The DOI matches its Crossref record; 126 of the 129 references it cites were found in a registry or an index.
A three-step model for the synaptic recruitment of AMPA receptors
Abstract
The amount of AMPARs at synapses is not a fixed number but varies according to different factors including synaptic development, activity and disease. Because the number of AMPARs sets the strength of synaptic transmission, their trafficking is subject to fine and tight regulation. In this review, we will describe the different steps taken by AMPARs in order to reach the synapse. We propose a three-step mechanism involving exocytosis at extra/perisynaptic sites, lateral diffusion to synapses and a subsequent rate-limiting diffusional trapping step. We will describe how the different trafficking steps are regulated during synaptic plasticity or altered during neurodegenerative diseases such as Alzheimer's.
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“The postsynaptic density is believed to regulate the number of glutamate receptors localized in the synapse and thereby preventing their diffusion out of the spine (Opazo and Choquet, 2011).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Opazo and Choquet, 2011
In the citing paper
“Mushroom shaped spines were found to retain AMPA receptors in the vicinity of the synapse for an increased period of time (Ashby et al., 2006; Ehlers et al., 2007; Opazo and Choquet, 2011, see Figure 3A).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Opazo and Choquet, 2011
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Cites
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Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
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Learning induces long-term potentiation in the hippocampus
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The molecular basis of CaMKII function in synaptic and behavioural memory
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PDZ domain proteins of synapses
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Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968
Seminars in Cell & Developmental Biology
Lee, H., & Kirkwood, A. (2011) · Cited by 692
Choquet, D., & Triller, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.013 · Cited by 560
Self-citationStructural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins
Greger, I. H., Watson, J. F., & Cull-Candy, S. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.009 · Cited by 392
Metadata
- Authors
- Opazo, P., & Choquet, D.
- Affiliations
- Université de Bordeaux (FR)
- Corresponding author
- Choquet, Daniel
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 46
- Issue
- 1
- Pages
- 1-8
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2090714277
- Cited by
- 190
- References
- 129
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 18 · 2019: 3 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 14 · 2014: 17 · 2013: 21 · 2012: 21
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- AMPA receptors, receptor trafficking, exocytosis, lateral diffusion, synaptic plasticity, Alzheimer's disease, synaptic transmission
- MeSH terms
- Alzheimer Disease, Animals, Exocytosis, Humans, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Long-Term Potentiation, Receptors, AMPA
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