The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Drug-induced liver injury: a comprehensive review
Abstract
Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. Although it has a low incidence amongst the general population, DILI accounts for most cases of acute liver failure with a fatality rate of up to 50%. While multiple mechanisms of DILI have been postulated, there is no clear causal relationship between drugs, risk factors and mechanisms of DILI. Current best practice relies on a combination of high clinical suspicion, thorough clinical history of risk factors and timeline, and extensive hepatological investigations as supported by the international Roussel Uclaf Causality Assessment Method criteria, the latter considered a key diagnostic algorithm for DILI. This review focuses on DILI classification, risk factors, clinical evaluation, future biomarkers and management, with the aim of facilitating physicians to correctly identify DILI early in presentation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RUCAM is considered a key diagnostic tool for DILI.
“These are guided by the standards of the internationally recognized Roussel Uclaf Causality Assessment Method, which is considered a key diagnostic tool for DILI [11].”
From Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM (2023) · cites this paper as [11]
DILI accounts for approximately 10-15% of acute liver failure cases.
“DILI accounts for approximately 10–15% of the cases of acute liver failure (ALF) and presents a major challenge for drug safety and development.[1]”
From Drug-induced liver injury: Diagnosis, management and the role of liver transplantation (2025) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Early indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085
EASL Clinical Practice Guidelines: Drug-induced liver injury
Andrade, R. J., Aithal, G. P., Björnsson, E. S., Kaplowitz, N., Kullak-Ublick, G. A., Larrey, D., & Karlsen, T. H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.014 · Cited by 1,276
Björnsson, E. S., Bergmann, O. M., Björnsson, H. K., Kvaran, R. B., & Olafsson, S. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.006 · Cited by 865
Drug-Induced Acute Liver Failure: Results of a U.S. Multicenter, Prospective Study
Reuben, A., Koch, D. G., & Lee, W. M. (2010) · Hepatology · doi:10.1002/hep.23937 · Cited by 772
Chen, M., Suzuki, A., Thakkar, S., Yu, K., Hu, C., & Tong, W. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.02.015 · Cited by 398
Risk Factors for Idiosyncratic Drug-Induced Liver Injury
Chalasani, N., & Björnsson, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.001 · Cited by 347
Acute Liver Failure Including Acetaminophen Overdose
Fontana, R. J. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.03.005 · Cited by 249
A revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, P. H., Lucena, M. I., Fontana, R. J., Bjornsson, E. S., Aithal, G. P., Barnhart, H., Gonzalez‐Jimenez, A., Yang, Q., Gu, J., Andrade, R. J., et al. (2022) · Hepatology · doi:10.1002/hep.32327 · Cited by 160
Flagged first, then by citations
Research works printed but not linked: 65
- 10.1053/jhep.2002.34857 · DOI · Paper page
- 10.1016/j.cld.2013.07.001 · DOI
- 10.1038/ajg.2014.131 · DOI · Paper page
- 10.1038/ajg.2017.98 · DOI · Paper page
