERJ (E-26/202.935/2017, E-26/202.795/2017, E-26/201.683/2017)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, brown adipose tissue, white adipose tissue browning, thermogenesis, adipocyte hypertrophy, mitochondrial biogenesis, lipid metabolism, high-fructose diet, metabolic disorders, dietary supplementation
MeSH terms
Animals, Organelle Biogenesis, Adipose Tissue, Brown, Docosahexaenoic Acids, Fructose, Gene Expression Regulation, Male, Mice, Inbred C57BL, Random Allocation, Eicosapentaenoic Acid, Thermogenesis, Subcutaneous Fat, Lipid Metabolism, Mice, Adipose Tissue, White

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