Negr1 controls adult hippocampal neurogenesis and affective behaviors

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948 · see citing works

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

Hyde, C. L., Nagle, M. W., Tian, C., Chen, X., Paciga, S. A., Wendland, J. R., Tung, J. Y., Hinds, D. A., Perlis, R. H., & Winslow, A. R. (2016) · Nature Genetics · doi:10.1038/ng.3623 · Cited by 784 · see citing works

Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130.

Gearing, D. P., Thut, C. J., VandeBos, T., Gimpel, S. D., Delaney, P. B., King, J., Price, V. L., Cosman, D. J., & Beckmann, M. P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07833.x · Cited by 590 · see citing works

Reactive astrocytes secrete lcn2 to promote neuron death

Bi, F., Huang, C., Tong, J., Qiu, G., Huang, B., Wu, Q., Li, F., Xu, Z., Bowser, R., Xia, X.-G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218497110 · Cited by 371 · see citing works

A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder

Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350 · see citing works

Reliable Activation of Immature Neurons in the Adult Hippocampus

Mongiat, L. A., Esposito, M. S., Lombardi, G., & Schinder, A. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005320 · Cited by 274 · see citing works

An excitatory synapse hypothesis of depression

Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

Ernst, M., Inglese, M., Waring, P., Campbell, I. K., Bao, S., Clay, F. J., Alexander, W. S., Wicks, I. P., Tarlinton, D. M., Novak, U., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.189 · Cited by 227 · see citing works

Diverse functional roles of lipocalin-2 in the central nervous system

Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K.-G., Lee, I.-K., & Suk, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.006 · Cited by 195 · see citing works

Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation

Mucha, M. W., Skrzypiec, A. E., Schiavon, E., Attwood, B. K., Kucerova, E., & Pawlak, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107936108 · Cited by 189 · see citing works

Studies of the release and turnover of a human neutrophil lipocalin

Axelsson, L., Bergenfeldt, M., & OHLSSON, K. (1995) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519509110257 · Cited by 132 · see citing works

Synaptic changes in the brain of subjects with schizophrenia

Faludi, G., & Mirnics, K. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.02.013 · Cited by 127 · see citing works

Characterization of a Novel Rat Brain Glycosylphosphatidylinositol-anchored Protein (Kilon), a Member of the IgLON Cell Adhesion Molecule Family

Funatsu, N., Miyata, S., Kumanogoh, H., Shigeta, M., Hamada, K., Endo, Y., Sokawa, Y., & Maékawa, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8224 · Cited by 119 · see citing works

Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice

Parker, C. C., Gopalakrishnan, S., Carbonetto, P. S., Gonzales, N. M., Leung, E., Park, Y. J., Aryee, E., Davis, J. R., Blizard, D. A., Ackert‐Bicknell, C. L., et al. (2016) · Nature Genetics · doi:10.1038/ng.3609 · Cited by 119 · see citing works

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders

Jun, H., Hussaini, S. M. Q., Rigby, M. J., & Jang, M. (2012) · Neural Plasticity · doi:10.1155/2012/854285 · Cited by 109 · see citing works

Hypothalamic–pituitary–adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function: Review

Kolber, B. J., Wieczorek, L., & Muglia, L. J. (2008) · Stress · doi:10.1080/10253890701821081 · Cited by 106 · see citing works

IgLON Cell Adhesion Molecules Are Shed from the Cell Surface of Cortical Neurons to Promote Neuronal Growth

Sanz, R., Ferraro, G. B., & Fournier, A. E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.628438 · Cited by 102 · see citing works

Decreased Anxiety, Altered Place Learning, and Increased CA1 Basal Excitatory Synaptic Transmission in Mice with Conditional Ablation of the Neural Cell Adhesion Molecule L1

Law, J. W. S., Lee, A. Y. W., Sun, M., Nikonenko, A. G., Chung, S. K., Dityatev, A. E., Schachner, M., & Morellini, F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10419.2003 · Cited by 101 · see citing works

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Direk, N., Williams, S., Smith, J. A., Ripke, S., Air, T., Amare, A. T., Amin, N., Baune, B. T., Bennett, D. A. A., Blackwood, D., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.013 · Cited by 97 · see citing works

A meta-analysis of clinical trials comparing mirtazapine with selective serotonin reuptake inhibitors for the treatment of major depressive disorder

Papakostas, G., Homberger, C. H., & Fava, M. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107083808 · Cited by 96 · see citing works

Lipocalin-2 is involved in emotional behaviors and cognitive function

Ferreira, A. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00122 · Cited by 96 · see citing works

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

Huyton, T., Zhang, J., Luo, C. S., Lou, M.-Z., Hilton, D. J., Nicola, N. A., & Garrett, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705577104 · Cited by 94 · see citing works

Neurogenesis in the Dentate Gyrus Depends on Ciliary Neurotrophic Factor and Signal Transducer and Activator of Transcription 3 Signaling

