Characterization of neural stem cells and their progeny in the sensory circumventricular organs of adult mouse
Abstract
Although evidence has accumulated that neurogenesis and gliogenesis occur in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, recent studies indicate the presence of neural stem cells (NSCs) in adult brains, particularly the circumventricular regions. In the present study, we aimed to determine characterization of NSCs and their progenitor cells in the sensory circumventricular organs (CVOs), including organum vasculosum of the lamina terminalis, subfornical organ, and area postrema of adult mouse. There were two types of NSCs: tanycyte-like ependymal cells and astrocyte-like cells. Astrocyte-like NSCs proliferated slowly and oligodendrocyte progenitor cells (OPCs) and neural progenitor cells (NPCs) actively divided. Molecular marker protein expression of NSCs and their progenitor cells were similar to those reported in the SVZ and SGZ, except that astrocyte-like NSCs expressed S100β. These circumventricular NSCs possessed the capacity to give rise to oligodendrocytes and sparse numbers of neurons and astrocytes in the sensory CVOs and adjacent brain regions. The inhibition of vascular endothelial growth factor (VEGF) signaling by using a VEGF receptor-associated tyrosine kinase inhibitor AZD2171 largely suppressed basal proliferation of OPCs. A single systemic administration of lipopolysaccharide attenuated proliferation of OPCs and induced remarkable proliferation of microglia. The present study indicates that sensory circumventricular NSC…
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This corroborates findings indicating the existence of neural stem cells in the OVLT, SFO, ME and AP.
“which corroborates findings indicating the existence of neural stem cells in the OVLT, SFO, ME and AP78–81.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [79]
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · see citing works
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969 · see citing works
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909 · see citing works
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works
Donato, R., Cannon, B. R., Sorci, G., Riuzzi, F., Hsu, K., Weber, D. J., & Geczy, C. L. (2012) · Current Molecular Medicine · doi:10.2174/156652413804486214 · Cited by 1,319 · see citing works
Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis
Weiss, S., Dunne, C., Hewson, J., Wohl, C. A., Wheatley, M., Peterson, A. C., & Reynolds, B. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07599.1996 · Cited by 1,219 · see citing works
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015 · see citing works
Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1425 · Cited by 971 · see citing works
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961 · see citing works
Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension
Curtis, M. A., Kam, M., Nannmark, U., Anderson, M. F., Axell, M. Z., Wikkelsø, C., Holtås, S., van Roon‐Mom, W., Björk‐Eriksson, T., Nordborg, C., et al. (2007) · Science · doi:10.1126/science.1136281 · Cited by 887 · see citing works
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 872 · cited 2× · see citing works
“It has been predicted that multipotent stem-like cells are present at ependymal layers in the third (Weiss et al. 1996; Xu et al. 2005) and fourth ventricle (Martens et al. 2002; Weiss et al. 1996) of adult brains and the central canal of the adult spinal cord (Martens et al. 2002; Weiss et al.…”
BackgroundMethodInfluentialRegulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843 · see citing works
Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance
Kokoeva, M. V., Yin, H., & Flier, J. S. (2005) · Science · doi:10.1126/science.1115360 · Cited by 704 · see citing works
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3079 · Cited by 502 · see citing works
LAFLAMME, N., & RIVEST, S. (2001) · The FASEB Journal · doi:10.1096/fj.00-0339com · Cited by 501 · see citing works
Hypothalamic tanycytes: a key component of brain-endocrine interaction
RODRIGUEZ, E., BLAZQUEZ, J., PASTOR, F., PELAEZ, B., PENA, P., PERUZZO, B., & AMAT, P. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)47003-5 · Cited by 475 · cited 1× · see citing works
“Tanycytes in the third ventricle are special ependymal cells that have long cellular processes extending into the hypothalamus and can transport macromolecules between the blood and cerebrospinal fluid compartments (Rodríguez et al. 2005; Mullier et al. 2010).”
