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A three-step model for the synaptic recruitment of AMPA receptors
Abstract
The amount of AMPARs at synapses is not a fixed number but varies according to different factors including synaptic development, activity and disease. Because the number of AMPARs sets the strength of synaptic transmission, their trafficking is subject to fine and tight regulation. In this review, we will describe the different steps taken by AMPARs in order to reach the synapse. We propose a three-step mechanism involving exocytosis at extra/perisynaptic sites, lateral diffusion to synapses and a subsequent rate-limiting diffusional trapping step. We will describe how the different trafficking steps are regulated during synaptic plasticity or altered during neurodegenerative diseases such as Alzheimer's.
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“The postsynaptic density is believed to regulate the number of glutamate receptors localized in the synapse and thereby preventing their diffusion out of the spine (Opazo and Choquet, 2011).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Opazo and Choquet, 2011
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“Mushroom shaped spines were found to retain AMPA receptors in the vicinity of the synapse for an increased period of time (Ashby et al., 2006; Ehlers et al., 2007; Opazo and Choquet, 2011, see Figure 3A).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Opazo and Choquet, 2011
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Extrasynaptic AMPA receptors in the dorsal horn: Evidence and functional significance
Kopach, O., & Voitenko, N. V. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.11.004 · Cited by 23
Gao, M., Ji, S., Li, J., & Zhang, S. (2019) · Neurological Research · doi:10.1080/01616412.2019.1672387 · Cited by 24
Metadata
- Authors
- Opazo, P., & Choquet, D.
- Affiliations
- Université de Bordeaux (FR)
- Corresponding author
- Choquet, Daniel
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 46
- Issue
- 1
- Pages
- 1-8
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2090714277
- Cited by
- 190
- References
- 129
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 18 · 2019: 3 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 14 · 2014: 17 · 2013: 21 · 2012: 21
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- AMPA receptors, receptor trafficking, exocytosis, lateral diffusion, synaptic plasticity, Alzheimer's disease, synaptic transmission
- MeSH terms
- Alzheimer Disease, Animals, Exocytosis, Humans, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Long-Term Potentiation, Receptors, AMPA
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