Cited by 190Neuroscience and Neuropharmacology ResearchCellular transport and secretionAlzheimer's disease research and treatments

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A three-step model for the synaptic recruitment of AMPA receptors

Opazo, Patricio, Choquet, Daniel·2011·Molecular and Cellular Neuroscience

DOI 10.1016/j.mcn.2010.08.014

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Abstract

The amount of AMPARs at synapses is not a fixed number but varies according to different factors including synaptic development, activity and disease. Because the number of AMPARs sets the strength of synaptic transmission, their trafficking is subject to fine and tight regulation. In this review, we will describe the different steps taken by AMPARs in order to reach the synapse. We propose a three-step mechanism involving exocytosis at extra/perisynaptic sites, lateral diffusion to synapses and a subsequent rate-limiting diffusional trapping step. We will describe how the different trafficking steps are regulated during synaptic plasticity or altered during neurodegenerative diseases such as Alzheimer's.

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(1999) · doi:10.1002/1531-8249(199912)46:6

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Authors: Opazo, P., & Choquet, D.
Affiliations: Université de Bordeaux (FR)
Corresponding author: Choquet, Daniel
ORCID: Opazo, Patricio
Choquet, Daniel
Venue: Molecular and Cellular Neuroscience
Publisher: Elsevier BV
Published: 2011-01
Volume: 46
Issue: 1
Pages: 1-8
ISSN: 1044-7431 (ISSN-L)
DOI: 10.1016/j.mcn.2010.08.014
OpenAlex: W2090714277
Cited by: 190
References: 129
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 18 · 2019: 3 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 14 · 2014: 17 · 2013: 21 · 2012: 21
FWCI: 1.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: AMPA receptors, receptor trafficking, exocytosis, lateral diffusion, synaptic plasticity, Alzheimer's disease, synaptic transmission
MeSH terms: Alzheimer Disease, Animals, Exocytosis, Humans, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Long-Term Potentiation, Receptors, AMPA

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A three-step model for the synaptic recruitment of AMPA receptors

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