Müller, S., Chakrapani, P. S. B., Schwegler, H., Hofmann, H., & Kirsch, M. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0234 · Cited by 88 · see citing works

Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion

Schäfer, M., Bräuer, A. U., Savaskan, N. E., Rathjen, F. G., & Brümmendorf, T. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.04.010 · Cited by 86 · see citing works

The Effect of Serotonin-Targeting Antidepressants on Neurogenesis and Neuronal Maturation of the Hippocampus Mediated via 5-HT1A and 5-HT4 Receptors

Segi‐Nishida, E. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00142 · Cited by 86 · see citing works

Functional Inactivation of the Genome-Wide Association Study Obesity Gene Neuronal Growth Regulator 1 in Mice Causes a Body Mass Phenotype

Lee, A. W. S., Hengstler, H., Schwald, K., Berriel-Diaz, M., Loreth, D., Kirsch, M., Kretz, O., Haas, C. A., de Angelis, M. H., Herzig, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041537 · Cited by 84 · see citing works

NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice

Szczurkowska, J., Pischedda, F., Pinto, B., Managò, F., Haas, C. A., Summa, M., Bertorelli, R., Papaleo, F., Schäfer, M. K. E., Piccoli, G., et al. (2018) · Brain · doi:10.1093/brain/awy190 · Cited by 75 · see citing works

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding

Um, J. W., Choi, T.-Y., Kang, H., Cho, Y. S., Choii, G., Uvarov, P., Park, D., Jeong, D., Jeon, S., Lee, D., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.081 · Cited by 74 · see citing works

IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons

Hashimoto, T., Yamada, M., Maekawa, S., Nakashima, T., & Miyata, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.069 · Cited by 71 · see citing works

Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters

Maccarrone, G., Ditzen, C., Yassouridis, A., Rewerts, C., Uhr, M., Uhlén, M., Holsboer, F., & Turck, C. W. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.021 · Cited by 68 · see citing works

Depression‐like behaviour in neural cell adhesion molecule (NCAM)‐deficient mice and its reversal by an NCAM‐derived peptide, FGL

Aonurm‐Helm, A., Jürgenson, M., Zharkovsky, T., Sonn, K., Berezin, V., Bock, E., & Zharkovsky, A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06471.x · Cited by 68 · see citing works

Biochemical and ultrastructural analyses of iglon cell adhesion molecules, kilon and obcam in the rat brain

Miyata, S., Matsumoto, N., Taguchi, K., Akagi, A., Iino, T., Funatsu, N., & Maekawa, S. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00873-4 · Cited by 66 · see citing works

Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

Ferreira, A. C., Santos, T., Sampaio‐Marques, B., Novais, A., Mesquita, S. D., Ludovico, P., Bernardino, L. I., Correia‐Neves, M., Sousa, N., Palha, J. A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.95 · Cited by 65 · see citing works

Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene

Singh, K., Loreth, D., Pöttker, B., Hefti, K., Innos, J., Schwald, K., Hengstler, H., Menzel, L., Sommer, C., Radyushkin, K., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00030 · Cited by 65 · see citing works

Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease

Ransome, M. I., Renoir, T., & Hannan, A. J. (2012) · Neural Plasticity · doi:10.1155/2012/874387 · Cited by 64 · see citing works

Microglial Toll-like Receptor 2 Contributes to Kainic Acid-induced Glial Activation and Hippocampal Neuronal Cell Death

Hong, J., Cho, I., Kwak, K. I., Suh, E. C., Seo, J., Min, H. J., Choi, S., Kim, C., Park, S. H., Jo, E., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132522 · Cited by 64 · see citing works

The IgLON Family Member Negr1 Promotes Neuronal Arborization Acting as Soluble Factor via FGFR2

Pischedda, F., & Piccoli, G. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00089 · Cited by 64 · see citing works

Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

Shen, Z., Cheng, Y., Yang, S., Dai, N., Ye, J., Liu, X., Lü, J., Li, N., Liu, F., Lü, Y., et al. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.08.016 · Cited by 64 · see citing works

Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder

Koido, K., Traks, T., Balõtšev, R., Eller, T., Must, A., Kõks, S., Maron, E., Tõru, I., Shlik, J., Vasar, V., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.74 · Cited by 63 · see citing works

The Burden of Mood Disorders

Wïttchen, H. (2012) · Science · doi:10.1126/science.1230817 · Cited by 61 · see citing works

Transcriptional Evidence for the Role of Chronic Venlafaxine Treatment in Neurotrophic Signaling and Neuroplasticity Including also Glutatmatergic- and Insulin-Mediated Neuronal Processes

Tamási, V., Petschner, P., Ádori, C., Kirilly, E., Andó, R. D., Tóthfalusi, L., Juhász, G., & Bagdy, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113662 · Cited by 60 · see citing works

Genetic Deletion of Lsamp Causes Exaggerated Behavioral Activation in Novel Environments

Catania, E. H., Pimenta, A. F., & Levitt, P. R. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.022 · Cited by 59 · see citing works

Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior

Sun, D., Sun, X.-D., Zhao, L., Lee, D.-H., Hu, J.-X., Tang, F., Pan, J., Mei, L., Zhu, X., & Xiong, W. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0019-2 · Cited by 56 · see citing works

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

Jang, S., Oh, D., Lee, Y., Hosy, E., Shin, H., van Riesen, C., Whitcomb, D. J., Warburton, J. M., Jo, J., Kim, D., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4176 · Cited by 52 · see citing works

Different spatial patterns of brain atrophy and global functional connectivity impairments in major depressive disorder

Zhuo, C., Zhu, J., Wang, C., Qu, H., Ma, X., & Qin, W. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9645-z · Cited by 52 · see citing works

Regulatory Network Analyses Reveal Genome-Wide Potentiation of LIF Signaling by Glucocorticoids and Define an Innate Cell Defense Response

Langlais, D., Couture, C., Balsalobre, A., & Drouin, J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000224 · Cited by 51 · see citing works

The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas

Boender, A. J., van Gestel, M. A., Garner, K. M., Luijendijk, M. C. M., & Adan, R. A. H. (2014) · Physiological Reports · doi:10.14814/phy2.12083 · Cited by 51 · see citing works

Stress-Induced Lipocalin-2 Controls Dendritic Spine Formation and Neuronal Activity in the Amygdala

Skrzypiec, A. E., Shah, R. S., Schiavon, E., Baker, E., Skene, N., Pawlak, R., & Mucha, M. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061046 · Cited by 47 · see citing works

The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking

Kim, H., Chun, Y., Che, L., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.043 · Cited by 41 · see citing works

Possible antidepressant effects and mechanism of electroacupuncture in behaviors and hippocampal synaptic plasticity in a depression rat model

She, Y., Xu, J., Duan, Y., Su, N., Sun, Y., Cao, X., Lao, L., Zhang, R.-X., & Xu, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.033 · Cited by 35 · see citing works

A simple reproducible and time saving method of semi-automatic dendrite spine density estimation compared to manual spine counting

Orłowski, D., & Bjarkam, C. R. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.05.009 · Cited by 34 · see citing works

The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors

Yang, L., Xu, T., Zhang, K., Wei, Z., Li, X., Huang, M., Rose, G. M., & Cai, X. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.002 · Cited by 33 · see citing works

Characterization of somatic Ca2+ clearance mechanisms in young and mature hippocampal granule cells

Lee, S. H., Ho, W., & Lee, S. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.03.004 · Cited by 22 · see citing works

Potential roles of NCAM/PSA-NCAM proteins in depression and the mechanism of action of antidepressant drugs

Wędzony, K., Chocyk, A., & Maćkowiak, M. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71507-x · Cited by 21 · see citing works

Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats

Kim, J. Y., Lee, J.-H., Kim, D., Kim, S. M., Koo, J., & Jahng, J. W. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.12044 · Cited by 15 · see citing works

The N‐terminal cytokine binding domain of LIFR is required for CNTF binding and signaling

He, W., Gong, K., Smith, D. K., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.061 · Cited by 10 · see citing works

Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury

Lee, H., Baek, J. Y., Min, H., Cho, I., Yu, S.-W., & Lee, S. J. (2016) · NeuroImmunoModulation · doi:10.1159/000449134 · Cited by 8 · see citing works

The genetics of obesity: From discovery to biology

Loos, R. J. F., & Yeo, G. S. H. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00414-z · Cited by 1,291 · see citing works

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions

Levey, D. F., Stein, M. B., Wendt, F. R., Pathak, G. A., Zhou, H., Aslan, M., Quaden, R., Harrington, K. M., Nuñez, Y. Z., Overstreet, C., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00860-2 · Cited by 422 · see citing works

Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders

Singh, K., Jayaram, M., Kaare, M., Leidmaa, E., Jagomäe, T., Heinla, I., Hickey, M. A., Kaasik, A., Schäfer, M. K., Innos, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41991-8 · Cited by 65 · see citing works

Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428 · see citing works

Differential neurogenesis in the adult rat dentate gyrus: an identifiable zone that consistently lacks neurogenesis

Melvin, N. R., Spanswick, S. C., Lehmann, H., & Sutherland, R. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05363.x · Cited by 8 · see citing works

190. Neurogenesis Inhibits Stress-Responsive Cells in the Ventral Dentate Gyrus

Anacker, C., Luna, V. M., Stevens, G. S., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.209 · Cited by 1 · see citing works

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

Bondolfi, L., Ermini, F., Long, J. M., Ingram, D. K., & Jucker, M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00083-6 · Cited by 264 · see citing works

A combination of running and memantine increases neurogenesis and reduces activation of developmentally-born dentate granule neurons in rats

Cahill, S. P., Martinovic, A., Cole, J. D., Seib, D. R., & Snyder, J. S. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112005 · Cited by 8 · see citing works