BackgroundThe life, death, and replacement of oligodendrocytes in the adult CNS
McTigue, D. M., & Tripathi, R. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05570.x · Cited by 455 · see citing works
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works
Central neurocircuitry associated with emesis
Hornby, P. J. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00849-x · Cited by 431 · see citing works
Chakravarty, S., & Herkenham, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4268-04.2005 · Cited by 396 · see citing works
Pastrana, É., Cheng, L.-C., & Doetsch, F. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810407106 · Cited by 381 · see citing works
Shanks, N., Windle, R. J., Perks, P. A., Harbuz, M. S., Jessop, D. S., Ingram, C. D., & Lightman, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090571897 · Cited by 374 · see citing works
Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons
Marín‐Burgin, A., Mongiat, L. A., Pardi, M. B., & Schinder, A. F. (2012) · Science · doi:10.1126/science.1214956 · Cited by 367 · see citing works
Kawamoto, S., Niwa, H., Tashiro, F., Sano, S., Kondoh, G., Takeda, J., Tabayashi, K., & Miyazaki, J. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01338-7 · Cited by 351 · see citing works
Mullier, A., Bouret, S. G., Prevot, V., & Dehouck, B. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22273 · Cited by 334 · see citing works
Neurogenesis in the ependymal layer of the adult rat 3rd ventricle
Xu, Y., Tamamaki, N., Noda, T., Kimura, K., Itokazu, Y., Matsumoto, N., Dezawa, M., & Idé, C. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.12.021 · Cited by 331 · see citing works
Halbach, O. V. B. U. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1196-4 · Cited by 314 · see citing works
Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
McNay, D. E. G., Briançon, N., Kokoeva, M. V., Maratos–Flier, E., & Flier, J. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43134 · Cited by 312 · see citing works
Kojima, T., Hirota, Y., Ema, M., Takahashi, S., Miyoshi, I., Okano, H., & Sawamoto, K. (2010) · Stem Cells · doi:10.1002/stem.306 · Cited by 307 · see citing works
Robins, S. C., Stewart, I., McNay, D. E., Taylor, V., Giachino, C., Goetz, M., Ninkovic, J., Briancon, N., Maratos-Flier, E., Flier, J. S., et al. (2013) · Nature Communications · doi:10.1038/ncomms3049 · Cited by 306 · see citing works
Langlet, F., Mullier, A., Bouret, S. G., Prevot, V., & Dehouck, B. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23355 · Cited by 295 · see citing works
Kerever, A., Schnack, J., Vellinga, D., Ichikawa, N., Moon, C., Arikawa‐Hirasawa, E., Efird, J. T., & Mercier, F. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0082 · Cited by 287 · see citing works
Martens, D. J., Seaberg, R. M., & van der Kooy, D. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02181.x · Cited by 237 · see citing works
Neural progenitor cells regulate microglia functions and activity
Mosher, K. I., Andres, R. H., Fukuhara, T., Bieri, G., Hasegawa‐Moriyama, M., He, Y., Guzman, R. G., & Wyss‐Coray, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3233 · Cited by 218 · see citing works
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses
Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K., & Kageyama, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018782108 · Cited by 198 · see citing works
Migaud, M., Batailler, M., Segura, S., Duittoz, A. H., Franceschini, I., & Pillon, D. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07521.x · Cited by 194 · see citing works
Nestin in central nervous system cells
Gilyarov, A. V. (2008) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-008-0025-z · Cited by 190 · see citing works
Circumventricular organs: A novel site of neural stem cells in the adult brain
Bennett, L., Yang, M., Enikolopov, G., & Iacovitti, L. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.007 · Cited by 186 · see citing works
Nax channel involved in CNS sodium-level sensing
Hiyama, T. Y., Watanabe, E., Ono, K., Inenaga, K., Tamkun, M. M., Yoshida, S., & Noda, M. (2002) · Nature Neuroscience · doi:10.1038/nn0602-856 · Cited by 180 · see citing works
