Circumventricular organs: A novel site of neural stem cells in the adult brain
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Neurogenesis in the adult mammalian nervous system is now well established in the subventricular zone of the anterolateral ventricle and subgranular zone of the hippocampus. In these regions, neurons are thought to arise from neural stem cells, identified by their expression of specific intermediate filament proteins (nestin, vimentin, GFAP) and transcription factors (Sox2). In the present study, we show that in adult rat and mouse, the circumventricular organs (CVOs) are rich in nestin+, GFAP+, vimentin+ cells which express Sox2 and the cell cycle-regulating protein Ki67. In culture, these cells proliferate as neurospheres and express neuronal (doublecortin+, beta-tubulin III+) and glial (S100beta+, GFAP+, RIP+) phenotypic traits. Further, our in vivo studies using bromodeoxyuridine show that CVO cells proliferate and undergo constitutive neurogenesis and gliogenesis. These findings suggest that CVOs may constitute a heretofore unknown source of stem/progenitor cells, capable of giving rise to new neurons and/or glia in the adult brain.
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This corroborates findings indicating the existence of neural stem cells in the OVLT, SFO, ME and AP.
“which corroborates findings indicating the existence of neural stem cells in the OVLT, SFO, ME and AP78–81.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [78]
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- Authors
- Bennett, L., Yang, M., Enikolopov, G., & Iacovitti, L.
- Affiliations
- Thomas Jefferson University (US)
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Iacovitti, Lorraine
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 41
- Issue
- 3
- Pages
- 337-347
- ISSN
- 1044-7431 (ISSN-L)
- PMC
- PMC2697272
- OpenAlex
- W2006340543
- Cited by
- 186
- References
- 56
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 15 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 15 · 2019: 8 · 2018: 10 · 2017: 15 · 2016: 9 · 2015: 16 · 2014: 13 · 2013: 12 · 2012: 9
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS043309, NS32519, R01NS032519, NS43309)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- circumventricular organs, adult neurogenesis, neural stem cells, stem/progenitor cells, nestin, glial fibrillary acidic protein, vimentin, SOX2, Ki-67, neurospheres, gliogenesis, subventricular zone, subgranular zone, intermediate filament proteins
- MeSH terms
- Doublecortin Protein, Animals, Cell Differentiation, Female, Glial Fibrillary Acidic Protein, Intermediate Filament Proteins, Male, Nerve Tissue Proteins, Neurons, Vimentin, Biomarkers, Cell Culture Techniques, Ki-67 Antigen, Third Ventricle, Fourth Ventricle, Cell Proliferation, Mice, Rats, Adult Stem Cells, Neurogenesis, SOXB1 Transcription Factors, Nestin
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