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Cited by 65Neurogenesis and neuroplasticity mechanismsCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis

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Guerra, Maria M., González, César, Caprile, Teresa, Jara, Maryoris, Vío, Karin, Muñoz, Rosa I., Rodríguez, Sara, Rodríguez, Esteban M.·2015·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2015.00480PMC PMC4689152
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Abstract

The dynamic and molecular composition of the cerebrospinal fluid (CSF) and, consequently, the CSF physiology is much more complex and fascinating than the simplistic view held for decades. Signal molecules either transported from blood to CSF or secreted into the CSF by circumventricular organs and CSF-contacting neurons, use the CSF to reach their targets in the brain, including the pre- and postnatal neurogenic niche. The subcommissural organ (SCO), a highly conserved brain gland present throughout the vertebrate phylum, is one of the sources for signals, as well as the choroid plexus, tanycytes and CSF-contacting neurons. The SCO secretes into the fetal and adult CSF SCO-spondin, transthyretin, and basic fibroblast growth factor. These proteins participate in certain aspects of neurogenesis, such as cell cycle of neural stem cells, neuronal differentiation, and axon pathfinding. Through the CSF, the SCO-secretory proteins may reach virtually any target in the embryonic and adult central nervous system. Since the SCO continues to secrete throughout life span, it seems likely that the neurogenetic property of the SCO compounds would be targeted to the niches where neurogenesis continues in adulthood. This review is aimed to bring into discussion early and new evidence concerning the role(s) of the SCO, and the probable mechanisms by which SCO compounds can readily reach the neurogenic niche of the subventricular zone flowing with the CSF to participate in the regulation of the neurogenic niche. As we unfold the multiples trans-fluid talks between discrete brain domains we will have more tools to influence such talks.

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  • The study identified tanycyte-like ependymal cell clusters specifically located in other CVOs: cluster 5243 in SFO, 5244 in OV, 5240 in AP, and hypendymal cell cluster 5263 in SCO.

    “We also identified tanycyte-like ependymal cell clusters that are specifically located in other CVOs (Fig. 4c): cluster 5243 in the subfornical organ (SFO), 5244 in the vascular organ of the lamina terminalis (OV (also known as OVLT)), 5240 in area postrema (AP), and the hypendymal cell cluster 5263 (marked by Sspo) (Extended Data Fig. 11e) in the subcommissural organ77 (SCO).”

    From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [77]

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Research works printed but not linked: 6

  1. Jara M. Rodríguez S. Salazar P. Jara C. Guerra M. Johanson C. (2014). “Subcommissural organ (SCO) explants grafted into hydrocephalic HTx rats secrete glycoproteins into the host cerebrospinal fluid,” in Proceedings of the 58 th Annual Meeting of Society of Research into Hydrocephalus and Spina Bifida June 25-28 Upsala.
  2. Leonhardt H. (1980). “Ependym und circumventricula¨ re organe,” in Neuroglia I. Handbuch der Mikroskopischen Anatomie des Menschen Part IV Vol. 10 eds Oksche A. Vollrath L. (Berlin: Springer Verlag) 177– 665.
  3. Meiniel A. (2001). SCO-spondin. A glycoprotein of the subcommissural organ/Reissner’s fiber complex: evidence of a potent activity on neuronal development in primary cell cultures. Microsc. Res. Tech. 52 484– 495. 10.1002/1097-0029(20010301)52:5<484::AID-JEMT1034>3.0.CO;2-0 11241859 · DOI
  4. Montecinos H. (1995). Identification of a Cerebrospinal Fluid-Specific Glycoprotein Probably Secreted by the Human Subcommissural Organ. M.Sc. thesis, Universidad Austral de Chile Valdivia.
  5. Rodríguez E. M. Oksche A. Montecinos H. (2001). Human subcommissural organ, with particular emphasis on its secretory activity during the fetal life. Microsc. Res. Tech. 52 573– 590. 10.1002/1097-0029(20010301)52:5<573::AID-JEMT1042>3.0.CO;2-6 11241867 · DOI
  6. Schöebitz K. Gonzalez C. Peruzzo B. Yulis C. R. Rodríguez E. M. (2001). Organ culture of the bovine subcommissural organ: evidence for synthesis and release of the secretory material. Microsc. Res. Tech. 52 496– 509. 10.1002/1097-0029(20010301)52:5<496::AID-JEMT1035>3.3.CO;2-I 11241860 · DOI

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Authors
Guerra, M. M., González, C., Caprile, T., Jara, M., Vío, K., Muñoz, R. I., Rodríguez, S., & Rodríguez, E. M.
Affiliations
  • Austral University of Chile (CL)
  • University of Concepción (CL)
Corresponding author
Rodríguez, Esteban M.
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2015-12-23
Volume
9
Pages
480-480
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2015.00480
PMC
PMC4689152
OpenAlex
W2191531305
Cited by
65
References
139
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 2
FWCI
0.59
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Universidad de Concepción
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
subcommissural organ, cerebrospinal fluid, neurogenesis, prealbumin, basic fibroblast growth factor, choroid plexus, tanycytes, subventricular zone, adult neurogenesis, neural stem cells, neuronal differentiation, axon guidance, circumventricular organs

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