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Bras, B. L., Barallobre, M. J., Homman‐Ludiye, J., Ny, A., Wyns, S., Tammela, T., Haiko, P., Karkkainen, M. J., Yuan, L., Muriel, M., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1646 · Cited by 177 · see citing works
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesisPreprint
Calvo, C.-F., Fontaine, R. H., Soueid, J., Tammela, T., Makinen, T., Alfaro-Cervello, C., Bonnaud, F., Miguez, A., Benhaim, L., Xu, Y., et al. (2011) · Genes & Development · doi:10.1101/gad.615311 · Cited by 169 · see citing works
Vascular Endothelial Growth Factor Regulates the Migration of Oligodendrocyte Precursor Cells
Hayakawa, K., Pham, L. A. T., Som, A. T., Lee, B. J., Guo, S., Lo, E. H., & Arai, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1944-11.2011 · Cited by 146 · see citing works
Xiong, Z., O'Hanlon, D., Becker, L. E., et al. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4902 · Cited by 120 · see citing works
Morita, S., & Miyata, S. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1421-9 · Cited by 112 · see citing works
Self-citationLin, R., Cai, J., Nathan, C. L., Wei, X., Schleidt, S. S., Rosenwasser, R. H., & Iacovitti, L. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.11.016 · Cited by 106 · see citing works
Prévot, V., Bellefontaine, N., Baroncini, M., Sharif, A., Hanchate, N. K., Parkash, J., Campagne, C., & Seranno, S. D. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02033.x · Cited by 105 · see citing works
Batailler, M., Droguerre, M., Baroncini, M., Fontaine, C., Prévot, V., & Migaud, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23514 · Cited by 101 · see citing works
Activity‐related, dynamic neuron‐glial interactions in the hypothalamo‐neurohypophysial system
Miyata, S., & Hatton, G. I. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10012 · Cited by 98 · see citing works
Self-citationWatanabe, E., Hiyama, T. Y., Shimizu, H., Kodama, R., Hayashi, N., Miyata, S., Yanagawa, Y., Obata, K., & Noda, M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00618.2005 · Cited by 93 · see citing works
Self-citationHarré, E. ‐., Roth, J., Pehl, U., Kueth, M., Gerstberger, R., & Hübschle, T. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00822.2001 · Cited by 82 · see citing works
Gautron, L., Lafon, P., Chaigniau, M., Tramu, G., & Layé, S. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00115-x · Cited by 77 · see citing works
Miyata, S., Takamatsu, H., Maekawa, S., Matsumoto, N., Watanabe, K., Kiyohara, T., & Hatton, G. I. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1184 · Cited by 72 · see citing works
Self-citationRummel, C. D., Voß, T., Matsumura, K., Korte, S., Gerstberger, R., Roth, J., & Hübschle, T. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20653 · Cited by 71 · see citing works
Genetic Methods to Identify and Manipulate Newly Born Neurons in the Adult Brain
Imayoshi, I., Sakamoto, M., & Kageyama, R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00064 · Cited by 70 · see citing works
Nakano, Y., Furube, E., Morita, S., Wanaka, A., Nakashima, T., & Miyata, S. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.12.013 · Cited by 67 · see citing works
Self-citationMannari, T., Morita, S., Furube, E., Tominaga, M., & Miyata, S. (2013) · Glia · doi:10.1002/glia.22488 · Cited by 65 · see citing works
Self-citationBain, J., Moore, L., Ren, Z., Simonishvili, S., & Levison, S. W. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0213-6 · Cited by 61 · see citing works
Lieblein‐Boff, J. C., McKim, D. B., Shea, D. T., Wei, P. Y., Deng, Z., Sawicki, C. M., Quan, N., Bilbo, S. D., Bailey, M. T., McTigue, D. M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0708-13.2013 · Cited by 57 · see citing works
Developmental roles for Homer: more than just a pretty scaffold
Foa, L. C., & Gasperini, R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05726.x · Cited by 52 · see citing works
Neurogenesis in the circumventricular organs of adult mouse brains
Hourai, A., & Miyata, S. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23206 · Cited by 50 · see citing works