- 10.1111/liv.12988 · DOI
- 10.1016/0895-4356(93)90101-6 · DOI · Paper page
- 10.1016/0895-4356(93)90102-7 · DOI · Paper page
- 10.7861/clinmedicine.16-6-s104 · DOI
- 10.4254/wjh.v6.i4.160 · DOI · Paper page
- 10.1016/j.gastro.2005.05.006 · DOI · Paper page
- 10.3390/ijms17010014 · DOI · Paper page
- 10.1111/j.1365-2125.2012.04395.x · DOI
- Lin NH, 2019, Medicine (Baltimore), 98
- 10.1055/s-0029-1240002 · DOI
- 10.2165/00148581-200709030-00008 · DOI
- 10.1212/WNL.46.2.465 · DOI
- 10.1212/WNL.47.6.1608 · DOI
- 10.1053/bega.2001.0249 · DOI
- 10.1002/hep.1840090222 · DOI
- 10.2165/00003088-200544010-00002 · DOI
- 10.1055/s-2002-30105 · DOI
- 10.3390/ijms17050714 · DOI
- 10.1053/j.gastro.2015.03.006 · DOI · Paper page
- 10.1002/hep.22895 · DOI · Paper page
- 10.1124/dmd.113.056267 · DOI · Paper page
- 10.3390/ijms22073441 · DOI
- 10.1124/dmd.114.059311 · DOI
- 10.1002/hep.26208 · DOI · Paper page
- 10.1093/ntr/nts145 · DOI
- 10.18632/oncotarget.4400 · DOI
- 10.1002/hep.28678 · DOI
- 10.3390/ijms18071335 · DOI
- 10.1021/tx1000865 · DOI
- 10.1016/j.tox.2014.03.009 · DOI
- 10.1021/tx300075j · DOI
- 10.1093/toxsci/kfn109 · DOI
- 10.1136/bmj.3.5765.18 · DOI
- 10.1053/j.gastro.2011.04.001 · DOI · Paper page
- 10.1002/hep.26077 · DOI
- 10.1002/hep.32440 · DOI
- 10.1002/hep.29195 · DOI
- 10.1111/liv.13174 · DOI
- 10.1002/hep.28945 · DOI
- 10.3390/ijms21010212 · DOI · Paper page
- 10.3389/fphar.2018.00699 · DOI
- 10.1001/jama.1982.03320420050032 · DOI
- 10.1016/j.ajem.2005.12.025 · DOI
- 10.3389/fphar.2022.876868 · DOI
- 10.1053/j.gastro.2009.06.006 · DOI · Paper page
- 10.1111/liv.13538 · DOI
- 10.1002/hep.26678 · DOI
- 10.1634/theoncologist.2018-0174 · DOI
- 10.1177/1758835919830826 · DOI
- 10.1016/j.jaut.2020.102514 · DOI
- 10.1007/s40264-021-01109-4 · DOI
- 10.1053/j.gastro.2020.08.063 · DOI
- 10.1016/j.ejca.2017.05.018 · DOI
- 10.1016/S0168-8278(05)80563-X · DOI
- 10.1111/liv.12632 · DOI
- 10.1111/j.1872-034X.2008.00427.x · DOI
- 10.1053/jhep.2001.22172 · DOI
- Biolato M, 2017, Eur Rev Med Pharmacol Sci, 21, 37
- 10.1111/j.1365-2796.2007.01818.x · DOI
- 10.1016/j.jhep.2012.03.017 · DOI
- 10.7326/0003-4819-137-12-200212170-00007 · DOI · Paper page
Cited by
Sorted by citations
Drug induced liver injury – a 2023 update
Allison, R., Guraka, A., Shawa, I. T., Tripathi, G., Moritz, W., & Kermanizadeh, A. (2023) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2023.2261848 · Cited by 167
Andújar-Vera, F., Alés-Palmer, M. L., Muñoz-de-Rueda, P., Iglesias-Baena, I., & Ocete-Hita, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713562 · Cited by 10
Drug-induced liver injury: Diagnosis, management and the role of liver transplantation
Ozturk, N. B., Uskudar, E., Toruner, M. D., Simsek, C., & Gurakar, A. (2025) · Hepatology Forum · doi:10.14744/hf.2024.2024.0003 · Cited by 9
Suenghataiphorn, T., Danpanichkul, P., Tribuddharat, N., & Kulthamrongsri, N. (2025) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2025.102627 · Cited by 6
Metadata
- Authors
- Hosack, T., Damry, D., & Biswas, S.
- Venue
- Therapeutic Advances in Gastroenterology
- Publisher
- SAGE Publications
- Published
- 2023-01
- Volume
- 16
- ISSN
- 1756-2848
- PMC
- PMC10031606
- Cited by
- 214
- References
- 8
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
