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Shared genetics between classes of obesity and psychiatric disorders: A large-scale genome-wide cross-trait analysis

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From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders

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Clinical and Molecular Cytogenetic Characterization of a de novo Interstitial 1p31.1p31.3 Deletion in a Boy with Moderate Intellectual Disability and Severe Language Impairment

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A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of neuronal growth regulator 1 (NEGR1) adhesion protein

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DIgLONs inhibit initiation of neurite outgrowth from forebrain neurons via an IgLON-containing receptor complex

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IgLONs form heterodimeric complexes on forebrain neurons

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Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction

Zhang, Y., Zhang, Q., Yi, Y., Yu, L.-L., Fan, N., Wu, Y., Wang, J., Dang, X., Guo, Y., Li, C., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03052-7 · Cited by 14 · see citing works

Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice

Kaare, M., Jayaram, M., Jagomäe, T., Singh, K., Kilk, K., Mikheim, K., Leevik, M., Leidmaa, E., Varul, J., Nõmm, H., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12121696 · Cited by 12 · see citing works

Key modules and hub genes identified by coexpression network analysis for revealing novel biomarkers for larynx squamous cell carcinoma

Zhang, H., Zhao, X., Wang, M., & Ji, W. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29288 · Cited by 12 · see citing works

Neuronal growth regulator 1 ( NEGR1 ) promotes the synaptic targeting of glutamic acid decarboxylase 65 ( GAD65 )

Su, F., Pfundstein, G., Sah, S. K., Zhang, S., Keable, R., Hagan, D. W., Sharpe, L. J., Clemens, K. J., Begg, D. P., Phelps, E. A., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16279 · Cited by 12 · see citing works

Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity

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OBCAM, an immunoglobulin superfamily cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes

Sugimoto, C., Maékawa, S., & Miyata, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06513.x · Cited by 11 · see citing works

In silico approach to identify non-synonymous SNPs with highest predicted deleterious effect on protein function in human obesity related gene, neuronal growth regulator 1 (NEGR1)

Kumar, P., & Mahalingam, K. (2018) · 3 Biotech · doi:10.1007/s13205-018-1463-0 · Cited by 10 · see citing works

Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands

Lee, J., Kim, S., Lee, B., Kim, Y.-B., Kim, K. H., Chung, G., Lee, S. J., Lee, S., Sun, W., Park, H., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106773 · Cited by 8 · see citing works

Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission

Li, S.-F., Ni, H., Wang, Y., Wu, X., Bi, J., Ou, H., Li, Z., Ping, J.-J., Wang, Z.-J., Chen, R., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03725-0 · Cited by 8 · see citing works

Pathogenic mechanisms in neuronal surface autoantibody-mediated encephalitis

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Proteomic Screen of Brain Glycoproteome Reveals Prion Specific Marker of Pathogenesis

Lamoureux, L., Simon, S. L. R., Waitt, B., & Knox, J. D. (2017) · PROTEOMICS · doi:10.1002/pmic.201700296 · Cited by 8 · see citing works

Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal Dementia

Natarajan, K., Eisfeldt, J., Hammond, M., Patra, K., Laffita‐Mesa, J. M., Andrade‐Talavera, Y., Birtele, M., Öijerstedt, L., Fisahn, A., Parmar, M., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01234-2 · Cited by 7 · see citing works

1p31.1 microdeletion including only NEGR1 gene in two patients

Tassano, E., Uccella, S., Giacomini, T., Fiorio, P., Tavella, E., Malacarne, M., Gimelli, G., Coviello, D. A., & Ronchetto, P. (2020) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2020.103919 · Cited by 7 · see citing works

IgLON5 deficiency produces behavioral alterations in a knockout mouse model

Landa, J., Serafim, A. B., Alba, M., Maudes, E., Molina‐Porcel, L., García‐Serra, A., Mannara, F., Dalmau, J. O., Graus, F., & Sabater, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347948 · Cited by 6 · see citing works

Overexpression of IgLON cell adhesion molecules changes proliferation and cell size of cortical astrocytes

Sugimoto, C., Morita, S., & Miyata, S. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2813 · Cited by 6 · see citing works

Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65)Preprint

Tan, R. P. A., Kozlova, I., Su, F., Sah, S. K., Keable, R., Hagan, D. W., Bustamante, S., Du, X., Osborne, B., Turner, N. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.08.479601 · Cited by 6 · see citing works

A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor

Mialon, M., Patrash, L., Granger, L., Weinreb, A., Özkan, E., Bessereau, J., & Pinan‐Lucarré, B. (2026) · Nature Communications · doi:10.1038/s41467-025-68141-1 · Cited by 5 · see citing works

The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review

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Shared genetic architecture and causal relationship between frailty and schizophrenia

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Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach

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The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development

Habicher, J., Sanvido, I., Bühler, A., Sartori, S., Piccoli, G., & Carl, M. (2024) · Genes · doi:10.3390/genes15030363 · Cited by 4 · see citing works

Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation

Reinsberg, A., Singh, K., Jayaram, M., Mikheim, K., Philips, M., & Vasar, E. (2025) · Brain Sciences · doi:10.3390/brainsci15121286 · Cited by 3 · see citing works

Type 2 diabetes: A side effect of the adaptation of neurons and fat cells to support increased cognitive performance

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Case report: A longitudinal study of an unusual rapidly progressive dementia case

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Lipid Anchors to Proteins

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Anti-IgLON5 Disease

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Functional Analysis of the Anorexia Mouse Mutation

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Faculty Opinions recommendation of Identification of common genetic risk variants for autism spectrum disorder.

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65-jährige Patientin mit respiratorischer Insuffizienz und horizontaler Blickparese

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NEGR1 can influence symptom severity in fluoxetine treated major depression disorder patientsPreprint

Bayoğlu, B., Akdeniz, G., Kocabaşoğlu, N., Poyraz, C. A., Dırıcan, A., & Cengiz, M. (2024) · Research Square · doi:10.21203/rs.3.rs-4421084/v1

Comparative Single-Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices

Ghoddousi, R. A. M., Levitt, P. R., Rady, Z., & Eagleson, K. L. (2025) · Developmental Neuroscience · doi:10.1159/000548617

Exploring the association of age at first sexual intercourse and lifetime number of sexual partners on neurological and psychiatric disorders: An observational and genetic study

Dong, Y., Zhong, J., Wang, J., Liu, X., & Sun, W. (2025) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13908

Cannabidiol alleviates ferroptosis after traumatic brain injury via the miR3203p/Negr1/ERK signaling axis

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A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals

Wang, M. H., Zhang, Y., Sun, R., Li, F., Zhang, T., Gu, X., Lou, J., Cao, L., Su, S., Zheng, H., et al. (2026) · Human Genetics · doi:10.1007/s00439-026-02887-6

Biochemical and ultrastructural analyses of iglon cell adhesion molecules, kilon and obcam in the rat brain

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IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons

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Untitled work

(2000) · doi:10.1002/1098-1063(2000)10:6

IgLON adhesion molecules participate in synapse formation of hippocampal neurons

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Characterization of a Novel Rat Brain Glycosylphosphatidylinositol-anchored Protein (Kilon), a Member of the IgLON Cell Adhesion Molecule Family

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