Self-citationExistence of a potential neurogenic system in the adult human brain
Nogueira, A. B., Sogayar, M. C., Colquhoun, A., Siqueira, S. A. C., Nogueira, A. B., Marchiori, P. E., & Teixeira, M. J. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-75 · Cited by 48 · see citing works
Retentive Multipotency of Adult Dorsal Root Ganglia Stem Cells
Singh, R. P., Cheng, Y., Nelson, P. B., & Zhou, F. (2009) · Cell Transplantation · doi:10.3727/096368909788237177 · Cited by 48 · see citing works
Morita, S., Furube, E., Mannari, T., Okuda, H., Tatsumi, K., Wanaka, A., & Miyata, S. (2015) · Cell and Tissue Research · doi:10.1007/s00441-014-2080-9 · Cited by 45 · see citing works
Self-citationFurube, E., Mannari, T., Morita, S., Nishikawa, K., Yoshida, A., Itoh, M., & Miyata, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0075 · Cited by 44 · see citing works
Self-citationSanin, V., Heeß, C., Kretzschmar, H. A., & Schüller, U. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01301.x · Cited by 44 · see citing works
Integration of thermal and osmotic regulation of water homeostasis: the role of TRPV channels
Sladek, C. D., & Johnson, A. K. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00270.2013 · Cited by 44 · see citing works
Harré, E. ‐., Roth, J., Gerstberger, R., & Hübschle, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02923-8 · Cited by 41 · see citing works
VEGF ‐dependent continuous angiogenesis in the median eminence of adult mice
Morita, S., Ukai, S., & Miyata, S. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12047 · Cited by 36 · see citing works
Self-citationMorita, S., & Miyata, S. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.2953 · Cited by 35 · see citing works
Self-citationWennström, M., Janelidze, S., Bay-Richter, C., Minthon, L., & Brundin, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109387 · Cited by 35 · see citing works
Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus
Taniguchi, Y., Inoue, N., Morita, S., Nikaido, Y., Nakashima, T., Nagai, N., Okada, K., Matsuo, O., & Miyata, S. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1110-5 · Cited by 30 · see citing works
Self-citationKim, J. H., Yu, K. S., Jeong, J. H., Lee, N. S., Lee, J., Jeong, Y. G., Yoo, Y. C., & Han, S. Y. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1178-x · Cited by 26 · see citing works
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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
Morita, S., Furube, E., Mannari, T., Okuda, H., Tatsumi, K., Wanaka, A., & Miyata, S. (2016) · Cell and Tissue Research · doi:10.1007/s00441-015-2207-7 · Cited by 88 · see citing works
Self-citationGuerra, M. M., González, C., Caprile, T., Jara, M., Vío, K., Muñoz, R. I., Rodríguez, S., & Rodríguez, E. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00480 · Cited by 65 · see citing works
Glial functions in the blood-brain communication at the circumventricular organs
Miyata, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.991779 · Cited by 66 · see citing works
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- Authors
- Furube, E., Morita, M., & Miyata, S.
- Affiliations
- Kyoto Institute of Technology (JP)
- Kobe University (JP)
- Corresponding author
- Miyata, Seiji
- Venue
- Cell and Tissue Research
- Published
- 2015-05-21
- Volume
- 362
- Issue
- 2
- Pages
- 347-365
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W252226765
- Cited by
- 47
- References
- 80
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 4
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26430071)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- neural stem cells, organum vasculosum of the lamina terminalis, subfornical organ, area postrema, adult neurogenesis, gliogenesis, oligodendrocyte precursor cells, neural progenitor cells, S100β, VEGF signaling, AZD2171, lipopolysaccharide, microglial proliferation, subventricular zone, subgranular zone
- MeSH terms
- Animals, Astrocytes, Brain, Male, Mice, Inbred C57BL, Neurons, Oligodendroglia, Vascular Endothelial Growth Factor A, Neurogenesis, Neural Stem Cells, Circumventricular Organs
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